ライフサイエンスコーパス: dietary restriction

1 oid hormone signalling), and eat-2 (putative dietary restriction).

2 of long-lived eat-2 mutant worms, a model of dietary restriction.

3 germline signalling, sensory perception, or dietary restriction.

4 ons, including mitochondrial dysfunction and dietary restriction.

5 m line largely insensitive to the effects of dietary restriction.

6 echanism by which SIRT3 regulates IDH2 under dietary restriction.

7 therefore does not explain the responses to dietary restriction.

8 athways that reveal a more genetic basis for dietary restriction.

9 ing full feeding and limits fecundity during dietary restriction.

10 p-7 and cup-4 mediate longevity increases by dietary restriction.

11 pan in Caenorhabditis elegans in response to dietary restriction.

12 n-like growth factor 1 (IGF-1) signaling and dietary restriction.

13 hat lead to bacterial avoidance behavior and dietary restriction.

14 lterations in the insulin/IGF pathway and by dietary restriction.

15 ht/obese subjects undergoing weight-loss via dietary restriction.

16 anisms associated with lifespan extension by dietary restriction.

17 y reverse the longevity-extending effects of dietary restriction.

18 fasting (ADF) represent 2 different forms of dietary restriction.

19 ould increase with leptin administration and dietary restriction.

20 te can sometimes be altered, for example, by dietary restriction.

21 a possible link between the TOR pathway and dietary restriction.

22 dy mass index, presumably indicating greater dietary restriction.

23 male SENCAR mice made vitamin A deficient by dietary restriction.

24 B6C3F1 mice are eliminated by apoptosis with dietary restriction.

25 ng protein-2 levels, a pattern suggestive of dietary restriction.

26 greater increase in longevity in response to dietary restriction.

27 daptation to maintain barrier immunity under dietary restriction.

28 on in fly fat body cells that was delayed by dietary restriction.

29 This may operate by a mechanism similar to dietary restriction.

30 c progression that was further attenuated by dietary restriction.

31 a key metabolite that mediates longevity by dietary restriction.

32 onsistent gene expression changes induced by dietary restriction.

33 00 g peas each week for 12 wk, with no other dietary restrictions.

34 ng pregnant or breastfeeding or having major dietary restrictions.

35 vere allergic reactions; however, it reduced dietary restrictions.

36 may cause confusion and lead to unnecessary dietary restrictions.

37 use it has prognostic implications and eases dietary restrictions.

38 augmented in the livers of mice subjected to dietary restriction, a known longevity-extending regimen

39 Dietary restriction, a potent intervention associated wi

40 Dietary restriction activates skn-1 in these two neurons

41 he most well-studied longevity intervention, dietary restriction, acts in-part through a cell non-aut

42 However, whether and how dietary restriction affects hematopoietic malignancies i

43 s indicate that peptone deprivation mediated dietary restriction affects lifespan in C. elegans in a

44 sing various aspects of calorie restriction, dietary restriction, aging, longevity, life span, adipos

45 associated with insulin/IGF-1 signaling and dietary restriction allow us to understand longevity fro

46 Dietary restriction alone, similar to topical steroids,

47 Dietary restrictions, along with the clinical complicati

48 Dietary restriction also increases life span and protect

49 Interestingly, dietary restriction also increases numbers of newly-gene

50 esembles the anti-ageing response induced by dietary restriction (also known as caloric restriction).

51 on with adequate nutrition (CRON) or without dietary restrictions (AMER).

52 We show that overall dietary restriction and amino acid deprivation cause ger

53 ism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve br

54 cifically required for lifespan extension by dietary restriction and by modulation of the TORC1 pathw

55 xpression of 4E-BP1 mediates the benefits of dietary restriction and can counter metabolic stress, an

56 interleukin-6 were significantly reduced by dietary restriction and correlated with adipose interleu

57 In rodents, both dietary restriction and decreased nutrient-sensing pathw

58 agents that mimick the beneficial effects of dietary restriction and exercise.

59 If this were the case, long life under dietary restriction and high fecundity under full feedin

60 e mechanisms for mediating life extension by dietary restriction and hormesis.

61 ion of a single longevity gene downstream of dietary restriction and hypoxia markedly alters behavior

62 araquat stress resistance downstream of both dietary restriction and inhibition of mTOR.

63 longevity by a mechanism distinct from both dietary restriction and insulin-like signaling.

64 triction in Drosophila mimicks the effect of dietary restriction and is associated with decreased rep

65 s that coordinate the organismal response to dietary restriction and maintain homeostasis when nutrie

66 Treatment requires life-long dietary restriction and monitoring of branched-chain ami

67 studies involving exercise training without dietary restriction and no weight loss demonstrate that

68 ssential enzyme and are currently treated by dietary restriction and other strategies to replace the

69 ith physiological metabolic stress caused by dietary restriction and profoundly suppressed leukemogen

70 Dietary restriction and reduced activity of nutrient-sen

71 understanding of the molecular mechanism of dietary restriction and suggest a role for counterintuit

72 gh prevalence of anxiety before the onset of dietary restriction and support proposals that in AN, CR

73 ges were the only cell population reduced by dietary restriction and that CD11c/CD206 (M2-type) and C

74 ns, show that NAE abundance is reduced under dietary restriction and that NAE deficiency is sufficien

75 were compared between patients treated with dietary restriction and those that received topical ster

76 Fibrosis resolved following both dietary restriction and topical steroids (3/17 and 5/9 p

77 ified in 65% to 85% of the patients, so some dietary restrictions and endoscopies after food challeng

78 Numerous dietary restrictions and endoscopies limit the implement

79 ntake, which may be reinforced by prescribed dietary restrictions and inadequate monitoring of the pa

80 The lack of effectiveness of dietary restrictions and restrictions regarding social c

81 s, encompass an array of strategies (such as dietary restrictions and supplementations) aimed at opti

82 determinant of the sensitivity of tumours to dietary restriction, and activating mutations in the pat

83 icularly swallowed topical corticosteroids), dietary restriction, and endoscopic dilation.

84 ctively, the available data suggest the that dietary restriction, and physical and mental activity, m

85 ote hallmark bulimic behaviors-binge eating, dietary restriction, and purging.

86 ell as gene expression signatures of ageing, dietary restriction, and replicative senescence based on

87 The lower side effect burden, lack of dietary restrictions, and ease of use of venlafaxine and

88 Dietary restriction appears to act as a general non-gene

89 Flies subjected to dietary restriction are protected from the lifespan-shor

90 -4 in lifespan determination is specific for dietary restriction, because it is not required for the

91 few years, greater ability to travel, fewer dietary restrictions, better preservation of residual ki

92 or lactation, use of soy products, or infant dietary restrictions beyond 4-6 months has any effect on

93 span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span

94 interactions between the microbiome, ageing, dietary restriction (caloric restriction and fasting), h

95 Other studies indicate that prolonged dietary restriction can attenuate many of the detrimenta

96 Even short-term dietary restriction can negatively impact physical activ

97 Severe dietary restriction, catabolic states and even short-ter

98 Adding essential amino acids to the dietary restriction condition increased fecundity and de

99 Compared with ad libitum feeding, dietary restriction consistently extends lifespan and de

100 opsies from individuals who underwent modest dietary restriction coupled with exercise also display s

101 Calorie or dietary restriction (CR) has attracted attention because

102 y decades of animal experiments showing that dietary restriction delays the aging process and decreas

103 Dietary restriction delays the incidence and decreases t

104 Very short-term caloric and saturated fat dietary restrictions do not lead to the same changes in

105 Indeed, early studies using DHA dietary restriction documented reduced light sensitivity

106 Dietary restriction does not affect a PTEN-null mouse mo

107 Intestinal FMO-2 is also activated by dietary restriction (DR) and is necessary for DR-mediate

108 Maternal dietary restriction (DR) buffers progeny from starvation

109 secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated wi

110 Dietary restriction (DR) can extend lifespan and might i

111 in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model or

112 Although dietary restriction (DR) can increase lifespan and reduc

113 Dietary restriction (DR) decreases body weight, improves

114 Dietary restriction (DR) delays aging, but the mechanism

115 o activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effects, but selectively induce

116 Dietary restriction (DR) extends healthy lifespan in div

117 Dietary restriction (DR) extends lifespan in multiple an

118 Dietary restriction (DR) extends lifespan in multiple sp

119 e retarded when the mice are maintained on a dietary restriction (DR) feeding regimen resulting in an

120 nging from humans to Caenorhabditis elegans, dietary restriction (DR) grants numerous benefits, inclu

121 Dietary restriction (DR) has been shown to increase life

122 Dietary restriction (DR) has been shown to prolong longe

123 Dietary restriction (DR) improves health, delays tissue

124 ke growth factor I (IGF-I) is lowered during dietary restriction (DR) in both humans and rats.

125 ositive regulator of lifespan in response to dietary restriction (DR) in Caenorhabditis elegans.

126 Dietary restriction (DR) increases life-span in organism

127 Dietary restriction (DR) is a metabolic intervention tha

128 Dietary restriction (DR) is a potent method to enhance l

129 Dietary restriction (DR) is a well-established means of

130 Dietary restriction (DR) is a widely conserved intervent

131 This increase in longevity by dietary restriction (DR) is coupled to profound benefici

132 Lifelong dietary restriction (DR) is known to decrease spontaneou

133 Dietary restriction (DR) is the most effective environme

134 Dietary restriction (DR) is the most robust means to ext

135 Dietary restriction (DR) is the most studied pro-longevi

136 Short-term dietary restriction (DR) may prevent organ damage from i

137 An intervention of dietary restriction (DR) partially ameliorates some TBI-

138 Dietary restriction (DR) reduces oxidative stress in sev

139 Dietary restriction (DR) slows aging in many animals, wh

140 Dietary restriction (DR) without malnutrition encompasse

141 Dietary restriction (DR), a moderate reduction in food i

142 Dietary restriction (DR), a reduction in food intake wit

143 Importantly, dietary restriction (DR), that has a conserved positive

144 Dietary restriction (DR), which positively affects healt

145 Dietary restriction (DR; sometimes called calorie restri

146 sm through brief restriction of food intake (dietary restriction, DR) prevents neuropathology in expe

147 erm 20 to 40% restriction in calorie intake (dietary restriction, DR), whose effects on cancer progre

148 Short-term dietary restriction drastically improved the survival ou

149 Dietary restriction elicits a genetically programmed res

150 This demonstrates that dietary restriction elicits robust compensatory changes

151 The mechanisms through which dietary restriction enhances health and longevity in div

152 Dietary restriction extends healthy lifespan in diverse

153 How dietary restriction extends life span may involve antici

154 Dietary restriction extends lifespan and retards age-rel

155 Herein, we demonstrate that dietary restriction extends lifespan in Drosophila melan

156 Dietary restriction extends longevity in diverse species

157 Dietary restriction extends the lifespan of numerous, ev

158 Mice were subjected to 40% dietary restriction for 3 weeks followed by induction of

159 pies are now established treatments, namely, dietary restriction for phenylketonuria and miglustat fo

160 Dietary restriction has been shown to have several healt

161 Dietary restriction has shown benefits in physiological,

162 and the pathway that mediates the effects of dietary restriction have evolved to respond to the nutri

163 In contrast, dietary restrictions have been shown to restore immune f

164 g insulin-like signaling and the response to dietary restriction, identified the cellular machineries

165 cytes, are required for life extension under dietary restriction in C. elegans.

166 espan extension induced by a novel method of dietary restriction in C. elegans.

167 rnal hatching, a phenotype closely linked to dietary restriction in C. elegans.

168 g the responses of lifespan and fecundity to dietary restriction in Drosophila.

169 Short-term dietary restriction in humans does appear to have benefi

170 sociated with the life-extending benefits of dietary restriction in model organisms.

171 food smells can block the health benefits of dietary restriction in multiple model organisms.

172 lternate-day fasting is a feasible method of dietary restriction in nonobese humans and whether it im

173 netic requirements for lifespan extension by dietary restriction in the nematode Caenorhabditis elega

174 e, a universal cellular energy generator and dietary restriction in the regulation of organismal life

175 In this Review, we discuss the effects of dietary restriction in these mammalian model organisms a

176 c1(/-) mice closely resembled the effects of dietary restriction in wild-type animals.

177 the role of oxalate, salt and animal protein dietary restrictions in the prevention of calcium stone

178 greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ri

179 he role of environmental factors, other than dietary restriction, in developmental reprogramming thro

180 We found that dietary restriction increased fly lifespan independently

181 n ob/ob mice, both leptin administration and dietary restriction increased G5 and G8 protein and bili

182 Furthermore, dietary restriction increased lifespan without increasin

183 brought about by administration of leptin or dietary restriction increases biliary cholesterol excret

184 Prolonged dietary restriction increases the life span in rodents.

185 Reduced food intake as a result of dietary restriction increases the lifespan of a wide var

186 Dietary restriction increases the longevity of many orga

187 osapentaenoyl ethanolamide not only inhibits dietary-restriction-induced lifespan extension in wild-t

188 To determine whether dietary restriction induces apoptosis in GST-II-positive

189 Our results indicate a mechanism by which dietary restriction influences physiology and aging.

190 chanism underlying the beneficial effects of dietary restriction involves stimulation of the expressi

191 Dietary restriction is a robust means of extending adult

192 Thus, the conservation of copper during dietary restriction is highly organ specific.

193 Identifying the most efficacious forms of dietary restriction is key for developing interventions

194 Dietary restriction is limited in advanced stages of CKD

195 Consensus was reached that maternal dietary restriction is not usually necessary to manage m

196 Dietary restriction is one of the most robust lifespan-e

197 Dietary restriction is the most widely used intervention

198 In yeast, span extension from dietary restriction is thought to be mediated by the hig

199 interaction between nutrition and longevity, dietary restriction is typically based on medium dilutio

200 Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in

201 Dietary restriction largely prevented this declining tra

202 sential role in Orsay virus infection of the dietary restriction-like (drl-1) gene, which encodes a s

203 tion and suggest a role for counterintuitive dietary-restriction-like therapy for human progeroid gen

204 Dietary restriction long term does, however, have detrim

205 addressed in this article is whether or not dietary restriction long term is feasible or beneficial

206 trate a role for RNA splicing homeostasis in dietary restriction longevity and suggest that modulatio

207 The neurotrophic factors induced by dietary restriction may protect neurons by inducing the

208 y is sufficient to extend lifespan through a dietary restriction mechanism requiring PHA-4.

209 ning both gene mutations that interfere with dietary restriction-mediated lifespan extension and cons

210 -4 and SKN-1, miRNAs transduce the effect of dietary-restriction-mediated lifespan extension in C. el

211 st, consistent with action of this drug as a dietary restriction mimetic.

212 way may influence the response of cancers to dietary restriction-mimetic therapies.

213 Three reported dietary restriction mimetics are mainly effective across

214 Developing dietary restriction mimetics targeting energy metabolism

215 Upon dietary restriction, MLL-AF9-induced murine acute myeloi

216 We developed a novel dietary restriction model in the rat that allows us to s

217 Like DR (dietary restriction), modulation of genes in the insulin

218 self-care (eg, adherence to medications and dietary restrictions, monitoring of symptoms and vital s

219 l on a fasting day may make this approach to dietary restriction more acceptable.

220 Here we report that a dietary restriction of 30% tripled the median and maxima

221 Moreover, dietary restriction of AGE is an effective and feasible

222 in growth failure that can be alleviated by dietary restriction of carbohydrates.

223 aintain their weight loss, including greater dietary restriction of fat and higher physical activity

224 BACKGROUND & AIMS: Dietary restriction of fermentable carbohydrates (a low

225 In celiac disease, the dietary restriction of gluten is curative of the intesti

226 Dietary restriction of phenylalanine has been the mainst

227 induced in 12 healthy adult men and women by dietary restriction of phylloquinone (40 microg/d, days

228 rsed the effects of minidose warfarin and of dietary restriction of phylloquinone on hemostasis and v

229 y was manifest both in vitro and in vivo, as dietary restriction of serine and glycine in mice was ab

230 The increased survival following dietary restriction of serine and glycine in these model

231 Here we show that dietary restriction of the essential amino acid methioni

232 how that such inhibition can be augmented by dietary restriction of upstream amino acid substrates, l

233 The life-extending effect of dietary restriction on ageing in Drosophila has also bee

234 pathways and likely mediates the effects of dietary restriction on aging.

235 anner that may overlap with known effects of dietary restriction on longevity.

236 e to flies in holidic medium and, similar to dietary restriction on oligidic food, amino acid dilutio

237 The impact of dietary restriction on physiologic function in humans is

238 es have shown that the beneficial effects of dietary restriction on the brain result in part from inc

239 hought to be a chronic illness that requires dietary restriction or chronic medical therapy.

240 Here we demonstrate that under conditions of dietary restriction or growth factor starvation, where P

241 irect role for endocannabinoid signalling in dietary restriction or lifespan determination has yet to

242 obese hosts that lost weight through either dietary restriction or treatment with semaglutide.

243 striction of serum l-Met, either via partial dietary restriction or with bacterial l-Met-degrading en

244 are achieved without developing significant dietary restrictions or clinical metabolic or nutritiona

245 gned to receive either conventional therapy (dietary restriction) or intensive therapy (either sulfon

246 re likely to attain histologic remission via dietary restriction (P < .0001).

247 Although insulin/IGF-1 signaling and dietary restriction pathways are currently viewed as bei

248 Dietary restriction per se is unlikely to emerge as a fe

249 f gammaH2AX DNA damage foci, indicating that dietary restriction preserves genome function by allevia

250 Our study also showed that dietary restriction prevented the age-related increase i

251 Dietary restriction promotes resistance to surgical stre

252 tants (insulin/insulin-like growth factor-1, dietary restriction, protein translation, mitochondrial

253 eir side effects and prescription-associated dietary restrictions reduce their suitability as a first

254 al models of these disorders have shown that dietary restriction (reduced calorie intake or intermitt

255 Our recent studies have shown that dietary restriction (reduced calorie intake) can increas

256 Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and

257 Dietary restriction reduces gut pathology in aging femal

258 otypes in which peptone deprivation mediated dietary restriction reduces lifespan.

259 epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, i

260 nd fertility for the African killifish and a dietary restriction regimen where both feeding time and

261 A dietary restriction regimen, known to extend life span,

262 associated with the salutary effects of this dietary restriction regimen.

263 intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is

264 Dietary restriction regimens, including fasting, have be

265 We show that distinct dietary restriction regimes and genetic pathways that in

266 ver, the mechanisms underlying the effect of dietary restriction remain elusive.

267 is disorder and its primary symptom, extreme dietary restriction, remains poorly understood.

268 However, the degree of dietary restriction required to achieve success may be q

269 cancer cell line, is sufficient to convert a dietary-restriction-resistant tumour into one that is di

270 Cancer cells that form dietary-restriction-resistant tumours carry mutations th

271 The dietary restriction response in Ercc1(/-) mice closely r

272 discuss accumulating data that suggest that dietary restriction results in many of the same physiolo

273 Mice undergoing dietary restriction retained 50% more neurons and mainta

274 Treatments such as enriched environment, dietary restriction, running and anti-depressants increa

275 with few food triggers, avoiding unnecessary dietary restrictions, saving endoscopies, and shortening

276 estriction-resistant tumour into one that is dietary-restriction-sensitive.

277 These data suggest that dietary-restriction stimulates NPY release resulting in

278 I trials in patients with EoE; and (3) novel dietary restriction strategies have evolved.

279 bit a shortened lifespan that is extended by dietary restriction, the most potent aging intervention

280 During intense electrical activity or dietary restrictions, the glucose level in the brain plu

281 anisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fe

282 E9 to E12 must be included within the 9-day dietary restriction to yield the expanded field.

283 Dietary restrictions to control serum phosphorus, which

284 extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevente

285 e-mRNA splicing with age that are reduced by dietary restriction via splicing factor 1 (SFA-1; the C.

286 d old animals fed ad libitum or subjected to dietary restriction, we find defects in global pre-mRNA

287 FOB tests were not rehydrated and dietary restrictions were imposed only for retesting bor

288 endent delay in anaphase onset, and inducing dietary restriction when the checkpoint is impaired incr

289 ghly sensitive to the anti-growth effects of dietary restriction, whereas others are resistant.

290 A dietary restriction which exceeds the limited capability

291 such as reduced insulin/IGF-1 signaling and dietary restriction, which are critical in determining t

292 to recapture the full potential benefits of dietary restriction, which humans can find difficult to

293 Dietary restriction, which is known to retard aging and

294 Dietary restriction, which promotes health and lifespan,

295 Dietary restriction, which reduces the level of insulin-

296 Dietary restriction with adequate nutrition is the gold

297 ssible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fec

298 his relation is of concern and suggests that dietary restrictions without attention to a possible res

299 The best avenue for humans to benefit from dietary restriction would be for pharmacological or bioa

300 y, we tested whether the loss of fat mass by dietary restriction would remove the major source of the