ライフサイエンスコーパス: differentiated cell

1 e continuous maintenance of cell identity in differentiated cells.

2 ial repair via induction of Wnt signaling in differentiated cells.

3 on injury and reprograms Lgr5(-) but Lgr4(+) differentiated cells.

4 Podocytes are non-proliferative, terminally differentiated cells.

5 ors as the initial step in the production of differentiated cells.

6 endolymphatic sacs demonstrates two types of differentiated cells.

7 ctivities and distinguishes pluripotent from differentiated cells.

8 toplasm in pluripotent P19 cells, but not in differentiated cells.

9 emotherapy-induced cell death less than more differentiated cells.

10 nic stem cells and mouse embryonic stem cell-differentiated cells.

11 ound to promote the degradation of ZFP809 in differentiated cells.

12 by assuring stable target gene repression in differentiated cells.

13 sable for maintaining cell identity genes in differentiated cells.

14 entiation-tRNAs' are active in non-dividing, differentiated cells.

15 as suppression of markers for adult stem and differentiated cells.

16 and lymphoid lineages, ultimately leading to differentiated cells.

17 uced apoptosis of GSCs with little effect on differentiated cells.

18 relative to epiblast stem cells (EpiSCs) and differentiated cells.

19 expression and X-chromosome inactivation in differentiated cells.

20 le in embryonic cells but highly unstable in differentiated cells.

21 l cycle and the tissue-specific functions of differentiated cells.

22 estinal (GI) adenocarcinoma by reprogramming differentiated cells.

23 activity and maintenance of the identity of differentiated cells.

24 vels in proliferating KCs and high levels in differentiated cells.

25 or damaged histones in long-lived terminally differentiated cells.

26 rs and other post-transcriptional factors in differentiated cells.

27 t to more N-linked sialoglycoproteins in the differentiated cells.

28 tion of pluripotent stem cells and partially differentiated cells.

29 o the Wnt-inactive inner bulge that contains differentiated cells.

30 or organizing noncentrosomal microtubules in differentiated cells.

31 ally facilitates malignant transformation of differentiated cells.

32 ttenuating the lipolysis pathway, but spared differentiated cells.

33 r knockout in hPSCs and in a wide variety of differentiated cells.

34 lst also facilitating egress of increasingly differentiated cells.

35 ll pluripotency and enable the generation of differentiated cells.

36 cells from primary cells, cancer cells, and differentiated cells.

37 ansposons, rather than DNA methylation as in differentiated cells.

38 tion of HbF up to 30% of total hemoglobin in differentiated cells.

39 n, transdifferentiation, or proliferation of differentiated cells.

40 in subpopulations of both lineage-primed and differentiated cells.

41 e skin, where it is expressed in nondividing differentiated cells.

42 ss intensely in a small subset of these more differentiated cells.

43 early-stage stem cells, progenitors and more differentiated cells.

44 s contributes to emergence of novel types of differentiated cells.

45 o efficiently stimulate this pathway in well-differentiated cells.

46 ins, and did so to a much lesser extent with differentiated cells.

47 it is required for proper differentiation in differentiated cells.

48 ted poly(I:C) is markedly diminished in well-differentiated cells.

49 oducing the proper number and proportions of differentiated cells.

50 iation increases from ES cells to terminally differentiated cells.

51 boring Lgr5+ stem cells, and villi harboring differentiated cells.

52 equestration by MRG-1 having a major role in differentiated cells.

53 rammed cells give rise to a full spectrum of differentiated cells.

54 reduced in embryonic stem cells compared to differentiated cells.

55 ed in cancer cell lines rather than healthy, differentiated cells.

56 worked efficiently for both iPSCs and human differentiated cells.

57 promoter DNA methylation in pluripotent and differentiated cells.

58 nsight into polycomb protein distribution in differentiated cells.

59 llowing fractionated IR, and contained fewer differentiated cells.

60 able barriers imposed by its specialized and differentiated cells.

61 A stability and oxidative phosphorylation in differentiated cells.

62 f cell states, from stem cells to terminally differentiated cells.

63 ing (undifferentiated) and nonproliferating (differentiated) cells.

64 silence genes that are not essential for the differentiated cell activity.

65 le groups of ependymoma predominantly harbor differentiated cells, aggressive groups are enriched for

66 In differentiated cells, aging is associated with hypermeth

67 uding stem cells, progenitor cells, and more differentiated cells, all of which have been extensively

68 ss the immature state of the cells, in vitro differentiated cells and adult human islets were compare

69 However, TKIs primarily target differentiated cells and do not eliminate leukemic stem

70 lamic-like neurons accounted for over 90% of differentiated cells and exhibited transcriptional profi

71 normal oral epithelial cells is confined to differentiated cells and is lytic.

72 for its regulation of signaling processes in differentiated cells and its destructive activation in A

73 skeleton as a component of the basal foot in differentiated cells and propose that the ZED tubulins a

74 ls the remarkable plasticity associated with differentiated cells and provides an unprecedented means

75 orithms to separate the progenitors from the differentiated cells and reconstruct the lineage hierarc

76 the accumulation of polyubiquitin chains in differentiated cells and stabilized by the proteasome in

77 crotubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored

78 eved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized

79 pon loss of Cltc, similar to what is seen in differentiated cells, and if so, how these altered prope

80 s (2-cell-specific genes) in pluripotent and differentiated cells, and pre-depleting cohesin in donor

81 exhibited 4-5 layers of well-stratified and differentiated cells, and we successfully produced funct

82 Cell-identity switches, in which terminally differentiated cells are converted into different cell t

83 data provide direct evidence that different differentiated cells are generated by different modes of

84 However, it is not clear how the two differentiated cells are generated from the ISC.

85 nt tumor-associated macrophages, these newly differentiated cells are phenotypically distinct, and li

86 he functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance.

87 mans indicates that TSCM cells are minimally differentiated cells at the apex of the hierarchical sys

88 luripotent, precursor, progenitor, and fully differentiated cells) based on changes in stage-dependen

89 epidermis and serve to replenish the loss of differentiated cells because of normal turnover or injur

90 speckles," are reciprocal in pluripotent and differentiated cells because of their cross-regulation.

91 can function in cell fate specification and differentiated cell behavior, and that a gene regulatory

92 une cells, cancer-associated fibroblasts and differentiated cells, blood vessels, and other extracell

93 tform can thus rapidly generate high quality differentiated cells, both neurons and potentially other

94 not affect cell proliferation or survival of differentiated cells but rather enhances the transition

95 tubules play an important role in polarizing differentiated cells, but little is known about how thes

96 gae mixed together in the same solution were differentiated cell-by-cell in real-time based on differ

97 In some tissues, differentiated cells can also revert to the stem cell ph

98 Moreover, terminally differentiated cells can be experimentally provoked to b

99 We investigated whether differentiated cells can give rise to SPEM using a nonge

100 Differentiated cells can re-enter the cell cycle to repa

101 addition, there are multiple routes by which differentiated cells can re-enter the pluripotent state.

102 In differentiated cells, chromosomes are packed inside the

103 ppresses mTORC1 to induce autodegradation of differentiated cell components and damaged organelles.

104 ble to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem

105 ation of mitochondrial network in terminally differentiated cells contributes to a broad spectrum of

106 d that the gene expression profiles of these differentiated cells could reveal the identities of gene

107 eep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline

108 We found that differentiated cells derived from isogenic iPSCs and nt-

109 ng beta-galactosidase in PW1(+) cells and in differentiated cells derived from PW1(+) cells.

110 function of mitochondria; however, in fully-differentiated cells, determining the structure of more

111 These fully differentiated cells display features of classical stem

112 red by day 8, with 1 and 12 muM ddC, whereas differentiated cells displayed defects of spare and maxi

113 As apparently terminally differentiated cells embedded in a mineralized extracell

114 Post-mitotic, differentiated cells exhibit a variety of characteristic

115 Differentiated cells exhibited expression of myogenic ma

116 Differentiated cells exhibited robust tetrodotoxin (TTX)

117 e landscapes as a general mechanism by which differentiated cells exit a committed state in response

118 nciple of organ growth where progenitors and differentiated cells expand in harmony with their surrou

119 he endogenous MIR520G locus is methylated in differentiated cells, exposure of DAOY cells to 5-aza-2'

120 In contrast to quiescent cells, terminally differentiated cells fail to maintain CENP-A levels.

121 e robust inflammatory responses in naturally differentiated cells, failed to activate NF-kappaB, the

122 ance of molecular pathways that maintain the differentiated cell fate and a key role for TGFbeta sign

123 m and progenitor cells and maintained in one differentiated cell fate but lost in others.

124 hanisms that drive neural progenitors into a differentiated cell fate in the nervous system.

125 geneous, containing cells linked to distinct differentiated cell fates.

126 alternatives for generating patient-specific differentiated cells for disease modeling and preclinica

127 ion in weak tissues, targeting both stem and differentiated cells for elimination.

128 Stem and differentiated cells frequently differ in their response

129 s measured by using quantitative PCR in TH17-differentiated cells from healthy women (n = 13) and men

130 molecular and functional characteristics of differentiated cells from human PSCs are primarily attri

131 homeostasis requires the production of newly differentiated cells from resident adult stem cells.

132 Differentiated cells from various tumors, or medium cond

133 and let-7f expression was decreased in TH17-differentiated cells from women compared with men.

134 we report the critical role of PRMT5 in GBM differentiated cells (GBMDC) grown in serum and GBM neur

135 abnormalities and preclinical application of differentiated cells generated by different reprogrammin

136 icating an intercellular signal arising from differentiated cells governing circadian clock-dependent

137 generating iMS cells from primary terminally differentiated cells has significant scope for applicati

138 To investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histo

139 o functional responsiveness of the resulting differentiated cells (HoxB8 neutrophils), little is know

140 In pluripotent and differentiated cells HP1beta is differentially localized

141 As in differentiated cells, hypermethylated sequences were enr

142 network safeguards nuclear organization and differentiated cell identity.

143 The plasticity of differentiated cells in adult tissues undergoing repair

144 Labeled SP cells give rise to terminally differentiated cells in bone marrow and intestines.

145 ellular dynamics as stem cells transition to differentiated cells in extinct and extant taxa [11].

146 paradigm for regulating the total output of differentiated cells in numerous other developmental pro

147 fferentiated cell marker LHX9, and a loss of differentiated cells in somatic cell lineages.

148 reversing the genetic sex of progenitors or differentiated cells in the fly intestine dramatically a

149 g action of mtROS and inflammasomes in fully differentiated cells in the retina, the removal of the d

150 Whether differentiated cells in the secretory complex are mainta

151 might be achieved by regulating functions of differentiated cells in the skeletal tissue while biasin

152 onocytes parallels the distribution found in differentiated cells in vitro, and that gene-specific 5-

153 ar that a radical change of cell identity of differentiated cells in vivo, triggered by injury or oth

154 ail of Cx32, a Cx expressed in polarized and differentiated cells, in regulating gap junction assembl

155 ial component for caveola assembly in highly differentiated cells, including adipocytes, smooth muscl

156 plifying cells, and the expected spectrum of differentiated cells, including goblet and endocrine cel

157 re than 80% of regenerated acini derive from differentiated cells, including myoepithelial and ductal

158 sdifferentiation and retrodifferentiation of differentiated cells, increases tumor heterogeneity.

159 cer-binding protein-alpha (C/EBPalpha), with differentiated cells increasingly secreting adiponectin,

160 The reprogramming of differentiated cells into induced pluripotent stem cells

161 ered an irreversible process, meaning that a differentiated cell is thought to be unable to return to

162 t and stable splicing patterns in terminally differentiated cells is critical to maintenance of speci

163 cyte lineages, although the phenotype of the differentiated cells is immature compared to adult hepat

164 Finally, continued CENP-A assembly in differentiated cells is nonessential for egg development

165 the generation of essential sphingolipids in differentiated cells is not well understood.

166 Characterization of differentiated cells is performed via flow cytometry and

167 ld belief that DNA methylation of terminally differentiated cells is permanent and essentially immuta

168 Furthermore, endocytic capacity in fully differentiated cells is rapidly modulated by changes in

169 A crucial feature of differentiated cells is the rapid activation of enhancer

170 FBP1 is barely detectable in normal differentiated cells; its overexpression in HCC tumors w

171 work of NSPCs is more effective than that of differentiated cells, leading to improved management of

172 similar levels of efficacy and contained all differentiated cell lineages.

173 Overexpression of miR-215 in poorly differentiated cell lines causes a decrease in clonogeni

174 olon tumors and used them to generate stably differentiated cell lines.

175 However, in differentiated cells, loss of HP1beta has the opposite e

176 for nucleotide analogues to inhibit HIV-1 in differentiated cells low in dNTPs.

177 These cells gain expression of de-differentiated cell markers CD44 and cytokeratin 5 (CK5)

178 This specialized set of pre-existing differentiated cells may be highly suitable for cell-bas

179 ids can exhibit some spatial organization of differentiated cells, methods that generate embryoid bod

180 is a useful model to study proliferating and differentiated cell mitochondrial toxicant exposures.

181 In comparison to more differentiated cells, naive ES cells utilize both glucos

182 (+) and Psca (+)) and a large population of differentiated cells (Nkx3.1 (+), Pbsn (+)).

183 ittle is known about how progenitor cell and differentiated cell numbers and proportions are maintain

184 potent stem cells having long telomeres, and differentiated cells obtained from human embryonic stem

185 sal(mid)-Pulse(hi), and Basal(lo)-Pulse(lo) (differentiated) cells occurred in expanding keratinocyte

186 hPSCs) have the capacity to give rise to all differentiated cells of the adult.

187 sted but was undetectable in fully quiescent differentiated cells or senescent cells.

188 entiation protocols usually result in partly differentiated cells or the production of a mix of cell

189 ual identity as they are reprogrammed into a differentiated cell, or risk tumorigenesis.

190 ome, RNAs isolated from undifferentiated and differentiated cell populations of normal, spontaneously

191 Microorganisms form biofilms containing differentiated cell populations.

192 tically inactive Dnmt3b isoform expressed in differentiated cells, positively regulates de novo methy

193 e support for the presence of organisms with differentiated cells (potentially an epithelial layer) i

194 tynereis dumerilii, with a rich diversity of differentiated cells present in relatively low number.

195 s (oocytes, embryos) and in smaller, further differentiated cells (primordial germ cells), and their

196 Differentiated cells produce albumin and apolipoprotein

197 liferation in response to IL-7, whereas more differentiated cells proliferated poorly.

198 dependence on FACT varies widely, with some differentiated cells proliferating normally in its absen

199 thylation increased during aging in MSCs and differentiated cells, providing a new avenue for the ide

200 iver and pancreas, relies on self-renewal of differentiated cells rather than a stem cell pool.

201 s highlights a continued need to explore how differentiated cells regulate microtubule geometry in vi

202 sic molecular basis underlying plasticity of differentiated cells remains largely unaddressed.

203 Moreover, Oct4 induction in various differentiated cells represses their lineage identity in

204 n signature of genes that remain bivalent in differentiated cells resolves into a cell cycle-independ

205 s, we found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyp

206 pathway prevents the removal of these poorly differentiated cells, resulting in the retention of cell

207 tural information for all cell lines tested: differentiated cells reveal pronounced structural orient

208 sfection of a 3HA-tagged construct into well-differentiated cells revealed that SLC26A9 is mostly pre

209 Furthermore, chondrogenically differentiated cell sheets adhere directly to cartilage

210 The thus differentiated cells showed a high mRNA and protein prod

211 neal endothelial cells (CECs) are terminally differentiated cells, specialized in regulating corneal

212 with transcriptional reprogramming and a de-differentiated cell state.

213 ire drug tolerance exhibit a more neuronally differentiated cell-state and expression of lineage-spec

214 egulatory networks that maintain functional, differentiated cell states are often dysregulated in tum

215 rtment are heterogenous and include multiple differentiated cell states.

216 jectory but instead represents several novel differentiated cell states.

217 operation, and the division of labor between differentiated cell subpopulations.

218 e propose that these cells may contribute to differentiated cell subsets via the generation of LGR5-e

219 e in oxidative phosphorylation in terminally differentiated cells such as cardiomyocytes.

220 er replenishment capacity compared with late differentiated cells (such as most CMV-specific cells).

221 ed to their memory phenotype, in which early differentiated cells (such as most M. tuberculosis-speci

222 he active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type-ind

223 tem cells is important for the production of differentiated cells suitable for transplantation.

224 (CBF, ASL, ion channel function, presence of differentiated cells, TEER) when developing in vitro lun

225 it more changes in expression in the one-day-differentiated cells than in Nanog-negative cells.

226 podocytes are highly specialized terminally differentiated cells that act as a filtration barrier in

227 a powerful and unlimited source to generate differentiated cells that can be used to study disease b

228 wal and differentiation into more terminally differentiated cells that downregulate Tcf-1 and express

229 nt, aging results in the expansion of highly differentiated cells that exhibit characteristics of cel

230 By converting terminally differentiated cells that harbor even a single oncogenic

231 al endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative pote

232 lls to replenish the tissues with functional differentiated cells that maintain the function of a tis

233 duce multiple outer cell layers of partially differentiated cells that show sporadic expression of al

234 In differentiated cells, the centrosome is often attenuated

235 pite ubiquitous expression of lamin A in all differentiated cells, the HGPS mutation results in organ

236 Unlike terminally differentiated cells, the impact of epigenetic dysregula

237 ing stem cells were engulfed by neighbouring differentiated cells through a draper-myoblast city-Rac1

238 xistence of cellular memory that persists in differentiated cells through many cell generations and c

239 ls are responsible for generating all of the differentiated cells, tissues, and organs in a multicell

240 b inactivation promotes the reprogramming of differentiated cells to a pluripotent state.

241 Cell plasticity, the ability of differentiated cells to convert into other cell types, u

242 n alternate approach is to induce terminally differentiated cells to dedifferentiate into multipotent

243 The inability of differentiated cells to maintain their identity is a hal

244 e infection or to trigger it in incompletely differentiated cells to prevent the seeding of the laten

245 cated molecular network has evolved to allow differentiated cells to re-enter the cell cycle (i.e., u

246 s and metazoa have the capacity to reprogram differentiated cells to stem cells.

247 Such an approach can produce differentiated cells to study physiology or pathophysiol

248 nents absent or misregulated in the in vitro differentiated cells, to probe the components involved i

249 ect of changing the plasticity of terminally differentiated cells toward pluripotency has completely

250 modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and resi

251 wed that subtle chromatin binding changes in differentiated cells translate into activation of the hi

252 osure to morphogens, or by conversion of one differentiated cell type into another by enforced expres

253 Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and

254 olonies that likely represent a distinct and differentiated cell type, pointing toward spatial cell d

255 essed together and specifically in a primary differentiated cell type: muscle.

256 l for probing developmental questions, while differentiated cell types allow the development of novel

257 Lateral inhibition patterns differentiated cell types among equivalent cells during

258 t is adapted to the specialized functions of differentiated cell types and opens new research avenues

259 of unbiased genetic screens in iPSC-derived differentiated cell types and provide a platform for sys

260 rchy in which stem cells sit at the apex and differentiated cell types are least susceptible to tumor

261 The formation of differentiated cell types from pluripotent progenitors i

262 ntity is continuously maintained in specific differentiated cell types long after sex determination o

263 organoid, we detect diverse progenitors and differentiated cell types of neuronal and mesenchymal li

264 Differentiated cell types often retain their characteris

265 logy to preserve complex stem/progenitor and differentiated cell types via long-term propagation of n

266 natal differentiation where fully functional differentiated cell types with limited lifespans arise.

267 mechanisms that maintain heterochromatin in differentiated cell types, how constitutive heterochroma

268 Its epithelium consists of several differentiated cell types, including acinar, ductal and

269 ed for the production and maintenance of all differentiated cell types, including the germline.

270 technology, which enables the derivation of differentiated cell types, such as neurons and glia, and

271 hyla to evolve tissue-level organization and differentiated cell types, such as neurons and muscle [9

272 otubules (MTs) are poorly understood in many differentiated cell types.

273 reveal structural details of stem cells and differentiated cell types.

274 resulting in complete dosage compensation in differentiated cell types.

275 lized dimorphic life cycle consisting of two differentiated cell types.

276 map the developmental history (ontogeny) of differentiated cell types.

277 self-renewing Lgr5(+) stem cells (ISCs) from differentiated cell types.

278 isogenic, and can be derived in an array of differentiated cell types; they are thus highly amenable

279 re traditionally considered to be terminally differentiated cells, unable to proliferate.

280 ent with their immunomodulatory activity, MV-differentiated cells upregulated expression of IL-10, ar

281 hes, which have revealed that, although some differentiated cells utilize conserved strategies to rem

282 ontext-specific (e.g. disease versus normal, differentiated cells versus stem cells or gene knockdown

283 cell culture and can also be reactivated in differentiated cells via nuclear reprogramming.

284 By day 13, differentiated cell viability was maintained but decline

285 corresponding membrane lipid composition of differentiated cells was performed by time-of-flight sec

286 ch is a non-limiting enzyme of glycolysis in differentiated cells, was tightly regulated in stem cell

287 key transcriptional regulators play in adult differentiated cells, we examined the effects of depleti

288 Exons included in differentiated cells were characterized by particularly

289 While stem cells and differentiated cells were distinguished by high and low

290 The polarized and differentiated cells were infected with a clinical isola

291 NV could infect only naive MEG-01 cells, and differentiated cells were refractory to virus infection/

292 riched within exons, unlike the situation in differentiated cells, where it binds heterochromatic sat

293 ic phenotypes that are reminiscent of normal differentiated cells, whereas others reflect the phenoty

294 luding low cellular stiffness in contrast to differentiated cells, which are stiffer.

295 Second, stem cells are vastly outnumbered by differentiated cells, which have a higher mutation rate-

296 ctions in cell numbers only among terminally differentiated cells while proliferation-competent proge

297 idered a homogenous population of terminally differentiated cells with a well-defined and highly cons

298 hypothesize that resident AMs are terminally differentiated cells with low responsiveness and limited

299 t conversion of skin biopsies into iPSCs and differentiated cells with minimal manual intervention.

300 its with a basal stem cell niche and luminal differentiated cell zone, stable, linear gradients of gr