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1 es for SSc-associated Raynaud phenomenon and digital ulcers.
2 and frequency of attacks, and resolution of digital ulcers.
3 ynaud's and skin ulcers, and of bosentan for digital ulcers.
4 ing the effect of treatment on prevention of digital ulcers.
5 ent, or mood, compared with patients without digital ulcers.
6 Bosentan can reduce the development of new digital ulcers.
7 , including acro-osteolysis, calcinosis, and digital ulcers.
8 eolysis (10 [37.0%] vs 62 [12.9%]; P < .01), digital ulcers (15 [55.6%] vs 173 [36.1%]; P = .04), and
9 ad a lower prevalence of previous or current digital ulcers (28.2% vs 53.1% in lcSSc; P < .001; and 6
10 ary assessments included healing of existing digital ulcers and evaluation of hand function using the
11 bosentan may be effective in preventing new digital ulcers and improving hand function in patients w
12 made in the classification and assessment of digital ulcers and in understanding ulcer pathogenesis,
13 scales and performed clinical assessments of digital ulcers and infarcts; patients completed the Heal
16 ssification and assessment of SSc-associated digital ulcers are also covered, alongside an overview o
26 imary outcome variable was the number of new digital ulcers developing during the 16-week study perio
34 ty, pain, and psychological impact of RP and digital ulcers in SSc can be measured by a small set of
36 mber of new systemic sclerosis (SSc)-related digital ulcers in two multinational clinical trials; and
37 and physician VAS ratings of RP activity, a digital ulcer/infarct measure, measures of disability an
40 able effects on the occurrence of upper limb digital ulcers or on other vascular manifestations of lc
41 Quinapril did not affect the occurrence of digital ulcers or the frequency or severity of RP episod
45 ence of new digital ulcers or improvement in digital ulcers showed significant associations with the
46 reatments available to both prevent and heal digital ulcers, some of which are also used in Raynaud p
48 with systemic sclerosis and active ischemic digital ulcers, treatment with macitentan did not reduce
49 In DUAL-2, the adjusted mean number of new digital ulcers was 1.44 in the 3-mg macitentan group (n