ライフサイエンスコーパス: digitoxin

1 ulators of RNA splicing, such as digoxin and digitoxin.

2 he direct synthesis of digitoxin and C1'-epi-digitoxin.

3 - and disaccharide analogues of digoxose and digitoxin.

4 The specific mechanism of digitoxin action is to block phosphorylation of the inhi

5 t does not abolish C-type inactivation since digitoxin (AgTxII) fails to block the ionic permeation o

6 Digitoxin also has effects on global gene expression in

7 Digitoxin and acetyldigitoxin were found to bind to a co

8 accharide glycal for the direct synthesis of digitoxin and C1'-epi-digitoxin.

9 As hypothesized, we also found that ouabain, digitoxin and digoxin blocked penetration by SARS-CoV-2

10 n-approved, small-molecule compounds such as digitoxin and digoxin have been in clinical usage for co

11 that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to h

12 an assay was developed for quantification of digitoxin and its metabolites from human serum samples a

13 ative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-b

14 annels may be part of the mechanism by which digitoxin and other active cardiac glycosides, such as d

15 Digitoxin and other cardiac glycosides are important, ce

16 wn that the cardiac glycoside drugs digoxin, digitoxin and ouabain blocked interaction of spike prote

17 The cardiac glycosides (CGs) digoxin, digitoxin and ouabain, which directly inhibit ATP1A1 fun

18 h was rescued by the cardiac glycoside drugs digitoxin and ouabain.

19 58 genes, 36 (62%) are similarly affected by digitoxin and related active analogues.

20 Digitoxin and structurally related cardiac glycoside dru

21 Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivative

22 c glycoside compounds like ouabain, digoxin, digitoxin, and gitoxin with their aglycones.

23 Clinical concentrations of ouabain and digitoxin are relatively safe for short term use for sub

24 eroids already in use in humans, digoxin and digitoxin, are potent inhibitors of multiple adenovirus

25 These agents included acetyldigitoxin and digitoxin as probes for the digitoxin site, phenol red a

26 tional class of II in a 1:1 ratio to receive digitoxin (at a starting dose of 0.07 mg once daily) or

27 We show here that digitoxin, at sub nM concentrations, can suppress hypers

28 Digitoxin belongs to a naturally occurring class of card

29 hanthidin) or digoxin-like CTS (digoxigenin, digitoxin, bufalin).

30 We propose that these digitoxin calcium channels may be part of the mechanism

31 We interpret this result to suggest that digitoxin can also partially mimic the genomic consequen

32 try of the lipid affects the kinetics of the digitoxin channel activity, but not the cation selectivi

33 These digitoxin channels are blocked by Al(3+) and La(3+) but

34 bodies against digitoxin promptly neutralize digitoxin channels in both cells and bilayers.

35 Digoxin and digitoxin concentrations close to or at the therapeutic

36 In isolated rat ventricular myocytes, the CG digitoxin (DGT) increased the incidence of arrhythmogeni

37 utants were analyzed for binding to digoxin, digitoxin, digoxigenin, and ouabain resulting in the gen

38 donor component present in the cardenolides digitoxin, digoxin, and gitoxin.

39 inhibitor reduces ERK phosphorylation, while digitoxin disrupts ion gradients, altering plasma membra

40 MEK inhibitor and digitoxin do not induce cell death in human melanocytes

41 Inhibition of alternative splicing with digitoxin followed by immunoprecipitation and immunoblot

42 the temperature did not alter the k(off) of digitoxin, generating a DeltaH(*) (k(off) ) of -10.4 +/-

43 event occurred in 29 patients (4.7%) in the digitoxin group and 17 (2.8%) in the placebo group.

44 ause occurred in 167 patients (27.2%) in the digitoxin group and 177 (29.5%) in the placebo group (ha

45 lure occurred in 172 patients (28.1%) in the digitoxin group and 182 (30.4%) in the placebo group (ha

46 vent occurred in 242 patients (39.5%) in the digitoxin group and 264 (44.1%) in the placebo group (ha

47 ion-to-treat population: 613 patients in the digitoxin group and 599 in the placebo group.

48 trisaccharide natural products digoxose and digitoxin has been developed.

49 Thus, before digitoxin implementation in designing and developing saf

50 herapeutic efficacy of the cardiac glycoside digitoxin in patients with heart failure and reduced eje

51 ch to evaluate the anti-cancer mechanisms of digitoxin in real-time.

52 anding the mechanism(s) by which digoxin and digitoxin inhibit adenovirus replication will guide the

53 occurring class of cardiac glycosides (CG); digitoxin is clinically approved for heart failure and k

54 ctivation is used, the glycorandomization of digitoxin leads to analogs that display significantly en

55 Treatment with digitoxin led to a lower combined risk of death from any

56 f these drugs, and we have hypothesized that digitoxin might mediate calcium entry into cells.

57 Multimers of digitoxin molecules also are able to form calcium channe

58 We report here that digitoxin molecules mediate calcium entry into intact ce

59 Three of these (digitoxin, nerifolin and peruvoside) are structurally an

60 All other antiinflammatory effects of digitoxin on NF-kappaB and c-Jun N-terminal kinase pathw

61 Antibodies against digitoxin promptly neutralize digitoxin channels in both

62 and prior to genome replication, digoxin and digitoxin show potential as antiviral agents for treatme

63 tyldigitoxin and digitoxin as probes for the digitoxin site, phenol red as a probe for the bilirubin

64 ction combinatorial relations we showed that digitoxin targets cancer cells in a time and dose-depend

65 Uniquely, 1B3 has a higher affinity for digitoxin than digoxin, the immunizing hapten, and a str

66 glycoside family, ouabain, gitoxigenin, and digitoxin, that inhibit placental sFlt1 production at na

67 additively or synergistically combined with digitoxin to induce cell death, inhibiting growth of pat

68 MEK inhibitor and digitoxin together cause intracellular acidification, mi

69 een successfully applied to the synthesis of digitoxin trisaccharide glycal for the direct synthesis

70 19 total steps from achiral 2-acylfuran, and digitoxin was fashioned in 15 steps starting from digito

71 otoxin was even more potent than digoxin and digitoxin when tested with HAdV-C5.

72 ac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species rangi

73 We therefore suggest that digitoxin, with its lengthy history of human use, deserv