ライフサイエンスコーパス: dihydrosphingosine

1 vented by supplementation with the precursor dihydrosphingosine.

2 -dependent reduction of 3-ketosphinganine to dihydrosphingosine.

3 able of phosphorylating both sphingosine and dihydrosphingosine.

4 pecifically dephosphorylate DHS-1-P to yield dihydrosphingosine.

5 al (TRP) channel by modulating the levels of dihydrosphingosine 1 phosphate (DHS1P) and sphingosine 1

6 a protein that specifically dephosphorylates dihydrosphingosine 1-phosphate (DHS-1-P), and we refer t

7 interaction between the sphingolipid agonist dihydrosphingosine 1-phosphate (dhS1P) and the transform

8 that another product of sphingosine kinase, dihydrosphingosine 1-phosphate (dhS1P), has an opposite

9 t increased levels of dihydrosphingosine and dihydrosphingosine 1-phosphate (DHS1P).

10 generates sphingosine 1-phosphate (S1P) and dihydrosphingosine 1-phosphate (dhS1P).

11 ignaling, sphingosine-1 phosphate (S1P), and dihydrosphingosine 1-phosphate (dhS1P).

12 of SPP and the related phosphorylated lipids dihydrosphingosine 1-phosphate and lysophosphatidic acid

13 pecific, dose-dependent, and competed off by dihydrosphingosine 1-phosphate and lysophosphatidic acid

14 ther structurally related compounds, such as dihydrosphingosine 1-phosphate and lysophosphatidic acid

15 ae, phosphorylated long chain bases, such as dihydrosphingosine 1-phosphate and phytosphingosine 1-ph

16 SB649146 displaced the S1P1 receptor agonist dihydrosphingosine 1-phosphate from membranes expressing

17 ive in both YSR2 and SUR2, which accumulated dihydrosphingosine 1-phosphate only, grew poorly.

18 YSR2 conferred sphingosine resistance to the dihydrosphingosine-1-P lyase-defective mutant (JS16) of

19 mentable carbon source at 25 degreesC, while dihydrosphingosine-1-phosphate (DHS-1-P) is only barely

20 Sphingosine-1-phosphate (S1P) and dihydrosphingosine-1-phosphate (DHS1P) are important sig

21 cenal, whereas hexadecanal is the product of dihydrosphingosine-1-phosphate (DHS1P) degradation.

22 ion, we propose that enhanced degradation of dihydrosphingosine-1-phosphate allows an alternative pro

23 base phosphate (LCB-P) lyase, encoded by the dihydrosphingosine-1-phosphate lyase1 (AtDPL1) gene and

24 e (DHS-1-P), and we refer to this protein as dihydrosphingosine-1-phosphate phosphatase.

25 ken together, these results identify YSR2 as dihydrosphingosine-1-phosphate phosphatase.

26 osphingosine into sphingosine-1-phosphate or dihydrosphingosine-1-phosphate respectively.

27 se-1-phosphates (sphingosine-1-phosphate and dihydrosphingosine-1-phosphate) and results in the in ut

28 D-erythro-4, 5-Dihydrosphingosine 1c and D-erythro-4,5-dihydroceramide

29 atment led to pronounced dihydroceramide and dihydrosphingosine accumulation, which preceded morpholo

30 Moreover, increasing dihydrosphingosine activates Mef2 activity through PDK1

31 Treatment of cells with dihydrosphingosine activates transcription of the TPS2 g

32 long chain bases (LCBs) phytosphingosine and dihydrosphingosine also suppressed the DspA/E-induced ye

33 Another SphK inhibitor, D,L-threo-dihydrosphingosine, also induced apoptosis and produced

34 inhibition of PKC by acute coexposure to the dihydrosphingosine analog safingol.

35 ansient increase in the concentration of C18-dihydrosphingosine and C18-phytosphingosine, more than a

36 re than a 100-fold transient increase in C20-dihydrosphingosine and C20-phytosphingosine, and a more

37 Subsequently dihydrosphingosine and dhS1P decrease at 48 h consistent

38 stitute an appreciable proportion of cardiac dihydrosphingosine and dihydroceramide, with distinct bi

39 ses occurred in more than one-third of total dihydrosphingosine and dihydroceramides in myocardium, a

40 sphingosine, and S1P but increased levels of dihydrosphingosine and dihydrosphingosine 1-phosphate (D

41 eramide formation from a free fatty acid and dihydrosphingosine and no activity with phytosphingosine

42 nt, the saturated long-chain sphingoid bases dihydrosphingosine and phytosphingosine (Phyto-Sph).

43 FA synthesis, accumulation of high levels of dihydrosphingosine and phytosphingosine, and accumulatio

44 nism by which sphingosine and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymor

45 ) exhibited both an enormous accumulation of dihydrosphingosine and sphingosine and a reduction in ph

46 Vmax of 0.3 micromol/min/mg), but d-erythro-dihydrosphingosine and the three unnatural stereoisomers

47 The molecular species of dihydrosphingosines and phytosphingosines and their 1-ph

48 , including sphingoid bases (sphingosine and dihydrosphingosine) and sphingoid base-1-phosphates (sph

49 malian SphK1 efficiently phosphorylated Sph, dihydrosphingosine, and 4,8-sphingadienine, but not the

50 ted the sphingoid bases phytosphingosine and dihydrosphingosine as the likely mediators of Cha1 up-re

51 ro-2-N-[12'-(1''-pyridinium)-dodecanoyl]-4,5-dihydrosphingosine bromide (C(12)-dhCCPS) to its 4,5-des

52 ollowing in vivo labeling with D-erythro-[3H]dihydrosphingosine, but it slightly affected labeling of

53 ingosine, phytosphingosine, sphingosine, and dihydrosphingosine, but not N-acetyldihydrosphingosine,

54 lecules, including 3-ketodihydrosphingosine, dihydrosphingosine, C(2)-phytoceramide (PHC), and steary

55 In contrast to long-chain bases (dihydrosphingosine [d18:0] and 4,8-sphingadienine [d18:2

56 and clinical isolates demonstrated elevated dihydrosphingosine (DHS) and phytosphingosine (PHS) leve

57 hich encodes an exporter of long chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS), and

58 Here we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two

59 Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has

60 We report herein that DL-threo-dihydrosphingosine (DHS), a competitive inhibitor of sph

61 The sphingosine analogue, D-L-threo-dihydrosphingosine (DHS), inhibits the SK enzyme competi

62 However, DL-lactosylceramides containing dihydrosphingosine did not bind.

63 C8-Cer) stereoisomers, N-octanoyl-DL-erythro-dihydrosphingosine (DL-e-DHC8-Cer), and a new ceramide d

64 , sphingoid phosphate phosphatase, lyase, or dihydrosphingosine hydroxylase were found to display the

65 duction of the levels of sphingosine but not dihydrosphingosine in response to PMA, and 4) induction

66 Dihydrosphingosine induces expression of a STRE-LacZ rep

67 ecrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipi

68 catalysing the conversion of sphingosine or dihydrosphingosine into sphingosine-1-phosphate or dihyd

69 Here our data suggest that accumulation of dihydrosphingosine is responsible for this phenotype.

70 nositol, diacylglycerol, ceramide, D,L-threo-dihydrosphingosine or N, N-dimethylsphingosine.

71 ntial for growth in the absence of exogenous dihydrosphingosine or phytosphingosine.

72 hingosine (DMS) and phytosphingosine but not dihydrosphingosine or sphingosine 1-phosphate.

73 f ceramide resulting from the N-acylation of dihydrosphingosine or sphingosine by ceramide synthase i

74 inositol, diacylglycerol, ceramide, DL-threo-dihydrosphingosine, or N,N-dimethylsphingosine.

75 is reversed by supplying 3-ketosphinganine, dihydrosphingosine, or phytosphingosine in the growth me

76 Both enzymes can use phytosphingosine, dihydrosphingosine, or sphingosine as substrate.

77 DPL1, the structural gene for dihydrosphingosine phosphate lyase, was selected as a hi

78 [(3)H]Dihydrosphingosine radiolabeling studies demonstrated th

79 [(3)H]inositol and [(3)H]dihydrosphingosine radiolabeling studies demonstrated th

80 romoter contains four STREs that may mediate dihydrosphingosine responsiveness.

81 whether cytotoxicity was enhanced by l-threo-dihydrosphingosine (safingol); (e) whether physiological

82 Labeling yeast cells with [(3)H]dihydrosphingosine showed that IPS were increased in the

83 nd L-erythro- was not as potent as D-erythro-dihydrosphingosine showing stereospecificity.

84 he inhibitor of sphingosine kinase, DL-threo-dihydrosphingosine, significantly increased the percenta

85 es and the sphingoid bases phytosphingosine, dihydrosphingosine, sphingosine, and sphingosine 1-phosp

86 ssion reduced lung and circulating levels of dihydrosphingosine, the product of SPT.

87 d C4 hydroxylase catalyzes the conversion of dihydrosphingosine to phytosphingosine.

88 SUR2 catalyzes conversion of dihydrosphingosine to phytosphingosine.

89 d-erythro-dihydrosphingosine was a better substrate than d-erythro

90 Surprisingly, d, l-threo-dihydrosphingosine was also phosphorylated by SPHK2.

91 st sphingoid backbones, phytosphingosine and dihydrosphingosine, were found to be most potent in this

92 strain upon labeling with D-erythro-[4, 5-3H]dihydrosphingosine, whereas overexpression of YSR2 incre

93 ons) and much stronger than that by DL-threo-dihydrosphingosine, which had been considered to be the

94 phingoid bases, C20 phytosphingosine and C20 dihydrosphingosine, which increased 6.4- and 10.8-fold o

95 tive inhibitor of ceramide synthase 2 toward dihydrosphingosine with an apparent K(i) of 2.15 microm.