ライフサイエンスコーパス: dinucleotide

1 as the reduced form of nicotinamide adenine dinucleotide.

2 ation with removal of methyl groups from CpG dinucleotides.

3 to various pathogens through sensing cyclic dinucleotides.

4 ls, to transport cGAMP and other 2'3'-cyclic dinucleotides.

5 with a central CpG/CpG and two outer CpA/TpG dinucleotides.

6 and out of phase with SS (where S is G or C) dinucleotides.

7 E7) mutants with elevated frequencies of UpA dinucleotides.

8 TT in UPD-Seq reads at different original TC dinucleotides.

9 6mA and all symmetric methylation at the ApT dinucleotides.

10 ut does not cleave the corresponding reduced dinucleotides.

11 methylation in many of the cytosine-guanine dinucleotides.

12 Surprisingly, ZCWPW1 also recognises CpG dinucleotides.

13 y host-derived or bacterially derived cyclic dinucleotides.

14 owing treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting that the STING path

15 urable phosphodiesterase activity toward the dinucleotide 2',3'-cyclic NADP.

16 enzymatic preparation of 2'-5',3'-5'-cyclic dinucleotides (2'3'CDNs) with use of cyclic GMP-AMP synt

17 ydroxymethylation occurs predominantly in CA dinucleotides (5hmCA) and it accumulates in regions flan

18 tive contributions of mutations at canonical dinucleotides (73%) and flanking noncanonical positions

19 ize and particularly affect homopolymeric or dinucleotide A or T stretch regions of the genome.

20 -containing VRACs transport cGAMP and cyclic dinucleotides across the plasma membrane.

21 cterial infection in mammalian cells, cyclic dinucleotide activation of STING induces interferon beta

22 To determine how CpG dinucleotides affect HIV-1 replication, we increased the

23 pplied to the stereoselective preparation of dinucleotide analogues featuring either a difluorophosph

24 in the biosynthesis of nicotinamide adenine dinucleotide and its derivatives in all organisms that s

25 reased NAD+ synthesis-nicotinic acid adenine dinucleotide and methyl nicotinamide-were elevated in sk

26 typical FMO aspects with the flavin adenine dinucleotide and NAD(P)H binding domains and a C-termina

27 d loss of intracellular nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide + hyd

28 interaction between the guanine base of the dinucleotide and the vacant G-triad, which acts as an an

29 of synthesizing pyrimidine containing cyclic dinucleotides and cyclic trinucleotides.

30 posure induced changes in DNAm at 27,812 CpG dinucleotides and in the expression of 3,857 transcripts

31 , in eukaryotes 5mC is most prevalent at CpG dinucleotides and is frequently associated with transcri

32 rically methylated and hydroxymethylated CpA dinucleotides and that this alternative binding selectiv

33 vely inhibits HIV-1 containing clustered CpG dinucleotides and this requires ZAP and its cofactor TRI

34 6mA occurred symmetrically at ApT dinucleotides and was concentrated in dense methylated a

35 DH (the reduced form of nicotinamide adenine dinucleotide) and FAD (flavin adenine dinucleotide) in v

36 However, with dinucleotide Ap4A as an agonist, BPTU suppressed the Ema

37 nto major grooves and SS (where S is G or C) dinucleotides are often found at sites that bend into mi

38 Cyclic dinucleotides are second messengers in the cyclic GMP-AM

39 CpG dinucleotides are suppressed in most vertebrate RNA viru

40 CpG dinucleotides are suppressed in the genomes of many vert

41 It reports the dinucleotides around the intron boundary and displays th

42 nt oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway

43 nd possibly also the decrease in CpG and UpA dinucleotides as immune stimulators.

44 Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unk

45 onses from both redox state and nicotinamide dinucleotide availability to regulate carbon fixation.

46 tion such as k-tuple nucleotide composition, dinucleotide-based auto covariance and global informatio

47 ns a pocket that selectively accommodates CG dinucleotide bases.

48 beta-Nicotinamide adenine dinucleotide (beta-NAD) is a key inhibitory neurotransmi

49 udies suggest that beta-nicotinamide adenine dinucleotide (beta-NAD) is an important inhibitory motor

50 In vitro assays demonstrated that the dinucleotide binds to the cytoplasmic regulatory subunit

51 nosine triphosphate and nicotinamide adenine dinucleotide, both pathways converging in the formation

52 Bacterial usage of the cyclic dinucleotide c-di-GMP is widespread, governing the trans

53 (A) microsatellite at the BAT-26 locus and a dinucleotide (CA) microsatellite in the coding region of

54 genomes, particularly brain, the CpG and CpA dinucleotides can be methylated at the 5-position of cyt

55 frequency of CpG dyads (two complementary CG dinucleotides) can be only indirectly inferred by overla

56 This cyclic dinucleotide (CDN) activates STING(8), which in turn act

57 Cyclic dinucleotide (CDN) agonists of stimulator of interferon

58 metabolic instability of the natural cyclic dinucleotide (CDN) ligands.

59 e cytosol by cGAS, which produces the cyclic dinucleotide (CDN) second messenger cGAMP to activate th

60 '-cyclic GMP-AMP (cGAMP) is the third cyclic dinucleotide (CDN) to be discovered in bacteria.

61 ng adjuvant target due to its role in cyclic dinucleotide (CDN)-driven anti-viral immunity; however,

62 mic administration of cGAMP and other cyclic dinucleotides (CDN), but little is known about how nanoc

63 Cyclic dinucleotides (CDNs) are second messengers conserved acr

64 Cyclic dinucleotides (CDNs) are secondary messengers used by pr

65 Cyclic dinucleotides (CDNs) have central roles in bacterial hom

66 Bacterial and host cyclic dinucleotides (cdNs) mediate cytosolic immune responses

67 ecombinant DENV NS1 administered with cyclic dinucleotides (CDNs), potent activators of innate immune

68 ant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytoki

69 synthase (cGAS) and generation of the cyclic dinucleotide cGAMP, followed by the induction of stimula

70 cGAS catalyzes the production of the cyclic dinucleotide cGAMP, resulting in type I interferon respo

71 nucleotide (d(AG)) and the other to a cyclic dinucleotide (cGAMP), are solved using NMR spectroscopy.

72 cal regeneration of the nicotinamide adenine dinucleotide cofactor.

73 T3-ITD N-regions have a G/C content (66.9%), dinucleotide composition (P < .001), and length characte

74 that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-

75 s do not control for biases in GC content or dinucleotide composition.

76 horylation, diminishing nicotinamide adenine dinucleotide concentrations and impairing cytokine produ

77 an (h) ZAP RNA-binding domain (RBD) and a CG dinucleotide-containing RNA target.

78 ant of high-affinity, specific binding to CG dinucleotide-containing RNA.

79 mammalian cells by virtue of its elevated CG dinucleotide content compared with endogenous mRNAs.

80 within the CpG (cytosine-phosphate-guanine) dinucleotide context across the genome using Maximum Lik

81 Both TLR9 and its ligand, the dinucleotide CpG, were present as cargo in IRAP(+) endos

82 surveying more than 400 000 cytosine guanine dinucleotide (CpG) sites measured from peripheral blood

83 c variants disrupting DNA methylation at CpG dinucleotides (CpG-SNP) provide a set of known causal va

84 on was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes u

85 ify associations at 720,077 cytosine-guanine dinucleotides (CpGs), with adjustment for maternal age,

86 Several dinucleotide cyclases, including cyclic GMP-AMP synthase

87 r that catalyses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the inductio

88 -quadruplex structure, one bound to a linear dinucleotide (d(AG)) and the other to a cyclic dinucleot

89 omplex I (Ndufs1, NADH [nicotinamide adenine dinucleotide] dehydrogenase [ubiquinone] iron-sulfur pro

90 Flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH) wa

91 n 1 (SIRT1), an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase in the proximal tubu

92 Here we report a flavin adenine dinucleotide-dependent enzyme, Morus alba Diels-Alderase

93 genome analysis indicates unusually low CpG dinucleotide depletion in KYAV compared to other ledante

94 ered DNA damage-induced nicotinamide adenine dinucleotide(+) depletion to underlie AF.

95 n and synthesis of an ITPA-specific chimeric dinucleotide (DIAL) that replaces the pyrophosphate leav

96 and induce cell death by forming intrastrand dinucleotide DNA adducts.

97 her metabolite caps including flavin adenine dinucleotide (FAD) and dephosphoCoA (dpCoA).

98 he riboflavin (RF) cofactors, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), are

99 at covalent attachment of the flavin adenine dinucleotide (FAD) cofactor is supported.

100 e LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidase

101 S sensor, which used DET-type flavin adenine dinucleotide (FAD) dependent glucose dehydrogenase (GDH)

102 Flavin-adenine dinucleotide (FAD) dependent glucose dehydrogenase (GDH)

103 enine dinucleotide (NADH), and flavin denine dinucleotide (FAD) in fresh brain samples of a mouse mod

104 y attach to the LSD1 cofactor flavin adenine dinucleotide (FAD) to inhibit demethylase activity, SP-2

105 l structures of the catalytic flavin adenine dinucleotide (FAD)- and heme-binding domains of Cylindro

106 ide (phosphate) (NAD(P)H) and flavin adenine dinucleotide (FAD).

107 sidue Cys108 and its cofactor flavin adenine dinucleotide(FAD), and prompts VVD switching from Dark s

108 that taking into account position-dependent dinucleotide features improved the design of effective s

109 et-site affinities, and a 100-fold impact of dinucleotides flanking each site.

110 l survival by enhancing nicotinamide adenine dinucleotide flux in injured neurons.

111 (A/G)-CANNTG-3', with an added outer Cp(A/G) dinucleotide; for example in the promoter for CNIH3, a g

112 PYV mutants with increased CpG dinucleotide frequencies showed a dose-dependent reducti

113 riction factor for viruses with elevated CpG dinucleotide frequencies.

114 ters, this results from an elevated 5'-GG-3' dinucleotide frequency and GC enrichment near transcript

115 structure predicts that DXO first removes a dinucleotide from 5'-OH RNA.

116 f production of reduced nicotinamide adenine dinucleotides from 91 potential energy substrates.

117 f targeted panels of single cytosine guanine dinucleotides from multiple independent loci.

118 remixing of FDHs with reduced flavin adenine dinucleotide generally results in abolishment of C4aOOH-

119 an Aspergillus flavus-derived flavin adenine dinucleotide glucose dehydrogenase (AfGDH) and an electr

120 Fungi-derived flavin adenine dinucleotide glucose dehydrogenases (FADGDHs) are curren

121 Codon-optimized RSV F containing fewer CpG dinucleotides had higher F expression, replicated more e

122 Cyclic dinucleotides have emerged as important secondary messen

123 , DNA methylation predominantly occurs at CG dinucleotides however, widespread non-CG methylation (mC

124 denine dinucleotide and nicotinamide adenine dinucleotide + hydrogen.

125 iction and demonstrate that this 5'-hydroxyl dinucleotide hydrolase (HDH) activity for DXO is higher

126 es by methylation of the C-phosphate-G (CpG) dinucleotide in DNA is essential for their long-term acc

127 HigA residue Arg40 recognizes a TpG dinucleotide in higO2, an evolutionary conserved mode of

128 nsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD(+)) during Waller

129 es capable of degrading nicotinamide adenine dinucleotide in its oxidized form (NAD(+)).

130 gnition domain (TRD loop) recognizes the CpG dinucleotides in a +1 flanking site-dependent manner.

131 to be capable of binding guanine-containing dinucleotides in micromolar affinity.

132 Frequencies of CpG and UpA dinucleotides in most plant RNA virus genomes show degre

133 While TET1 binds to CpG dinucleotides in promoters using its CXXC domain, TET1 a

134 The majority of CpG dinucleotides in the human genome are methylated at cyto

135 denine dinucleotide) and FAD (flavin adenine dinucleotide) in vitro.

136 ation at over 400 000 CpGs (cytosine-guanine dinucleotides) in 5 population-based cohorts including 6

137 re, it was also shown that GNA nucleotide or dinucleotide incorporation increases resistance against

138 Variants affecting essential splice-site dinucleotides inhibit splicing, whereas the impact of va

139 The guanine base of the dinucleotides interacts with a vacant G-triad, forming f

140 vely yields the reactive imidazolium-bridged dinucleotide intermediate required for copying.

141 ch other to form a 5'-5'-imidazolium bridged dinucleotide intermediate.

142 To explore this conundrum, we varied this AU dinucleotide into all possible permutations and analyzed

143 a structural interpretation as to why the AU dinucleotide is conserved during evolution.

144 n, which mostly occurs in the context of CpG dinucleotide, is installed by two denovo DNA methyltrans

145 red H3K27me3 spreading from cytosine guanine dinucleotide islands, which is reminiscent to the report

146 quence (e.g., codon usage, codon pair usage, dinucleotide/junction dinucleotide usage, RNA structure

147 preferentially catalyzes RNA cleavage at UN dinucleotide junctions (k(obs) = 0.9 h(-1) for UU cleava

148 outperform genomic signatures defined at the dinucleotide level in distinguishing between taxonomic s

149 ccompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions

150 ov models of order one, also called adjacent dinucleotide matrices (ADMs).

151 ressive association of DNA methylation at CG dinucleotides (mCG), mCH accumulates on Xi in domains wi

152 MBD1 binds to methylated cytosine-guanine dinucleotides (mCGs) within the sequence of sh-dsDNA.

153 formation in the first exon promoted by CpG dinucleotide methylation as a regulator of hTERT express

154 els of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide, and N1-methyl-4-pyrido

155 3TG-3'(where the numbers indicate successive dinucleotides), modification of the central E-box 2CG ha

156 incorporated into mRNA, the CCl2-substituted dinucleotide most efficiently promoted cap-dependent tra

157 ) for the NA group of nicotinic acid adenine dinucleotide (NAAD) inside endolysosomes of interleukin

158 synthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD(+) Some members of the NadE f

159 dence suggests that the nicotinamide adenine dinucleotide (NAD(+) ) precursor nicotinamide riboside (

160 carboxylic acid cycle, OX-PHOS, nicotinamide dinucleotide (NAD(+) ) synthesis, and reversed the defec

161 lyses the hydrolysis of nicotinamide adenine dinucleotide (NAD(+)) and is a candidate molecule for re

162 cap, a non-canonical 5' nicotinamide adenine dinucleotide (NAD(+)) cap can tag certain transcripts fo

163 de novo biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) in mammals.

164 Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for redox reactions,

165 Nicotinamide adenine dinucleotide (NAD(+)) is a critical coenzyme for cellula

166 Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor for redox

167 dative stress response, nicotinamide adenine dinucleotide (NAD(+)) is emerging as a metabolic target

168 Nicotinamide adenine dinucleotide (NAD(+)) is essential not only for the harv

169 Changes in nicotinamide adenine dinucleotide (NAD(+)) levels that compromise mitochondri

170 hat exogenously applied nicotinamide adenine dinucleotide (NAD(+)) moves systemically and induces sys

171 Nicotinamide adenine dinucleotide (NAD(+)) participates in intracellular and

172 Nicotinamide adenine dinucleotide (NAD(+)) plays a critical role in energy me

173 ) is a newly discovered nicotinamide adenine dinucleotide (NAD(+)) precursor vitamin.

174 e recently described 5' nicotinamide-adenine dinucleotide (NAD(+)) RNA in bacteria.

175 volutionarily conserved nicotinamide adenine dinucleotide (NAD(+)) synthase and neuroprotective facto

176 Mitochondria require nicotinamide adenine dinucleotide (NAD(+)) to carry out the fundamental proce

177 ribosyltransferases use nicotinamide adenine dinucleotide (NAD(+)) to modify target proteins with ADP

178 cellular production of nicotinamide adenine dinucleotide (NAD(+)) via nicotinamide phosphoribosyltra

179 utonomous generation of nicotinamide adenine dinucleotide (NAD(+)) via the kynurenine pathway (KP) re

180 Supplementation of nicotinamide adenine dinucleotide (NAD(+)) with nicotinamide riboside partial

181 s the main precursor of nicotinamide adenine dinucleotide (NAD(+)), a coenzyme essential for DNA repa

182 Nicotinamide adenine dinucleotide (NAD(+))-dependent ADP-ribosylation plays i

183 via increased levels of nicotinamide adenine dinucleotide (NAD(+)).

184 de novo biosynthesis of nicotinamide adenine dinucleotide (NAD(+)).

185 the final enzyme of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway.

186 AIMS: The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) cat

187 kout mice display lower nicotinamide adenine dinucleotide (NAD) levels, and an imbalance in the NAD m

188 nt of dependence on the nicotinamide adenine dinucleotide (NAD) metabolic pathway in cancer.

189 Nicotinamide adenine dinucleotide (NAD) provides an important link between me

190 KYNU, two genes of the nicotinamide adenine dinucleotide (NAD) synthesis pathway, are causative of c

191 Nicotinamide adenine dinucleotide (NAD), a ubiquitous coenzyme, is required f

192 eported the presence of nicotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a

193 ), one of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent lysine deacylases, catalyze

194 cal immobilization with nicotinamide adenine dinucleotide (NAD).

195 ed vitamin precursor of nicotinamide adenine dinucleotide (NAD).

196 h as PARPs that utilize nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer monomer or

197 evels of the redox coenzyme nicotine adenine dinucleotide (NAD+), elevated total intracellular ATP le

198 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme, Sirtui

199 r energy in the form of nicotinamide adenine dinucleotide (NAD+).

200 ne nucleotides (AMP, ADP, and ATP), pyridine dinucleotides (NAD(+) and NADH), and short-chain acyl-Co

201 ction by downregulating nicotinamide adenine dinucleotide(+) (NAD(+))/reduced form of nicotinamide ad

202 (PCET) reaction between nicotinamide adenine dinucleotide (NADH) and a protein-bound flavin (FMN) cof

203 ), tryptophan residues, nicotinamide adenine dinucleotide (NADH) and vitamin A were scanned on sturge

204 of tryptophan, reduced nicotinamide adenine dinucleotide (NADH), and flavin denine dinucleotide (FAD

205 lly oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)-an important coenzyme in living cell

206 phosphate (NADPH), and nicotinamide adenine dinucleotide (NADH).

207 activity, elevating the nicotinamide adenine dinucleotide (NADH/NAD(+)) ratio and decreasing expressi

208 e levels, disrupted the nicotinamide adenine dinucleotide (NADH/NAD(+)) ratio, and decreased intracel

209 duction rate of reduced nicotinamide adenine dinucleotides (NADH) from 91 potential energy substrates

210 NOCT specifically and directly converts the dinucleotide NADP(+) into NAD(+) and NADPH into NADH.

211 Here, we show that NOC utilizes the dinucleotide NADP(H) as a substrate, removing the 2' pho

212 ore, sA3G was shown to bind a deoxy-cytidine dinucleotide near the catalytic Zn(2+), yet not in the c

213 alter RNA splicing, and 13 essential splice dinucleotide, nonsense, and short insertion or deletion

214 eplication in mutants with increased CpG/UpA dinucleotides occurred immediately after viral entry, wi

215 CXXC family, which binds to unmethylated CpG dinucleotides of DNA and through enzymatic activities fo

216 NYN eliminated the deleterious effect of CpG dinucleotides on HIV-1 RNA abundance and infectious viru

217 ono- and bicistronic constructs, and CpG/UpA-dinucleotide optimization of reporter genes allowed repl

218 e tryptophan-kynurenine-nicotinamide adenine dinucleotide (oxidized; NAD+) pathway is closely associa

219 ningitidis-Nme2Cas9-that recognizes a simple dinucleotide PAM (N(4)CC) that provides for high target

220 lish that our hybrids can target all adenine dinucleotide PAM sequences and possess robust and accura

221 g the lengths of coding sequence regions and dinucleotide percentages to identify orthologs.

222 RSV alone reduced nicotinamide adenine dinucleotide phosphatase oxidase (NADPH oxidase) levels,

223 hereas the NOX2 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 2) and NOX4 (N

224 nit 2) and NOX4 (NADPH [nicotinamide adenine dinucleotide phosphatase] oxidase subunit 4) were upregu

225 Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cA

226 Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)

227 nicotinamide moiety of nicotinamide adenine dinucleotide phosphate (NADP(+) ) for the NA group of ni

228 Nicotinamide adenine dinucleotide phosphate (NADP(+)) is essential for produc

229 loiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP(+) are cycled ra

230 f dFB neurons through a nicotinamide adenine dinucleotide phosphate (NADPH) cofactor bound to the oxi

231 sis and regeneration of nicotinamide adenine dinucleotide phosphate (NADPH) in p53-deficient cancer c

232 ng power in the form of nicotinamide adenine dinucleotide phosphate (NADPH) is required to mitigate o

233 emia linked to impaired nicotinamide adenine dinucleotide phosphate (NADPH) production and imbalanced

234 ME1 also promotes nicotinamide adenine dinucleotide phosphate (NADPH) production, lipogenesis,

235 tration of glutathione, nicotinamide adenine dinucleotide phosphate (NADPH), and nicotinamide adenine

236 ficantly higher reduced nicotinamide adenine dinucleotide phosphate levels, reduced reactive oxygen s

237 ignalling axis and that nicotinamide adenine dinucleotide phosphate oxidase (NOX)-dependent ROS produ

238 -mediated activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX).

239 ations are prominent, including nicotinamide dinucleotide phosphate oxidase defects in chronic granul

240 Nicotinamide adenine dinucleotide phosphate oxidase isoform 2 is an enzyme co

241 The NOX (nicotinamide adenine dinucleotide phosphate oxidase) family includes seven un

242 These pathways include nicotinamide adenine dinucleotide phosphate oxidase, which generates microbic

243 , likely by stimulating nicotinamide adenine dinucleotide phosphate oxidase.

244 such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited.

245 e, 3-nitrotyrosine, and nicotinamide adenine dinucleotide phosphate oxidases).

246 te the possible role of nicotinamide adenine dinucleotide phosphate reduced form oxidases (NOXs) in M

247 n by generating reduced nicotinamide adenine dinucleotide phosphate to enhance biosynthesis and by re

248 ) (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR

249 NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase-dependent killing and, i

250 nosine triphosphate and nicotinamide adenine dinucleotide phosphate, and have become attractive bioca

251 kers of senescence, and nicotinamide adenine dinucleotide phosphate, reduced form oxidases (NOXs) wer

252 lcholinesterase (AChE), nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d), glutamic ac

253 cell therapy decreased nicotinamide adenine dinucleotide phosphate-oxidase 2 and inducible nitric ox

254 vity, cellular oxidized nicotinamide adenine dinucleotide phosphate/NADPH levels, phagocytic reactive

255 fluorescence of reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) and flavin adenine di

256 autofluorescent reduced nicotinamide adenine dinucleotide (phosphate), NAD(P)H, has been previously e

257 sively mobilized by nicotinic acid adenosine dinucleotide-phosphate (NAADP): both Ca(2+) mobilization

258 r with increased NADPH (nicotinamide adenine dinucleotide phosphateoxidase) activity and mitochondria

259 tern, namely anti-WW/SS pattern, in which WW dinucleotides preferentially occur at DNA sites that ben

260 As via endonucleolytic cleavage at CA and UA dinucleotides, preferentially at scissile bonds located

261 at, in adult mouse cells, hypomethylated CpG dinucleotides preserve a nearly complete archive of tiss

262 In this study, we observe changes in dinucleotide production, transcription elongation comple

263 ce-derived features, such as sparse profile, dinucleotide profile, position weight matrix profile, Ma

264 dinucleotide synthetase cGAS and the cyclic dinucleotide receptor STING.

265 tathione (GSH/GSSG) and nicotinamide adenine dinucleotide reduced/oxidized forms (NADH/NAD(+)) are cr

266 , which generates NADH (nicotinamide adenine dinucleotide, reduced form) from NAD, underlies how ALDH

267 identified 155, 46, and 168 cytosine-guanine dinucleotide regions associated (FDR-P < 0.05) with the

268 ed significantly associated cytosine-guanine dinucleotide regions for 82 transcripts (false discovery

269 Dinucleotide relative abundances are considered an idios

270 Here we show that TA-dinucleotide repeats are highly unstable in MSI cells an

271 In the absence of WRN, the expanded TA-dinucleotide repeats are susceptible to cleavage by the

272 NA replication direction and is caused by TG-dinucleotide repeats.

273 and also attained increased cytosine guanine dinucleotide responsiveness.

274 Many CFSs are enriched with AT-dinucleotide rich sequences (AT-DRSs) which have the pot

275 synthase (cGAS) and production of the cyclic dinucleotide second messenger 2',3'-cyclic GMP-AMP (cGAM

276 Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes

277 Although many dinucleotide short tandem repeat (diSTR) markers are ava

278 revented explanation of the origin of cyclic dinucleotide signalling in mammalian innate immunity.

279 (S (p) and R (p)) at six different flanking dinucleotide sites, i.e. XT and TX (X = A, C, or G), and

280 w database to include genomic codon-pair and dinucleotide statistics of all organisms with sequenced

281 structing candidate chains in representative dinucleotide steps and refining the models against SAXS

282 es are seen in the base stacking of pairs in dinucleotide steps, arising from energetically favorable

283 Cyclic dinucleotide STING agonists may comprise a novel class o

284 However, CC>TT dinucleotide substitution, which is also commonly observ

285 re a strong preference for pyrimidine-purine dinucleotides surrounding the TSS.

286 activation of the recently discovered cyclic dinucleotide synthetase cGAS and the cyclic dinucleotide

287 es, oligonucleotides having 5'TC3' or 5'CT3' dinucleotide target sites, and different flanking bases

288 We report that HIFs fail to bind CpG dinucleotides that are methylated in their consensus bin

289 or in human cells that senses foreign cyclic dinucleotides that are released during bacterial infecti

290 with ~10-bp periodic WW (where W is A or T) dinucleotides that oscillate in phase with each other an

291 s acetolactate synthase, is a flavin adenine dinucleotide-, thiamine diphosphate- and magnesium-depen

292 ective receptors that allow these two cyclic dinucleotides to control very different biological funct

293 erapeutic opportunities, ranging from cyclic dinucleotides to genome methylation inhibitors, angiogen

294 ibonuclease REXO2 degrades mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non

295 terised, whether an analogous process drives dinucleotide underrepresentation in plant viruses remain

296 age, codon pair usage, dinucleotide/junction dinucleotide usage, RNA structure around the frameshift

297 bs cycle to generate NADH and flavin adenine dinucleotide, which are further oxidized by the respirat

298 s and depletes cellular nicotinamide adenine dinucleotide, which leads to mitochondrial dysfunction.

299 nical initiation with pyrimidine/purine (YR) dinucleotide, while translation machinery-associated gen

300 methylation of cytosine at the specific CpG dinucleotides will participate in quartet formation, cau

301 ING domains couple the recognition of cyclic dinucleotides with the formation of protein filaments to