ライフサイエンスコーパス: diploid

1 ccharomyces cerevisiae strains are typically diploid.

2 es suggest that most BAs are mononuclear and diploid.

3 d when a single copy of a gene is deleted in diploids.

4 linked selection and rampant gene flow from diploids.

5 nces versus matched S. cerevisiae hemizygous diploids.

6 n that recombination can occur in interphase diploids.

7 emonstrated for sex-specific selection among diploids.

8 ian haploid cells rapidly become enriched in diploids.

9 differentiated faster than those of related diploids.

10 nother axis of advantage for polyploids over diploids.

11 ear-tetraploids is twice as large as in near-diploids.

12 (i.e. low plasticity in fitness) relative to diploids.

13 (Fraxinus pennsylvanica) is an outcrossing, diploid (2n = 46) hardwood tree species, native to North

14 to meiotic restitution and the production of diploid (2n) pollen grains.

15 aired haploid nuclei, they are thought to be diploid (2n).

16 ly quiescent tumor precursors with ancestral diploid/2N genomes and normal Pten/chr19 are observed in

17 es reveals no evidence of less proliferative diploid/2N lesions in Type 1 tumors.

18 e strong resistance to RKN, derived from the diploid A. stenosperma, is transferrable and expressed i

19 accessions of allopolyploid (AD-genome) and diploid (A- and D-genome) Gossypium were evaluated for a

20 aea), fair representation was kept for other diploids (A. duranensis, A. stenosperma, A. cardenasii,

21 , and LKO hepatocytes remained predominantly diploid after extensive proliferation.

22 Epigenetic profiling in diploid, allopolyploid, and domesticated cotton shows th

23 he MS5 in B. napus is inherited from a basic diploid ancestor of B. rapa.

24 on (90.2%) filtered reads were mapped to the diploid ancestors of peanut.

25 quencing of 41 groundnut accessions and wild diploid ancestors, a total of 58,233 unique and informat

26 increase of gene diversity compared to their diploid ancestors.

27 Both groups included diploid and aneuploid tumors.

28 culated a broad geographic sample of natural diploid and autotetraploid alfalfa (Medicago sativa) lin

29 l C. albicans in that they are predominantly diploid and can become homozygous at the mating locus th

30 ies do not have sex chromosomes; females are diploid and males are haploid, with sex usually determin

31 The fruits of diploid and octoploid strawberry (Fragaria spp) show sub

32 The liver contains diploid and polyploid hepatocytes (tetraploid, octaploid

33 haracterized; however, it is unclear whether diploid and polyploid hepatocytes function similarly in

34 Diploid and polyploid hepatocytes responded similarly to

35 ion to reconstruct unspecified haplotypes in diploid and polyploid organisms.

36 Complexes of diploid and polyploid species have formed frequently dur

37 ied to optimize genomic prediction for other diploid and polyploid species.

38 ta was able to form viable hybrid seeds with diploid and tetraploid A. arenosa, associated with the r

39 present a reference map of meiotic stages in diploid and tetraploid S. tuberosum using fluorescence i

40 me-wide allele-specific expression data from diploid and triploid hybrids of S. alburnoides and compa

41 nts of EPA and DHA per mass of the filets in diploid and triploid specimens were similar.

42 We conducted reciprocal crosses using two diploid and two hexaploid populations each crossed to te

43 ore, "mutome" analyses in highly polymorphic diploids and single-cell bottleneck lineages revealed a

44 r among higher order polyploids than between diploids and tetraploids, and unreduced gametes may faci

45 rm of seeds from balanced crosses (diploid x diploid) and lethal (diploid x tetraploid) and viable pa

46 Whereas Ccne1(T) mice accumulated near-diploid aneuploid cells in multiple tissues and organs,

47 gaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes.

48 tion of the polyploid A. hypogaea over other diploid Arachis species cultivated by humans.

49 Assays in diploids are consistent with deleterious mutations in di

50 entiated from their diploid parents than the diploids are from each other.

51 hich atypical spores, such as aneuploids and diploids, are advantageous.

52 e family members in several monocots/dicots, diploid as well as polyploid plant species.

53 We present a method named diploid assembly (DipAsm) that uses long, accurate reads

54 elop a human genome benchmark derived from a diploid assembly for the openly-consented Genome in a Bo

55 iable, 5 million base-pair (bp) region where diploid assembly is particularly useful - the Major Hist

56 embly 22, the first chromosome-level, phased diploid assembly of the C. albicans genome, coupled with

57 el pedigree sequence graph based approach to diploid assembly using accurate Illumina data and long-r

58 ertions and 4,095 deletions supported by >=1 diploid assembly.

59 Multiple types of neurons and glia that are diploid at eclosion, become polyploid in the adult Droso

60 dopsis arenosa, a well characterized natural diploid-autotetraploid plant species, to address these q

61 ulations of Arabidopsis arenosa, a naturally diploid-autotetraploid species.

62 recessive, low-prolamin mutation (lys3a) in diploid barley.

63 The mt(+/-) thallus strain released diploid biflagellate zoids, with ultrastructure and beha

64 se assemblies do not correctly represent the diploid biology of an individual.

65 ion factor regulates cell differentiation in diploid C. albicans cells, as EFG1 hemizygous cells unde

66 Remarkably, the ancestral and diploid Camelina genomes were shaped by complex chromoso

67 Genomes of diploid camelinas (Camelina hispida, n = 7; Camelina lax

68 Diploids can also enter a protective, nondividing cellul

69 d by heterozygosity at the IME1 locus, those diploids can enter quiescence.

70 Some wild diploids can only enter cellular quiescence, which indic

71 We reveal that diploid cardiomyocyte abundance across 41 species confor

72 ac regenerative capacity dominantly comprise diploid cardiomyocytes, raising the hypothesis that card

73 was significantly higher in aneuploid versus diploid cases, and so were gains of the oncogenes MYC an

74 ccination (2 doses of 0.1 mL ID of the human diploid cell culture rabies vaccine [HDCV] at days 0 and

75 Accordingly, we generated a diploid cell line from divergent parents and applied hap

76 ree" saturation genome editing approach in a diploid cell line to simultaneously score 2,542 variants

77 chanisms are likely to synergize to maintain diploid cell populations.

78 WT diploid cells also showed a proliferative advantage, ent

79 fungal pathogen Candida albicans, mating of diploid cells generates tetraploid products that return

80 Moreover, we show that diploid cells in mosaic embryos undertake compensatory p

81 romatin we have established 'isogenic' human diploid cells in which PARP1 and/or PARP2, or PARP3 are

82 is approach to evolve genetic instability in diploid cells of the budding yeast Saccharomyces cerevis

83 near-tetraploid, we transiently transfected diploid cells with siRNA against ESPL1/Separase, a prote

84 arasexual cycle as tetraploid cells, but not diploid cells, exhibit genome instability and reduce the

85 In diploid cells, FANCJ is believed to operate in homologou

86 tation and oxidative respiration relative to diploid cells.

87 disadvantage of haploid cells compared with diploid cells.

88 istant to DNA damage-induced cell death than diploid cells.

89 achieved by applying our recently developed diploid chromatin conformation capture (Dip-C) method to

90 r ASHIC-ZIPM method produced fine-resolution diploid chromatin maps and 3D structures and provided in

91 6, Cast, and hybrid mice, to investigate the diploid chromatin organization and epigenetic regulation

92 , such that the overall level of mononuclear diploid CMs between the two strains is similar.

93 lutionary pressure for C. albicans to become diploid could derive from its use of farnesol.

94 303 haploids can enter quiescence, but their diploid counterparts cannot.

95 racterized a segregating population from two diploid cultivars, Rosa x hybrida cv H190 and Rosa wichu

96 orward and low-cost method for creating true diploid de novo assemblies.

97 of complex structural variants and complete diploid de novo assembly of NA12878.

98 re we describe a reference-free workflow for diploid de novo genome assembly that combines the chromo

99 g, SV detection, scaffolding, cost-effective diploid de novo genome assembly, and other long DNA sequ

100 sing diverse PDR inducers and the homozygous diploid deletion collection, we applied this biosensor s

101 st stages of sex-chromosome evolution in the diploid dioecious herb Mercurialis annua on the basis of

102 s of chemotherapy on the basis of histology, diploid DNA index, chromosome arm 1p or 11q loss of hete

103 nction, or with unfavorable histology and/or diploid DNA index, were eligible.

104 nd analyzed high-quality genome sequences of diploid (E. haploclada), tetraploid (E. oryzicola), and

105 that subsequently recurred (MGG70RR) showed diploid EGFR, suggesting inhibitor-mediated elimination

106 ressing green fluorescent protein (GFP) into diploid embryos.

107 that HCMV infection or treatment of ARPE-19 diploid epithelial cells with DNA-damaging agents, etopo

108 ESCs manifested in the same location as the diploid ESCs.

109 ntages of total FA of triploids and immature diploid females significantly differed from that of matu

110 ) compared to that of triploids and immature diploid females.

111 Applying OligoFISSEQ to human diploid fibroblast cells, we show how four rounds of seq

112 erse models of senescence triggered in human diploid fibroblasts (WI-38, IMR-90) and endothelial cell

113 This correlation was significant in WI-38 diploid fibroblasts and weak in HeLa cells, indicating p

114 at oncogenic RAS-induced senescence in human diploid fibroblasts is accompanied by extensive enhancer

115 U2OS cells or TERT-immortalized normal human diploid fibroblasts results in decreased expression of t

116 s significantly differed from that of mature diploid fish.

117 Petunia x hybrida cv 'Mitchell Diploid' floral volatile benzenoid/phenylpropanoid (FVBP

118 the reads in the related genome of the wild diploid Fragaria vesca revealed differences between the

119 erize the function of this gene, we used the diploid frog Xenopus tropicalis We discover that Dyrk1a

120 containing 34,916 genes, confirming that the diploid gene number in the Solanaceae is around 35,000.

121 lternation between multicellular haploid and diploid generations that facilitated efficient dispersal

122 s, which might lead to incorrect modeling of diploid genome architecture.

123 polyploids of various ages and their likely diploid genome donors or close relatives.

124 Yet, imbalanced alleles, especially from diploid genome regions, are poorly explored in cancer.

125 alable capability for determining the actual diploid genome sequence in a sample, opening the door to

126 reported the genome size based on 2C values (diploid genome) when it is more common to present it as

127 n the context of cis-related variants from a diploid genome.

128 heet junctions are needed for formation of a diploid genome.

129 aploid genome (n), most mammalian cells have diploid genomes (2n).

130 variety of sequencing datasets from trios of diploid genomes are becoming available.

131 ion that enables read alignment across 2,800 diploid genomes encompassing 12.6 million SNPs and 4.0 m

132 of producing accurate and chromosomal-scale diploid genomes of all individuals in a pedigree, while

133 ies will soon permit the routine assembly of diploid genomes, which will revolutionize genomics by re

134 hallenging to detect small-scale variants in diploid genomes.

135 d phase single-nucleotide variants (SNVs) in diploid genomes.

136 l allele-specific chromatin organizations in diploid genomes.

137 hat moves one step closer to fully resolved, diploid genomes.

138 Allopolyploid accessions from either diploid genomic group did not show significant differenc

139 have been obtained by sequencing 602 Mb of a diploid genotype using a strategy that combined long-rea

140 estimate haplotype frequencies and r(2) from diploid genotypes under Hardy-Weinberg Equilibrium.

141 telinum from north-east Brazil, the D-genome diploid Gossypium klotzschianum from the Galapagos Islan

142 spanning the Gli-2 locus was analyzed in the diploid grass, Aegilops tauschii, the ancestral source o

143 Specifically, mature diploids had higher percentage of EPA and DHA in their m

144 assembly performance to existing methods for diploid, haploid and trio-binned human samples and repor

145 esults demonstrated that different clades of diploid Helianthus species showed evolutionary patterns

146 ive phylogenetic analysis of GS evolution in diploid Helianthus species.

147 terized, demonstrating a 20-fold increase in diploid hepatocytes and maintenance of the diploid state

148 n LKO mice were driven, at least in part, by diploid hepatocytes capable of rapid proliferation.

149 Conclusion: Diploid hepatocytes proliferate faster than polyploids,

150 c selection acting at some point between the diploid heterozygous parents and progeny genotyping and

151 Consequently, the existing diploid Hi-C analyses are based on sparse and inaccurate

152 ods impute allele-specific contact maps from diploid Hi-C data and simultaneously infer allelic 3D st

153 However, current methods for analyzing diploid Hi-C data cannot fully distinguish between homol

154 Additionally, in the analyses of diploid Hi-C datasets in mouse and human, our ASHIC-ZIPM

155 that polyploids developed slower compared to diploids; however, tetra- and hexaploids, but not octapl

156 patterns of phase as key characteristics of diploid human exomes and provides evidence for their fun

157 -passage human embryonic lung cells or MRC-5 diploid human fibroblasts, the cells used for vaccine pr

158 lymer model to study the organization of the diploid human genome.

159 For diploid human genomes sequenced to 30x HiFi coverage, Hi

160 Like a diploid hybrid, allopolyploids will have two versions, o

161 lization in bacterial mutualisms relative to diploids, illustrating another axis of advantage for pol

162 sample DNA, which, due to low copy numbers (diploid in humans), lead to inherent data sparsity (1-10

163 SVs are common, with 31.5% of diploid individuals harboring a SV in genes larger than

164 tion site-associated DNA sequencing, and for diploid Ipomoea trifida and autotetraploid potato utiliz

165 d with calcification and genes unique to the diploid life stages of E. huxleyi significantly increase

166 A diploid-like behaviour at metaphase I involving bivalent

167 oidisation process returning polyploids to a diploid-like state over time.

168 of the Brachypodium species complex, and the diploid lines provided a resource that allows complex tr

169 A core set of diverse B. distachyon diploid lines was selected for whole genome sequencing a

170 Diploid males were found in many UK nests, while microsa

171 overy rate twice as high as the conventional diploid-mating approach and a processing time nearly one

172 hat the evolution of larger GS in Helianthus diploids may be more permissible in habitats with longer

173 e been key to understanding gene function in diploid model organisms, are missing in many polyploid c

174 generate homozygous single- and double-gene diploid mutants.

175 Strong diploid mutator phenotypes produced a form of genetic an

176 owever, because of genetic diversity and the diploid nature of the human genome, we hypothesize that

177 All Saimiri species apparently have a diploid number of 2n = 44 but vary in the number of chro

178 s the chromosomal rearrangements in this low-diploid-number group of Proechimys species.

179 Galapagos Islands, followed by the A-genome diploids of Africa and Asia.

180 ching process, randomly applying events to a diploid oncogenome, altering probabilities of proliferat

181 rease ploidy, and animal models with healthy diploid-only livers have not been available.

182 ale meiosis, haploid eggs are generated from diploid oocytes.

183 erall, 1897 samples were classified into two diploid or allopolyploid species, and then further group

184 liver contains a mixture of hepatocytes with diploid or polyploid (tetraploid, octaploid, etc.) nucle

185 In addition, diploid or polyploid hepatocytes from wild-type (WT) mic

186 s also were coded as apomictic or sexual and diploid or polyploid.

187 model, it is unclear how homolog pairing in diploids or environmental conditions influence overall g

188 species diversification rates than those of diploids or lineages with lower polyploid frequencies.

189 e two sequences that make up the genome of a diploid organism (i.e. haplotypes), but for an unknown n

190 nd sperm gametes to form the genome of a new diploid organism.

191 Gene-drive systems in diploid organisms bias the inheritance of one allele ove

192 Diploid organisms have two homologous copies of their DN

193 netic and genetic cis-regulatory elements in diploid organisms may cause allele specific expression (

194 ion-diffusion model for sexually reproducing diploid organisms to study how a locally introduced gene

195 l to study the effects of paleopolyploidy in diploid parental species, as well as the effects of rece

196 from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells e

197 more climatically differentiated from their diploid parents than the diploids are from each other.

198 tween resynthesized allopolyploids and their diploid parents.

199 The irreversibility of this process renders diploid partial apomicts evolutionarily short-lived, and

200 Strong resistance is present in the wild diploid peanut relatives.

201 These patterns include haploid- and diploid-phase sex determination, isogamous mating system

202 the breeding habits and genetic diversity of diploid populations.

203 density reference-based haplotype maps using diploid potato clones as parents.

204 the 1.67-Gb haplotype-resolved assembly of a diploid potato, RH89-039-16, using a combination of mult

205 DNA sequence data of 202 wild and cultivated diploid potatoes, Solanum section Petota, to explore its

206 Although mammalian genomes are diploid, previous studies extensively investigated the a

207 Diploid primordial germ cells (PGCs) are a potential mea

208 as one natural tetraploid and its synthetic diploid produced via haploid induction, to estimate tran

209 During meiosis, diploid progenitor cells undergo one round of DNA replic

210 Aegilops tauschii is the diploid progenitor of the D genome of hexaploid wheat (T

211 We identified the extant relatives of each diploid progenitor species and provide support for the N

212 es, both descendants from the merger of four diploid progenitor species into a single nucleus more th

213 nd a paternal, extinct Fragaria iinumae-like diploid progenitor, probably in Beringia during the Plei

214 able elements in these allopolyploids, their diploid progenitors and in corresponding synthetic hybri

215 aploid forage crop derived from two European diploid progenitors confined to extreme coastal or alpin

216 wo ways - by fixation of heterozygosity from diploid progenitors in allopolyploids, and by generation

217 We estimate that the two diploid progenitors successively diverged from Benincase

218 Arabidopsis (Arabidopsis thaliana) and their diploid progenitors, as well as one natural tetraploid a

219 ana allopolyploids reflect their dynamics in diploid progenitors.

220 ion is part of the standing variation in its diploid progenitors.

221 allotetraploid Brachypodium hybridum and its diploid progenitors.

222 or introgression of new variability from the diploid progenitors.

223 -Sequencing (GBS) was applied in a set of 53 diploid Prunus rootstocks and five scion cultivars from

224 13, N(6)H) arose from hybridization between diploids related to C. neglecta (n = 6, N(6)) and C. his

225 Ipomoea imperati is a wild diploid relative of sweet potato with the capability of

226 d species are more differentiated than their diploid relatives and if the climatic niches of polyploi

227 ultivariate niche differentiation than their diploid relatives.

228 otetraploid cottons and their tetraploid and diploid relatives.

229 es in hexaploid wheat and its tetraploid and diploid relatives.

230 Phylogenetic comparative analyses of diploids revealed significant negative associations of G

231 products were used as nanopriming agents for diploid (Riverside) and triploid (Maxima) watermelon see

232 The diploid S. italica genome contains 32 TPS genes, 17 of w

233 es and characterize de novo mutations in 274 diploid Saccharomyces cerevisiae mutation accumulation l

234 As a reference, diploid salmon kept under equal conditions and with equa

235 s to 2E[r(2)](1 - E[r(2)])/n, where n is the diploid sample size.

236 m6dA are found on a single chromosome from a diploid sample, suggesting inheritance.

237 s pattern formation, venom production, haplo-diploid sex determination, and host-symbiont interaction

238 ] is a sexually-compatible weedy relative of diploid sorghum [Sorghum bicolor (L.) Moench].

239 us that links its chromosomes to the related diploid Sorghum and complex polyploid sugarcanes.

240 accession of Mentha longifolia (L.) Huds., a diploid species ancestral to cultivated peppermint and s

241 genome organization of a clonally propagated diploid species and provides insights into technological

242 In Central Europe, the diploid species Arabidopsis lyrata and Arabidopsis areno

243 ait loci (QTLs) is now a routine practice in diploid species but is far less advanced in autotetraplo

244 , expansion and relative stasis, with annual diploid species evolving smaller GS with the highest rat

245 ypium hirsutum is generally susceptible, the diploid species G. arboreum is a natural source for resi

246 ons, SNPs polymorphic between tetraploid and diploid species were included for use in cultivated and

247 ed high-quality polymorphic clusters between diploid species, 47 116 polymorphic markers between cult

248 hybridisation between increasingly divergent diploid species.

249 ter hybridization between a tetraploid and a diploid species.

250 gh RCs during spermatogenesis, from two-cell diploid spermatogonia to clusters of 64 post-meiotic hap

251 nized differentiation process, starting with diploid spermatogonia, which include germ-line stem cell

252 e isolates generating up to 46% aneuploid or diploid spores.

253 ns regulate development of the multicellular diploid sporophyte in both mosses and flowering plants;

254 e progression and endoreplication during the diploid sporophyte phase.

255 Hypomethylated and highly expressed genes in diploid sporophytes included genes involved in morphogen

256 thylome profiles of haploid gametophytes and diploid sporophytes of a multicellular alga.

257 al life cycles alternate between haploid and diploid stages, the transitions between which are deline

258 n diploid hepatocytes and maintenance of the diploid state even after extensive proliferation.

259 rates tetraploid products that return to the diploid state via a non-meiotic process of depolyploidiz

260 ze and can be maintained in both haploid and diploid states.

261 The diploid status of most cells correlates with the number

262 ations, as heterozygotes, into the ancestral diploid strain caused genetic instability.

263 Some diploid strains with fewer than two mutations per megaba

264 Diploid strains, derived by mating haploids of various g

265 m this 17.4 Mb genome, we find an unexpected diploid structure for most chromosomes and a propionate

266 but not plasticities between polyploids and diploids, suggesting that increased genomic redundancy i

267 Introduction of SSD1 to W303 diploids switches fate, in that it rescues cellular quie

268 are consistent with deleterious mutations in diploids tending towards recessivity.

269 es produced pentaploids exclusively, whereas diploid-tetraploid crosses produced both triploids and t

270 ploids, and unreduced gametes may facilitate diploid-tetraploid reproduction.

271 d not only each type of gametophyte but also diploid thalli carrying the mt(-) and mt(+) genome (mt(+

272 In diploids, the order of transcriptome abundance is centra

273 Relative to homozygous diploids, the presence of multiple homologs or homeologs

274 We created haploid and heterozygous diploid Tn7 insertional mutagenesis libraries in S. uvar

275 ntal problem in studying gene regulation and diploid transcriptome profiles, with two key challenges:

276 y control gene expression for the haploid-to-diploid transition during sexual reproduction in the uni

277 y reduced in the tetraploids compared with a diploid variety, which likely indicates meiotic adaptati

278 Ploidy (diploid vs polyploid states) and breeding system (self-i

279 opsis thaliana tetraploid lines and isogenic diploids, we show that transcriptome abundance doubles i

280 Seq) to exploit pan-genome variation in wild diploid wheat and rapidly clone four stem rust resistanc

281 onses to postanthesis N and S supply for the diploid wheat einkorn (Triticum monococcum).

282 istance gene Sr60, a race-specific gene from diploid wheat Triticum monococcum L. that encodes a prot

283 In contrast to diploids, where genotype frequencies remain constant aft

284 sed on sexually antagonistic selection among diploids, which has been shown to be a potent driver of

285 lls doubles in tetraploid plants compared to diploid, while the degree of change and relationship to

286 -passage) and senescent (late-passage) human diploid WI-38 fibroblasts.

287 ype collection of six allopolyploid and five diploid wild strawberry (Fragaria) taxa in three climati

288 in accumulation and distribution observed in diploid woodland strawberry (F. vesca) and octoploid cul

289 he endosperm of seeds from balanced crosses (diploid x diploid) and lethal (diploid x tetraploid) and

290 raploid) and viable paternal excess crosses (diploid x tetraploid nrpd1).

291 nced crosses (diploid x diploid) and lethal (diploid x tetraploid) and viable paternal excess crosses

292 variety of healthy human and disease state X diploid (XX) cells.

293 genetic events cause genetic instability in diploid yeast cells, and propose that similar, heterozyg

294 consistently decreases cellular longevity in diploid yeast cells.

295 disease genes into a pool of 4653 homozygous diploid yeast deletion mutants with unique barcode seque

296 Together, these results reveal that the diploid yeast genome has a dynamic and complex 3D organi

297 igree approach on a simulated trio of pseudo-diploid yeast genomes with different heterozygosity rate

298 the 4,732 strains comprising the homozygous diploid YKOC.

299 ogametes by haploid microgametes, results in diploid zygotes, around which a protective wall develops

300 , meiosis completion and formation of normal diploid zygotes.