ライフサイエンスコーパス: direct action

1 ce of gabazine or tetrodotoxin, indicating a direct action.

2 ure levels are a key determinant of proposed direct actions.

3 utcome (R-O) associations that underlie goal-directed action.

4 ent, but also joint attention and joint goal-directed action.

5 s for observation and execution of an object directed action.

6 ion and reprogramming of a naturalistic goal-directed action.

7 tion of the medial prefrontal cortex in goal-directed action.

8 also operate for the visual guidance of goal-directed action.

9 dopamine in a key position to promote reward-directed action.

10 action-outcome contingencies to control goal-directed action.

11 rds themselves, rather than stored memories, directed action.

12 te responses of neurons proximal to the goal-directed action.

13 cessing in the hippocampus may modulate goal-directed action.

14 standing the spatiotemporal dynamics of goal-directed action.

15 alizing touch in space is essential for goal-directed action.

16 his is true for perception, but not for goal-directed action.

17 vestigate the planning and execution of goal-directed actions.

18 nally driven inputs for the planning of goal-directed actions.

19 rons and stimulus-guided choice between goal-directed actions.

20 cessing of number magnitudes and environment-directed actions.

21 ordinate reliable execution of flexible goal-directed actions.

22 coming more and DLS less engaged during goal-directed actions.

23 similar activity was observed for non-object directed actions.

24 ey roles in our normal and pathological goal-directed actions.

25 response is significantly greater for object directed actions.

26 g object directed and meaningless non-object directed actions.

27 microcircuits that ultimately influence goal-directed actions.

28 erving spatial awareness and oculomotor goal-directed actions.

29 mance of recently acquired instrumental goal-directed actions.

30 omponents of the MNS in understanding object-directed actions.

31 d the passive observation of particular goal-directed actions.

32 t sensory information that best informs goal-directed actions.

33 rming body-directed grooming actions and leg-directed actions.

34 on is elaborated in terms of meaningful goal-directed actions.

35 ific impairment in the ability to alter goal-directed actions.

36 is likely due to their common role in object-directed actions.

37 , leading to a conscious integration of goal-directed actions.

38 and the NAc core in the performance of goal-directed actions.

39 ns involved in the cognitive control of goal-directed actions.

40 ence unless the events are initiated by goal-directed actions [1].

41 suggests that the ACC selects extended goal-directed actions according to their learned costs and be

42 As expected, observing goal-directed actions activated a parietofrontal network know

43 A goal-directed action aiming at an incentive outcome, if repea

44 in relation to its role in controlling goal-directed action and reward-guided behaviors, yet very li

45 c activity disrupts the neural bases of goal-directed action and thus renders behavior habitual.

46 These mediators exert potent leukocyte directed actions and control vascular inflammation.

47 e and infer tool functions from others' goal-directed actions and demonstrations.

48 th dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediati

49 my in instrumental conditioning between goal-directed actions and habits that are distinguishable on

50 asks typically consist of a series of target-directed actions and often require choices about which t

51 longitudinal effect of social defeat on goal-directed actions and prefrontal cortical activity in mic

52 ce-processing system in representing subject-directed actions and supporting social cognition.SIGNIFI

53 has an established role in representing goal-directed actions and their outcomes, it is not known whe

54 was associated with observation of the goal-directed action, and a smaller part with the perception

55 abuse modulate learning of habitual and goal-directed actions, and can also modify long-term plastici

56 Goal-directed actions are sensitive to work-related response

57 t object directed and meaningless non-object directed actions are subserved by different neuronal net

58 Goal-directed actions are supported by orbitofronto-striatal

59 ation of addiction, related to impaired goal-directed actions, as well as countervailing resilience s

60 tnatal cortical neurons does not rely on its direct action at the cytosol/mitochondria but is exclusi

61 Zn(2+) and death of CA1 neurons, although a direct action at the time of the rise in Zn(2+) is unpro

62 upport the hypothesis that some GAs, through direct actions at TRP channels, increase postsurgical pa

63 mechanisms for adapting the control of goal-directed actions based on dissociable dimensions of feed

64 alues and the subsequent choice between goal-directed actions based on those values.

65 der crowded conditions, whereas its plus end-directed action, being less space-hungry, is not.

66 n alter the excitability of GnRH neurons via direct action, but the intracellular signaling cascades

67 ovements, implying a functional role in goal-directed actions, but not necessarily more covert forms

68 assembly factors from importin beta, and 2) direct action by transportin binding and inhibiting asse

69 uption in the balance between flexible, goal-directed action control and habitual behavior.

70 ce in circuitry underlying habitual and goal-directed action control, which may represent a fundament

71 ty of OFC-DS terminals is necessary for goal-directed action control.

72 ion-making that allows for habitual and goal-directed action control.

73 ring engagement in non-self-referential goal-directed actions (default mode of brain function).

74 Goal-directed actions depend on our capacity to integrate the

75 was present in FGF23-null mice, indicating a direct action distinct from Klotho's known role as a cor

76 pantomimes (iconic representations of object-directed actions; e.g., playing guitar), emblems (conven

77 nflammation and display specific, epithelial-directed actions focused on mucosal homeostasis.

78 ciations, as well as the performance of goal-directed actions guided by previously acquired associati

79 ignment of reward or inventive value to goal-directed actions has been found to involve the basolater

80 medial striatum (pDMS) is necessary for goal-directed action; however, the role of the direct (dSPN)

81 s been implicated in the acquisition of goal-directed actions; however, no direct evidence of learnin

82 ted reduction of lipid synthesis by E2 via a direct action in islets, and PERalpha-/- mice were predi

83 effects of opioids result solely from their direct action in the CNS.

84 part by neutralizing this effect, either by direct action in the growth cone or indirectly by transc

85 imulate glucose-dependent insulin release by direct action in the pancreas and to promote secretion o

86 To determine whether Cn exerts direct actions in osteoblasts, we generated mice lacking

87 ertwined roles of sensation, experience, and directed action in navigation has been facilitated by th

88 s, we examined the role of pDMS SPNs in goal-directed action in rats and found that whereas dSPNs wer

89 ontrol processes are critical to select goal-directed actions in flexible environments.

90 ntribution of these sources of value to goal-directed actions in people with schizophrenia (SZ) (n =

91 to be necessary for the acquisition of goal-directed actions in rodents.

92 the performance of, and choice between, goal-directed actions in tests of outcome-specific Pavlovian-

93 re required to select among remembered, goal-directed actions in the same places; (ii) the same neuro

94 MaR1(n-3 DPA), each exerted potent leukocyte directed actions in vivo.

95 tion, and it tests whether knowledge of goal-directed actions, including an assumption that actors ma

96 blish that, in mice, the acquisition of goal-directed actions induced plasticity in both D1- and D2-S

97 D patients have difficulties performing goal-directed actions, instead exhibiting repetitive stimulus

98 s well established, but the mechanism of any direct action is mysterious because stathmin binds to mi

99 The ability to sustain goal-directed action is essential for success in many domains

100 whether the involvement of the mPFC in goal-directed action is limited to the acquisition or to the

101 ability to shift between repetitive and goal-directed actions is a hallmark of cognitive control.

102 Choice between goal-directed actions is determined by the relative value of

103 ow that our capacity to infer rational, goal-directed action likely arose at least as far back as the

104 In addition to their DNA synthesis-directed actions many nucleoside analogs trigger apoptos

105 Sustainment of goal-directed action may require suppression of vHP because o

106 The direct-action model is shown to be more accurate than th

107 of proadipogenic factors in adipocytes, with direct action noted at the CAAT enhancer-binding protein

108 articipants viewed (i) short films of object-directed actions (ODAs) which were either semantically m

109 lar change in relative gene expression is by direct action of a CSF can be confounded by endogenous m

110 behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA do

111 ected mice from tumors in vivo, suggesting a direct action of Ab on the tumor cells.

112 etion of PIP2 itself from the membrane, or a direct action of activated Galpha(q) on TASK channels.

113 contrast, inhibition of TRPM8 is caused by a direct action of activated Galphaq independent of the ph

114 We provide evidence for the direct action of Ago2 in mitochondrial translation by cr

115 and Galpha(q)-coupled receptors requires the direct action of both Gbetagamma and Galpha(q) on PLCbet

116 mewhat controversial, favoring an immediate, direct action of calcium on ciliary beating and a second

117 retinohypothalamic projection, suggesting a direct action of cannabinoids on the retinohypothalamic

118 An in vitro assay confirms the direct action of caspase-8 cleavage on IRF-3.

119 NF-AT detected herein may form the basis of direct action of CsA on IL-22 expression by T cells, whi

120 lling is monitored and modulated through the direct action of DNA-repair factors.

121 Consistent with a direct action of doxorubicin, enhancement of nucleosome

122 ulture method of the mammary gland where the direct action of estrogens can be tested during embryoni

123 be a result of surface restructuring by the direct action of fluoride at the crystal surface.

124 These data provide support for the direct action of GABA on mechanisms of acetylcholine rel

125 This phenotype can be attributed to a direct action of galectin-8 on primary cultures of osteo

126 of a reduction in AMPAR expression or of the direct action of gamma-8.

127 ion, express the GH receptor, suggesting the direct action of GH on these cells.

128 ong chain fatty acid levels but also through direct action of glucose on PPARalpha.

129 receptors represent a therapeutic target for direct action of GnRH analogues on certain proliferating

130 ial cell movement into the lung requires the direct action of hedgehog signaling.

131 HSPCs promote repair after stroke maybe via direct action of HSPC-derived MT-I and could therefore b

132 sites is thought to depend critically on the direct action of IFN-gamma on macrophages, this premise

133 LC migration is thought to require the direct action of IL-1beta and IL-18 on LC.

134 Direct action of IL-1beta is likely not the cause of the

135 ominantly by activated CD4 T cells, and that direct action of IL-21 on CD8 T cells was critical for t

136 A direct action of IL-23 on primary melanocytes, shown to

137 In contrast with studies suggesting that the direct action of inflammatory cytokines on muscle is suf

138 bolite within the MEP pathway rather than by direct action of IspE.

139 take and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocor

140 ulation of non-BM-derived cells, not through direct action of leptin on Th1 immunity.

141 opreventive effect of fish oil is due to the direct action of n-3 PUFA and not to a reduction in the

142 While the direct action of NIC on central neurons appears to be es

143 This direct action of norepinephrine in the POAH was tested i

144 ACV infection, we found that this reflects a direct action of OX40 expressed by CD8 T cells.

145 TRPM2 channel activation can occur through a direct action of oxidants on TRPM2 channels or indirectl

146 ls, but it is not known if this was due to a direct action of P-CREB on the CART gene promoter.

147 The direct action of PFC on posterior regions can be directl

148 anges in channel activation rather than by a direct action of phosphorylation on the capsaicin bindin

149 t time that LT synthesis is inhibited by the direct action of protein kinase A (PKA) on 5-LO.

150 These data could be explained by a direct action of Rab3A on the fusion pore, or by Rab3A-d

151 n', has traditionally been attributed to the direct action of radially oriented diaphragmatic muscle

152 rgeting of transport machinery, suggesting a direct action of soluble alpha-synuclein on trafficking

153 es to the presence of Xf, rather than to the direct action of the bacterium.

154 tion of the annexin A2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex.

155 activities of IL-4 can be attributed to the direct action of this cytokine on myeloid effector cells

156 ic and pharmacological studies identifying a direct action of TSH on the skeleton.

157 nse to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic

158 We further demonstrated that direct action of type I IFN on NK cells, but not on dend

159 , our findings demonstrate the importance of direct action of type I IFNs on NK cells to mount effect

160 ral infection is critically dependent on the direct action of type I interferons (IFN-Is) on CD8 T ce

161 The mechanisms include the direct action of uric acid on smooth muscle and vascular

162 To determine whether direct actions of AT(1) receptors in epithelial cells of

163 These findings suggest that direct actions of AT1A receptors in VSMCs are essential

164 , indicating that they did not arise through direct actions of cADPR or Ca(2+) on the IP(3)R, but lik

165 porter Npt2a in alphaKL-null mice supporting direct actions of cKL in the absence of mKL.

166 ciated heart injury may be attributed to the direct actions of fructose on cardiomyocytes.

167 lism in states of GH resistance results from direct actions of GH on lipid uptake and de novo lipogen

168 We propose that these direct actions of glucose on the arousal- and metabolism

169 Our findings demonstrate that direct actions of gonadal steroids in GHRH neurons modul

170 Direct actions of increased bile acids on bile acid rece

171 ns and signaling pathways is a result of the direct actions of intact lycopene or its derivatives.

172 The results indicate direct actions of K(ATP) channel modulators within hair

173 Our data reveal the direct actions of NRG1 signaling in ErbB4-expressing int

174 The direct actions of SCG10 on microtubules themselves and o

175 Some brain sexual dimorphisms, however, are direct actions of sex chromosome genes that are not medi

176 We trace this paradox to two direct actions of SHH: promoting quiescent-SC proliferat

177 lpha conjugate (mAb-IFN-alpha) could kill by direct actions of the monoclonal antibody (mAb) and IFN-

178 Here we investigated the direct actions of the proresolution mediator resolvin E1

179 that IH after vascular injury is due to the direct actions of thrombin on mobilized VPs.

180 These enhancements were not due to the direct actions of TLR ligands on LCs, but mainly depende

181 It has proven difficult to show direct actions of UVA as a carcinogen in human cells.

182 eptor(s) involved in mediating the leukocyte-directed actions of RvD5n-3 DPA and identified GPR101 as

183 l role for GPR101 in mediating the leukocyte-directed actions of RvD5n-3 DPA.

184 nts or communicative gestures, as non-object directed actions of the upper limb are not well characte

185 ating a role for SPM in mediating the immune-directed actions of this supplement.

186 manner and that Cdk5 suppresses ERKs through direct action on a novel site in MAP kinase/ERK kinase (

187 The effect of pioglitazone appears to be a direct action on beta cells, as islets from mice treated

188 However, information about its direct action on cancer cells is limited.

189 rt disease and may act, at least in part, by direct action on cardiac fibroblasts and myocytes to alt

190 AnxA1 has a direct action on cardiac macrophage polarization toward

191 g Th2 responses during allergen challenge by direct action on CD4 T cells; however, these studies did

192 ffects of long-acting GLP1R agonists are via direct action on CNS GLP1R or the result of downstream a

193 n of reward circuitry is more complex than a direct action on DA neurotransmission.

194 TRPV4-mediated mechanism of sensitization by direct action on dissociated primary afferent neurons.

195 he PepT1 transport function probably through direct action on enterocytes.

196 gical improvements were most likely due to a direct action on EP4 receptors expressed on collecting d

197 inal goblet cell differentiation not through direct action on epithelial cells but indirectly through

198 mate fails to trigger GABA release through a direct action on GABAergic terminals under physiological

199 sses the NF-kappaB signaling pathway through direct action on IkappaB kinase (IKK).

200 spinal cord, such effects may be mediated by direct action on microglial cells.

201 the steady-state catastrophe frequency by a direct action on microtubules, and furthermore, they ind

202 These results reveal that STZ has a direct action on neurons and modulates the expression an

203 gh-density lipoprotein (HDL) cholesterol has direct action on numerous cell types that influence card

204 ese results suggest that besides the claimed direct action on organoarsenicals, ArsH contributes to r

205 DTG expression requires the PIFs, indicating direct action on PIF activity, rather than a parallel an

206 ediones result, at least in part, from their direct action on podocytes, similar to glucocorticoids.

207 duction, kisspeptin and GnIH, exert a strong direct action on POMC neurons.

208 d the evoked release of GABA, both through a direct action on presynaptic H(3) receptors (presumably

209 est that stathmin can promote catastrophe by direct action on protofilament structure and interaction

210 d that the inhibitor kills parasites through direct action on PSAC.

211 al GCs can mediate the stress effect through direct action on RFRP cells.

212 s to whether this suppression results from a direct action on sensory neurons and what are the cellul

213 Therefore, along with direct action on specific brain substrates, central effe

214 thymocyte progenitors, possibly through its direct action on TARPP.

215 RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.

216 whether the activity of ArsH was linked to a direct action on the arsenic compounds tested, arsH1 and

217 that an early step in the signal cascade is direct action on the cell membrane potential.

218 solated arteries showed that this occurs via direct action on the endothelium.

219 secretion was unaffected, arguing against a direct action on the exocytotic machinery.

220 ctions have always been assumed to be due to direct action on the heart since the larval heart was no

221 as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome prolife

222 ivert the cytolytic machinery, impairing its direct action on the plasma membrane.

223 al axons and their postsynaptic targets by a direct action on the vesicle fusion machinery.

224 amo-pituitary-adrenal (HPA) axis function by direct action on these neurons, we examined the effects

225 s elusive whether RPL11 inactivates MDM2 via direct action on this zinc finger domain and what is the

226 ifferentiation of fungus-specific T cells by direct action on those cells, cooperation with non-T cel

227 In addition, plinabulin exerts a direct action on tumor cells, resulting in apoptosis.

228 to inhibit gastric transit was the result of direct action on vagovagal reflex circuitry in the dorsa

229 rus entry was demonstrated to be by both the direct action on virus particles and the interference on

230 e to energy homeostasis by regulating CBT by direct actions on AdipoR1 and R2 in the POA.

231 ase in glutamate release probability with no direct actions on AMPAR function.

232 that the calcineurin effect was mediated by direct actions on astrocytes.

233 clast differentiation and bone remodeling by direct actions on bone, rescuing OPG production and rest

234 ic and cardiac inflammatory response through direct actions on both the ischemic myocardium and leuko

235 loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage.

236 BDZs) enhance GABA(A) receptor inhibition by direct actions on central BDZ receptors (CBRs).

237 Whether CRP has direct actions on endothelium and the mechanisms underly

238 ecific antibodies mediate protection through direct actions on fungal cells and through classical mec

239 ematopoietic stem cell proliferation by both direct actions on hematopoietic cells and through modula

240 l effects were mediated at least in part via direct actions on hepatocytes and were preserved in hepa

241 sm for inducing neoangiogenesis through both direct actions on local TrkB-expressing endothelial cell

242 promoting the M2 macrophage phenotype and by direct actions on muscle cells.

243 t bacterial infections regulate pain through direct actions on sensory neurons, and specific receptor

244 ons of dec-RRLL-cmk represent the sum of its direct actions on SKI-1 and indirect actions on caspase-

245 RXDX-106 exhibited its effects via direct actions on TAM RTKs expressed on intratumoral mac

246 morphine inhibited the hypocretin system by direct actions on the cell body that include reduced spi

247 H) activates the behavioral sequence through direct actions on the central nervous system.

248 ones (ETHs) initiate these behaviors through direct actions on the CNS.

249 cts on fetal anthropometry could result from direct actions on the fetus and/or placenta.

250 e and release of catecholamines and may have direct actions on the microvasculature.

251 r to have multiple beneficial effects, their direct actions on the myocardium have the potential to l

252 ing a predictor of coronary events, may have direct actions on the vessel wall in the evolution of at

253 iated vascular mineralization and in part to direct actions on the VSMC.

254 to induction of osteocyte apoptosis through direct actions on these cells.

255 discharge through a depolarization involving direct actions on TIDA neurons.

256 through their own experience producing goal-directed action, or does some knowledge of others' actio

257 Stress promotes a shift from goal-directed action-outcome learning toward habitual stimulu

258 induced an ipsilateral response bias in goal-directed action performance.

259 Understanding object-directed actions performed by others is central to every

260 rdiac subtypes in the resultant populations: direct action potential phenotyping under current-clamp,

261 Contingency theories of goal-directed action propose that experienced disjunctions be

262 The success of these goal-directed actions relies on 3D sensorimotor transformatio

263 The performance of goal-directed actions relies on an animal's previous knowledg

264 ional basis of the visual processing of goal-directed actions remains largely unclear.

265 s (13 females) whether the visuomotor object-directed action representation system that includes left

266 ion, manipulable objects activated an object-directed action representation system that includes left

267 li specifically engage the visuomotor object-directed action representation system, in a constitutive

268 Adaptive goal-directed actions require the ability to quickly relearn

269 Goal-directed actions requiring prospective planning pervade

270 distractor triggers suppression during goal-directed action, resulting in enhanced efficiency and ac

271 To determine its direct actions, SAA was administered into murine lung, l

272 imulus, while the regions implicated in goal-directed action selection contained information about bo

273 and posterior cingulate cortices during goal-directed action selection in the training phase, whereas

274 An essential aspect of goal-directed action selection is differentiating between beh

275 between premature response impulses and goal-directed action selection is manipulated.

276 ng the neuroanatomy and neurobiology of goal-directed action selection on the one hand, and habit for

277 entral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavi

278 In tasks involving goal-directed action selection, striatal neural activity has

279 t that striatal activity is involved in goal-directed action selection.

280 effect of distinct striatal pathways in goal-directed action selection.

281 the mOFC is a key regulator of "online" goal-directed action selection.

282 mental distinction between habitual and goal-directed action selection.

283 ccess to vision yet are able to perform goal-directed actions successfully.

284 information, while regions involved in goal-directed action, such as ventromedial and dorsolateral p

285 The characteristics of goal-directed actions tend to resemble those of previously ex

286 distractors produced less disruption in goal-directed action than weakly salient distractors.

287 and control of diastolic blood pressure are direct actions that should be taken to reduce the rate o

288 gorithm cannot explain many flexible or goal-directed actions that have been demonstrated behaviorall

289 RvE2 (1-10 nM) carries potent leukocyte-directed actions that include: 1) regulating chemotaxis

290 oth ethanol drinking and the shift from goal-directed action to habitual behavior.

291 operating in parallel with a system for more direct action-value learning.

292 In contrast, flexible goal-directed action was predicted by estimated tract strengt

293 In contrast, in a task requiring no goal-directed action, we found greater attentional interferen

294 Chemogenetic inhibition of OFC disrupts goal-directed actions, whereas optogenetic activation of OFC

295 work was preferentially active during object directed actions, whether observed or executed.

296 experienced or predicted value to guide goal-directed actions while undergoing functional magnetic re

297 cription-independent mechanism involving its direct action with a subset of Bcl-2 family member prote

298 s observed a series of movies depicting goal-directed actions, with the sequence controlled so that s

299 amines by low-dose psychostimulants involves direct action within the PFC, reflecting an intrinsic pr

300 ation between object directed and non-object directed actions within the human mirror system.