ライフサイエンスコーパス: directional selection

1 ia easily-testable mechanisms such as linear directional selection.

2 hism similar to that observed under positive directional selection.

3 ws genealogy and extended LD consistent with directional selection.

4 rapid increases in frequency expected under directional selection.

5 ineage, features that point to the action of directional selection.

6 lar to those expected under models of recent directional selection.

7 ear several hallmarks of the effects of past directional selection.

8 e frequency spectra do not support models of directional selection.

9 We were unable to detect either balancing or directional selection.

10 e protein sequence has changed rapidly under directional selection.

11 tion-dependent traits, even under consistent directional selection.

12 inversion breakpoints or are near targets of directional selection.

13 hat some of the loci have experienced recent directional selection.

14 out the costs usually associated with strong directional selection.

15 suggests the possibility of species-specific directional selection.

16 lyses of the rotational dynamics that define directional selection.

17 bird species, reducing temporal variation in directional selection.

18 infertility-risk alleles may be explained by directional selection.

19 ing that the observed change was a result of directional selection.

20 vidence consistent with the action of linear/directional selection.

21 entually be fixed by either genetic drift or directional selection.

22 y aligns with the phenotypic dimension under directional selection.

23 were unavailable in populations subjected to directional selection.

24 equences of modular patterns being molded by directional selection.

25 ates evolution by increasing the strength of directional selection.

26 from 2008 to prospect for loci under recent directional selection.

27 between Oryza species were partly driven by directional selection.

28 features characterising spatial variation in directional selection.

29 ion pathways under neutral, stabilizing, and directional selection.

30 tion; and detect recent balancing as well as directional selection.

31 ersity can both be shaped by stabilizing and directional selection.

32 causative mutations as a response to strong directional selection.

33 extended haplotype, consistent with positive directional selection.

34 infer the mutation rate and the strength of directional selection.

35 Estimates of the magnitude of directional selection (absolute value of beta) were expo

36 Conversely, directional selection accelerates the loss of small- and

37 of the cardini group) provides evidence for directional selection across species.

38 These results are best explained by positive directional selection acting at or near intron 7 and dem

39 mary statistics to quantify recent transient directional selection acting on a complex trait.

40 pulation differentiation are consistent with directional selection acting on the class IIalpha-linked

41 y scenarios and suggests a history of strong directional selection acting on the posterior lobe.

42 in both African and non-African samples; and directional selection, acting during the geographic expa

43 In contrast, directional selection acts to alter the developmental pr

44 In the presence of such strong directional selection, alleles enhancing a particular tr

45 ivity will evolve under conditions of strong directional selection, an observation that helps interpr

46 We analyze this interaction of directional selection and background selection and study

47 among synonymous mutations for a gene under directional selection and capable of adapting via synony

48 tive genetic variance of traits under strong directional selection and fixation of genes conferring t

49 fy the prerequisites for adaptive evolution (directional selection and heritable genetic variation) t

50 y weak relative to classical models, such as directional selection and overdominance.

51 ality in these bees and demonstrate how both directional selection and release from constraint can sh

52 upported by evidence of regions under recent directional selection and temporal analysis in this cont

53 compared to orthologs, suggesting increased directional selection and/or relaxed selection on both g

54 he average recognition ability (a measure of directional selection) and the standard deviation of rec

55 tionary processes (evolutionary drift and/or directional selection), and potentially migration at the

56 ic-based) plasticity due to ecotype-specific directional selection, and 23 of those responded to proj

57 Here, we apply models of neutral drift, directional selection, and positive frequency-dependent

58 dN/dS) are a clear indicator of positive, or directional, selection, and several recently developed m

59 om D. simulans suggests that many targets of directional selection are shared between these species.

60 elevated divergence, which have experienced directional selection, are derived from divergent sortin

61 re (1984-1997) that reported the strength of directional selection as indexed by standardized linear

62 these two proteins are evolving under strong directional selection, as has been reported for the alph

63 Most models of positive directional selection assume codominance of the benefici

64 g-term effects of genetic interactions under directional selection assuming no mutation or dominance,

65 ts, we found high incidence of signatures of directional selection at 19 loci.

66 on random field population genetics model of directional selection at DNA sites.

67 at there has been historical but not current directional selection at fimA between E. coli and Salmon

68 ed that thermogenic capacity is under strong directional selection at high altitude.

69 from all 6 populations identified signals of directional selection at known drug-resistance loci, inc

70 ngly suggest this reduction is due to recent directional selection at or near per within D. p. bogota

71 biased genes, are enriched for signatures of directional selection at the gene expression level.

72 , respectively; and there was no significant directional selection at the pfmdr1 Y184F locus.

73 To characterize the signature of directional selection at this locus, we surveyed DNA seq

74 for all traits apart from horn growth, with directional selection being stronger under more adverse

75 vel, we find gene expression differences and directional selection between humans and chimpanzees mor

76 evidence for an unusual mix of balancing and directional selection but no evidence of stable geograph

77 Several other QTL experienced strong directional selection, but only in one site and seasonal

78 This is possibly influenced by directional selection, but the slightly higher variance

79 None of the mutations were suggestive of directional selection by ARTs.

80 We also demonstrate that directional selection can have marked effects on the mod

81 We show that directional selection, compared to stabilizing selection

82 ization) or greatest for traits under strong directional selection (condition dependence), but few st

83 heses, the femur was subject to little or no directional selection despite having shorter values by l

84 ion mean be close enough to the optimum that directional selection does not overwhelm balancing selec

85 on caused by the expanding range itself, and directional selection due to the presence or absence of

86 tween EUR and EAS populations is caused by a directional selection, due mainly to a local adaptation

87 sure or temporal variation in the targets of directional selection during breeding probably associate

88 and that inherited polymorphisms may undergo directional selection during clonal expansion of tumors.

89 We identify directional selection during the incipient stages of sym

90 volution is free to proceed at high rates of directional selection during the organization of a new s

91 Hv, we can quantitatively estimate that the directional selection exerted by Hv males on Hs females

92 ins of the European geographic range, strong directional selection favored outlier phenotypes charact

93 xtreme values predicted fewer livebirths and directional selection favoring higher oxygen saturation

94 ility represents a quality signal, we expect directional selection favouring stable singers.

95 simple mathematical model, we show that weak directional selection for a large neonate, a narrow pelv

96 assembled into new combinations under strong directional selection for adaptation to the novel trophi

97 found evidence for stabilising selection and directional selection for earlier breeding, although the

98 ion subjected to 10 recurrent generations of directional selection for early flowering in a single te

99 istance, and provides compelling evidence of directional selection for glyphosate insensitivity in ad

100 two environments were considered separately, directional selection for height was detected under low

101 utionary partners that can alternate between directional selection for high fertilization ability and

102 These were selected using bi-directional selection for immobility in the forced swim

103 e basis of the directionality of QTL, strong directional selection for increased achene size appears

104 static genetic variance and evidence of past directional selection for increased body size.

105 There is no indication of directional selection for increased human microsatellite

106 > 18 000 pairwise challenges, we documented directional selection for increased phage resistance, co

107 hes zero, providing the potential for strong directional selection for increasing predator speed at h

108 The directional selection for insecticide resistance due to

109 election on reproductive lifespan as well as directional selection for longer reproductive lifespan.

110 geographic hypotheses, the humerus was under directional selection for longer values by latitude.

111 ure of genetically based niche variation and directional selection for niche evolution in the experim

112 etic variation in the microhabitat niche and directional selection for niche evolution were not detec

113 genetic drift, even in the face of constant directional selection for one particular protein archite

114 eradication programs to deliberately disrupt directional selection for resistance could improve invas

115 ral accession, indicating past occurrence of directional selection for seed size.

116 elative abundances than constraints based on directional selection for specific functional traits, al

117 ted a depressed He, consistent with positive directional selection for sulfa resistance mutations.

118 Directional selection for traits consistently occurred i

119 rventions such as isolation may have induced directional selection for viral evolution.

120 ryza sativa-infecting isolates showed higher directional selection from host and subsequently tends t

121 s coevolution processes is greatly driven by directional selection from host plants.

122 have found robust statistical evidence that directional selection has acted on male traits, by confi

123 Positive directional selection has driven the evolutionary fixati

124 ggesting that at least one episode of strong directional selection has occurred in the region.

125 stigation of nucleotide diversity supports a directional selection hypothesis.

126 o do so, we considered a coalescent model of directional selection in a sensible demographic setting,

127 ic hitchhiking, we analyze a simple model of directional selection in a subdivided population.

128 Evidence suggests that directional selection in allopolyploids rarely acted on

129 We find a robust signal of directional selection in ancient West Eurasians on 170 s

130 phic bottlenecks and detecting signatures of directional selection in bottlenecked populations, despi

131 Strong directional selection in concert with genetic hitchhikin

132 Colony size was under both stabilizing and directional selection in different years, and reversals

133 nd indicate that the putative involvement of directional selection in host-parasite coevolution and g

134 le of a polygenic trait that has experienced directional selection in humans.

135 nity genes, suggesting an important role for directional selection in immune system protein evolution

136 e presence of glyphosate and strong negative directional selection in its absence may indicate that t

137 al data spanning over a century shows strong directional selection in many crops, as well as on natur

138 genes whose regulation likely evolves under directional selection in one or a handful of cell types.

139 QTL) sign test to evaluate the importance of directional selection in phenotypic divergence.

140 an be mapped by looking for the signature of directional selection in polymorphism data.

141 However, the overall importance of directional selection in shaping the W chromosome is unk

142 genes whose regulation likely evolved under directional selection in the ancestral primate lineage.

143 the required trait combination, rather than directional selection in the component traits.

144 extreme outliers with a high probability of directional selection in the high-altitude populations.

145 stence and appears to have been under strong directional selection in the last 5,000 years, evidenced

146 aration of a founding population followed by directional selection in the new environment.

147 The combination of strong positive directional selection in the presence of glyphosate and

148 Responses to directional selection in the tibia and radius induced a

149 Long-term, single-trait, bi-directional selection in the Virginia chicken lines has

150 sumed to be a source of strong and sustained directional selection in the wild.

151 ic diversity, and genetic evidence of recent directional selection in this important human pathogen.

152 The FY region in the Hausa shows evidence of directional selection in two independent properties of t

153 d histone deacetylases have undergone strong directional selection, including a particularly strong s

154 re consistent with the action of positive or directional selection, including an 18-fold enrichment o

155 mpensatory changes and adaptive changes from directional selection, indicating single nucleotide poly

156 namics: The first is a rapid phase, in which directional selection introduces small frequency differe

157 lly, the false-discovery rate is higher when directional selection involves a recessive rather than a

158 Directional selection is a major force driving adaptatio

159 One potential effect of directional selection is an increase in linkage disequil

160 The strongest evidence of directional selection is found in a region of bab2 that

161 ry phenotypes suggest stabilizing selection, directional selection is more commonly reported.

162 consensus among students of speciation that directional selection is the primary cause of speciation

163 Evolutionary theory predicts that directional selection leads to evolutionary change while

164 ecent selection, we find little evidence for directional selection, likely due to low statistical pow

165 selection is how sexual traits under strong directional selection maintain underlying genetic variat

166 oral head breadth show signs of responses to directional selection matching ecogeographic hypotheses,

167 owing a population bottleneck, the signal of directional selection may be hard to detect because many

168 id substitution are attributable to positive directional selection, not to a relaxation of purifying

169 hese parameters and the frequency with which directional selection occurs, the genomic scale over whi

170 owing asymmetric subgenome domestication for directional selection of long fibers.

171 nd some candidate duplicates where positive (directional) selection of beneficial mutations (Ka/Ks >

172 Recurrent directional selection on a partially recombining chromos

173 differential gene expression resulting from directional selection on blood feeding within a polymorp

174 f cichlid trophic evolution is the result of directional selection on chromosomal packages that encod

175 ndirect selection on recombination caused by directional selection on desiccation tolerance.

176 be explained by differences in the effect of directional selection on duplicated homoeologs.

177 of strongly selected deleterious mutations, directional selection on favorable alleles (causing hitc

178 Common gardens show directional selection on flowering time that reverse bet

179 goals were to characterize the signature of directional selection on FY*O in sub-Saharan Africa and

180 The ubiquity of skew and strong directional selection on juvenile body size imply that h

181 under high nutrients, we found evidence for directional selection on leaf number and height, and for

182 We demonstrated significant directional selection on multiple traits across populati

183 We also demonstrate directional selection on nectar traits, which is likely

184 Directional selection on parasitoid behaviour in each te

185 Strong directional selection on Pgm-3 in this form, involves wo

186 human polygenic traits, revealing signals of directional selection on pigmentation, life history, gly

187 onary "arms race." This could lead to strong directional selection on RNAi genes, but to date their e

188 We found evidence for across-treatment directional selection on the means for leaf number, flow

189 ion of allelic effects suggests a history of directional selection on the posterior lobe.

190 ariable conditions, which resulted in strong directional selection on thermal performance traits.

191 ycatchers (Ficedula hypoleuca), we show that directional selection on timing of reproduction intensif

192 tudy increased, but recently declined again, directional selection on timing of reproduction showed a

193 Also, our results suggest substantial directional selection on wing size but not shape.

194 onferring competitive asymmetries can induce directional selection, opposing diversification.

195 Lack of convincing evidence for directional selection or selective sweeps argues against

196 When the population is subject to directional selection or to deleterious mutations, incre

197 r are consistent with stabilizing selection, directional selection, or diversifying selection.

198 iven to fixation or loss by genetic drift or directional selection, or may be maintained in a polymor

199 tions displaying evidence of diversifying or directional selection, or mutations with a high selectio

200 ne Sry, which also appears to have undergone directional selection over a short evolutionary period.

201 earlier studies concluding that CPP is under directional selection over the climatic gradient of Nort

202 lls can explain how GCs maintain an adequate directional selection pressure over a large range of aff

203 rectional mutation pressure, rather than the directional selection pressure, is mainly responsible fo

204 If a trait has a history of directional selection, QTL effects should be mostly in t

205 lection occurs, the genomic scale over which directional selection reduces levels of linked variation

206 ifferent years, and reversals in the sign of directional selection regularly occurred.

207 ctive pressures including both balancing and directional selection, resulting in exceptional genetic

208 wo of the six phages also imposed additional directional selection, resulting in strongly increased r

209 The roles of positive directional selection (selective sweeps) and negative se

210 id sequence of Adh-Twain evolved rapidly via directional selection shortly after it arose.

211 this gene across Africa with no evidence of directional selection suggesting a limited role for knoc

212 genetic variance, there was no indication of directional selection, suggesting instead a history of o

213 ngly variable levels of gene duplication and directional selection that correlate with their function

214 a classic example of a heritable trait under directional selection that does not result in an evoluti

215 s of guppies were subjected to an episode of directional selection that mimicked natural processes.

216 ber of immune-system genes that may be under directional selection (that is, selection favouring chan

217 y heritable variation and are under opposing directional selection, their evolution is constrained by

218 tion greatly, however, and that the apparent directional selection thereby caused can be substantial.

219 investigate the statistical power to detect directional selection through contrasts of DNA variation

220 ics provides predictions for the response to directional selection through the breeder's equation, bu

221 ciation approach, we characterize signals of directional selection throughout the genome, identifying

222 ly related species could exert strong enough directional selection to cause evolution of these signal

223 ization (NEO-F), in which one copy undergoes directional selection to perform a novel function after

224 rk also challenges the long-standing view of directional selection towards optimal codons, and provid

225 it test for discriminating rejections due to directional selection (true positive) from those due to

226 Simulations of positive directional selection, under parameter values appropriat

227 l framework for the study of stabilizing and directional selection using data from between-species di

228 d blood pressure, showing strong evidence of directional selection, varying among human groups.

229 In O. rufipogon, the recent directional selection was found in the Pi-ta region, whi

230 Directional selection was predicted in part by drought c

231 Directional selection was rejected in three populations

232 lar rates when genes thought to evolve under directional selection were excluded from the analysis.

233 alancing selection, yet data consistent with directional selection were observed at other codons.

234 ncestral and maintained across species under directional selection, whereas the single-locus (superge

235 variation can be used to identify targets of directional selection, which are expected to have reduce

236 implementing a coalescent model of positive directional selection with arbitrary dominance.