ライフサイエンスコーパス: disaggregation

1 including protein folding, degradation, and disaggregation.

2 tic roles of Hsp104 and Hsp70 during protein disaggregation.

3 ATP binding and hydrolysis to drive protein disaggregation.

4 able to cooperate with it to mediate protein disaggregation.

5 energy with its substrate proteins to drive disaggregation.

6 ial independence from the Hsp70 chaperone in disaggregation.

7 he ER, where the former is also required for disaggregation.

8 rimary wave of aggregation followed by rapid disaggregation.

9 es ClpB to inhibition and diminishes amyloid disaggregation.

10 eoligomerization is not required for protein disaggregation.

11 ave distinct activities in promoting protein disaggregation.

12 ation of aggregates in a state competent for disaggregation.

13 tyrosine-bearing pore-loop to drive protein disaggregation.

14 antitatively monitor protein aggregation and disaggregation.

15 04 with the mechanistic scaffold to catalyze disaggregation.

16 ously correlated to rates of aggregation and disaggregation.

17 SSD1 is required for Hsp104-mediated protein disaggregation.

18 xhibited impaired aggregation accompanied by disaggregation.

19 were reflected in rapid cell aggregation and disaggregation.

20 machines involved in protein degradation and disaggregation.

21 oned normally in thermotolerance and protein disaggregation.

22 uction of HSP70, a feedback regulator of PRD disaggregation.

23 atography were completely stable and gave no disaggregation.

24 , these chaperones cannot facilitate protein disaggregation.

25 l motion, which is indispensable for protein disaggregation.

26 limiting kinetic barrier in pressure-induced disaggregation.

27 ractions do not dominate pressure effects on disaggregation.

28 tic small-molecule drug that induces protein disaggregation.

29 f therapeutic agents for their prevention or disaggregation.

30 rier formation close to the time of periderm disaggregation.

31 ed Tau fibrils, resulting in their efficient disaggregation.

32 with chemical kinetics to study a-synuclein disaggregation.

33 s, such as participatory mechanisms and data disaggregation.

34 s1) JDPs at the individual stages of protein disaggregation.

35 them less accessible for chaperone-mediated disaggregation.

36 and independently interfering with merozoite disaggregation.

37 is not primarily a result of binding, but of disaggregation.

38 ending from nascent chain folding to protein disaggregation.

39 of J-protein complexation and cooperation in disaggregation.

40 sponsive flexibility during Hsp104-catalyzed disaggregation.

41 in aggregates targeted by metazoan Hsp70 for disaggregation.

42 of molecular chaperones involved in protein disaggregation.

43 s inhibition of aggregation and promotion of disaggregation.

44 that blocks Abeta aggregation, and promotes disaggregation.

45 vbL complexes serve as chaperones in protein disaggregation.

46 l regulatory role of the ClpB NTD in protein disaggregation.

47 naK/Hsp70 system and ClpB/Hsp104 for protein disaggregation.

48 ently than Hsp104 requires Hsp70 for protein disaggregation.

49 egase activity and must separate for protein disaggregation.

50 Their disaggregation activities crucially depend on partner pr

51 s A and B unleashes highly efficient protein disaggregation activity in human and nematode HSP70 syst

52 HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro.

53 ClpG ATPase and disaggregation activity is thereby directly controlled b

54 fibril nucleation and elongation with strong disaggregation activity on preformed fibrils and prevent

55 pore loop tyrosine, it is not essential for disaggregation activity.

56 binding as the molecular basis of autonomous disaggregation activity.

57 ClpB can collaborate with the DnaK system in disaggregation, although activity is reduced.

58 Disaggregation analyses showed that disorders were assoc

59 shock factor 1, and DAF-16 regulate opposing disaggregation and aggregation activities to promote cel

60 Our initial analysis of yeast Arb1/Abcf2 in disaggregation and animal ABCF proteins in embryogenesis

61 ng, inhibit protein aggregation, and promote disaggregation and clearance of misfolded aggregates ins

62 d was actually enhanced, but at 380 mg/L PHA disaggregation and colloidal stability were promoted.

63 us form, the Abeta peptides are resistant to disaggregation and degradation by a number of denaturing

64 otein aggregation has been well-studied, the disaggregation and dissolution of existing amyloid fibri

65 n fuel LCI by providing spatial and temporal disaggregation and enhanced chemical speciation, thereby

66 wed photoinduced isomerization, which caused disaggregation and enhancement in fluorescence.

67 brils on the kinetic pathway to EGCG-induced disaggregation and have determined its cryoEM structure.

68 Since NO can induce platelet disaggregation and phosphoinositide 3-kinase (PI3-kinase

69 the chaperones hsp70 and hsp40 that promote disaggregation and protein degradation.

70 therefore, play an essential role in protein disaggregation and protein folding.

71 ly that dynamic coordination between protein disaggregation and proteolysis is required to survive pr

72 Saccharomyces cerevisiae, Hsp104 facilitates disaggregation and reactivates aggregated proteins with

73 man ClpB), couples ATP hydrolysis to protein disaggregation and reactivation.

74 Disaggregation and reaggregation of Xnr-2-producing tiss

75 duced distribution changes lead to community disaggregation and reassembly.

76 y in the 8-ring aggregates, implying partial disaggregation and reassociation.

77 s of guanidine hydrochloride (GdmHCl) foster disaggregation and refolding of denatured and aggregated

78 er conditions used for optimal high pressure disaggregation and refolding, the native state is greatl

79 Among these processes, the role of mush disaggregation and remobilisation within the plumbing sy

80 Surprisingly, disaggregation and resolubilization of thermally denatur

81 nf], Il1b, Ccl3/4) indicated that all tissue disaggregation and separation protocols activate MPS cel

82 rotein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist.

83 ly, translocation, activation, inactivation, disaggregation, and degradation of proteins.

84 arms of the PN (protein synthesis, folding, disaggregation, and degradation), leading to the proposa

85 ynthesis, folding, trafficking, aggregation, disaggregation, and degradation.

86 technologies that combine tissue digestion, disaggregation, and filtration.

87 Hsp70 chaperones assist in protein folding, disaggregation, and membrane translocation by binding to

88 inhibition of platelet aggregation, platelet disaggregation, and P2Y12 reactivity index.

89 membrane fusion, membrane transport, protein disaggregation, and protein refolding.

90 t higher phosphate concentrations cause more disaggregation, and the interaction between phosphate an

91 gregation surveillance that regulate protein disaggregation are likely to play a major role in cell s

92 ing into account DOM dynamics, bridging, and disaggregation are needed for a comprehensive modeling o

93 gh the roles of the individual chaperones in disaggregation are not well understood.

94 n, molecular facilitators of alpha-synuclein disaggregation are still generally unknown.

95 of how the two JDP classes regulate protein disaggregation are still unknown.

96 focuses on the less explored advantages of "disaggregation" as a novel sensing mechanism and its rec

97 teins, static light-scattering analysis, and disaggregation assays, we report that the noncanonical s

98 reactions without agitation resulted in less disaggregation at slower rates, indicating that the prot

99 In disaggregation baicalein causes fragmentation throughout

100 ermines the specificity required for protein disaggregation both in vivo and in vitro, as well as for

101 e that the M-domain is essential for protein disaggregation, but dispensable for Hsp104 ATPase- and s

102 vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020.

103 However, when we measured protein disaggregation by ClpB heterohexamers in conjunction wit

104 Disaggregation by fish species group reveals distinct ge

105 orting of deworming coverage should consider disaggregation by geography, wealth, and sex with incorp

106 destabilizes Sup35 prions and promotes their disaggregation by Hsp104, Hsp70, and Hsp40.

107 the Hsp70 chaperone, which allows efficient disaggregation by supporting Hsp104 binding to aggregate

108 was more susceptible to destabilization and disaggregation by the chaperones than 87V.

109 However, for emissions of PN and BC, disaggregation by vehicle manufacturers for diesel passe

110 atory infections, and meningitis, as well as disaggregations by subcause for chronic kidney disease,

111 Disaggregation can also be monitored using detergents.

112 Anti-IL-1RI mAb inhibited disaggregation caused by IL-1alpha and IL-1beta, but not

113 Upon reoxygenation, rapid UBP1 SG disaggregation coincides with the return of the stabiliz

114 operation with IbpB, protein aggregates in a disaggregation-competent state.

115 by which CypD achieves this and suggest that disaggregation could be one of the many functions of thi

116 which indicators (required and optional) and disaggregations countries apply.

117 The increased rate of PrP(Sc) disaggregation did not correlate with either the conform

118 The disaggregation/dissolution of Abeta fibrils occurred nea

119 estion that destruction of prions by protein disaggregation does not adequately explain the curing.

120 Instead, disaggregation dominates the signal turn-on, and is thus

121 th edema formation but with AQP4 aggregation/disaggregation dynamics and their link with the actin cy

122 resistant to fibril formation, more prone to disaggregation, enzymatic digestion and degradation by t

123 dent on the size of the aggregates, and that disaggregation experiments can provide a powerful method

124 pectroscopy, limited-proteolysis, and fibril disaggregation experiments, suggesting the fibril twist

125 pproach in health disparities research, data disaggregation faces methodological and political challe

126 Disaggregation followed first-order kinetics and was acc

127 Periderm disaggregation follows and recapitulates barrier pattern

128 The process from aggregation to disaggregation generally causes a recovery or enhancemen

129 nteract with topography to influence bedrock disaggregation, groundwater flow, chemical weathering, a

130 ompared to aggregation, its reverse process, disaggregation, has received much less attention and is

131 nhibiting aggregation and promoting filament disaggregation have been discovered, but knowledge of th

132 To facilitate protein disaggregation, Hsp104 cooperates with Hsp70 and Hsp40 c

133 OS(agg) with LBP and sCD14 promoted LOS(agg) disaggregation in an albumin-dependent fashion to comple

134 K-ClpB machineries, which facilitate protein disaggregation in an ATP-dependent manner, determines th

135 fy heat-triggered aggregation and subsequent disaggregation in budding yeast, identifying >170 endoge

136 ClpB middle domain are defective in protein disaggregation in collaboration with DnaK.

137 Protein disaggregation in Escherichia coli is carried out by Clp

138 AA(+) ring translocase, which drives protein disaggregation in nonmetazoan eukaryotes.

139 reased monosome peak with moderate ribosomal disaggregation in polysome profiles and the greatly incr

140 hibited greater potential towards TTR fibril disaggregation in vitro compared to the parent drug.

141 ia, and correlate with cooperative action in disaggregation in vitro.

142 g PPIase activity prevented its capacity for disaggregation in vitro.

143 ICT), aggregation-induced emission (AIE) and disaggregation-induced emission (DIE), MICE has not been

144 Disaggregation into 16 ethnicity groups showed important

145 study, we demonstrate that AQP4 aggregation/disaggregation into OAP influences the biology of glioma

146 After disaggregation into subgroups, prevalence of suicidal id

147 Protein disaggregation involves polypeptide extraction from aggr

148 Virus aggregation-disaggregation is a complex process and predicting the b

149 P101 or class I sHSPs, implying that protein disaggregation is important for optimal proteasomal degr

150 The ClpB-mediated disaggregation is linked to translocation of polypeptide

151 a battery of techniques, we demonstrate that disaggregation is possible under conditions close to phy

152 ough the N domain is dispensable for protein disaggregation, it is sensitive to point mutations that

153 Our disaggregation landscape and kinetics analyses indicate

154 s a tightly regulated, ATP-powered molecular disaggregation machine.

155 made possible by the presence of a powerful disaggregation machine.

156 Although biochemical analyses identified disaggregation machinery components required for resolub

157 mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homolo

158 We conclude that the activity of the Hsp70 disaggregation machinery is a double-edged sword, as it

159 The Hsp70 disaggregation machinery processed recombinant fibrils a

160 [URE3], and [PIN(+)] depends on the protein disaggregation machinery that includes Hsp104, Hsp70, an

161 likely enhancing the function of a cytosolic disaggregation machinery.

162 AQP4 disaggregation may potentiate invasiveness potential, wh

163 simulation in explicit solvent to study the disaggregation mechanism of the GNNQQNY fibrils and to i

164 in an ATP- and DNAJA1-dependent manner, in a disaggregation mechanism whereby the two paralogous chap

165 balanced comparison between aggregation and disaggregation mechanism, and focuses on the less explor

166 ouse model to show that patterns of periderm disaggregation mirrors barrier formation.

167 rk together to achieve the broad folding and disaggregation needs of the cell.

168 New insights into the structural biology of disaggregation obtained from NMR studies are described,

169 Rapid disaggregation of 87V PrP(Sc) by the cell may contribute

170 osomes targeting the brain and promoting the disaggregation of Abeta assemblies and evaluated their e

171 ADP-induced platelet aggregation and induces disaggregation of ADP-stimulated platelets by an NO-medi

172 Macrophage-mediated disaggregation of aggregated and fused LDL is a mechanis

173 We studied the disaggregation of aggregates composed of B78H1 cells tra

174 Disaggregation of AgLDL was verified by gel-filtration c

175 S and produce similar macrophage release and disaggregation of AgLDL.

176 g a role for Hsp110 in the prevention and/or disaggregation of alpha-synuclein pathology.

177 egation of the Abeta(42) peptide and promote disaggregation of amyloid fibrils, as observed by ThT fl

178 ence of a stable reactive species created by disaggregation of amyloid fibrils.

179 tion has been separated and characterized by disaggregation of amyloid fibrils.

180 nsive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of human mus

181 her, cells lacking Hsp26 are impaired in the disaggregation of an easily assayed heat-aggregated repo

182 Disaggregation of Asian American ethnic groups revealed

183 mineral-EPS associations by inducing partial disaggregation of bentonite and aggregation of ferrihydr

184 This asymmetry is reversible upon disaggregation of blastomeres of the two- and four-cell

185 nced mesenchymal Spry1 and Spry4 expression, disaggregation of BMP4-positive mesenchymal cells and lo

186 f Abeta aggregates in vitro and promotes the disaggregation of both alpha-syn and Abeta aggregates.

187 he most detailed available reference counts: disaggregation of coarse census counts reaches [Formula:

188 ow sensitive detection of minority variants, disaggregation of complex parasite mixtures, and scalabl

189 ciled global glacier loss estimates enable a disaggregation of continental land mass changes and a qu

190 sistant spores, but nutrients caused partial disaggregation of fruiting bodies.

191 the individual/household level, and lack of disaggregation of gun homicide data by gender and race/e

192 racking included expanded donor coverage and disaggregation of health areas for additional disbursing

193 se-based costing studies that facilitate the disaggregation of health budgets at a national level.

194 ain CU1000 grown attached to plastic and the disaggregation of highly autoaggregated clumps of CU1000

195 eness, but also by the transient aggregation/disaggregation of homo- or heteromeric building blocks.

196 egon birth certificates that allowed for the disaggregation of hospital births into the categories of

197 thodology based on preparation and enzymatic disaggregation of intact marrow plugs, which yields dist

198 al cells and cell activation correlated with disaggregation of lipooligosaccharides.

199 inding protein- (LBP) and sCD14-dependent 1) disaggregation of LOS and 2) LOS activation of human umb

200 albumin in facilitating LBP:sCD14-dependent disaggregation of LOS(agg) or activation of endothelial

201 as malate dehydrogenase (MDH), and inhibits disaggregation of luciferase in vitro Experiments with f

202 ton, disassembly of actin microfilaments and disaggregation of microtubules all consistently failed t

203 ion as a mitochondrial chaperone involved in disaggregation of misfolded proteins, resulting from str

204 ous squid Hsp(c)70 to mediate binding and/or disaggregation of mutant SOD1 protein, abrogating toxici

205 ectopic overexpression of PML precludes the disaggregation of ND10 but has no effect on viral replic

206 (iii) Disaggregation of ND10 structures is not an obligatory e

207 nergistic activity of both chaperones in the disaggregation of oligomeric OmpX aggregates.

208 oscopy revealed that NaOH steeping increased disaggregation of parenchyma cells.

209 Demonstration of the formation and disaggregation of particle assemblies suggests strategie

210 In vitro, sHsps enhance Hsp104-catalyzed disaggregation of pathological amyloid forms of alpha-sy

211 of global mRNA translation was suggested by disaggregation of polysomes into free ribosomes, which o

212 apid inhibition of protein synthesis and the disaggregation of polysomes.

213 ssegregation in proliferating cells, but not disaggregation of polytene chromosomes in salivary gland

214 vented aggregation of A beta(42) and induced disaggregation of preformed A beta(42) fibrils down to n

215 '-beta-galactosidase and did not lead to the disaggregation of preformed inclusion bodies.

216 accharomyces cerevisiae, the Hsp104-mediated disaggregation of protein aggregates is essential for th

217 of this chaperone in mediating ATP-dependent disaggregation of protein aggregates that accumulate in

218 erones in the oligomerization, assembly, and disaggregation of proteins known to be abnormally folded

219 Significant changes in the rate of disaggregation of protofibrils in 5% TFE result not only

220 Our data suggest that the kinetics of disaggregation of PrP(Sc) following cellular uptake is i

221 Disaggregation of race and ethnicity analysis revealed s

222 Disaggregation of race and ethnicity revealed that Filip

223 Digitization, having triggered disaggregation of radiology's professional service model

224 his heterogeneity was limited by the lack of disaggregation of results, including by factors such as

225 olate (SDC) enabled efficient extraction and disaggregation of SWNT prior to NIRF analysis.

226 ted to surfactant reorganization rather than disaggregation of SWNTs bundles or shear-induced alignme

227 e to change, because digitization has caused disaggregation of the chain.

228 chemokine ligand (CCL) 19 was paralleled by disaggregation of the dermal lymphoid-like tissue.

229 adicals than free MB, possibly due to better disaggregation of the dye in solution.

230 Disaggregation of the indicators by the main equity stra

231 Disaggregation of the receptors leads to their rapid dep

232 ssociated with fructose binding, but instead disaggregation of the sensor in the presence of fructose

233 Disaggregation of the spherical nuclear bodies termed pr

234 ial uncouplers or dissipated by drug-induced disaggregation of the spheroids.

235 has been assumed to arise from the complete disaggregation of the Sup35 prion polymers.

236 sing scRNA-Seq, analyse the effect of tissue disaggregation on gene expression, and optimise data pro

237 , the chaperones involved, and the effect of disaggregation on PrP(D) seeding activity are unclear.

238 cling and there is no requirement for tissue disaggregation or cell culture.

239 effect of the SBD mutation in reconstituted disaggregation or refolding reactions in vitro.

240 cterization without the need for antibodies, disaggregation or viable cells.

241 rted sensors and probes seem to work through disaggregation phenomena, the proper interpretation of t

242 The microscopy studies show an aggregation-disaggregation phenomenon in the presence of different e

243 owave treatment and related to the polymer's disaggregation phenomenon observed.

244 ClpG exhibits high, stand-alone disaggregation potential without involving any partner c

245 ows increased thermal stability and enhanced disaggregation power compared to Hsp70/ClpB, enabling it

246 protein unfolding activity of Hsp104 to the disaggregation process, providing the yeast protein-reco

247 cal model based on competing aggregation and disaggregation processes in kinetic steady-state equilib

248 However, attempts to identify protofibril disaggregation products using dynamic light scattering,

249 We used the polyGln disaggregation protocol of Wetzel et al. to dissolve the

250 With the use of a special disaggregation protocol, the highly aggregation prone A

251 etection of blood characteristics, including disaggregation, radial migration and cross-linking fibri

252 ry degeneration in part owing to reduced tau disaggregation, raising the possibility that VCP may rep

253 in at least two kinetic phases, with initial disaggregation (rate constant approximately 1 h(-1)) fol

254 r stress, it was found that average cellular disaggregation rates were a factor of 1.3 +/- 0.4 times

255 Aggregate disaggregation rates were obtained and compared to disso

256 es with cellular avidity, measured from cell disaggregation rates.

257 rucial for specificity and efficiency of the disaggregation reaction.

258 proteins, and possess defects in chemotaxis, disaggregation, receptor up-regulation, and bactericidal

259 proteins; and possess defects in chemotaxis, disaggregation, receptor upregulation, and bactericidal

260 ll known, and we hypothesized that much like disaggregation, refolding, degradation, and even normal

261 Disaggregation relies on Hsp70 function and on ATP-depen

262 12 AAA+ domains is co-ordinated to catalyze disaggregation remained unexplained.

263 tein aggregation is a reversible process but disaggregation requires help from other proteins such as

264 Disaggregation requires the ATPase activity of the const

265 vely during redox-controlled aggregation and disaggregation, respectively.

266 Disaggregation shows that the effects of use are largely

267 After tumor disaggregation, staining with a fluorochrome-conjugated

268 ion of Ly108 is rapidly lost after thymocyte disaggregation, suggesting dynamic contact-mediated regu

269 ta(1-11) antibody in the absence of oligomer disaggregation suggests a possible oligomer rearrangemen

270 Here we show that the yeast disaggregation system directly disperses heat-induced bi

271 However, it is unknown whether an analogous disaggregation system exists in the Endoplasmic Reticulu

272 P100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone

273 ne, although at low pyridine concentrations, disaggregation takes many hours to reach equilibrium.

274 gesting that varying sensitivity to the cell disaggregation technique was not responsible.

275 sential facilitator of LBP/sCD14-induced LOS disaggregation that is required for activation of endoth

276 Data disaggregation, the breakdown of data into detailed subc

277 er, the process of chaperone-mediated PrP(D) disaggregation, the chaperones involved, and the effect

278 Essential for disaggregation, the ClpB middle domain (MD) is a coiled-

279 Upon disaggregation, the in vivo dephosphorylation of the Fce

280 blood viscosity, increased aggregation, and disaggregation threshold of GD RBCs compared with contro

281 in with a high degree of spatial and product disaggregation to assess the impacts of increasing local

282 iated cellular integrity and Hsp104-mediated disaggregation to ensure the survival of cells with fewe

283 ution of these aggregation reactions induced disaggregation to monomers as measured by size exclusion

284 structural property of CyP40 that may permit disaggregation to occur in an energy-independent manner.

285 al effects, from vasodilatation and platelet disaggregation to synaptic plasticity.

286 hagy-vacuole pathway, and chaperone-mediated disaggregation to the clearance of arsenite-induced prot

287 nude mice, and following tumor excision and disaggregation, tumor cells were cultured with the cytok

288 l highlights the importance of technological disaggregation, uncertainty quantification, and regional

289 (TFE) are different from those that promote disaggregation under milder conditions (5% TFE).

290 Data disaggregation underpins data equity, which uses communi

291 unoblotting for rpS6 showed modest polysomal disaggregation upon fasting.

292 tor in serum that mediated AgLDL release and disaggregation was plasmin generated from plasminogen by

293 ric concentrations of N744 also promoted tau disaggregation when added to mature synthetic filaments.

294 why the N domain is dispensable for protein disaggregation when Hsp70/40 is present, yet essential f

295 illized state, resulting in endwise filament disaggregation when it was added to synthetic filaments.

296 y influences the conditions when aggregation/disaggregation will occur, making predictions difficult

297 e kinase and can be inhibited by FcepsilonRI disaggregation with monovalent hapten.

298 r the measurement, membranes were removed by disaggregation with the calcium-chelator phosphate buffe

299 ClpB double mutant is inactive in substrate disaggregation with the DnaK system, although each singl

300 evealed bimodal effects indicative of fibril disaggregation, with aggregation catalysis occurring at