ライフサイエンスコーパス: disarm

1 has catastrophic effects if this feature is disarmed.

2 emoselective glycosylation which relies on a disarmed [2.2.2] l-ido lactone motif.

3 ow we show that in neutrophils P. gingivalis disarms a host-protective TLR2-MyD88 pathway via proteas

4 anti-IgE antibodies that safely and rapidly disarm allergic effector cells.

5 sesses diverse defense mechanisms, including DISARM and Hachiman, not found in Atabeyarchaeia.

6 putative bacterial immune systems including DISARM and Pycsar antiphage operons.

7 und to be in between that of the "torsional" disarmed and an armed donor.

8 s or others with a firearm to be temporarily disarmed and prevented from purchasing firearms for 3 we

9 of action (repellency, preprandial killing, disarming and postprandial killing), we develop target p

10 The bacterium also dysregulates, disarms, and evades host immune responses to maintain ch

11 egies span from killing (new antibiotics) to disarming (antivirulence) the pathogen.

12 This modified armed-disarmed approach is relying on the observation that 2-N

13 es as opposed to classic Fraser-Reid's armed-disarmed approach leading to cis-trans and cis-cis linka

14 this study was to evaluate the potential of disarmed Atx to deliver either ASOs or siRNA.

15 S. aureus with the ability to simultaneously disarm both innate and adaptive compartments of the host

16 Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functio

17 Thus, uncommitted T cells can be disarmed, but immune privilege is unable to protect from

18 ntrinsic immune defense against HCMV that is disarmed by the virus.

19 Furthermore, soluble PC5A/PACE4 can target/disarm cell surface PAR1 through cleavage at Arg46 downw

20 re, we report cryo-EM structures of the core DISARM complex, DrmAB, both alone and in complex with an

21 indings were used to perform the first armed-disarmed coupling between two benzylated glucosyl donors

22 Here, we report on a new defence system, DISARM (defence island system associated with restrictio

23 While the recently discovered DISARM (Defense Island System Associated with Restrictio

24 The armed and disarmed donors lead to product formation in 5 min, show

25 ved in plant immunity that works by directly disarming effector proteins.

26 Disarming ester protecting groups were necessary to coun

27 the l-glycero-d-gluco isomer with the least disarming gauche,gauche side-chain conformation was the

28 synthesized for the first time by the armed-disarmed glycosylation method between two thiotolylglyco

29 conditions, BCF not only activates armed and disarmed glycosylimidate donors but also increases the n

30 f beta-O-aryl glycosides from both armed and disarmed glycosylimidates with weakly nucleophilic pheno

31 Additional disarming groups further decreased the alpha-selectivity

32 ulosis and enteropathogenic Escherichia coli disarm host cells by injecting cell cycle inhibiting fac

33 deregulate lymphocyte receptor expression to disarm host immune control.

34 mechanism to deregulate T cell activation to disarm host immune surveillance.

35 ttle is known about which parasite effectors disarm human immune responses.

36 therefore, represents a potential target for disarming immune responses.

37 bacterial toxin that targets host cells and disarms immune defenses.

38 optotic BCL-2 family proteins are frequently disarmed in relapsed and refractory cancer through genet

39 Herpesviruses encode multiple factors that disarm innate immune signaling to evade host anti-viral

40 must also overcome many challenges, such as disarming innate immune signaling and accessing host nut

41 Our results suggest that DISARM is a new type of multi-gene restriction-modificat

42 DISARM is composed of five genes, including a DNA methyl

43 t leukocytes lacking cognate HLA ligands can disarm KIR+ NK cells in a manner that may decrease HLA-

44 SIGN to subvert the host immune responses by disarming MAPK pathway in DCs.

45 hat four of the five genes are essential for DISARM-mediated defence, with the fifth (PLD) being redu

46 phage DNA and that the B. paralicheniformis DISARM methylase modifies host CCWGG motifs as a marker

47 previously unrecognized capacity of SIgA to "disarm" microbial pathogens on mucosal surfaces and prev

48 t versatile evolutionary innovators, able to disarm multiple chemical plant defenses.

49 ucts, perhaps released from granulomas, from disarming myeloid cells prior to their encounter with wh

50 of the steric A-value and of its moderately disarming nature, as reflected in the pKa of propargyl a

51 The residual NPOE is converted into disarmed NPG, which is refractory to the reaction condit

52 Bacteria can indirectly disarm NSPs by protecting bacterial substrates against N

53 3-step route from 1 to a new type of highly disarmed O-4 iduronate thioglycoside, which is an effect

54 e response of cancer cells to CD8(+) T cells disarmed of their killing activity.

55 e as a therapeutic candidate facilitates the disarming of bacterial virulence without affecting bacte

56 e that pUL36 DUB activity contributes to the disarming of these host responses.

57 This cleavage results in a disarming of thrombin-activated calcium signaling throug

58 cid accumulation induced by infection with a disarmed pathogen.

59 ally, developing new treatments that seek to disarm pathogens without killing them, or that modulate

60 nmental optimization, and the utilization of disarmed pathogens as antagonists are strategies with po

61 n mapping studies show that HDAC3 inhibition disarms pathological astrocyte gene expression and funct

62 approach, which targets virulence factors to disarm rather than kill pathogens and thus attenuates th

63 is of 1,2-trans-linked oligosaccharides, the disarmed reducing end of which can be activated for imme

64 We further show that DISARM restricts incoming phage DNA and that the B. para

65 n system (T6SS) to survive in macrophages by disarming Rho-type GTPases, causing actin cytoskeletal d

66 immune barriers, as an alternative target to disarm S. aureus.

67 fect tissue function by either activating or disarming signal transduction mediated by proteinase-act

68 We next explored the effects of disarming specific aspects of the immune system on the r

69 findings reveal how the poxvirus F17 protein disarms specific mitochondrially orchestrated responses

70 yzed co-cultivation conditions and different disarmed strains of Agrobacterium to improve transformat

71 Both depend on disarmed strains of Agrobacterium tumefaciens to deliver

72 f virulence genes were added to three common disarmed strains.

73 was incorporated into the conventional armed-disarmed strategy.

74 ivation encountered in the traditional armed-disarmed strategy.

75 We name this new approach the "inverse armed-disarmed" strategy, because it allows for the chemoselec

76 Our findings unveil a 'disarming' strategy of neutrophils that depletes protein

77 n the electron-withdrawing capability of the disarming substituent at the 6-position, i.e., on the nu

78 Both proteases interacted with and disarmed surface GEC PAR1, but there was no detectable i

79 neering the Bacillus paralicheniformis 9945a DISARM system into Bacillus subtilis has rendered the en

80 This result differs from the classic armed-disarmed technique, according to which usually cis-trans

81 ogenesis, primarily by enabling the virus to disarm the host cell type IFN defense system.

82 fs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing.

83 This ability to disarm the IFN-beta response offers an explanation for t

84 ry: to induce expression of VZV genes and to disarm the IFN-dependent antiviral defense through a nov

85 be targets MAP kinases in dendritic cells to disarm the immune response.

86 ets are readily infected without the need to disarm the immune system or alter the gut microbiota.

87 tion and also modify the host environment to disarm the innate immune response.

88 Thus, gp120 may be used by HIV-1 to disarm the monocyte response to inflammatory stimulation

89 uires the appropriate sequence of touches to disarm the system.

90 Thus, rather than disarming the antiviral activity induced by IFN-beta pre

91 herbivore for tolerating, circumventing, or disarming the defenses.

92 protein levels is important with respect to disarming the IFN response during productive infection.

93 sites and that this strategy is critical for disarming the innate immune response for viral survival.

94 reactive viral DNA end from the active site, disarming the viral nucleoprotein complex.

95 uggest a model whereby UV-induced DNA damage disarms the immune system in a manner similar to that ob

96 When effective, the plant immune system disarms the infectious necrotroph of its pathogenic arse

97 and response system as most DR genes do, Hm1 disarms the pathogen directly.

98 ialdehyde dehydrogenase, is responsible for 'disarming' the final aldehydic intermediate.

99 idious manner by which interbacterial toxins disarm their targets emphasizes the highly evolved natur

100 rease phagocytosis of circulating ICs, while disarming their inflammatory potential.

101 proaches involve clearing senescent cells by disarming their pro-survival pathways with 'senolytics';

102 r for activation of T cells) on these cells, disarming their suppressive activity.

103 hemo-selective glycosylations with armed and disarmed thioglycosides have been successfully used exte

104 er process is shown to affect both armed and disarmed thioglycosides, cause anomerization of the carb

105 ile that can readily activate both armed and disarmed thioglycosides, via glycosyl triflates, in a ma

106 e diamondback moth (Plutella xylostella) has disarmed this elemental defense.