ライフサイエンスコーパス: discovery

1 tional group in medicinal chemistry and drug discovery.

2 emerging approach in modern anticancer drug discovery.

3 ty-building in global marine natural product discovery.

4 t identification is a major obstacle in drug discovery.

5 epresent a new era for noninvasive biomarker discovery.

6 standing challenges in natural products drug discovery.

7 e, and to continue the pursuit of novel drug discovery.

8 s structural biology, cell imaging, and drug discovery.

9 diagnostics, functional proteomics, and drug discovery.

10 ollowed by sequencing analysis and DNA motif discovery.

11 WAS) are still the primary steps toward gene discovery.

12 ent the relevance of peptidomimetics in drug discovery.

13 a comprehensive strategy for natural product discovery.

14 processes is an important first step of drug discovery.

15 great promise for disease modeling and drug discovery.

16 ancer, and is an important biomarker in drug discovery.

17 technologies to enable next-generation drug discovery.

18 rs in recombinant systems has precluded drug discovery.

19 ys in the early ADME profiling space in drug discovery.

20 promising characteristics as sources for NP discovery.

21 cs has led to an exponential growth in virus discovery.

22 ignificantly streamline therapeutic antibody discovery.

23 on and classification and advances biomarker discovery.

24 d protein chimeras have been used in epitope discovery.

25 interaction prediction and literature-based discovery.

26 subsequently be used in other tools for loop discovery.

27 have been a crucial component of many recent discoveries.

28 Since its discovery 150 years ago, the neural crest has intrigued

29 We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 x 10(-22)) and r

30 These discoveries advanced our understanding of the evolution

31 assays, used routinely in antimalarial drug discovery, against the whole organism.

32 Here we apply causal discovery algorithms to sea level pressure data from a l

33 recent developments in allergen and epitope discovery, allergy diagnostics and immunotherapy.

34 The numerous discoveries and innovative concepts realized in motile m

35 ys that were opened in neuroscience by major discoveries and set the stage for the next 50 years.

36 However, fundamental discoveries and technological translations of chiral nan

37 Here, we review the discovery and biology of HRP2, as well as the strengths

38 Ls represents a significant challenge to the discovery and characterization of biologically relevant

39 mixture analysis and subsequent accelerated discovery and characterization of new natural products.

40 Here we describe the discovery and characterization of ST-2262, a Na(V)1.7 in

41 In contrast, the recent discovery and clinical validation of highly potent selec

42 of mitophagy pathways and prospects for drug discovery and consider intervention points for mitophagy

43 te and describes novel opportunities for the discovery and development of drugs for metabolic reprogr

44 lation is an attractive target for antiviral discovery and development of new live attenuated vaccine

45 erpretation of medical images as well as the discovery and development of new therapies.

46 The model-informed drug discovery and development paradigm is now well establish

47 ges the current paradigm of traditional drug discovery and development, which usually takes years fro

48 anels provide genetic resolution for variant discovery and functional characterization, as well as di

49 ending from environmental monitoring to drug discovery and industrial biotechnology.

50 s machine learning to automate the selective discovery and isolation of novel RiPPs.

51 Preclinical studies describing their discovery and mechanism of action, coupled with emerging

52 Herein, we describe the discovery and optimization of a class of potent, orally

53 This Review focuses on discovery and preclinical development projects and has f

54 ient and cost-effective tool for drug target discovery and prioritization.

55 present an integrated approach to materials discovery and qualification to insert new materials into

56 gnificantly associated with ADHD risk in the discovery and replication data sets.

57 Meta-analysis of discovery and replication samples identified association

58 bases, thus presenting new opportunities for discovery and research.

59 Combining high-throughput discovery and subsequent structure-function characteriza

60 We report the serendipitous discovery and synthesis of an indigoid "semi-Nindigo" (2

61 l molecules suitable for fragment-based drug discovery and the cystic fibrosis C2-corrector clinical

62 ve focuses on various aspects of ocular drug discovery and the recent advances therein.

63 al studies, including glycan-based biomarker discovery and therapeutics.

64 ized devices replacing animal models in drug discovery and toxicology studies.

65 key considerations and challenges for their discovery and translation are discussed.

66 t-generation" approaches that are needed for discovery and understanding but that do not always fit n

67 ics in nephrology has largely focused on the discovery and validation of biomarkers, but the systemat

68 select the proper controls to minimize false discoveries, and experimental variations among biologica

69 nonconventional organisms have had in these discoveries, and outline new avenues of investigation to

70 ed the best trade-off between true and false discoveries, and this advantage is more apparent in data

71 l variants, we present two methods of driver discovery, and identify regions that are significantly a

72 lymerization kinetics, accelerating reaction discovery, and optimization of polymer coatings.

73 vanced biomedical information management and discovery applications.

74 ontrols for our whole-genome gene expression discovery approach.

75 Many discoveries are recent, and the findings described in th

76 These discoveries argue that bacterial membrane potential dyna

77 gh it provides invaluable resources for drug discovery as well as understanding of disease mechanisms

78 hese findings are critical for rational drug discovery, as limiting a virtual screen to a single conf

79 enable realistic physical models and advance discovery at the interface of geometry and cellular proc

80 dence in the discovered mutations, moves the discovery back in the past to a common ancestor.

81 Chirality is important in drug discovery because stereoselective drugs can ameliorate t

82 This work will not only fuel kinase degrader discovery, but also provides a blueprint for evaluating

83 udy of such processes, as well as the recent discoveries by leading investigators with an emphasis on

84 Finally, we propose that RNA ligand discovery can benefit from using progress made within th

85 Here, we outline recent discoveries, challenges, and future trends for circulati

86 Seven decades after its discovery, CN1 remains a morbid and potentially fatal di

87 the same direction of association as in the discovery cohort.

88 Participants in a "discovery" cohort, with known NE-MNV identified on swept

89 ed vector DNA libraries, thereby raising the discovery cost of novel vectors.

90 This discovery could help create super-intense narrow band th

91 pes realized to expedite medicinal chemistry discovery cycles.

92 s: HR 1.24, 95% CI 1.02-1.51; p=0.034 in the discovery dataset; 1.10, 0.98-1.20; p=0.10 in the valida

93 ble hematologic malignancy, as an incidental discovery during molecular analysis of a nonhematologic

94 have provided an up-to-date account of drug discovery efforts targeting selected enzymes (MbtI, MbtA

95 ls associated with exclusive focus of ligand discovery efforts within only one framework.

96 ding of which can substantially advance drug discovery efforts.

97 These discoveries expand our understanding of how eggshell col

98 00 additional Utah suicides unrelated to the discovery families.

99 To validate the discovery feature of LPHAMS, we characterized one of the

100 n recognizing key features and control false discoveries for class-imbalance learning.

101 n autoimmunity and the importance of antigen discovery for improved understanding of disease mechanis

102 Since their discovery, giant viruses have expanded our understanding

103 Chagas drug discovery has been hampered by a lack of validated assay

104 Perhaps the most fertile area for discovery has been the formation of lignins, including t

105 For decades, traditional drug discovery has used natural product and synthetic chemist

106 These discoveries have led to numerous clinical trials that ha

107 Recent discoveries have shed light on this process and how it f

108 Together, these discoveries highlight the lysosome as a regulatory hub f

109 These discoveries illuminate base editing, enable editing at p

110 These discoveries illustrate how a biological materials strate

111 This discovery implies that epigenetic mechanisms, and their

112 hin the nervous system have intersected with discoveries in immunology in unexpected ways to rapidly

113 s will benefit from understanding the latest discoveries in neutrophil biology and how these novel fu

114 Discoveries in this field provided insights into primary

115 The discovery in 1976 of waterfowl as the primary reservoir

116 Since their discovery in 2007(1), much effort has been devoted to un

117 Since the groundbreaking discovery in 2018 that the synthesis of a bottleable nuc

118 form, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant

119 -driven decisions and accelerating knowledge discovery in life sciences.

120 y's activities, with the intent of enhancing discovery in public health." As a foundational step in i

121 tion has contributed to different aspects of discovery in the chemical sciences.

122 gies have recently fueled an exciting era of discovery in the field of chromosome structure and nucle

123 This discovery indicates a protective capacity of the endogen

124 hanisms and on the approaches for biomarkers discovery is also provided, including genetic studies an

125 Enabling data reuse and knowledge discovery is increasingly critical in modern science, an

126 Zebrafish models are a powerful system for discovery, live imaging, and functional investigation of

127 Our discoveries may uncover new potential interventional str

128 yping and wearable technologies, and how new discovery may be advanced through machine learning appro

129 We created discovery (n = 2405) and validation (n = 2313) cohorts u

130 from the Psychiatric Genomics Consortium for discovery (N=19,210) and ADHD data from the Lundbeck Fou

131 Both cohorts (discovery: n = 182; replication: n = 326) included treat

132 may contribute an understanding to previous discoveries of RV activation in ALS affected patients.

133 This Review outlines recent discoveries of the interplay between circadian rhythms,

134 proach and ethos that have resulted from the discoveries of the last few decades.

135 With the serendipitous discoveries of translated ORFs encoded upstream and down

136 sting of 62 screening candidates yielded the discovery of 10 new agonist chemotypes with sub-micromol

137 The discovery of a diverse microbial community in smectite-r

138 Here, we report the discovery of a family of endoplasmic reticulum (ER) tran

139 These mechanistic insights assisted the discovery of a new Ti(salen) catalyst, which substantial

140 Here, we report the discovery of a novel chemical series of non-bile acid FX

141 The hit-to-lead optimization led to the discovery of a novel chemotype series exemplified by the

142 ucture-activity relationship, leading to the discovery of a novel DBO, ANT3310, which uniquely has a

143 ed colorimetric readout of this assay to the discovery of a novel monoclonal antibody (mAb) sandwich

144 We present the discovery of a novel radical cation formed through one-e

145 Herein, we report the discovery of a novel series of reversible and selective

146 Here, we report the discovery of a pharmacological treatment that thins F-ac

147 In this report we describe the discovery of a potent and selective DYRK1A inhibitor GNF

148 e 2-sulfonylpyridine reactive group with the discovery of a selective covalent modifier of adenosine

149 Herein, we report the discovery of a series of JAK1-selective kinase inhibitor

150 tively, is identified, which accelerates the discovery of a series of new oxide perovskite catalysts

151 We previously described the discovery of a small molecule, (+)SW033291, that binds w

152 Despite the discovery of acesulfame and PFAS in most OSPW samples, t

153 The chemical proteomic discovery of alpha-chloroacetamide (alphaCA) compounds t

154 process on a synthetic scale, leading to the discovery of an Amadori-type rearrangement of dopegal in

155 Here we report the discovery of an articulated and very well-preserved skel

156 The recent discovery of an HCV-like rodent hepacivirus (RHV) enable

157 case under the HOPE Act at our center where discovery of an HIV-specific issue led to a turndown of

158 Specifically, the discovery of an intracellularly active complement system

159 The discovery of an unexpected high-concentration doping eff

160 ectional circuits.SIGNIFICANCE STATEMENT The discovery of anterograde transneuronal spread of AAV1 ge

161 host interactions that should facilitate the discovery of antiviral drugs for this important zoonotic

162 the importance of phenotype-specificity for discovery of asthma genes and epistasis.

163 S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthe

164 The discovery of CD4(+) T cell subset-defining master transc

165 with nanometer resolution, facilitating the discovery of complex and dynamic protein networks.

166 rmeability, and low efflux culminated in the discovery of compound 1, which exhibited target engageme

167 This led to the discovery of compound BAY 1214784, an orally available,

168 ional constant by Henri Cavendish(1) and the discovery of Coulomb's law.

169 The discovery of D1-mGlu5 functional heteromers mediating ma

170 eening strategy, which can lead to the rapid discovery of drug leads with clinical potential in respo

171 the progression of liver diseases and in the discovery of drugs for the treatment of these disorders.

172 ected to facilitate rational structure-based discovery of drugs targeting the cannabinoid system.

173 Until the discovery of DUX4 and its causal role in FSHD, most tria

174 The discovery of fluorescence two centuries ago ushered in,

175 Since the discovery of functionally competent, energy-consuming br

176 The recent discovery of grove of giant trees over 80 meters tall in

177 has led to important insights, including the discovery of guidance rules that attacking predators use

178 These findings highlight the discovery of IACS-13909 as a potent, selective inhibitor

179 The discovery of impaired hippocampal synaptic plasticity in

180 Despite the discovery of ipRGCs nearly two decades ago, there is sti

181 The discovery of JAKs and STATs and their roles in cytokine

182 The discovery of keratinocyte-sensory neuron synaptic-like c

183 n Duman, we provide a historical note on the discovery of ketamine and its putative mechanisms.

184 ncluding novel ligand identification and the discovery of loss-of-function mutations associated with

185 CTSRs can, therefore, aid in the discovery of major regulatory mechanisms and allow relia

186 bstantial additional insights, including the discovery of mechanisms that trigger and propagate kidne

187 The recent discovery of meningeal lymphatics in mammals is reshapin

188 These findings will help efforts towards the discovery of microbial-derived repellent/oviposition-det

189 cance of genetic variants and to utilize the discovery of molQTLs in precision medicine.

190 -coupled receptors, has directly enabled the discovery of most drugs developed to modulate receptor s

191 as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in th

192 The discovery of MYD88 and CXCR4 mutations in WM has facilit

193 rise of antibiotic resistance and declining discovery of new antibiotics has created a global health

194 fraction studies up to 27 GPa, we report the discovery of new high-pressure polymorphs of the feldspa

195 lp to deepen our understanding and guide the discovery of next-generation water harvesting materials.

196 The discovery of non-native kelp washed up on Antarctic beac

197 P peak co-occurrences across RBPs enable the discovery of novel co-interacting RBPs.

198 small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein

199 als materials provide a new platform for the discovery of novel physics and effects.

200 a RiPP genome mining algorithm aimed at the discovery of novel RiPP classes.

201 t the global rise in metabolic syndrome, the discovery of novel signaling roles for metabolites, and

202 Since the discovery of ocular dominance plasticity, neuroscientist

203 Here we report the discovery of over 300 new imine reductases and the produ

204 These results are then applied to the discovery of p53-like binders to MDM2, and to a family o

205 This discovery of POLGARF unveils a previously undescribed me

206 he development of which will be aided by the discovery of potent and selective antibodies against rel

207 Herein, we report the discovery of second-generation GluN2C/D-selective NMDAR-

208 CNS innate immune populations and may enable discovery of selective neuroprotective strategies.

209 ew material and the holotype, leading to the discovery of several new morphological features, such as

210 q data, presenting analytical challenges for discovery of somatic indels in tumor transcriptome.

211 f chromosome-scale phased assemblies for the discovery of structural variants (SVs), including thousa

212 Discovery of such a feeding behavior in this ancient, te

213 ethods have been developed to facilitate the discovery of such non-classical secreted proteins; howev

214 ed breast cancer for three decades until the discovery of tamoxifen.

215 y Rolf Kemler and Masatoshi Takeichi for the discovery of the cadherin family of Ca(2+)-dependent cel

216 hlight issues and perspectives raised by the discovery of the first pharmaceutical strongly affecting

217 In this minireview, we highlight the discovery of the monofunctional glycosyltransferases Rod

218 In addition, the discovery of the new RE-hpt-MOF-1 and RE-ken-MOF-1 famil

219 Inspired by the discovery of the nonselective aminotransferase inactivat

220 The discovery of the opposing functions of BRCA1 and the p53

221 Since the discovery of the pioneering bimetallic {MnII4[MIV(CN)8]2

222 ctivity, and oral bioavailability led to the discovery of the potent, highly selective, orally availa

223 w dominate previously coral-rich reefs.(6-8) Discovery of the powerful grazing capability of the Cari

224 The discovery of the role of the PD familial genes PTEN-indu

225 Our recent discovery of the strong room temperature ferromagnetism

226 In the three decades since the discovery of the Wallerian degeneration slow (Wld(S)) mo

227 n these large multigene families still await discovery of their biochemical functions.

228 Discovery of their importance in regulation of excitabil

229 rk that was specifically associated with the discovery of this embedded structure.

230 A strategic screening approach led to the discovery of this novel ligand, which was successfully a

231 detection of lung cancer might result in the discovery of thyroid incidentalomas.

232 These studies culminated in the discovery of TNO155, (3S,4S)-8-(6-amino-5-((2-amino-3-ch

233 This strategy may also be employed for the discovery of unconventional spherical assemblies in othe

234 asma cells and plasmablasts could enable the discovery of useful antibodies for therapeutic or resear

235 Combinatorial approaches to materials discovery offer promising potential for the rapid develo

236 and RyR2, in addition to the impact of such discoveries on intracellular Ca(2+) dynamics and biophys

237 In this review, we will discuss the recent discoveries on non-viral gene delivery systems.

238 Drug discovery organizations can choose from several operatio

239 This discovery paves the way to elucidate how polar Tfp machi

240 In the discovery phase, we performed genome-wide miRNA expressi

241 To address this challenge, a biomarker discovery pipeline was developed to integrate gene expre

242 To accelerate the cardiac drug discovery pipeline, we set out to develop a platform tha

243 In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclon

244 howing great potential in improving the drug discovery process.

245 rget space at an early stage during the drug discovery process.

246 ld bypass the time-consuming and costly drug-discovery process.

247 Discovery, production, trafficking, and consumption of i

248 peline provides a roadmap for rapid antibody-discovery programmes against viral pathogens of global c

249 eletal ring systems is of importance to drug discovery programmes and natural product synthesis.

250 tic effect is a critical aspect for all drug discovery programs.

251 s advanced to implementation in several drug discovery programs.

252 s successfully used in several 'inverse drug discovery' programs that use high-throughput techniques

253 ich have been shown to be capable of driving discovery projects.

254 This discovery prompted us to collect data from nine addition

255 This discovery provides a new avenue for stabilizing mixed io

256 In a broader context, this discovery provides insight into the role of previously u

257 Our discovery provides temporal and spatial clues of the ear

258 cant enrichments across nine diseases (false discovery rate < 0.05) (for example, NKX3-1 for prostate

259 Strong evidence of association (false discovery rate <0.05) was found between PD and a positiv

260 ic traits in cross-sectional analyses (false discovery rate <0.10), and 8 of these proteins had pQTLs

261 at higher abundance in the SLD group (false discovery rate <= 1%).

262 s was associated with urinary As after false discovery rate (FDR) correction (FDR < 0.05).

263 Accurate estimation of false discovery rate (FDR) of spectral identification is a cen

264 introduce an extension of the Irreproducible Discovery Rate (IDR) method called IDR2D that identifies

265 trols, respectively (fold change >= 2; false discovery rate [FDR] < 0.05).

266 sting following the Benjamini-Hochberg false discovery rate [FDR] showed that 18 miRNAs were signific

267 nucleotide regions for 82 transcripts (false discovery rate [FDR]-P < 0.05).

268 te a broad assessment of the empirical false discovery rate across other subject areas and characteri

269 ough data augmentation under preserved false discovery rate control.

270 computed efficiently enough to enable false discovery rate estimation via permutation.

271 , 95% CI - 0.015, 0.046, adjusted mean false discovery rate Open Access = 0.241 vs. closed access = 0

272 e significantly related to depression (false discovery rate q < .05).

273 cally significant evidence of a higher false discovery rate, on average, for Open Access versus close

274 imulation (TMS) for treatment of depression (discovery sample, N=30; active replication sample, N=81;

275 broad audience; applications can range from discovery science through clinical trials to clinical pr

276 This discovery sets HR3 as a new candidate target for antivir

277 While many gene discovery studies in the past were led by knowledge in t

278 d an excellent platform for preclinical drug discovery studies.

279 mportant framework for structure-guided drug discovery targeting MCTs.

280 ated research, particularly involved in drug discovery targeting metalloenzymes.

281 improved mixture-based, high-throughput drug discovery techniques.

282 ation-profiling approach will enable further discoveries that change the natural history of CF lung d

283 c strategy toward 4 and report the series of discoveries that prompted the design of this cascade cou

284 ent examples of de novo biosynthetic pathway discovery that employ various innovative approaches.

285 rently facilitates new avenues for materials discovery that have not been fully explored.

286 ction between these two pathways through our discovery that human aminolevulinic acid dehydratase (AL

287 The discovery that MAAs are upregulated under FR light suppo

288 The discovery that noble-transition alloys can excel at hot-

289 The discovery that one bacterial effector evolved to target

290 Our discovery that podocytes become sensitized to AngII-indu

291 However, the discovery that the members of the merozoite PfRH5-PfCyRP

292 esearchers can immediately extrapolate novel discoveries through easy-to-understand plots.

293 ities for successfully bridging neuroscience discovery to clinical practice.

294 ed virtual screening and fragment-based drug discovery to identify compounds likely to bind PRLR and

295 ic access to leubethanol will enable pathway discovery to more complex serrulatane diterpenoids which

296 fer an overview of studies focusing on miRNA discovery using profiling techniques and bioinformatic m

297 s and educators working in the areas of drug discovery, vaccine design, and biomedical and biotechnol

298 RCCs accelerate functional variant discovery via decreasing the number of segregating varia

299 sent and future value of simulation for drug discovery, we review key applications of advanced method

300 lysis platform that couples dominant pattern discovery with a corresponding structural representation