ライフサイエンスコーパス: disease-related gene

1 RPS6 is a potential novel disease-related gene.

2 rays have been widely used to discover novel disease related genes.

3 eferred for genetic testing for almost 1,900 disease-related genes.

4 cused on studying G4s in promotor regions of disease-related genes.

5 ion of newly discovered missense variants in disease-related genes.

6 GEMMs for the functional characterisation of disease-related genes.

7 within RefSeq genes, especially within known disease-related genes.

8 approach is sufficient to discover groups of disease-related genes.

9 ely used for medical studies to detect novel disease-related genes.

10 -DNA structures are abundant in promoters of disease-related genes.

11 ession analysis may improve the detection of disease-related genes.

12 tide microarray-based mutational analysis of disease-related genes.

13 determining sequence alteration in multiple disease-related genes.

14 d 2, apolipoprotein E, and other Alzheimer's disease-related genes.

15 cerning the identification of novel melanoma disease-related genes.

16 of known muscle class-specific and inherited disease-related genes.

17 identification of developmental, aging, and disease-related genes.

18 profile complex diseases and discover novel disease-related genes.

19 large-scale bulk sample data in prioritizing disease-related genes.

20 ieving genome-wide resolution of variants in disease-related genes.

21 targeted testing of seven major Parkinson's disease-related genes.

22 d for future studies as possible Parkinson's disease-related genes.

23 models have provided important links between disease-related genes and behavioral impairment.

24 We collected an initial set of known disease-related genes and built an interaction network b

25 inal feature are providing new insights into disease-related genes and developmental pathways.

26 d accumulation of our knowledge on diseases, disease-related genes and drug targets, network-based an

27 ted the predicted interactions for two human disease-related genes and identified 14 new modifiers.

28 ing spatial expression patterns, identifying disease-related genes and interactions, and improving sp

29 nt, and further allows the identification of disease-related genes and pathways that play similar rol

30 ed mice provides resources to identify novel disease-related genes and pathways.

31 increasing confidence for identification of disease-related genes and pathways.

32 hod to an AD dataset, and identified several disease-related genes and processes demonstrating the us

33 cular microRNAs, have been shown to modulate disease-related genes and processes.

34 , we find that some subsets are enriched for disease-related genes and RNA signatures.

35 s are liable to affect the functions of core disease-related genes and that most heritability can be

36 he new function of two previously identified disease-related genes and the potential of one developme

37 for moving toward a more complete catalog of disease-related genes and variants.

38 ession changes in enteric neurons, show that disease-related genes are dysregulated with aging, and i

39 y, we show that Satb2 and Fezf2 regulate two disease-related genes, Auts2 (Autistic Susceptibility Ge

40 ng routinely identifies missense variants in disease-related genes, but functional characterization i

41 line settings might be used to help identify disease-related genes by guiding the development of back

42 ion, identification, and characterization of disease-related genes by means of positional cloning.

43 ation that selects and prioritizes potential disease-related genes by using a highly curated and upda

44 ated the capability of AAV2.retro to deliver disease-related gene cargo to biologically-relevant NHP

45 The glomerular disease-related gene, CD2AP, exhibited an STR replacemen

46 s the first report of an association between disease-related gene CNV and variation in protein expres

47 lyploids and provide evidence of constrained disease-related gene copy numbers in Echinochloa.

48 f hereditary sequence variants identified in disease-related genes directly affects clinical manageme

49 Co-expression of Parkinson's disease-related genes DJ-1, parkin, Pink1, UCH-L1, or sy

50 tional clues of previously unknown genes and disease-related genes during early brain development.

51 The accelerated discovery of disease-related genes emerging from genomic studies has

52 ties of microbes with weak associations with disease related gene expression.

53 scriptional activity, escalating Alzheimer's disease-related gene expression and pathogenesis.

54 Transcriptome analysis revealed distinct disease-related gene expression profiles depending on an

55 iologically sensible findings, including the disease-related gene expressions, copy number variations

56 dromes, as well as the identification of new disease-related genes for dilated cardiomyopathy, idiopa

57 UDEP, epilepsy, heart disease or respiratory disease-related genes from previous published reports an

58 diseases suggest that PhenoSV can determine disease-related genes from SVs.

59 same number of genes, and up to 75% of human disease-related genes have Drosophila homologues [1].

60 es a high degree of connectivity among these disease-related genes, highlighting RBFOX1 as a key fact

61 to dissect the epigenetics of silencing of a disease-related gene in its natural chromosomal context.

62 uce heritable, site-specific modification of disease-related genes in human cells without purine sequ

63 uce heritable, site-specific modification of disease-related genes in human cells.

64 rticles can efficiently and precisely modify disease-related genes in living cynomolgus monkeys (Maca

65 oenvironment and modulates the activation of disease-related genes in lung fibroblasts from healthy a

66 can be explained by segregation of Alzheimer disease-related genes in these families or shared enviro

67 nflammation and reduction in known astrocyte disease-related genes including those of immediate early

68 gene product, are prevalent in a variety of disease-related genes, including APC (implicated in colo

69 ted with decreased expression of products of disease-related genes, including K16, iNOS, IFN-gamma, I

70 determine if STR replacements occurred near disease-related genes, including previously unstudied ST

71 Additionally, multiple Parkinson's disease-related genes, including VPS35 and LRRK2, also r

72 rimental data suggest that BFDCA can cluster disease-related genes into functional DC subunits and es

73 dentified in macaque, and that expression of disease-related genes is largely conserved between the t

74 A mosaic pathogenic variant in a disease-related gene may cause an atypical phenotype in

75 However, 15 families had variants in disease-related genes not typically associated with LGMD

76 tentially susceptible rare variants within a disease-related gene or a genetic region.

77 ternative and effective approach to identify disease-related genes or loci has been verified.

78 s has documented the presence of at least 10 disease-related genes or loci linked to Parkinson's dise

79 enhances the potential for CNS modulation of disease-related gene pairs using a unimolecular siRNA.

80 were undiagnosed on a targeted neuromuscular disease-related gene panel did not improve our diagnosti

81 ophagy pathway controlled by the Parkinson's disease related genes PINK1 and PARKIN and is mechanisti

82 Another glomerular disease-related gene, rabphilin 3A, exhibited at least t

83 Another challenge is that determining disease-related genes requires laborious experiments.

84 To narrow the search for candidate disease-related genes, RGC genes were mapped to known di

85 Mutations in other disease-related genes suggest a potential relationship w

86 ine Mendelian Inheritance in Man database of disease-related genes, suggesting that exosome analysis

87 ative methods to have higher power to detect disease-related genes than non-integrative methods.

88 PROTACs have the potential to inactivate disease-related genes that are considered undruggable by

89 With this biosensor, we detected three disease-related genes that were the human immunodeficien

90 he identification of an increasing number of disease-related genes, the molecular defect in many case

91 Together with mapping of disease-related genes, this transcriptomic mapping of th

92 transcription factor targets to identifying disease-related genes to causality inference.

93 contributions of critical neurodegenerative disease-related genes to neuropathogenesis.

94 Knocking down expression of disease-related genes using small interfering RNAs (siRN

95 Potentially disease related gene variants are common in non-ischemic

96 bunits and estimate the regulatory impact of disease-related genes well.

97 eletions and one duplication) involved in 10 disease-related genes were selected for validation by us

98 ss to individual environmental antigens, and disease-related genes, which promote distinctive aspects

99 An example of this is the analysis of disease-related genes within sub-populations of blood or

100 ble the study of the spatial distribution of disease-related genes within the genome.

101 e pathogenicity of protein variants in human disease-related genes would have a marked effect on clin