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1 mbranes, while liquid ordered membranes were disfavored.
2 path to the Diels-Alder products, are highly disfavored.
3 er contributed, the more it was excluded and disfavored.
4 te is entropically favored and enthalpically disfavored.
5 N-C(alpha) bond cleavage in zwitterions was disfavored.
6 ive elimination or sigma-bond metathesis are disfavored.
7 e Ser67, to the cis- and/or trans-enamine is disfavored.
8 tly that such a pathway would be kinetically disfavored.
9 erted into the active site, is energetically disfavored.
10 at metal centers prior to C-H activation is disfavored.
11 F, with the latter channel being kinetically disfavored.
15 otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates.
19 -trisubstituted pyrrole; when enolization is disfavored, a [1,3] rearrangement occurs prior to enoliz
20 This suggests that fish oil-enriched diets disfavor AA oxygenation by altering the composition of t
22 the S/T-2 and S/T+1 positions, but strongly disfavors acidic residues (Asp or Glu) at the S/T-2 posi
24 addition to the 14e (pincer)Ir fragments but disfavor addition to the 16e complexes (pincer)IrH(2) or
25 active intermediates is shown to support the disfavored addition to enolate acceptors to an absolutel
26 e reported that YTHDC1 prefers guanosine and disfavors adenosine at the position preceding the m(6)A
28 ay be designed to generate thermodynamically disfavored alkenyl chlorides and fluorides in high yield
29 s the most pronounced optimum for K(+) while disfavoring all other biologically important cations (e.
31 in, these residues play an important role in disfavoring alternate states and are especially importan
32 mistry to favor fluorophore biosynthesis and disfavor alternative reactivity, we identify strategies
33 omplexes with bulky biaryl phosphine ligands disfavor amine binding to favorable conformations of oxi
35 hydroxyl group of HCO(3)(-) is particularly disfavored and apparently does not occur in any of the c
37 the tautomeric equilibrium is enthalpically disfavored and entropically favored by the increase in s
38 mponents for Sp1-3 but is more enthalpically disfavored and entropically favored with increasing Cys
39 n benzene, C-C cleavage is thermodynamically disfavored, and is brought about only by transient highl
40 SSs) with 12-bp spacers, should be extremely disfavored, and the cryptic RSS used for V(H) replacemen
41 o 5,4-bicyclic products is thermodynamically disfavored, and these cyclobutenamides instead rearrange
42 the unpaired nucleotide to the energetically disfavored anti conformation required for Watson-Crick p
46 cals; however, loss of the thermodynamically disfavored aryl radicals remains competitive with methyl
47 te is driven by enthalpy and is entropically disfavored as shown by anoxic isothermal titration calor
51 y, interactions between WT and G mutants are disfavored at the earliest stages of FUS nucleation.
52 substituents on the sulfonamide nitrogen are disfavored at the PNMT active site more so than at the a
53 rate-limiting and substrates that sterically disfavor attainment of the reactive conformation for dec
54 t nucleophilic attack from the alpha face is disfavored because an eclipsed H-2 will be encountered.
55 ogous interaction of P218 with human DHFR is disfavored because of three species-dependent amino acid
56 ed reversal of selectivity to form otherwise disfavored beta-aldehyde products in the hydroformylatio
57 to a wide range of statistically favored and disfavored beta-turn mutations and implicate a loosely a
58 of the alkene substituent as opposed to the disfavored bisecting conformation found in the Minor-TS.
59 trations of free HBpin and (n)BuNH(2) and so disfavors both hydroboration and dehydrocoupling while a
60 operative ethidium binding that allows for a disfavored but nonetheless possible intercalation into n
61 he secondary structure into an energetically disfavored, but functional, conformation and emphasize a
62 hydride transfer reaction is predicted to be disfavored by >20 kcal/mol, and the activation energy is
70 the NTP through the main channel is greatly disfavored by electrostatic repulsion between the NTP an
71 d make large contributions to stability, and disfavored by external A(+).C wobbles, which have high f
72 ropic orientation of the aggregates are both disfavored by high concentrations of salt (>200 mM NaCl)
73 ne to trans-(PH3)2IrX are generally strongly disfavored by increased sigma-donation from the ligand X
75 the death of an actor are typically strongly disfavored by natural selection, and yet many bacteria u
79 es-equilibrated hydroperoxide binding at Ti, disfavored by stronger surface Bronsted acidity, and rat
80 r, substrates with a net negative charge are disfavored by the channel, probably due to the negativel
82 en tBID and BCL-XL is driven by enthalpy but disfavored by the entropy associated with the conformati
87 is domain (ligand binding and demethylation) disfavor CheA binding such that it loses key contacts an
88 ility of IDPs promotes water exchange, which disfavors classical amide (1)H-detection, while (13)C-de
89 ith automatic agents; globalized environment disfavors cognitive control, while also promoting strate
90 tate, several of which are too weak - or are disfavored compared to other binding modes - to be obser
91 rrier becomes so much higher that it is also disfavored compared to the 5- and 7-exo-dig cyclizations
93 amyloid-like interactions are energetically disfavored compared with the native state, but entropica
95 st-guest chemistry and favoring of otherwise disfavored conformations of large guests has been achiev
97 systematically enumerated and classified the disfavored conformations that restrict short polyalanyl
98 ed to the steric bulk of the ammonium moiety disfavoring conformations in which hydrogen-bonding to t
100 ent at editing cytosine in the GC context, a disfavored context for wild-type APOBEC1 deaminase, whil
102 t contact between agents can either favor or disfavor control, depending on whether controlled agents
103 henylalanine is trapped in the energetically disfavored, coplanar conformation of the TS of the bond
109 hich is similar in magnitude to the (2)H-EIE disfavoring Cys-ketimine (from which the third state for
113 -7.6 kcal mol(-1)) while being entropically disfavored (DeltaS degrees approximately -24 cal mol(-1)
114 le iron site, whereas the dissociated methyl disfavors desorption into gas phase under the reactive c
115 nism of dimerization, features that favor or disfavor dimerization, thermodynamic and kinetic factors
118 ry mode that leads to the C5-alpha epimer is disfavored due to higher levels of allylic strain betwee
120 where condensation of Ge adatoms on SiO2 is disfavored due to the extremely short re-evaporation tim
123 termination by ETV was accomplished through disfavored energy requirements as well as steric constra
124 states on fullerenes is shown to accelerate disfavored enolate addition and exo Diels-Alder reaction
125 a more than 100-fold rate enhancement of the disfavored enolate addition reaction that coincides with
127 ther natural products involves a kinetically disfavored epoxide-opening cyclic ether formation, a rea
128 , coordination of NH3 to the Ir(I) center is disfavored even more strongly by increasing sigma-donati
130 H5 or H7 packaging signals are significantly disfavored for incorporation into a human H3N2 virus in
131 on of the circular genome that is favored or disfavored for new insertions but there are notable hots
135 ng non-covalent cross-linking of fibrils and disfavoring formation of pathogenic steric zippers.
138 These demographic fluctuations ultimately disfavor growth compared to nucleation and can suppress
139 eractions; however, nonspecific interactions disfavor guanine, while still favoring unpaired RNA stru
140 achinery, we defined a general approach that disfavors helical transitions leading to post-fusion con
144 ding to formation of a product that would be disfavored if the reaction proceeded by passage over kin
145 stic symbioses (the "Red Queen effect"), but disfavored in certain mutualistic symbioses (the "Red Ki
146 mbrane shape, with the E2 state being likely disfavored in cholesterol-rich bilayers relative to the
149 complexes) are predicted to be energetically disfavored in reactions involving fluorobenzenes with a
150 acetylation, and H3 K4 methylation, but was disfavored in regions rich in transcription-inhibiting m
151 e supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced by the orth
152 onfiguration, the hosts occupy binding sites disfavored in the binary complexes because of the chemic
153 tion, and is favored in blackwater lakes but disfavored in the clearwater habitat of the transplant p
158 ng in response to drug therapy despite being disfavored in the wild-type background, and provide the
162 formation of an R-loop structure that can be disfavored in vitro and in vivo by ribonuclease H1 overe
163 ation trans to H4 at 180 degrees is strongly disfavored, in excellent agreement with the MD results.
164 nt during formate formation is energetically disfavored, in line with the excellent catalyst stabilit
166 ith ligation of NEDD8 shifting equilibria to disfavor inactive CAND1-bound closed architectures, and
167 tant specificity determinant; it selectively disfavors interactions with dicarboxylic substrates and
168 , suggesting a role of the phosphodianion in disfavoring intermediate release and in modulation of th
171 genes controlled by both NRF-1 and NRF-2 and disfavor its membership in the immediate early response
179 otonated throughout the reaction coordinate, disfavoring mechanisms that involve a stable tyrosinate
180 in the absence of cyclopropyl ring opening, disfavoring mechanisms that involve unpaired electron de
181 was first arrested by adding lysolipids that disfavored membrane merger, and the lipids were subseque
182 We hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the cha
183 rategy to prepare for sedentary existence by disfavoring migration away from a substrate on which a b
184 s, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for Drosophila
186 r-frequency carbon-fluorine stretching modes disfavor non-radiative relaxation pathways and boost the
188 uences that significantly delay assembly are disfavored not only because unintegrated OMPs are subjec
190 y regulated genes whose sequences inherently disfavor nucleosome formation within the gene but favor
193 curs at unprecedented densities and directly disfavors nucleosomes, contributing to nucleosome positi
194 These studies identified favored as well as disfavored nucleotides and demonstrated the previously u
196 drochloride indicates that the P25A mutation disfavors oligomerization mediated by intermolecular hem
199 een evolutionarily conserved to specifically disfavor one dimerization state and, as a result, indire
200 hese unfavorable motifs produce interactions disfavoring one outcome to indirectly promote another on
201 tionally constrained amino acids that favor, disfavor, or exclude the gauche (-), the gauche (+), or
205 bstituents energetically favor reduction and disfavor oxidation, and give formal potentials that corr
206 ion that increasing sigma-donation by X also disfavors oxidative addition of N-H bonds to trans-(PH3)
207 es control substrate-cofactor disposition to disfavor oxygen rebound and permit halogen coupling to p
208 chmidt reaction is diverted into a typically disfavored pathway by the presence of an aromatic group
209 ability to direct a chemical reaction down a disfavored pathway, even when a more favorable mechanism
214 In particular, the HOMO of [Co2(DPXM)(O2)]+ disfavors proton transfer to the bound oxygen species, f
216 the mechanistic basis for this energetically disfavored regiostereochemistry has been less clear.
217 hat a conventional inner-sphere mechanism is disfavored relative to an unusual stepwise outer-sphere
218 ate that the complex with weaker affinity is disfavored relative to the complex with higher affinity.
219 es of the constrained ligands were uniformly disfavored relative to their flexible controls, demonstr
222 ethylation rates of CpG sites in favored and disfavored sequence contexts by forming compensatory int
223 than one order of magnitude, with nucleosome-disfavoring sequences resulting in lower noise and more
224 tional structure of nucleosome favouring and disfavoring sequences with respect to their basic buildi
225 titutively active, synthetic with nucleosome-disfavoring sequences, and in the absence of RPD3, a glo
226 tion sigma(DM)/m < 0.47 cm(2)/g (95% CL) and disfavoring some proposed extensions to the standard mod
227 port that carbonic acid, a thermodynamically disfavored species that is challenging to investigate ex
228 or the introduction of steric bulk leads to disfavored steric interactions with the receptor, and/or
229 these neomycin-class antibiotics into a TAR-disfavored structure has no deleterious effect on bindin
231 transcription of both genes is statistically disfavored, suggesting mutually exclusive LCR-gene conta
234 airs, equilibration of the thermodynamically disfavored tautomer was attempted with acids and bases b
235 rade and utilize host-derived substrates and disfavor taxa that prefer complex plant polysaccharides.
242 ]-sigmatropic rearrangement, and a tactic to disfavor the [1,3] pathway and increase the efficiency o
243 y reaction conditions that thermodynamically disfavor the [2,3] rearrangement step and thereby make t
244 ubsites +1 to +5 are oriented such that they disfavor the binding of malto-oligosaccharides that bear
248 valent residue in CD38, Thr-221, is shown to disfavor the cyclizing folding of the substrate, resulti
249 hylether as an H-cluster ligand and strongly disfavor the dithiomethylammonium as a catalytic base fo
251 ural differences in the vicinity of Cys(101) disfavor the facile oxidation of this residue that is fu
253 tion is to promote disordered aggregates and disfavor the formation of ordered nuclei and dissociatio
255 Basic ligands favor the metalation step but disfavor the formation of the catalytically active sigma
256 lters how N-Myc interacts with SCF(FbxW7) to disfavor the generation of Lys48-linked polyubiquitin ch
257 ies for interlayer interactions that instead disfavor the high protein densities of ordered arrangeme
258 x can generate entropic forces that favor or disfavor the projection of spherical and finger-like ext
260 ituted 1,2-diethynylbenzenes, steric effects disfavor the thermal C1-C6 diradical cyclization reactio
263 r interactions in an ABC heterotrimer, while disfavoring the 26 competing oligomers (i.e., AAA, ABB,
264 t that Lys67 may be replaced by an arginine, disfavoring the conjugate base mechanism, distinguishing
267 Mutations appear to enhance misfolding by disfavoring the formation of correct structure rather th
268 n atypical planar conformation, both factors disfavoring the reaction of the reduced flavin with diox
270 linkers, while an N-P motif, which strongly disfavors the attachment of N-glycans, is commonly obser
271 Y promotes a helical ssDNA conformation that disfavors the binding of gp32 and initiates the assembly
273 55 is not essential for turnover but greatly disfavors the mechanistically unproductive binding of l-
274 positive charge at position 15 substantially disfavors the stacked state but retains much of the bind
275 the equilibrium toward the bent states, and disfavors the straight state to the extent that it is no
279 o a conformational change by the enzyme that disfavors this form in its equilibrium with Ala aldimine
283 sence renders RTK to a less potent enzyme by disfavoring transphosphorylation of activation loop tyro
289 ty, simultaneously favors reliable peaks and disfavors unreliable peaks using a weighted ratio betwee
290 that disrupt key intermolecular interactions disfavor vMIA's mitochondrial recruitment of Bax, and in
291 contrast, these radical processes are highly disfavored when generating unstable phenyl and primary a
293 facing transition of apo MsbA is found to be disfavored when the periplasmic gate is open and facilit
294 In these cases, 6- and 7-substitution was disfavored, whereas 8-substitution was largely tolerated
295 pockets, aliphatic hydrophobic residues are disfavored, whereas aromatic side chains are enriched.
296 elation of neutral lipid DOPE by the AuNP is disfavored which inturn promotes stability of vesicle st
299 dinucleotide steps, traditionally thought to disfavor Z-DNA, can be incorporated within heterogeneous