ライフサイエンスコーパス: disinhibit

1 iganded HCN1, which occurs as though already disinhibited.

2 nsistent with the hypothesis that mu-opioids disinhibit 5-HT neurons, an effect attenuated by direct

3 neurons were not hyperactive, despite being disinhibited, (5) optogenetic inhibition of the STN exac

4 In dependent rats, beta receptors disinhibit a subpopulation of CeA neurons, contributing

5 Blockade of gap junctions disinhibited a subpopulation of SDH neurons and reduced

6 mbranes, also unclamps spontaneous fusion by disinhibiting a secondary Ca(2+) sensor.

7 Gi/o and a DA dip leads to a PKA increase by disinhibiting A2aR/Golf, but D2+ MSNs could also respond

8 ntrast, delta-opioid receptor (DOR) agonists disinhibited ACC pyramidal neuron responses to MThal inp

9 e consistent with GABAA receptor antagonists disinhibiting acetylcholine release in the PnO to result

10 ose that hypoactivity in the vmPFC engenders disinhibited activity of the amygdala and, consequently,

11 RECK release disinhibits ADAM (a disintegrin and metalloproteinase) p

12 shown that axon growth through CNS myelin is disinhibited after neurotrophic factor administration by

13 r and anxiety, which in turn, is proposed to disinhibit aggressive behaviors.

14 ducing cells to glucose and dilp2 secretion, disinhibited AKH secretion in corpora cardiaca and cause

15 tory pairs, and of a bacterial effector that disinhibits an E3 ubiquitin ligase.

16 dentate gyrus of the dorsal hippocampus are disinhibited and (2) disinhibition occurs because GABAer

17 of the externalizing superspectrum, and the disinhibited and antagonistic spectra.

18 nglia where behaviors leading to rewards are disinhibited and behaviors leading to no reward are supp

19 interneuron-->L5 pyramidal neuronal circuits disinhibited and ENGC<-->L2/3 interneuron-->L5 pyramidal

20 Networks with reduced GABA were disinhibited and had altered gamma oscillations in respo

21 ersonality change with blunting of affect or disinhibited and inappropriate behaviour; and language d

22 Gsk3alpha is disinhibited, and S536-phosphorylated epsilon subunit of

23 therefore downstream dopamine cells will be disinhibited; and thus, this could potentially result in

24 ized AMPA, NMDA receptors), unperturbed, and disinhibited (antagonized GABA(A) receptors).

25 or in p53-overexpressing transgenic mice can disinhibit antitumor T cell immunity and augment the eff

26 extrasubicular inputs and pharmacologically disinhibited, are sufficient to initiate synchronous epi

27 facial expressions, indicating a difficulty disinhibiting attention towards painful faces.

28 ontributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette

29 n patients with schizophrenia is abnormal or disinhibited automatic spreading activation of semantic

30 synergistically enhanced neuronal survival, disinhibited axon growth and promoted axon regeneration

31 variant frontotemporal dementia (85%), with disinhibited behavior as the prominent feature.

32 mit a nonspecific genetic risk for offspring disinhibited behavior, including tobacco use.

33 specific genetic risk to their offspring for disinhibited behavior.

34 ay prime instrumental behavior with DA while disinhibiting behavior by lowering ACh.

35 of alpha-synuclein and worsens mortality and disinhibited behaviors in tauopathy mice.

36 enic mice had aging-dependent repetitive and disinhibited behaviors, with synaptic deficits selective

37 Disinhibited behaviour, a risk factor for overconsumptio

38 anism by which the agonists histamine or ATP disinhibit BKA channel activity.

39 Overall, DA disinhibits BLA, at least in part, by suppressing GABA r

40 or coupling to only one G protein at a time, disinhibiting both intracellular domains elicits a great

41 this mechanism, top-down inhibitory neurons disinhibit bottom-up cortical circuits, a prominent circ

42 events and mirror their pattern of spread in disinhibited brain slices over millimeters.

43 hat tVTA GABA neurons lose their capacity to disinhibit, but not to inhibit, VTA DA cells after chron

44 ions of POMC cells activated by 5-HT2CRs and disinhibited by 5-HT1BRs.

45 c13s, in which the basal state of Munc13s is disinhibited by C1 domain activation into a state of fac

46 The PVN was disinhibited by microinjecting a GABA(A) receptor antago

47 Second, SSTs are generally disinhibited by reduced PV activity regardless of thalam

48 Spontaneous release was disinhibited by region I mutation and found to correlate

49 Spontaneous release was disinhibited by region I mutations and found to correlat

50 time, that "presympathetic" PVN neurons are disinhibited by the neuropeptide substance P (SP) acting

51 PKA phosphorylation of Rad, which disinhibits Ca(v)1.3 channels and cAMP-dependent activat

52 EC(GABA) suppresses this local inhibition to disinhibit CA3 activity with compartment and pathway spe

53 cular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastat

54 RPP-32 neurons in IM by high dopamine levels disinhibits CeM and triggers autonomic arousal.

55 The Purkinje cell firing decrease disinhibits cerebellar nuclear cells, which then produce

56 es axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth.

57 atment reduces miR-383-5p levels, which then disinhibits CNTF receptor components to sensitize neuron

58 ted HCO3- efflux, alkalinizing the cleft and disinhibiting cone CaV channels.

59 iception is associated with more excitatory (disinhibited) connections, whereas placebo responses cor

60 ve intestinal polypeptide (VIP) are known to disinhibit cortical neurons.

61 tinal peptide-expressing interneurons (VIPs) disinhibit cortical pyramidal cells through inhibition o

62 doubles maximal synthase activity, partially disinhibits cytochrome c reductase activity, and lowers

63 the capacity of the tVTA to inhibit, but not disinhibit, DA cells after chronic opiate exposure may c

64 s) suppress lateral inhibition from iMSNs to disinhibit dMSNs, which are known to facilitate locomoti

65 A neurons within the ventral tegmental area, disinhibiting dopamine neurons and causing a rapid rise

66 behavioural plasticity, at least in part by disinhibiting dopamine neurons in the ventral tegmental

67 receptors (CB1Rs) on GABAergic neurons that disinhibit dopaminergic neurons in the ventral tegmental

68 ts GABA neurons, inhibiting them and thereby disinhibiting dopaminergic activity and release.

69 referentially by BOS, suggesting that area X disinhibits dopaminergic neurons by inhibiting VP.

70 receptors (CB(1)Rs) the activation of which disinhibits dopaminergic neurons in the ventral tegmenta

71 We propose that disinhibiting dormant dopaminergic neurons by blocking e

72 eworks support the proposition that ATD thus disinhibits dorsal raphe-originating serotonergic contro

73 stantia nigra can simultaneously inhibit and disinhibit downstream structures, while the dopaminergic

74 nhibits striatopallidal function measured as disinhibited downstream activity in the globus pallidus.

75 tion could be driving avoidance responses by disinhibiting downstream areas.

76 reases SCN neuronal activity, which we posit disinhibits downstream orexigenic responses.

77 ther granule cells in epileptic gerbils were disinhibited during the interictal period, IPSPs were re

78 neurons are activated by non-sensory inputs, disinhibiting E and FS neurons.

79 a and PAG in juveniles, we pharmacologically disinhibited each of the two subdivisions of the mPFC an

80 Disinhibited eaters were characterised by a reduced HRV

81 BG was related to hunger but only in low disinhibited eaters.

82 y the interactive effects of restrained and disinhibited eating and self-reported dieting to lose we

83 explored for the first time the influence of disinhibited eating and vagal tone (heart rate variabili

84 A behavioral index of disinhibited eating in children was used to measure chil

85 Although disinhibited eating is positively associated with higher

86 findings highlight novel mechanisms by which disinhibited eating leads to obesity and insulin resista

87 eating and dieting moderate the influence of disinhibited eating on weight change.

88 ting questionnaire (TFEQ) was used to assess disinhibited eating.

89 egree of the participants' tendencies toward disinhibited eating.

90 This could occur because CFTR loss can disinhibit ENaC, and ENaC activity can drive absorption.

91 inhibits cerebellar cortical cells, thereby disinhibiting exafferent responses in IP.

92 ervates calretinin inhibitory neurons, which disinhibit excitatory neurons.

93 irectly regulate the mesolimbic DA system by disinhibiting excitatory hypothalamic neurons.

94 evidence on the validity and utility of the disinhibited externalizing and antagonistic externalizin

95 Mechanistically, loss of SMAD4 disinhibits flow-mediated KLF4-TIE2-PI3K/Akt signaling,

96 By using mice harboring a disinhibited form of the IL-4 receptor, we developed an

97 ecifically reducing Galpha(s) signaling also disinhibited FSHbeta expression, suggesting the presence

98 ited GABA release, whereas blocking the MORs disinhibited GABA release.

99 neurons and in the adult mouse brain in vivo disinhibited glycogen synthase kinase 3beta (GSK3beta) b

100 -expressing interneurons, which are known to disinhibit hippocampal microcircuits.

101 Estrogen transiently disinhibits hippocampal CA1 pyramidal cells in adult fem

102 dea that the dominant M1 has the capacity to disinhibit homologous representations in the contralater

103 f spatial memory and that hippocampal damage disinhibits hypothalamic-pituitary-adrenocortical (HPA)-

104 Propranolol-treated pigs exhibited a disinhibited immune response to systemic infection, clea

105 induced by paralimbic processes involved in disinhibiting impulsive motor responses to rewarding or

106 n of the DMS iMSNs activity, suggesting that disinhibiting iMSNs decreases reward-seeking behaviors.

107 ore, beta-catenin-dependent signaling may be disinhibited in Fzd6(-) (/) (-) HSPCs.

108 r indicate that the cAMP/PKA pathway becomes disinhibited in the prefrontal cortex with advancing age

109 Whether the PFC becomes disinhibited in this model and alters decision making re

110 involving the basal ganglia and thalamus are disinhibited in Tourette syndrome patients.

111 eroids, these findings suggest that S1 might disinhibit innate immune processes in brain by reducing

112 disinhibition in neuronal circuits and how a disinhibited interaction between NMDA-receptor-mediated

113 's disease patients with greater chorea were disinhibited is consistent with the theory that chorea a

114 the OMV, whereas bicuculline, an antagonist, disinhibited it.

115 w that PD-associated LRRK2 mutations display disinhibited kinase activity and induce a progressive re

116 d that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and cont

117 dial medulla (RVM), the suppression of which disinhibits LC neurons to drive spinal noradrenergic ant

118 sm by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal

119 ation of LH neurons and is not the result of disinhibiting LH cells by disrupting transmission at GAB

120 during salient sensory stimulation, L-ITCcs disinhibit local and distant principal neurons, acting a

121 parvalbumin (PV)-expressing interneurons and disinhibit local excitatory neurons.

122 may acutely suppress dopamine release while disinhibiting local glutamatergic signaling to restore d

123 arvalbumin-expressing interneurons (PV-INs), disinhibiting local microcircuits.

124 s initially to reduce activity in the NTS to disinhibit mechanisms that suppress daytime feeding.

125 Inhibition of these GABA interneurons disinhibits medial SN and VTA dopamine neurons, producin

126 Therefore, rTMS of the experimentally disinhibited motor cortex induces within-representation

127 y sub-networks, providing a basis for Dyn to disinhibit mPFC circuits.

128 neurons by MRN injections of 8-OH-DPAT would disinhibit MS/DB neurons, allowing them to burst rhythmi

129 This switch disinhibited muscle fatty acid oxidation and drove Cori

130 This suggests that disinhibited NALCN may cause the puzzling phenomenon of

131 abeled with calretinin, which are thought to disinhibit neighboring excitatory neurons, suggesting fa

132 e, optogenetic silencing of DRN GABA neurons disinhibited neighboring 5-HT neurons and prevented the

133 Using the partially disinhibited neocortical slice preparation, activity is

134 prolonged and recurrent neuronal bursting in disinhibited networks.

135 HN by suppressing GABAergic transmission and disinhibiting neural circuits within the neurogenic nich

136 lt primary DRG and retinal cultures promoted disinhibited neurite growth when cells were stimulated w

137 owth factor receptor activation and promotes disinhibited neurite outgrowth.

138 t neuronal bursting that were simulated in a disinhibited neuronal network.

139 previously unidentified mechanism that could disinhibit neurons transmitting nociceptive information

140 cleaves the ECD from both NgR and TROY, and disinhibits neurotrophic factor (NTF) stimulated RGC neu

141 Furthermore, PL-core and IL-shell inhibition disinhibited nonreinforced but not reinforced cue respon

142 ockdown of p75NTR also inactivates Rho-A and disinhibits NTF-stimulated RGC neurite outgrowth in cult

143 ns, thus downregulating their activities and disinhibiting nucleus accumbens (NAc) projecting DA neur

144 se in intracellular Ca(2+) mobilization than disinhibiting only one, suggesting a positive functional

145 ndothelial inactivation, which can either be disinhibited or amplified, depending on the stimulus.

146 ctrum, with some correlates more specific to disinhibited or antagonistic spectra, and others relevan

147 tex (OFC) in humans has been associated with disinhibited or socially inappropriate behaviour and emo

148 In that view, the lesions 'disinhibit' or 'release' the laughter and crying centre.

149 d been classified as behaviorally inhibited, disinhibited, or neither in laboratory assessments.

150 intestinal peptide (VIP) interneurons, which disinhibit other interneurons.

151 nputs to pC1 neurons and oviINs, sex peptide disinhibits oviDNs to enable egg laying after mating.

152 inobutyric acidergic (GABAergic)] neurons to disinhibit PAG output rather than directly on medullary-

153 Inhibition of GABA release from CCK neurons disinhibits parvalbumin (PV) interneurons and, as a cons

154 rically coupled, primarily inhibit MLI1s and disinhibit PCs, and are well suited to gating cerebellar

155 In RBD, degeneration of this circuitry disinhibits phasic motor commands originating from motor

156 s of opioid receptor activation would likely disinhibit POMC neuron activity and higher concentration

157 mulus signal to drive avoidance responses by disinhibiting PPT neurons.

158 n during periadolescence elicits an enduring disinhibited prefrontal local field potential (LFP) resp

159 uron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs,

160 nic or stress-induced activity which in turn disinhibits prepotent motivated behaviors.

161 velopment rather than the manifestation of a disinhibited primitive brain.

162 ral amygdala (BLA) promotes fear learning by disinhibiting principal neurons (PNs) and enabling synap

163 d in endocannabinoid mobilization, which can disinhibit PrL-PFC projection neurons, we investigated w

164 ibute to negative and cognitive symptoms and disinhibits projections to mesostriatal regions to contr

165 may indicate genetic risk for a dimension of disinhibiting psychiatric disorders, including childhood

166 r VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons.

167 , lower OLM activity reduced theta power and disinhibited pyramidal cells, resulting in increased bas

168 Alcohol binge drinking disinhibited pyramidal neurons by augmenting SST neurons

169 gamma-aminobutyric acid (GABA) interneurons disinhibiting pyramidal cells may be relevant to this hy

170 teraction 5-HT is released into the vCA1 and disinhibits pyramidal neurons through 5-HT1(B) receptors

171 pha-synuclein abnormalities in the brainstem disinhibit rapid eye movement sleep motor activity, lead

172 gh which POMC neurons could be inhibited, or disinhibited, rapidly in response to food availability.

173 cal and biochemical evidence that in acutely disinhibited rat neocortical slices, robust release of g

174 ity between the two substitutions completely disinhibits reductase activity and further reduces the E

175 1cells release glycine at those synapses and disinhibit responses of OFF mRGCs.

176 Neurotrophins released by AG1478 stimulated disinhibited retinal ganglion cell axon growth in centra

177 ow release of CRH during familiar encounters disinhibits rLS neurons, thereby suppressing social inte

178 activity in a mouse model of Dravet syndrome disinhibited RTN chemoreceptors and destabilized breathi

179 Thus, dopaminergic neurons can be disinhibited selectively by complex sensory stimuli via

180 as gambling, compulsive eating, shopping, or disinhibited sexual behaviours, which can have a severe

181 promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity.

182 ork modeling predicted, and experiments with disinhibited slices confirmed, that stimuli targeting up

183 iven trial, triggered network-wide bursts in disinhibited slices had remarkably similar time courses

184 ormal LTP was induced in picrotoxin-treated, disinhibited slices.

185 ompletely inhibited LTP in both standard and disinhibited slices.

186 ols of symptoms of autism spectrum disorder, disinhibited social engagement, and inattention and over

187 trum disorder, inattention and overactivity, disinhibited social engagement, conduct or emotional pro

188 ole of Htr2c expressed by LPBN neurons is to disinhibit sodium appetite.

189 on in the LS, which failure in Magel2KO mice disinhibited somatostatin (SST) neurons and disrupted so

190 and subcortical inputs and then inhibits or disinhibits specific thalamic relay cells, so that appro

191 To disinhibit SST(+) interneurons, we inactivated the gamma

192 Therefore, the auditory cortex was in a disinhibited state during propofol-mediated LOC.

193 inducing a transition from an inhibited to a disinhibited state.

194 Moreover, inhibited and disinhibited states are characterized by low- and high-f

195 s activity is upregulated, (3) despite being disinhibited, STN neurons are not hyperactive, and (4) S

196 nected with stress dysregulation, serving to disinhibit stress responses and allow for glucocorticoid

197 ular excitatory afferents, pharmacologically disinhibited subicular slices generated hyper-synchronou

198 h higher guanfacine doses also appeared less disinhibited, suggesting enhanced ventromedial-orbital P

199 d the speed of snake recognition and clearly disinhibited sympathetic arousal as manifested by increa

200 major spinal sympathetic outflow (T6 level) disinhibits sympathetic neurons from supraspinal control

201 PP2 resulted in the significant reduction of disinhibited synaptic currents to healthy control levels

202 rons in response to proteasome inhibition or disinhibiting synaptic activity with bicuculline.

203 ly by inhibiting non-target lexical items or disinhibiting target ones.

204 suggest that sensorimotor beta-band rhythms disinhibit task-relevant populations, whereas alpha-band

205 y, extending the memory trace by transiently disinhibiting taste cortical activity dramatically exten

206 f LRP1 in vascular SMC (smLRP1(-/-)) in mice disinhibited TGFbeta1-CTGF (connective tissue growth fac

207 hypothesis that NMDA-R blockade in RtN would disinhibit thalamocortical networks.

208 other, thus allowing the indirect pathway to disinhibit the contralateral lSC and trigger licking.

209 mechanism through which ethanol may globally disinhibit the DLS.

210 tion reduced Purkinje cell firing, which may disinhibit the output activity of the deep cerebellar nu

211 pharmacology was used to locally inhibit or disinhibit the PH immediately before behavioral measures

212 ons during reward such that they selectively disinhibit the pyramidal layer henceforth.

213 y be a compensatory mechanism that serves to disinhibit the reduced sensory input.

214 asts over the grating patch in an attempt to disinhibit the response.

215 the superior colliculus (SC), but they also disinhibit the saccadic system by removing the potent in

216 inhibition of the SNpr/GPi should, in turn, disinhibit the thalamus to facilitate movement.

217 at release of histamine from TMN neurons can disinhibit the TMN and suppresses the activity of sleep-

218 strated that cholinergic inhibition of NGFCs disinhibited the apical dendrites of layer 2/3 pyramidal

219 reduced basal activity of RyanR2-EQ channels disinhibited the autophagic pathway and led to increased

220 s create psychotomimetic states by similarly disinhibiting the activity of PFC pyramidal neurons.

221 nover contributes to thermal hyperalgesia by disinhibiting the channel.

222 nist could have antidepressant properties by disinhibiting the firing of these neurons, resulting in

223 onstrated its potential to control cancer by disinhibiting the immune system.

224 e neurons, which inhibit CeL output, thereby disinhibiting the medial subdivision of CeA and releasin

225 d the disinhibition hypothesis by reversibly disinhibiting the SC ipsilateral to a visual cortical le

226 xtracellular K(+) from 3.0 to 8.5 mM and (2) disinhibiting the slice using 3 mM pentylenetetrazol or

227 cular CRH inhibits the septum, which in turn disinhibits the amygdala, resulting in a constellation o

228 Ca(2+)/calmodulin (CaM) binding disinhibits the autoregulatory domain, allowing autophos

229 horizontal cell hyperpolarization with NBQX disinhibits the Ca(2+) signals produced by pH-sensitive

230 Across species, alcohol exposure disinhibits the DLS by dampening GABAergic transmission

231 basal activity of type 2 ryanodine receptors disinhibits the neuronal autophagic pathway and leads to

232 g; P < 0.05), suggesting that Y2R antagonism disinhibits the NPY neuron thus stimulating feeding in o

233 knockdown of GluClalpha in principal neurons disinhibits the odor responses of these neurons.

234 corpus callosum of postnatal day (P)1-6 rats disinhibits the production of spindle bursts (SBs) withi

235 damage to the crossed nigrotectal projection disinhibits the superior colliculus ipsilateral to the c

236 tion neurons selectively in patches, thereby disinhibiting their firing in response to cortical input

237 2+) reduces photoreceptor Ca(2+) signals, it disinhibits them at 10 mum, an effect reminiscent of ear

238 oderately diminished during normal stress to disinhibit these loci.

239 lic nucleotide-gated (HCN) channels but also disinhibited these neurons by acting on presynaptic 5-HT

240 y to resting levels of CSNA and HR, but when disinhibited, they can produce large increases in CSNA a

241 differentiate between disorganized thinking, disinhibited thought expression and deliberate creativit

242 omelanocortin (POMC) neurons, which are also disinhibited through a 5-HT1BR-mediated suppression of l

243 cessary for accurate splicing, without which disinhibited TNF signaling triggers hematopoietic cell d

244 stcrossing, the ROBO1 and ROBO2 isoforms are disinhibited to prevent midline reentry and to guide pos

245 n the usual care group and more signs of the disinhibited type in both groups.

246 ly to placement in foster care; signs of the disinhibited type showed less robust resolution with fos

247 Signs of the disinhibited type were highest in the usual care group,

248 inhibited type) and indiscriminately social (disinhibited type) reactive attachment disorder in Roman

249 nths) was associated with fewer signs of the disinhibited type.

250 fusion activity, and overexpression of this disinhibited version caused ER collapse.

251 c to VTA inhibit local GABA release, thereby disinhibiting VTA neurons.

252 ed, activation of mu opioid receptors (MORs) disinhibits VTA dopaminergic neurons projecting to the n

253 This in turn disinhibits warm-PNs and sums with feed-forward excitati

254 by constitutive association with p85, and is disinhibited when the SH2 domains of p85 bind to tyrosyl

255 demonstrate a range of ways that Ndfips can disinhibit WWP2.