ライフサイエンスコーパス: disinhibition

1 aired function of spinal inhibitory neurons (disinhibition).

2 efrontal synaptic activity toward a state of disinhibition.

3 ains from psychotic patients, and suggesting disinhibition.

4 excite these pyramidal neurons via parallel disinhibition.

5 ariants within 3q26 in neural and behavioral disinhibition.

6 ce, respectively, through GABAergic synaptic disinhibition.

7 ggressive cancer cell behavior through Notch disinhibition.

8 increasing reasoning difficulty, apathy, and disinhibition.

9 avoidance behaviour, consistent with orexin disinhibition.

10 vasoactive intestinal peptide (VIP)-mediated disinhibition.

11 tential long-term toxicities, and behavioral disinhibition.

12 tion of endocannabinoid-mediated peritetanic disinhibition.

13 ed Na(v) 1.1 function in interneurons causes disinhibition.

14 neralized epilepsy exhibit cerebral cortical disinhibition.

15 tic risk reflecting aggressive-disregard and disinhibition.

16 stic computational modeling, namely cortical disinhibition.

17 correlated factors: aggressive-disregard and disinhibition.

18 e context for a novelty-induced reduction of disinhibition.

19 ing background inhibition to provide greater disinhibition.

20 ting of reward, another on motor or response disinhibition.

21 ral abnormalities, such as hyperactivity and disinhibition.

22 ither subregion induced a general behavioral disinhibition.

23 ibres through neural circuitry that includes disinhibition.

24 dditional excitation mediated by glycinergic disinhibition.

25 ression of synaptic inhibition and on-demand disinhibition.

26 that is independent of glutamatergic network disinhibition.

27 evalent, problem behaviours characterised by disinhibition.

28 factors, semantic impairment and behavioural disinhibition.

29 otor cortex (M1), which results from overall disinhibition.

30 ntry during T cell activation through Ca(2+) disinhibition.

31 ain, increasing dopamine neuron activity via disinhibition.

32 eates a mechanism whereby cAMP mediates PP2A disinhibition.

33 sociative memories can occur through focused disinhibition.

34 idal cell assemblies at the theta trough via disinhibition.

35 tent with increased neuronal activity due to disinhibition.

36 ns may be the cause of supraspinal GABAergic disinhibition.

37 0.0003), apathy (40% versus 4%, P < 0.0001), disinhibition (16% versus 2%, P = 0.009), irritability (

38 mong symptomatic patients were apathy (23%), disinhibition (18%), memory impairments (12%), decreased

39 nds had high rates of symmetry (49%) but not disinhibition (5%).

40 ing crucial player in this implementation is disinhibition--a transient break in the balance of excit

41 tical disinhibition, but not thalamocortical disinhibition, accompanied this OD plasticity.

42 cussions including novelty seeking, response disinhibition, aggression, and substance abuse.

43 ve, language and visuospatial function, less disinhibition, agitation/aggression and night-time behav

44 on subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagem

45 Although the D2R-mediated disinhibition alone is sufficient to gate t-LTP at a nor

46 role in ocular dominance plasticity, causing disinhibition among open-eye-biased principal neurons, w

47 Disinhibition and activation of C-Raf by depolarization-

48 Stronger evidence exists for treating disinhibition and antagonism than negative affectivity,

49 ble across years, as have sex differences in Disinhibition and Boredom Susceptibility.

50 te two features of neural plasticity-somatic disinhibition and compartmentalized dendritic spiking.

51 ctively, these results demonstrate dendritic disinhibition and elevated calcium levels in dendritic s

52 ulation-specific local excitation, GABAergic disinhibition and excitation through electrical coupling

53 We propose that L4 restricts disinhibition and gates OD plasticity independent of a c

54 atients who had lower levels of 6-mo and 1-y disinhibition and hunger (beta = 0.13-0.29, P < 0.01 in

55 ore weight and reported greater decreases in disinhibition and hunger at 1- and 10-y follow-ups (all

56 ginal monograph in 1872 provided evidence of disinhibition and impaired social cognition.

57 eads to reduced release of GABA, followed by disinhibition and increased release of glutamate from ro

58 rons reliably patterned STN activity through disinhibition and inhibition, respectively.

59 edictive, particularly scores for behavioral disinhibition and major depressive disorder.

60 tion potential initiation causes multisystem disinhibition and network hyperexcitability, which can w

61 esynaptic CB1Rs, leading to VTA dopaminergic disinhibition and reinstatement of cocaine CPP.

62 or the apparently paradoxical combination of disinhibition and severe akinesia.

63 brake that is lost following KCC2-dependent disinhibition and that the decrease in STEP61 activity d

64 nic variants for association with behavioral disinhibition and the use/misuse of nicotine, alcohol, a

65 is known about interneurons specializing in disinhibition and their in vivo function.

66 d alpha6(R46W) mutation could cause neuronal disinhibition and thus increase susceptibility to genera

67 aracterized by heightened risk of behavioral disinhibition and violence.

68 al basis for the association between dietary disinhibition and weight gain.

69 gamma power is increased with pyramidal cell disinhibition and with remission from MDD.

70 y expenditure coupled with higher hunger and disinhibition and/or delayed satiation compared with nev

71 pecially poor impulse control and behavioral disinhibition), and movement (including parkinsonism and

72 luding trait impulsiveness and compulsivity, disinhibition, and also impatience; and (ii) participant

73 posttreatment levels of cognitive restraint, disinhibition, and hunger and 1-y changes in these eatin

74 of study participants, showed that euphoria, disinhibition, and nighttime behaviors were significant

75 APP overexpression, including hyperactivity, disinhibition, and spatial learning and memory deficits.

76 treating specific DSM-5 BPD traits, notably disinhibition, antagonism, and some aspects of negative

77 y impairment and behavioural changes such as disinhibition, apathy, compulsiveness and loss of empath

78 e of six clinically discriminating features (disinhibition, apathy/inertia, loss of sympathy/empathy,

79 ics associated with excessive inhibition and disinhibition are observed in patients with eating disor

80 of orexin-A neurons, and their CB1-mediated disinhibition, are a consequence of leptin signaling imp

81 d to greater postoperative impulsiveness and disinhibition as assessed by the neuropsychiatric instru

82 increasing tic symptom severity and motoric disinhibition as demonstrated by a finger tapping test.

83 avioral variant frontotemporal dementia with disinhibition as the prominent feature, with or without

84 DA neuron excitation was likely mediated by disinhibition because local antagonism of gamma-aminobut

85 Therefore, prefrontal hypoactivation and disinhibition both cause attentional deficits.

86 ate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumo

87 Intracortical disinhibition, but not thalamocortical disinhibition, ac

88 As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic

89 Subsequent cortical disinhibition by reduced PV cell activity allows for exc

90 The branch-specific disinhibition can be achieved despite dense interneurona

91 e sensory representations of trauma, sensory disinhibition can constitute a sensory mechanism of intr

92 Apart from attentional deficits, prefrontal disinhibition caused additional neurobehavioral changes

93 TP in mature ACx can be unmasked by cortical disinhibition combined with activation of cholinergic in

94 an outward current from inhibitory synapses (disinhibition) combined with an increase in an inward cu

95 Remarkably, this prefrontal disinhibition could be normalized following a single acu

96 Such disinhibition could lead to the selective amplification

97 ositive feedback, such as activity-dependent disinhibition, could provide these uncommon timing featu

98 assessed in an open field with a measure of disinhibition defined as a greater increase in explorati

99 We named this disinhibition-dementia-parkinsonism-amyotrophy complex.

100 However, the mechanisms underlying this disinhibition diverge significantly as epilepsy progress

101 algorithmic flexibility of this motif beyond disinhibition due to the mutual influence between networ

102 s report that thalamic activation occurs via disinhibition during pauses in the firing of inhibitory

103 t a link between glutamate-mediated cortical disinhibition, effective-connectivity deficits, and comp

104 s permanently) and are instead driven by the disinhibition exhibited in the selfie (studies 4-7).

105 ne levels of anxiety/depression, inattention/disinhibition, externalizing, subsyndromal manic, and af

106 tional status, whereas scores on the genetic disinhibition factor score were more strongly associated

107 pes were high and statistically significant (disinhibition factor=0.35, SE=0.03; symmetry factor=0.39

108 f a cued appetitive task and that behavioral disinhibition following vmPFC inactivation depends on do

109 ty pauses, which allow a transient window of disinhibition for medium spiny neurons.

110 bipolar cells and is mediated by presynaptic disinhibition from a wide-field mechanism extending >0.5

111 thic pain, BDNF-mediated loss of inhibition (disinhibition) gates the potentiation of excitatory GluN

112 rcuitry: intrinsic sensory hyperactivity and disinhibition give rise to frontal overload and disrupt

113 od valuation signal that was compared across disinhibition group and satiety state.

114 itual diet, those with the highest levels of disinhibition had higher BG levels after thirty minutes

115 y balance by decreasing inhibition, and thus disinhibition has emerged as a major mechanism by which

116 artate (NMDA) receptors, and pharmacological disinhibition have demonstrated that impairment of the f

117 ted states between persons with high dietary disinhibition (HD) and low dietary disinhibition (LD).

118 ACC) excitotoxic lesions and pharmacological disinhibition; however, a causal relationship has not be

119 re-derived perceptions of dietary restraint, disinhibition, hunger, and control of eating.

120 In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartat

121 eral homotopic cortex hinders recovery (the 'disinhibition' hypothesis).

122 ontext for a novelty-induced facilitation of disinhibition (i.e., a greater increase in exploratory a

123 pread behavioural change, with more frequent disinhibition, impulsivity, loss of empathy and repetiti

124 ld a state of frequency-dependent prefrontal disinhibition in adulthood comparable to that seen in th

125 investigated the neural basis of behavioural disinhibition in behavioural variant frontotemporal deme

126 nmodulation plays a key role in pathological disinhibition in conditions such as ischemia and epileps

127 to spatial navigation are causally linked to disinhibition in different compartments of projection ne

128 ve the field forward by revealing attenuated disinhibition in prefrontal motor areas during movement-

129 t-evoked pain was associated with attenuated disinhibition in prefrontal motor areas, as evidenced by

130 e receptor function in second-order neurons, disinhibition in the dorsal horn and glia cell activatio

131 t, as evidenced by reduced hyperactivity and disinhibition in the P301S mice.

132 sclosure risks (i.e., people exhibit greater disinhibition in their selfies, studies 1 and 2).

133 balances in SynCAM 1 KO mice resulted in CA3 disinhibition, in agreement with reduced feedforward inh

134 e dependent on the suppression of sIPSCs, or disinhibition, in that blockade of inhibitory synaptic t

135 d be predicted to be produced by hippocampal disinhibition, including increased ventral tegmental are

136 Accordingly, the pattern of prefrontal LFP disinhibition induced by periadolescent MK-801 treatment

137 c input following MD in adult mice, and this disinhibition induces a "lower PV network configuration"

138 Dietary disinhibition is a behavioral trait associated with weig

139 Disinhibition is a cardinal feature of the behavioural v

140 Behavioural disinhibition is a common feature of the syndromes assoc

141 g from milliseconds to days, suggesting that disinhibition is a conserved circuit mechanism contribut

142 and modeling approach suggests that cortical disinhibition is a fundamental pathological modification

143 f layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.

144 Thus, disinhibition is a rapid homeostatic plasticity mechanis

145 ning photostimulation to investigate whether disinhibition is confined to the critical period by ngr1

146 Here, we show that KCC2-dependent disinhibition is coupled to increased GluN2B-mediated sy

147 Disinhibition is due primarily to chloride dysregulation

148 tational modeling further showed that VIP(+) disinhibition is necessary for goal-directed learning an

149 The low [Co(2+)] disinhibition is pH sensitive.

150 Disinhibition is related to right ATL and orbitofrontal

151 Furthermore, this mGlu7-mediated disinhibition is required for induction of LTP at the SC

152 We show that although somatic disinhibition is sufficient to form place fields, dendri

153 ircuit functions, such as gain modulation or disinhibition, is starting to reveal canonical circuit m

154 re the ganglion cell fires, generating timed disinhibition just before the ganglion cell spikes.

155 h dietary disinhibition (HD) and low dietary disinhibition (LD).

156 Striatal disinhibition leads to the formation of motor tics resem

157 ivity and network interactions following the disinhibition, maintaining the normal encoding of behavi

158 o have increased genetic risk for behavioral disinhibition, major depressive disorder, depressive sym

159 These negative functional consequences of disinhibition may include reduced working memory-related

160 ndicate the relevance of both inhibition and disinhibition mechanisms for precise spatiotemporal coor

161 including serotonergic strategies to improve disinhibition.media-1vid110.1093/brain/awv133_video_abst

162 is study defines a novel mechanism of spinal disinhibition mediated by a TNFalpha-TNFR1-p38 pathway w

163 R antagonist, ketamine on NMDAR function and disinhibition-mediated glutamate release.

164 of opiates, and also challenge the canonical disinhibition model of opiate reward.

165 s during visual stimulation, challenging the disinhibition model.

166 quency tuning should render pup odor-induced disinhibition more effective for high-frequency stimuli,

167 resulting from an increase in excitation and disinhibition occurring in two respective types of senso

168 However, it is unclear how disinhibition, occurring at the single-cell level, inter

169 orientation-selective excitation in part by disinhibition of a tonic NMDA receptor-mediated input ar

170 mine and cAMP-regulated signaling leading to disinhibition of ARPP-16 and increased PP2A action.

171 We also observe concomitant disinhibition of auditory responses in deep-layer pyrami

172 bition by valueless objects, which generated disinhibition of cdlSNr neurons and inhibition of superi

173 or elsewhere) to CeL, ultimately leading to disinhibition of CeM neurons.

174 sult from long-term depression (LTD)-related disinhibition of cholinergic neurons in the vestibular n

175 kappaB), sequesters GR expression leading to disinhibition of CRF.

176 eurons in the VTA that subsequently leads to disinhibition of DA neurons.

177 Disinhibition of different functional territories leads

178 subtypes, ultimately resulting in a powerful disinhibition of direct pathway MSNs.

179 ency range to a higher frequency, suggesting disinhibition of DMN activity.

180 tion of midbrain GABA neurons and consequent disinhibition of dopamine (DA) neurons in the ventral te

181 been thought to be mediated by GABA-induced disinhibition of dopamine (DA) neurons in the VTA.

182 n learning, including enhanced excitation or disinhibition of dopamine neuron activity, blockade of d

183 parahippocampal gyrus, possibly related to a disinhibition of dopamine neurons.

184 use disorder, the end result of which may be disinhibition of downstream "effector" regions that regu

185 pid reduction of PV interneuron activity and disinhibition of excitatory neurons, which are known hal

186 ous reduction in PV interneuron activity and disinhibition of excitatory neurons.

187 ch may reflect either reduced anxiety and/or disinhibition of exploratory-like behavior.

188 Activation of the circuit occurs via disinhibition of GABAergic inputs onto vlPAG output neur

189 o elicit antidepressant-like behavior, using disinhibition of GABAergic interneurons.

190 tivity due, at least in part, to glycinergic disinhibition of GAD67 cells.

191 urons are a major contributor to the central disinhibition of gamma-aminobutyric acid type A receptor

192 MDAR activity on inhibitory neurons leads to disinhibition of glutamate neurons increasing synaptic a

193 acting combinations supports the therapeutic disinhibition of individuals with strongly interacting K

194 Here we show that tonic disinhibition of left motor cortex during prism adaptati

195 dissociation of PRC2 from LINC00313 and the disinhibition of LINC00313-induced repression of cell mo

196 actions of SRIF may serve to counteract the disinhibition of M1 ipRGCs caused by SRIF inhibition of

197 ial circuit basis for SST interneuron-evoked disinhibition of medial prefrontal cortex output neurons

198 These findings raise the possibility that disinhibition of mesolimbic dopamine pathways contribute

199 albumin (PV) neuronal dysfunction leading to disinhibition of mesostriatal dopamine neurons.

200 on of the mTOR antagonist rapamycin leads to disinhibition of neuronal networks as measured on microe

201 in the beta-band is directly related to the disinhibition of neuronal populations involved in the co

202 elies on two mechanisms (MST-MT feedback and disinhibition of opponent motion signals in MT) to expla

203 ocesses contributing to chronic pain, spinal disinhibition of pain signaling to higher cortical cente

204 PS is a result of central sensitization with disinhibition of pain signals rather than increased peri

205 fTgDyrk1Amice, which suggests that selective disinhibition of parvalbumin interneurons would result i

206 We identify disinhibition of phosphatase and tensin homolog deleted

207 3 during memory discrimination via transient disinhibition of principal cells.SIGNIFICANCE STATEMENT

208 demonstrate that salient events often elicit disinhibition of projection neurons that favors excitati

209 wo interneuron populations and the resulting disinhibition of pyramidal cells.

210 through inhibitory neurons, resulting in the disinhibition of pyramidal neurons.

211 ly a decrease in Slow Wave Sleep, but also a disinhibition of REM (rapid eye movement) sleep, demonst

212 lly mediated increase of HR and BGL suggests disinhibition of sympathetic outflow as a possible mecha

213 thesis that the beta-band rhythm governs the disinhibition of task-relevant neuronal populations, whe

214 reover, ketamine could produce inhibition or disinhibition of the 40 Hz response in a temporally dyna

215 Our results suggest that disinhibition of the Akt-signalling pathway may provide

216 This effect did not result from disinhibition of the APC/C.

217 ling within the inferior olive or reduce the disinhibition of the cerebellar cortex on the deep cereb

218 ctility was due to hyperexcitability and not disinhibition of the circuitry.

219 statin-positive (SST+) neurons suggests that disinhibition of the cortex via VIP+ cells, which inhibi

220 t from the nucleus tractus solitarius and/or disinhibition of the CVLM unmasked tonic glycinergic inh

221 Whereas pharmacological disinhibition of the ECN unmasked wake-related reafferen

222 gonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mi

223 of early visual processing, likely due to a disinhibition of the homotopic left posterior parietal c

224 egulation of hypothalamic levels of BDNF and disinhibition of the HPA axis.

225 r, it has been proposed that it is linked to disinhibition of the human mirror-neuron system [1-4] an

226 Importantly, the compound does not lead to disinhibition of the hypothalamus-pituitary-adrenal axis

227 d by DA D2 agonists and thus seem related to disinhibition of the indirect striatal pathway.

228 t of GABAergic activity in RAIC promotes the disinhibition of the locus ceruleus, which in turn inhib

229 Focal disinhibition of the NAc core in freely behaving rats le

230 Disinhibition of the pFL with bicuculline and strychnine

231 n it was induced by hypercapnia, hypoxia, or disinhibition of the pFL.

232 e stress responses was tested via inhibition/disinhibition of the PH.

233 e ingestion is promoted by glucose-dependent disinhibition of the RS1-Reg-blocked exocytotic pathway

234 ed striato-pallidal transmission, leading to disinhibition of the STN and increased activation of STN

235 ges observed during tic expression following disinhibition of the striatal motor territory.

236 eurons that project from SNpr results in the disinhibition of the targets to which these neurons proj

237 etween the two attention networks; namely, a disinhibition of the ventral network by its dorsal count

238 mpairment caused by PTX, indicating that the disinhibition of these neurons by PTX was responsible fo

239 Disinhibition of this classically limbic territory leads

240 ration of fluoxetine reversed the behavioral disinhibition of tPA(-/-) mice, further supporting an im

241 eriaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excit

242 tection task involves local connectivity and disinhibition of visual cortex, while training on a feat

243 t that BLA inactivation disrupts PPI through disinhibition of VP.

244 Drug-induced disinhibition of VTA DA neurons has been linked to rewar

245 ns participate in the loss of opiate-induced disinhibition of VTA DA neurons observed during protract

246 ed inhibition, providing a circuit locus for disinhibition of whisker-evoked responses observed in L2

247 2 MAPK in hippocampal mossy fiber terminals, disinhibition of zinc-sensitive MAPK tyrosine phosphatas

248 is decreased in PAH, leading to enhancement (disinhibition) of TGFbeta1 signals and that the PPARgamm

249 and can counter metabolic stress, and 4E-BP1 disinhibition on mTORC1 repression may be neuroprotectiv

250 Disinhibition or direct activation of MnPO neurons induc

251 anesthetized rats that local pharmacological disinhibition or optogenetic excitation of the RTN/pFRG

252 paired processing speed, personality change, disinhibition or stereotypy; six had pure memory impairm

253 cal activity group reported higher levels of disinhibition (P = 0.07) and cravings for savory foods (

254 ore frequently in bvFTD than ALS-FTD: social disinhibition (p<0.001), inertia (p<0.001), loss of symp

255 fer, MT) was significantly associated with a disinhibition phenotype, derived from bi-factor modellin

256 y conceivably underlie the symptoms of motor disinhibition presenting as tics and psychiatric manifes

257 This disinhibition promotes anxiety and physiological hyperar

258 intains the chosen behavior, and (3) lateral disinhibition promotes sequence transitions.

259 lement behavioral choice, (2) local feedback disinhibition provides positive feedback that consolidat

260 by a sequence of excitation, inhibition, and disinhibition, raising the question of how these stimuli

261 by stimulation of glutamatergic afferents is disinhibition, rather than reduced excitatory transmissi

262 l evidence for prefrontal hypoactivation and disinhibition (reduced GABAergic inhibition), possibly r

263 1279 genes associated with disinhibition-related brain regions were identified, whi

264 cular and circuit components underlying this disinhibition remain unknown.

265 e-exposed animals through GABAergic synaptic disinhibition, represent a new class of rapidly-acting a

266 of INs and suggest that the SOM IN-mediated disinhibition represents an important circuit mechanism

267 ge from baseline to 6 mo and for measures of disinhibition, restrained eating, and dieting.

268 t to elicit an enduring state of PFC network disinhibition resulting from a developmental impairment

269 early adolescence can elicit a state of mPFC disinhibition resulting from a functional impairment of

270 Blocking disinhibition reversed the downregulation of STEP61 as w

271 elated symptoms (TSC-40) were collected; the disinhibition scale of the three-factor eating questionn

272 Disinhibition scores were significantly and positively a

273 d insulin resistance and emotional eating or disinhibition showed higher brain reactivity to food cue

274 EPSCs driven by primary afferents following disinhibition, supporting the view that the analgesic ef

275 e" interaction would produce a more profound disinhibition than seen with haploinsufficiency that is

276 These interactions can result in FKBP5 disinhibition that has been shown to contribute to a num

277 On the macro-scale, following NAc disinhibition, the animals manifested prolonged hyperact

278 l derivative, reverses inflammation-mediated disinhibition through a specific interaction with hetero

279 Abeta prevents this endocannabinoid-mediated disinhibition, thus leaving synaptic inhibition more int

280 We propose that ngr1 limits disinhibition to close the critical period for OD plasti

281 s, but the contribution of this form of fast disinhibition to cortical function is unknown.

282 eely behaving rats before and after striatal disinhibition to explore the factors underlying the timi

283 onse correlated with increases in behavioral disinhibition toward the logo of the consumed beverage (

284 ypes have a center-surround organization but disinhibition unmasks more excitatory input to excitator

285 chanisms of cognitive impairments underlying disinhibition, using horizontal saccadic latencies that

286 ng compulsions, repetitive writing tics) and disinhibition (uttering syllables/words, echolalia/palil

287 ediated through rapid and sustained cortical disinhibition via downregulation of PV-specific NRG1 sig

288 Moreover, via this lateral disinhibition, VIP cells in vivo make local and transien

289 The failure of disinhibition was associated with a loss of glutamatergi

290 Such cocaine-induced mPFC disinhibition was not observed in adult-exposed animals.

291 Such a disinhibition was not observed when MK-801 was given dur

292 To induce prefrontal hypoactivation or disinhibition, we microinfused the GABA-A receptor agoni

293 mediated neurite growth promotion and myelin disinhibition were abrogated by CRMP2 inhibition and lar

294 Semantic impairment and social disinhibition were linked to a similar but more extensiv

295 We propose a mechanism of disinhibition, wherein APs suppress Ca(2+) syntillas, wh

296 the delay reflects rapid homeostasis through disinhibition, which masks the onset of Hebbian weakenin

297 sk scores were significantly associated with disinhibition, while Tourette syndrome and ADHD risk sco

298 uron microcircuits results in pyramidal cell disinhibition with important consequences for synaptic p

299 VIP(+) interneurons balancing inhibition and disinhibition within the network.

300 s are dependent on the location of the focal disinhibition within the striatum; however, the factors