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1 , with some experimental data suggesting its dispensability.
2 oxical contrast to their apparent functional dispensability.
3 al properties, including its essentiality or dispensability.
4 onship with levels of expression and protein dispensability.
5 ation and replication) or not and of protein dispensability.
6 his is the dominant explanation for apparent dispensability, accounting for 37-68% of dispensable gen
7  lights on global characteristics of protein dispensability and evolution.
8 e analysis, the relationship between protein dispensability and evolutionary rate has remained unconf
9 hly significant relationship between protein dispensability and evolutionary rate, and explains why t
10                                       First, dispensability and expression have independent, signific
11 w that although we may reasonably infer that dispensability and expression have significant effects o
12 ma regarding the apparent prevalence of gene dispensability and found that most genes do contribute t
13          The dependence between PGL and gene dispensability and interactivity is much stronger than t
14 ion of regulatory elements to explore genome dispensability and organization.
15  several mammals, we characterize functional dispensability as the propensity for the ancestral eleme
16 risons with S. cerevisiae predicted diverged dispensability at 12% of conserved orthologs, and valida
17                              This structural dispensability but functional indispensability of Rpn10
18                           Comprehensive gene dispensability comparisons with S. cerevisiae predicted
19 can explain the long-standing paradox of ESC dispensability during postembryonic times.
20 onsequence of expression similarity and gene dispensability, each being correlated with a third facto
21 aboratory can be used to filter data sets of dispensability estimates, removing variates that are unl
22 put genomic databases that establish protein dispensability, expression and interaction networks enab
23         Several variables, including protein dispensability, expression, functional density, and gene
24  (C57BL/6 x C3H)F(1) mice, we found that the dispensability for CD4(+) T-cell help for the H-2(b)-res
25 ing to the packaging signal), suggesting its dispensability for DI vRNA propagation.
26     This finding explains the YEATS domain's dispensability for leukemogenesis when ENL/AF9 is transl
27                                Despite their dispensability for normal growth and development, DCs ha
28  essential or dispensable according to their dispensability for parasite survival under nutrient-repl
29 omyces cerevisiae, we found that a protein's dispensability had significant correlations with its evo
30 red simultaneously can determine their joint dispensability, i.e., their propensity for synthetic sic
31 high-throughput experimental testing of gene dispensability in Saccharomyces uvarum, a sister species
32                                 Its apparent dispensability in the spindle checkpoint might be due to
33 cessary stability to overcome their inherent dispensability in water environment but also fine-tuned
34 ionship is highly conserved, so that protein dispensability in yeast is also predictive of evolutiona
35                                      Protein dispensability is fundamental to the understanding of ge
36                      In our studies, protein dispensability is represented as a fitness score that is
37 e question of what the mechanistic basis for dispensability is, and whether it is the result of selec
38                                We tested the dispensability of 55 regions of the ADP1 chromosome usin
39 g homozygous gene knockouts that suggest the dispensability of a variety of human genes.
40 rference cells grew normally, suggesting the dispensability of activated 20 S proteasome in T. brucei
41 or native cellular IAP as a cofactor and the dispensability of caspase inhibition.
42                       The results reveal the dispensability of charge in the Glu(110) locus of IL-5 f
43                                          The dispensability of checkpoints in multicellular organisms
44 chanistic explanation for cell-type-specific dispensability of DC.
45                                 The apparent dispensability of DExH/D-box proteins in E.coli contrast
46 nalyze the yeast data and show that the high dispensability of duplicate genes with low expression si
47 -rich repeat receptors, does not explain the dispensability of EDS1 and SID2 in defense against GPA.
48  phosphoproteins, potentially explaining the dispensability of ErbB3 for tumorigenicity and PI3K acti
49                           To investigate the dispensability of FoxA factors for maintaining this regu
50                         In demonstrating the dispensability of GRP94, our finding points to the impor
51                                          The dispensability of Ii for control of L. major allowed gen
52  paralogs sufficiently explains the apparent dispensability of individual WGD genes.
53 ould code for homologs of KpsF, the apparent dispensability of KpsF remains provisional.
54 icient to sponge let-7, which reconciles the dispensability of LIN28B.
55                     To better understand the dispensability of maternal and zygotic Sqt, we sought ou
56 tudies with HeLa cells confirm the essential dispensability of mengovirus's poly(C) tract but reveal
57                                    Given the dispensability of Mindin in normal tissue physiology, ta
58                                          The dispensability of N(6) hydrogen bonding for proficient T
59 ated c-Rel is readily degraded, implying the dispensability of N-terminal sequence; in contrast, a se
60                                          The dispensability of NBD2 in the folding of more N-terminal
61                                          The dispensability of ORC is further supported by an examina
62 ally high conservation and contrast with the dispensability of other ultraconserved elements for viab
63 etastases on continued Wnt signaling and the dispensability of p53 for tumor regression, we find that
64                                 The apparent dispensability of prelamin A suggested that lamin A-rela
65         These data suggest that, despite the dispensability of proper chromosome segregation in megak
66                             In contrast, the dispensability of Rad18 for TLS in chicken DT40 cells wo
67                 It is re-emphasized that the dispensability of sequences is not an indicator of their
68                                          The dispensability of TAD boundaries and the necessity of th
69   Using Deltaie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611
70   Using Deltaie611 MCMV, we demonstrated the dispensability of the canonical ie3 gene product pIE611
71                          Here, we report the dispensability of the cotranslational SRP protein transl
72                                    Given the dispensability of the dynein tail in dynein motility in
73 t fraction of genes in the genome, given the dispensability of the eye for viability and fertility of
74        Our data, therefore, help explain the dispensability of the GCP4/5/4/6 core and highlight the
75 contrast, we confirm previous reports on the dispensability of the glycoprotein for infection of prim
76 ling of the interaction, leading to a global dispensability of the HX motif for trimeric complex form
77 ver been an unequivocal demonstration of the dispensability of the latter element for this process us
78  1) deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency o
79 TPase domains of human Cdc6 and Orc1 and the dispensability of the N-terminal segments of Orc1 and Or
80             A requirement for the Notch1 and dispensability of the Notch2 receptor has been demonstra
81 -independent outer kinetochore assembly, and dispensability of the outer kinetochore for constraining
82 ull bioactivity of mini-Ins demonstrates the dispensability of the PheB24-PheB25-TyrB26 aromatic trip
83                                          The dispensability of the TSKb20 response in the control of
84  Skp-like protein (ASK) interactions and the dispensability of the unique N-terminal LOV domain in th
85                These results demonstrate the dispensability of the V1-V2 sequences of SIVmac239 for v
86 e from their littermate controls, indicating dispensability of these two members of the Foxo transcri
87                                          The dispensability of this amino acid, the only amino acid w
88                                          The dispensability of viral SP has allowed construction of n
89                                          The dispensability of Yap1 in normal intestinal homeostasis
90                                              Dispensability provides an advantageous genetic system t
91         It is unknown, however, whether such dispensability reflects insignificance of the ancestral
92 ene expression, gene duplication and genetic dispensability, stem cell division and cancer risk, and
93 a of mutants allow us to investigate protein dispensability systematically at the genome scale.
94 ctor machine were applied to predict protein dispensability through high-throughput data.
95 lar patterns of conditional essentiality and dispensability under various environmental conditions ca
96                  Consistent with kinetoplast dispensability, V-ATPase defective cells were oligomycin
97                               Each protein's dispensability was estimated by the growth rate of mutan
98 ility by generating DNA ends, shown by their dispensability when ends are provided by I-SceI endonucl
99 le gene deletions in yeast to assess protein dispensability, which we relate to evolutionary rate est