ライフサイエンスコーパス: dissociation rate

1 ffinity for ACE2 was reduced due to a faster dissociation rate.

2 aM with an associated increase in the Ca(2+) dissociation rate.

3 ate phosphorylation through increases in ADP dissociation rate.

4 triplex stability by decreasing the triplex dissociation rate.

5 72K) decreased DNA binding by increasing the dissociation rate.

6 al transporter EAAT3 as a result of a slower dissociation rate.

7 ntial occupation was observed despite a high dissociation rate.

8 urement of the dissociation constant and the dissociation rate.

9 1 nm primarily because of a decrease in the dissociation rate.

10 T1-TPP1 bound to the primer decreased primer dissociation rate.

11 effects of SRI-compounds on cocaine-mediated dissociation rate.

12 lecular interactions and increases GPIbalpha dissociation rate.

13 ing kinetics is characterized by a very slow dissociation rate.

14 g by a greater-than-sixfold reduction of the dissociation rate.

15 association rate with no major change in the dissociation rate.

16 nce-specific changes in both association and dissociation rates.

17 cal parameters such as enzymatic binding and dissociation rates.

18 NPs, they can exhibit different association/dissociation rates.

19 iation (approaching the diffusion limit) and dissociation rates.

20 cule measurements of tubulin association and dissociation rates.

21 primarily derives from large differences in dissociation rates.

22 ates to be used for examining solute-protein dissociation rates.

23 n through alteration of both association and dissociation rates.

24 al parameters that determine association and dissociation rates.

25 A-protein binding through increasing protein dissociation rates.

26 binding within the nucleosome by decreasing dissociation rates.

27 hanical feedback between MyoII advection and dissociation rates.

28 spersion allowed the determination of Ca(2+) dissociation rates (~30 s(-1)).

29 he 38 lead compounds altered the radioligand dissociation rate, a hallmark of allosteric behavior.

30 residue in the enzyme seems to increase the dissociation rate, although the drug retains its inhibit

31 hus leverages the wide variation in membrane dissociation rates among different gamma-subunit types t

32 ivalent effects, with a significantly slower dissociation rate and 4-24-fold higher potency compared

33 The CD44s-fibrin pair has a lower unstressed dissociation rate and a higher tensile strength than CD4

34 Guided by a kinetic model, the oligomer dissociation rate and equilibrium constants were seen to

35 the proximal heme pocket, restored normal O2 dissociation rate and equilibrium constants, and reduced

36 altered O(2) binding, exhibits a faster heme dissociation rate and has a lower reduction potential co

37 , W50Pra]Ts1 for Nav with high affinity, low dissociation rate and reduced toxicity while retaining t

38 ons is achieved with both an increase in the dissociation rates and a decrease in the rate of peptide

39 CI in vitro, including affinity, association/dissociation rates and binding ratio.

40 saccharide chains of peptidoglycan, reducing dissociation rates and increasing binding affinity.

41 Our extensive measurements of dissociation rates and specific-nonspecific relative bin

42 t-translocation state by decreasing the dNTP dissociation rate, and increased the affinity for pyroph

43 haracterizing their apparent association and dissociation rates, and for determining their relative i

44 rate approximately 2-fold and increasing the dissociation rate approximately 10-fold, implicating thi

45 exponential decay model, from which relative dissociation rates are determined for all peptides with

46 Dissociation rates are determined from interfacial resid

47 ilarly affected by pH at both ends, although dissociation rates are differentially affected.

48 The initial SF and subsequent triplet pair dissociation rates are found to be more rapid in the mon

49 Yet, the dissociation rates are nearly the same for both iRBC-rec

50 The requisite microcanonical dissociation rates are obtained from ab initio transitio

51 tional state, greatly increasing the product dissociation rate as compared to the intrinsic pathway t

52 in filaments, Aip1 also augments the monomer dissociation rate at both the barbed and pointed ends of

53 hrough mutation reduces both association and dissociation rates by factors of ~10(4), while minimally

54 g the possibility of deliberately increasing dissociation rates by incorporating hairpins into single

55 at regulate TF dynamics in vivo and increase dissociation rates by orders of magnitude are not known.

56 ameters, including molecular association and dissociation rates, by fitting the model to experimental

57 to VLA-4 integrin, modulation of the ligand dissociation rate can be observed for different LFA-1 af

58 ed for error correction as a function of the dissociation rate coefficient, strand valency, and seed

59 mass-action model, in which association and dissociation rate coefficients are concentration-depende

60 eas the major population of Syt-7 C2AB has a dissociation rate comparable to its C2A domain, suggesti

61 ng molecule, but with a significantly faster dissociation rate compared to the tetraintercalators.

62 and by contrast, the 15-fold decrease of the dissociation rate concurs to stabilize the pentameric co

63 ensity (Bavail) and the apparent equilibrium dissociation rate constant (1/appKD) under in vivo condi

64 The reduction in K(d) results from a reduced dissociation rate constant (from 16 s(-1) to 0.3 s(-1) i

65 ed for both AMT and RMT in the S31N, but the dissociation rate constant (k(2)) is dramatically increa

66 ecovery after photobleach indicated that the dissociation rate constant (k(off)) for f-PPE was signif

67 study the association rate constant (k(on)), dissociation rate constant (k(off)), and equilibrium dis

68 The dissociation rate constant (k(off), s(-1)) of each multi

69 g both the association rate constant and the dissociation rate constant at the necessary ratio to cre

70 easurements indicate that this variant has a dissociation rate constant essentially equivalent to the

71 ons of fenofibrate were able to increase the dissociation rate constant for [(3)H]-CP55940 at the CB1

72 low membrane dissociation and an increase of dissociation rate constant for a construct lacking the a

73 ferent DNA concentrations, we determined the dissociation rate constant for the specific complex and

74 om the reaction medium and the fact that its dissociation rate constant is non-significantly differen

75 The dissociation rate constant kd (off-rate) is the componen

76 onstant kon and no significant effect on the dissociation rate constant koff.

77 nstant of k(+) = 5 x 10(5) M(-1) s(-1) and a dissociation rate constant of <3s(-1).

78 This indicates that the dissociation rate constant of DOX from lung tissue compo

79 P-perturbed M230 resonance, and enhances the dissociation rate constant of the NVP, resulting in an i

80 The rate-limiting dissociation rate constant of the tetra-intercalator com

81 The dissociation rate constant of the TWEAK-Fn14 interaction

82 chanism of the parent ferrocene, leading the dissociation rate constant to increase by several orders

83 ions, such as the association rate constant, dissociation rate constant, affinity constant, as well a

84 ffinity was mainly due to an increase in the dissociation rate constant, but a significant decrease i

85 ffinity was largely due to a lowering of the dissociation rate constant, Koff.

86 esis of allosteric residues affects only the dissociation rate constant, suggesting that binding foll

87 al model, we are able to extract the dimer's dissociation rate constant.

88 (1)), compensated by a correspondingly small dissociation rate constant.

89 iron, high oxygen affinity, and slow oxygen dissociation rate constant.

90 ygen affinity, and a relatively rapid oxygen dissociation rate constant.

91 Carbon monoxide dissociation rate constants (k(-CO)) and corresponding a

92 , DeltaH degrees , DeltaS degrees ) and O(2) dissociation rate constants (k(-O(2)), DeltaH(double dag

93 4 and 15 were similar to those for ID 1, but dissociation rate constants (k(d)) were 4- to 10-fold hi

94 um binding constants (K(eq)) and association/dissociation rate constants (k(on) and k(off)).

95 nstants (Ka) or global affinities (nKa') and dissociation rate constants (kd) for testosterone with s

96 ) approximately 10(4)-10(5) M(-1) s(-1), and dissociation rate constants (koff) approximately 10(-4)-

97 st affinity extraction to determine both the dissociation rate constants and equilibrium constants fo

98 ns of thrombin, and provides association and dissociation rate constants and equilibrium dissociation

99 SPR allows for analysis of association and dissociation rate constants and modeling of biomolecular

100 With the QCM setup, the association and dissociation rate constants and the associated equilibri

101 ular interaction (namely the association and dissociation rate constants and the association constant

102 been able to show that both association and dissociation rate constants are decreased when a partner

103 Moreover, the intermolecular binding and dissociation rate constants are quantitatively and indep

104 tudies yield the values of hybridization and dissociation rate constants as 9.6 x 10(4) M(-1) s(-1) a

105 Ferric heme association and dissociation rate constants at 10 degrees C were as foll

106 ws weaker salt dependence of the binding and dissociation rate constants compared with AmPrbetaCD.

107 The measured dissociation rate constants for BLIP-II and various beta

108 d that they all have similar association and dissociation rate constants for complex formation, despi

109 sive collection of published equilibrium and dissociation rate constants for CuFS and NiFS complexes,

110 or rapid association rate constants and slow dissociation rate constants for ligand binding.

111 embranes to measure both the association and dissociation rate constants for O1 and O4 antibodies bin

112 Both association and dissociation rate constants for these ligands are obtain

113 t molecules, and the agonist association and dissociation rate constants from both the closed- and op

114 veral YFP variants and detect slow kinetics (dissociation rate constants in the range of 0.1-1 s(-1))

115 confirmed these results by showing increased dissociation rate constants induced by Pepcan-12.

116 M(-1) s(-1) for monomers and heterodimer and dissociation rate constants k(-1) of approximately 9 x 1

117 Association and dissociation rate constants obtained for a reversible pr

118 The dissociation rate constants obtained for soluble HSA wit

119 In the absence of competitive ligands, the dissociation rate constants of ABA-X-BY630 from A(1) and

120 nging from 2 x 10(-6) M to 2 x 10(-9) M, and dissociation rate constants of approximately 6 s(-1) to

121 t separation and purification by determining dissociation rate constants of compounds in crude reacti

122 Lower limits for the very high formation and dissociation rate constants of the model 1:1 pyridine-he

123 Conversely, the dissociation rate constants of the ternary complexes var

124 tes, there were hardly any variations in the dissociation rate constants of these molecules with resi

125 In sharp contrast, however, dissociation rate constants prove to be exponentially se

126 ower for the W51H mutants, while the cyanide dissociation rate constants range from 3 times slower to

127 xes in a DGT system was used to estimate the dissociation rate constants that provided the best agree

128 (Phi), and the acetylcholine association and dissociation rate constants were approximately temperatu

129 The antibody-antigen association and dissociation rate constants were determined for the anti

130 Calcium dissociation rate constants were determined for the visi

131 tant alphaG153S, the choline association and dissociation rate constants were temperature-dependent (

132 The measured spontaneous dissociation rate constants were validated with SPR usin

133 um constants, K(eq), that span ~6 orders and dissociation rate constants, k(diss), that span ~7 order

134 ly quantify antibody-antigen association and dissociation rate constants, kon and koff, in a single e

135 ly measures antibody-antigen association and dissociation rate constants, kon and koff.

136 es with variation in affinity due to altered dissociation rate constants, suggesting that changes in

137 ly longer than predictions based on chemical dissociation rate constants, suggesting that SH2 modules

138 ach other only in oxygen affinity and oxygen dissociation rate constants, two factors key to their di

139 ence spectroscopy to measure association and dissociation rate constants, we show that hydrophobic in

140 nding kinetic constants, the association and dissociation rate constants, yields k(a) of (7.21 +/- 0.

141 ten fold), with no effect on the microscopic dissociation rate constants.

142 -dimensional distribution of association and dissociation rate constants.

143 whereas mutation of charged residues affects dissociation rate constants.

144 that this is primarily due to differences in dissociation rate constants.

145 g affinities, association rate constants and dissociation rate constants.

146 nce, was fast, with high association and low dissociation rate constants.

147 We propose a dissociation rate controlled mechanism of allosteric, no

148 association rates to the D2 receptor, while dissociation rates correlate with prolactin elevation.

149 Here we show that association rates, but not dissociation rates, correlate with EPS.

150 Our results suggest that dissociation rates could account for the recently descri

151 It is also observed that the dissociation rate decreases after heat shock, whereas th

152 concentrations that SRP-RNC association and dissociation rates depend on nascent chain length and th

153 dissociation with two distinct regimes: the dissociation rate depends weakly on the applied force at

154 tions that dramatically altered the ligand's dissociation rate despite only marginally influencing it

155 alization experiments can accurately measure dissociation rates despite their limited spatiotemporal

156 The dNTP association and dissociation rates do not vary as a function of voltage,

157 nd its selectivity manifests in differential dissociation rates; e.g., the protein releases a 2-Amino

158 Pulsatility emerges at intermediate dissociation rates, enabling convergent advection of Myo

159 ding two PIP molecules as evident by a lower dissociation rate for Atg18 in comparison with its PIP b

160 D-1 is principally due to the 3-fold smaller dissociation rate for PD-L2 binding.

161 We observe both a remarkably low dissociation rate for wild type HCV NS5B, and a highly d

162 ha-thio elemental effect of 1.5, varying DNA dissociation rates for the binary complex (0.043 s(-1))

163 Microscopic dissociation rates for the chimeric mutants (~10 s(-1))

164 nt frequencies and corresponding binding and dissociation rates for the different Rev-RRE stoichiomet

165 resonance analyses revealed 33 times faster dissociation rates for the LVXEF ligand when compared wi

166 measuring THRX-198321-evoked changes in the dissociation rates for the orthosteric radioligands, [N-

167 ata, we derived estimates of association and dissociation rates for the test set of antagonists, iden

168 solution, provides evidence that the subunit dissociation rate from a microtubule tip increases as th

169 le assembly kinetics assume that the subunit dissociation rate from a microtubule tip is independent

170 r trimer nucleus formation, faster phosphate dissociation rate from polymerized actin, and faster nuc

171 not cytotoxic, and showed substantially long dissociation rates from PLA2.

172 ntrolled most prominently by association and dissociation rates from RAS-GTP and by RAS-GTP concentra

173 the corona proteins based on their relative dissociation rates from the NPs was developed, employing

174 imulations, we have computed association and dissociation rates from the transition-path sampling.

175 xtracted for a wide range of association and dissociation rates, gradient slopes, and curvatures, and

176 y weakly dependent on sequence; however, the dissociation rate greatly increases from <0.006 s(-1) to

177 the presence of GTP (3.69 +/- 0.65 nM), at a dissociation rate >10(-2) s(-1).

178 determination of association rate constants, dissociation rates have received less attention.

179 of the salt concentration dependence of the dissociation rate, however, shows that the predictions f

180 binders had subnanomolar affinities with low dissociation rates (i.e., kd values around 1 x 10(-3) s(

181 be observed for compounds with modestly slow dissociation rates (i.e., residence times >0min but </=2

182 -Boltzmann effects can influence the overall dissociation rate in the gas.

183 ombined with measurements of in vitro Ca(2+) dissociation rates in fully reconstituted WT and cardiac

184 T) can provide direct information on complex dissociation rates in natural waters.

185 a bonds that show high dynamicity (high bond dissociation rate), in the form of either linear polymer

186 The Y390F dissociation rate increase is suppressed when complexes

187 nd that because both the association and the dissociation rates increase at higher free subunit conce

188 pidly bind PAC-1 from 2-90 min, although the dissociation rate increased at later times, indicative o

189 Dissociation rates increased linearly with constant forc

190 strongly influenced by its surroundings: the dissociation rate increases as the concentration of the

191 tions (millimolar MgATP), not only the dimer dissociation rate increases, but also the dimerization r

192 , ROC(N1437H) was found to have a slower GTP dissociation rate, indicating that N1437H might interrup

193 e characterized by fast association and slow dissociation rates, indicating formation of stable compl

194 slocation rates and the dNTP association and dissociation rates, individually at each dNTP concentrat

195 Thus, the slower SQ(-) dissociation rate is a direct physical consequence of th

196 relationship between hotregion size and the dissociation rate is also investigated and, using hotspo

197 ting, but at approximately 90 s(-1), the ADP dissociation rate is comparable to the 30 s(-1) k(cat).

198 The odorant-dissociation rate is only available for a few odorant-re

199 accessible to nuclease digestion and RAD-51 dissociation rate is reduced.

200 However, a relatively slow dissociation rate is required for the proposed deaminase

201 and dissociation constant (Kd), but not the dissociation rate (k off) from the target, by concentrat

202 s decreased from 4 to 1 nucleotide (nt), the dissociation rate (k(off) ) for P-site tRNA increases by

203 s such as the rupture length (chi(beta)) and dissociation rate (k(off)) are extracted using the model

204 mmaretroviral enzyme has a remarkably higher dissociation rate (k(off)) from DNA, which also results

205 simulations, we find that the lower membrane dissociation rate (k(off)) of Rok at the tissue boundary

206 y, the effects of ribosomal mutations on the dissociation rate (k(off)) of various tRNAs from the P s

207 epend not only on monovalent association and dissociation rates (k(off) and k(on)), but also on a mul

208 we determined association rates (k(on)) and dissociation rates (k(off)), as well as NAM affinities w

209 Slower dissociation rates (koff) of the lead compounds were obs

210 timer technology, we quantified the TCR:pMHC dissociation rates (koff) of tumor-specific vaccine-indu

211 d, increased association rates and decreased dissociation rates lead to a strong decrease in the effe

212 , still allow formation of a stable complex (dissociation rate <0.006 s(-1)), suggesting that extreme

213 ces sometimes exceeds the enhancement of the dissociation rate measured in pulling experiments, indic

214 alysis of relaxation dispersion data and THF dissociation rates measured by stopped-flow spectroscopy

215 ich represent the fastest Xe association and dissociation rates measured for a high-affinity, water-s

216 ate of 0.0016 +/- 0.0001 muM(-1) s(-1) and a dissociation rate of 0.00020 +/- 0.00005 s(-1) at 37 deg

217 ued motor integrity, and calculated a stator dissociation rate of 0.038 s(-1).

218 The dissociation rate of 3 nM BODIPY-TMR-CGP was 0.09 +/- 0.

219 41 or SRI-30827 following cocaine slowed the dissociation rate of [(3)H]WIN35,428 binding in WT hDAT

220 A dependence of the dissociation rate of a DNA-protein complex on competitor

221 Here, assessment of the dissociation rate of a fluorescent analog of CGP 12177 [

222 We further observed a strong increase in the dissociation rate of adsorbed CO upon exposure to hydrog

223 Loss of spliceosome subunits increases the dissociation rate of cohesin from chromatin and abrogate

224 ut through short-range effects that slow the dissociation rate of ColE9 TBE from its complex with Tol

225 rbed end, causing a 300-fold increase in the dissociation rate of CP from the end (i.e. uncapping).

226 ted that IkappaBalpha markedly increases the dissociation rate of DNA from NF-kappaB.

227 A low dissociation rate of DNAJB6 from Abeta42 aggregates lead

228 We find that the dissociation rate of EcoRI-DNA-specific complexes at 80

229 tidine, His27, which may increase the proton-dissociation rate of His19.

230 Because of the exceptionally slow dissociation rate of IgE-FcepsilonRI complexes, such all

231 We determined that the product dissociation rate of MPG at the hotspot codons was appro

232 n binding but by dramatically increasing the dissociation rate of protein complexes from their DNA-bi

233 Using steady-state approximations, the dissociation rate of PS in cavitating bubble systems was

234 s (TCs) at the ribosomal A-site enhances the dissociation rate of such TCs from their L7/L12 tethers.

235 These Ca(2+)-induced events decrease the dissociation rate of synaptotagmin-1 membrane binding wh

236 is probably due to a significant increase in dissociation rate of the antagonist in the presence of B

237 d NR was 5.00 x 10(4) M(-1) s(-1), while the dissociation rate of the complex was 0.36 s(-1), at 25 d

238 latory nascent peptides, determines the slow dissociation rate of the extended macrolides from the ri

239 ional diffusion during active unwinding, the dissociation rate of the helicase also exhibits sequence

240 xtent of Hsc70 association with CFTR nor the dissociation rate of the Hsc70-CFTR complex.

241 The dissociation rate of the met-alpha.AHSP complex (k(AHSP)

242 , causing reduced stability and an increased dissociation rate of the mutant complex as compared with

243 lly decreased that for GDP by increasing the dissociation rate of the nucleotide.

244 We measured the overall dissociation rate of the polymerase-DNA complex and the

245 Here we examine the subunit dissociation rate of the trimeric membrane enzyme, diacy

246 s and revealed alphaIIbbeta3 association and dissociation rates of 4500+/-100s(-1) and 2.1+/-0.1s(-1)

247 o1 current kinetics provided association and dissociation rates of 7.0 x 10(5) M(-1) s(-1) and 0.11 s

248 The dissociation rates of Cas and two other adhesion molecul

249 ong timescales despite the rapid binding and dissociation rates of Dps.

250 tion of the channel by increasing the proton dissociation rates of His-19.

251 These measurements reveal the microscopic dissociation rates of HMGB from DNA.

252 ric-based measurements of monomeric TCR-pMHC dissociation rates of living CD8(+) T cells on a wide av

253 stic time scales governing the formation and dissociation rates of metal-nanoparticle complexes in de

254 and between predicted IC(50) values and true dissociation rates of peptide-MHC class II complexes.

255 Both the binding and dissociation rates of Reb1 and Cbf1 are significantly sl

256 r massively identifying the odorant-receptor dissociation rates of relevance to flies.

257 ta yield reliable values for the spontaneous dissociation rates of single-molecule specific bonds, an

258 We show that the arrival and dissociation rates of SRP binding to RNCs vary according

259 rmined equilibrium constants and association/dissociation rates of the chromophores with free tryptop

260 the SPIONs were collected regardless of the dissociation rates of the complexes.

261 This was accomplished by measuring the DNA dissociation rates of wild-type AraC and heterodimeric A

262 The dependence of the dissociation rate on applied force was obtained using pr

263 ated an exponential dependence of the unit's dissociation rate on the force delivered to the rotor.

264 advances in kinetic models to predict alkane dissociation rates on solid surfaces.

265 e bound complex of pKID:KIX via altering the dissociation rate, phosphorylation can facilitate effect

266 3 + 1) hybrid structure is controlled by the dissociation rate, rather than the association rate of l

267 ) and Mn(2+) substantially decrease the dNTP dissociation rate relative to Mg(2+), while Ca(2+) also

268 DDX1 and adenylyl-imidophosphate, while the dissociation rates remained unchanged.

269 , with K(i)* = 0.13 muM, and an atypical low dissociation rate (residence time tau = 205 min).

270 tablishes two stable regimes of high and low dissociation rates, resulting in MyoII planar polarity.

271 Transient complexes with fast association/dissociation rates showed distinct mobility change from

272 DRaCALA yielded a dissociation constant and dissociation rate similar to previously reported values.

273 bicans cell surface (~2 nN) and showed a low dissociation rate, suggesting a highly stable bond.

274 and with the aptamer but does not impact its dissociation rate, suggesting an S(N)1-like mechanism wh

275 site mutations caused a decrease in the dNTP dissociation rate, suggesting that they perturb Phi29 DN

276 s also provide estimates for force-dependent dissociation rates, suggesting that kinesin-1 and the mi

277 and in vivo We report in vitro PNP-inhibitor dissociation rates (t(1/2)) from 3 to 31 min for seven I

278 ncentration profile, and an odorant-receptor dissociation rate tensor, and quantitatively describe th

279 hese precomplexes are weak, with much larger dissociation rates than suggested elsewhere.

280 Direct transfer is characterized by a dissociation rate that depends on total DNA concentratio

281 ic and steric factors result in an effective dissociation rate that is approximately sevenfold slower

282 rimarily ascribed to the increase in exciton dissociation rates through the PCBDR/DNA interface and t

283 D2 receptors and integrates association and dissociation rates to calculate the net rate of reversal

284 a novel approach by relating the changes in dissociation rates upon mutation to the energetics and a

285 istance to 7 mol/L urea) and slower antibody dissociation rates using surface plasmon resonance.

286 resistance, respectively) and lower antibody dissociation rates using surface plasmon resonance.

287 saturation of fH binding to fHbp, even when dissociation rates varied over 10-fold.

288 At 20 muM Ca(2+), the dissociation rate was substantially lower, indicating in

289 t 37 degrees C, which represents the slowest dissociation rate we have observed for any beta2 adrenoc

290 es including explicit consideration of their dissociation rates, we derive energy distributions with

291 old-slower inhibition onset, slower apparent dissociation rate, weaker voltage dependence, and comple

292 These effects on the BODIPY-TMR-CGP dissociation rate were markedly enhanced in beta1-adreno

293 that for binding of fH to fHbp, and the MAb dissociation rates were >500-fold lower than that for fH

294 ments, and receptor-scaffold association and dissociation rates were adjusted to fit single-molecule

295 We found that 1), two-dimensional dissociation rates were comparable to three-dimensional

296 de interaction kinetics and showed that slow dissociation rates were mediated by large hydrophobic co

297 responsible for the cooperativity, while the dissociation rates were responsible for the anticooperat

298 ontrol the diffusional encounter but not the dissociation rate, which is critical for the establishme

299 the sensitivity to determine association and dissociation rates, with accuracy and precision dependin

300 ondition, only the proteins with slow enough dissociation rates would be collected with the NPs in th