ライフサイエンスコーパス: dissociative

1 ansition state that is concerted rather than dissociative.

2 limination are very shallow, and several are dissociative.

3 20 patients with classical dystonia revealed dissociative (42 versus 0%, P = 0.001) and affective dis

4 PK phosphatase 1 in the lung, confirming the dissociative action of CpdA.

5 g EEG rhythm phase is likely to underlie the dissociative actions of ketamine, since it is during thi

6 Surprisingly, Mte1 antagonizes the D-loop-dissociative activity of Mph1-MHF and exerts a procrosso

7 the plasma were likely to be responsible via dissociative addition to the disulfide bond (RSSR'), giv

8 nto the mechanisms that are operative in the dissociative adsorption and absorption of hydrogen on/in

9 ered to undergo orientational transitions by dissociative adsorption and dehydrogenation reactions in

10 uarter of impinging oxygen molecules undergo dissociative adsorption and eventual incorporation into

11 Ir facilitate C-C bond splitting via ethanol dissociative adsorption and Ir promotes dehydrogenation

12 y functional theory calculations predict the dissociative adsorption of a single water molecule (E ad

13 Dissociative adsorption of Cl(2) gas on the gold surface

14 This was accomplished by studying the dissociative adsorption of formic acid on oxygen-presatu

15 On O-sat Pt(111), the integral heat of the dissociative adsorption of formic acid to make monodenta

16 Upon dissociative adsorption of H(2) , the average distance o

17 Dissociative adsorption of H(2) on Pt is significantly w

18 We tracked the dissociative adsorption of H2O onto the GaN(0001) surfac

19 deposited on the CeO2(111) surface to study dissociative adsorption of methanol and its subsequent d

20 Dissociative adsorption of methanol at different sites o

21 he enthalpy and sticking probability for the dissociative adsorption of methyl iodide were measured o

22 Au(111) in an orientation that changes upon dissociative adsorption of molecular chlorine, a result

23 mposed of two characteristic stages, namely, dissociative adsorption of oxygen followed by partial ox

24 s have been formed on the Pt(111) surface by dissociative adsorption of their respective alkyl and fl

25 d to play the decisive role in promoting the dissociative adsorption of water molecules and subsequen

26 and/or OH surface species resulting from the dissociative adsorption of water.

27 n a single collision reaction with Cl and in dissociative adsorption on a Ni surface bear some striki

28 The ease of methanol dissociative adsorption on nanoceria support and the tai

29 Similarly, its integral heat of dissociative adsorption to make bidentate formate (HCOOb

30 rface of the nanoparticles, but some undergo dissociative adsorption, leading to oxide species on the

31 Ir alloy that is rather inactive for ethanol dissociative adsorption, we propose that splitting the C

32 ctive Mo-rich sites that can undergo dynamic dissociative adsorption/desorption processes with molecu

33 the groups with regard to psychotomimetic or dissociative adverse effects.

34 Ketamine, a dissociative agent, functions uniquely and requires its

35 aging of neural activity revealed that these dissociative agents elicited a 1-3-Hz rhythm in layer 5

36 of the transition states for associative and dissociative alkylation reactions.

37 S1 is dissociative along that N-N coordinate to form the singl

38 s known to induce an unusual state known as "dissociative anaesthesia").

39 al (C3) carbon atom in the double bond under dissociative and associative conditions.

40 s in ZIF-8 proceed via a competition between dissociative and associative exchange mechanisms, and gu

41 otinamide cleavage reaction employs a highly dissociative and concerted displacement mechanism: the c

42 ectivity that is traced to competing solvent-dissociative and nondissociative dissociative pathways f

43 r knowledge, this is the first evidence of a dissociative and potentially beneficial role of elevated

44 m severity and the frequency and severity of dissociative and psychotomimetic effects.

45 ct at the NMDA receptor complex, but without dissociative and psychotomimetic side effects of ketamin

46 O-mannosylation and beta-C-mannosylation are dissociative and S(N)1-like.

47 ffects and perceptual alterations, including dissociative and somaesthetic effects, increased plasma

48 The exchange is dissociative and zero order in [COE].

49 Both the stepwise (or dissociative) and the concerted (or associative) pathway

50 rylation reaction catalyzed by PKA is mainly dissociative, and Asp166 serves as the catalytic base to

51 stinct hydrolytic modes of action: exo, endo-dissociative, and endo-processive.

52 edation-unconsciousness, sedation-analgesia, dissociative anesthesia, pharmacologic non-REM sleep, an

53 tor with IC50 values similar to those of the dissociative anesthetic (S)-(+)-ketamine.

54 Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosi

55 Abuse of the dissociative anesthetic ketamine can lead to a syndrome

56 have confirmed the potential utility of this dissociative anesthetic medication for treatment of majo

57 Ketamine, a dissociative anesthetic, is experiencing a clinical resu

58 Recognition that dissociative anesthetics block the N-methyl-D-aspartate

59 Dissociative anesthetics that antagonize the N-methyl-D-

60 NMDA receptor (NMDAR) antagonists are dissociative anesthetics, drugs of abuse, and are of the

61 ommon types of electron-upconverting systems-dissociative (based on unimolecular fragmentations) and

62 racted information about the associative and dissociative behavior of the origami.

63 The dissociative binding efficiency of oxygen over Pd(n)/TiO

64 of photochemical reactions are likely to be dissociative, but hydride complexes may be designed with

65 port the experimental results confirming the dissociative character of the excited states formed upon

66 tion reaction with a transition state of 70% dissociative character.

67 lines of evidence indicate a mechanism with dissociative character.

68 te-limiting S(N)2-like transition state with dissociative characteristics for CVIM, while, due to the

69 Dissociative charge exchange of CH5+ with Cs, coupled wi

70 eve the (chemically) accurate calculation of dissociative chemisorption and scattering probabilities.

71 bove 150 degrees C, which is consistent with dissociative chemisorption into NO and atomic O accompan

72 posed mechanism may be broadly applicable to dissociative chemisorption of NH3 on other metal oxide s

73 the monomer phenylene units formed from the dissociative chemisorption of p-diiodobenzene.

74 s with water, which can be attributed to the dissociative chemisorption of water at specific surface

75 dsorption modes, molecular physisorption and dissociative chemisorption.

76 he calculations also provide support for the dissociative course of the key 1,3-shift step.

77 e developed a novel set of collision-induced dissociative cross-linking reagents and methodology for

78 mbination of electrostatic collision-induced dissociative cross-linking reagents that differentially

79 echanistic crossover from the concerted to a dissociative CS(N)Ar type of reactivity for aryl electro

80 Analysis of KIEs indicated a highly dissociative D(N)A(N) (S(N)1) stepwise mechanism with ve

81 e Escherichia coli MTAN reaction undergoes a dissociative (D(N)A(N)) (S(N)1) mechanism with little in

82 Dissociative deamidation occurs along the N-C(alpha) bon

83 For 1-ole, substitution was dissociative (deltaG(double dagger)(diss)), and in combi

84 reactions of p-oxidophenylnitrene formed by dissociative deprotonation of p-azidophenol indicate eit

85 H(2)(-)-substituted phenylnitrene, formed by dissociative deprotonation of p-azidotoluene, with CS(2)

86 re-dependent decrease in the temperature for dissociative desorption was observed for both amino acid

87 Compared to the patients without a dissociative disorder diagnosis, patients with a dissoci

88 d during the study had previously received a dissociative disorder diagnosis.

89 ealed that only four (5%) patients in whom a dissociative disorder was identified during the study ha

90 ociative disorder diagnosis, patients with a dissociative disorder were significantly more likely to

91 terviewed patients received a diagnosis of a dissociative disorder.

92 s (35%) completed a structured interview for dissociative disorders (Dissociative Disorders Interview

93 rgest mean dissociation scores were found in dissociative disorders (mean scores >35), followed by po

94 The high prevalence of dissociative disorders found in this study may be relate

95 study was to assess the prevalence of DSM-IV dissociative disorders in an inner-city outpatient psych

96 ctured interview for dissociative disorders (Dissociative Disorders Interview Schedule).

97 Dissociative disorders were highly prevalent in this cli

98 The rate constants of oxidative and dissociative dissolution of Ag(0) and Ag(I) species asso

99 state of E:R-HsPNP is altered from the fully dissociative DN*AN character for HsPNP to a late phospha

100 can occur as a result of trauma, epilepsy or dissociative drug use(13,14), but despite its substantia

101 such as lysergic acid diethylamide (LSD) and dissociative drugs such as phencyclidine (PCP) and the s

102 37YTEYLSSAF545 deletion had an insignificant dissociative effect.

103 erspective examines the relationship between dissociative effects and acute and longer-lasting antide

104 nual cingulate, which strongly predicted its dissociative effects and increased activity in mid-poste

105 ll tolerated with minimal psychotomimetic or dissociative effects and was not associated with clinica

106 These data indicate dissociative effects of mediators of Ras activity on coc

107 Ketamine also has short term dissociative effects, in which individuals report altere

108 pressive symptoms without psychotomimetic or dissociative effects.

109 ly, accompanied by brief psychotomimetic and dissociative effects.

110 on of transient negative ions, decaying into dissociative electron attachment (DEA) and electronic ex

111 Damage to DNA via dissociative electron attachment has been well-studied i

112 bulk water and as such are incompatible with dissociative electron attachment reactions in DNA.

113 nism that couples vibrational excitation and dissociative electron attachment steps.

114 as biological radiation damage arising from dissociative electron attachment.

115 Our investigations also suggest that dissociative electron capture is the main ionization rou

116 that reduction of 5 may occur by a concerted dissociative electron transfer (DET) mechanism (i.e., el

117 that CMPs are electron donors and the first dissociative electron transfer from CMPs was likely to b

118 examined within the mechanistic framework of dissociative electron transfer in the presence of a Lewi

119 sing Saveant's theory pertaining to stepwise dissociative electron transfer.

120 ysis of the activation reaction according to dissociative electron-transfer (DET) theory suggests tha

121 Recently, we have discovered a unique dissociative electron-transfer mechanism of action of ci

122 troscopic measurements confirm the effective dissociative electron-transfer reaction between TMPD and

123 These results are consistent with a dissociative electrophilic alkylation mechanism where th

124 on at one of the sites, is consistent with a dissociative electrophilic alkylation of the indole ring

125 that the crosslink exchange mechanism (i.e., dissociative exchange or associative exchange) plays in

126 y and Depression Scale and the Peritraumatic Dissociative Experience Questionnaire were used.

127 Dissociative experiences commonly occur in response to t

128 ay in part predict individual differences in dissociative experiences due to ketamine use.

129 xiety and Depression Scale and Peritraumatic Dissociative Experiences Questionnaire 3 months after in

130 discharge and 86 completed the Peritraumatic Dissociative Experiences Questionnaire at ICU discharge

131 Event Scale-Revisited and the Peritraumatic Dissociative Experiences Questionnaire within 8 days aft

132 Correlations of baseline measures with the Dissociative Experiences Scale and endogenous opioid sys

133 pleted self-report measures of dissociation (Dissociative Experiences Scale) and trauma history (Trau

134 ribution of dissociation, as assessed by the Dissociative Experiences Scale, within different categor

135 re, the Limbic Symptom Checklist-33, and the Dissociative Experiences Scale.

136 ucleus and the lateral prefrontal cortex and dissociative experiences.

137 ectrical stimulation of this region elicited dissociative experiences.

138 ndo formation of carbon-based tribofilms via dissociative extraction from base-oil molecules on catal

139 O2 of uracil underlies the UDG activity in a dissociative fashion, Tth UDGb relies on multiple cataly

140 ues observed, associative for (Py)LCu(I) but dissociative for (NMe(2))LCu(I) and (Im)LCu(I); these re

141 ic stabilization to TTR, thus inhibiting its dissociative fragmentation and subsequent aggregation to

142 acute psychogenic memory loss (also known as dissociative/functional amnesia), and still fewer studie

143 trapped synaptic complex correlates with the dissociative half-life of the STI observed with HIV IN-D

144 a kappa-opioid receptor agonist and atypical dissociative hallucinogen found in Salvia divinorum.

145 Potential psychotomimetic, dissociative, hemodynamic, and general adverse effects a

146 ctronically similar to the oxocarbenium-like dissociative hPNP transition state, DADMe-ImmH is more p

147 Authors explore the limit case of dissociative identity disorder in order to explore how a

148 Dissociative identity disorder was diagnosed in five (6%

149 iple pathways that are either associative or dissociative in nature.

150 ed issue, as to whether it is associative or dissociative in nature.

151 nce energy of C(2)H(5)(+) is consistent with dissociative ionization of C(2)H(5)OO via the Franck-Con

152 yl cation signal suggests its formation from dissociative ionization of C(2)H(5)OO.

153 proton generation in few-cycle laser-induced dissociative ionization of ethanol and water on SiO(2) n

154 with respect to its performance as a soft or dissociative ionization source.

155 duty cycle the plasma evolved from a soft to dissociative ionization source.

156 te significantly to the hydrogen elimination dissociative ionization yield.

157 We conclude that ultrafast dissociative-ionization could be a promising technique f

158 The photo-induced dissociative-ionization of lanthanide complexes Ln(hfac)

159 -like actions of ketamine, but is spared its dissociative-like properties and abuse potential.

160 g affinity values (K(D)), in part because of dissociative losses from tetramer-stained cells.

161 [DEDAM] plots is interpreted according to a dissociative mechanism (D).

162 eal that Ti(citrate)3 reacts with HBED via a dissociative mechanism and that the stability of TiHBED

163 g to an associative mechanism, rather than a dissociative mechanism as in the Haber-Bosch process.

164 an associative mechanism or (ii) a stepwise dissociative mechanism in which the alkylation step is r

165 arkably, our results show a new RNA-specific dissociative mechanism in which the bulk water accepts t

166 putative dinitrosyl intermediate forms via a dissociative mechanism in which the endogenous His ligan

167 (3)P)(3)Rh(Cl)] with free PPh(3) (THF) via a dissociative mechanism occurs exclusively from the sites

168 *)Ph (H* = H, D) with MeI is suggestive of a dissociative mechanism on the basis of DFT calculations.

169 -Ir-Py, undergo degenerate Py exchange via a dissociative mechanism with activation parameters for Ph

170 sters undergo fast transesterification via a dissociative mechanism, caused by internal catalysis of

171 ether these knots arise by a processive or a dissociative mechanism.

172 NMR spectroscopy and are in agreement with a dissociative mechanism.

173 rom cationic Pd(IV) fluoride complexes via a dissociative mechanism.

174 le dagger) = 14(4) eu) are consistent with a dissociative mechanism.

175 library peptide was shown to occur through a dissociative mechanism.

176 hosphoenolpyruvate to phosphonopyruvate by a dissociative mechanism.

177 od sexual abuse (36.4%, n=12), premorbid non-dissociative mental illness (81.1%, n=27) and employment

178 colon carcinoma (HCT-8) cells can exhibit a dissociative, metastasis-like phenotype (MLP) in vitro w

179 ackbone of xyloglucan nonspecifically with a dissociative mode of action and relaxed backbone regiosp

180 ed to as motor conversion disorder (DSM-IV), dissociative motor disorder (ICD-10) and 'psychogenic' p

181 as a manifestation of conversion disorder or dissociative motor disorder.

182 The transition state of E:R-HsPNP is fully dissociative, N7-protonated hypoxanthine (C1'-N9 distanc

183 they are more closely related to the highly dissociative nature of the transition state.

184 photransfer center is asymmetric, poised for dissociative nucleophilic substitution.

185 als the dominating associative path over the dissociative ones.

186 akening the Pt-OOH* bond and suppressing the dissociative OOH* to O* pathway.

187 echanism for prenyltransfer reactions may be dissociative or associative with early to late transitio

188 he intermediary of free protein, and a fully dissociative or jumping mechanism to translocate between

189 Together, this points to dissociative OS-SET (SET to a sigma* orbital concerted w

190 we deduce that the first step of oxidation, dissociative oxygen adsorption, occurs uniformly over ma

191 al deficits in memory retention for temporal dissociative passive avoidance and object recognition me

192 he potential surface for the associative and dissociative paths is very flat and that the relative he

193 ule rupture and re-folding, in which a steep dissociative pathway accounted for the high plateau modu

194 parture of the second anthracene, and (ii) a dissociative pathway in which [P2A] fragments to P2 and

195 tion was enhanced under conditions where the dissociative pathway predominates.

196 rm into the active cis-form occurs through a dissociative pathway with a calculated DeltaH(0 K)() = 3

197 a five-coordinate, 16 electron complex by a dissociative pathway.

198 d 2 preferentially initiate according to the dissociative pathway; for the less bulky olefins (BuVE,

199 ing solvent-dissociative and nondissociative dissociative pathways for the elimination of LiCl and Li

200 ked changes in the relative contributions of dissociative pathways in both cases, compared to the abs

201 ics held true at the inductive, plateau, and dissociative phases of the GC response, suggesting a ste

202 ntrance brings a conserved lysine to trigger dissociative phosphoryl transfer of gamma-phosphate from

203 catalysis follows an in-line, predominantly dissociative, phosphotransfer reaction mechanism, and th

204 ture to 80 K, we have been able to study the dissociative photochemistry of the triiodide anion (I3(-

205 hotofragment coincidence measurements of the dissociative photodetachment (DPD) of the F(-)(H2O) anio

206 emission from a long-lived anionic state and dissociative photodetachment via absorption of a second

207 The photoionization and dissociative photoionization of glycerol are studied exp

208 Furthermore, the dissociative photoionization of the glycerol dimer is in

209 e: increased entropy, characteristic for the dissociative processes, and stereoelectronic influences

210 e found to contribute to the associative and dissociative processes, mimicking naturally occurring re

211 matic differences between these two types of dissociative processes.

212 Abrogation of the tight binding and slow dissociative properties of ITMN-191 is observed with pro

213 ng partial agonism as the main driver of its dissociative properties.

214 )(H2O)n]* activated complexes either undergo dissociative proton transfer, resulting in deprotonation

215 the aromatic ring, which is described as the dissociative protonation site.

216 e exposed to UV photons and other sources of dissociative radiation, and if sufficiently mobile the r

217 er a wide range (5.5-8.9), consistent with a dissociative reaction mechanism that is rate-limited by

218 lg) = -1.6 +/- 0.2, consistent with a highly dissociative reaction mechanism.

219 molecule physisorbed at a surface can induce dissociative reaction of one adsorbate bond.

220 uncovered, and the unexpected discovery of a dissociative reactional center, sheds light on the evolu

221 Here we introduce a strategy to avoid dissociative reactions by including a molecular hot exci

222 data conclusively show that, even for highly dissociative reactions involving beta-close ion pair (be

223 tent with non-homology-induced two rounds of dissociative recombination by Flp, the first to generate

224 ) in diffuse clouds and the recognition that dissociative recombination of H(3)(+) is fast has led to

225 cular the rates of radiative association and dissociative recombination.

226 n-ricin recognition loop of 28S rRNA and the dissociative ribocation transition state established for

227 d be generated along with CO(2) in the usual dissociative route.

228 Methoxy-mediated dissociative routes become prevalent at higher temperatu

229 and computational studies have established a dissociative S(N)1 transition state for Escherichia coli

230 '-(14)C and 9-(15)N) suggest that MTAP has a dissociative S(N)1 transition state with its cationic ce

231 ss new predictions regarding diffraction and dissociative scattering of H2 under such conditions.

232 However, acute dissociative side effects and eventual fading of antidep

233 However, whether ketamine's dissociative side effects are necessary for its antidepr

234 tamine induces undesired psychotomimetic and dissociative side effects that limit its clinical use.

235 ressant efficacy without psychotomimetic and dissociative side effects.

236 but antidepressant effects were preceded by dissociative side effects.

237 We characterize a dissociative single-displacement (S(N)i) mechanism consi

238 Several dissociative singlet states are also observed, correspon

239 [1'-14C] and [9-15N] KIEs indicate a highly dissociative SN1 transition state with low bond order to

240 , a strong preference is observed for a more dissociative solvent-assisted pathway.

241 as a significant increase in measurements of dissociative state after ketamine initiation (p < .05),

242 ubjects produced complex content in a trance dissociative state suggests they were not merely relaxed

243 asures, including the Clinician-Administered Dissociative States Scale, the Brief Psychiatric Rating

244 hiatric Rating Scale, Clinician-Administered Dissociative States Scale, verbal fluency, Hopkins Verba

245 cused on the spiritual experiences involving dissociative states such as mediumship, in which an indi

246 ttachment (DEA) and electronic excitation of dissociative states.

247 ere we provide mechanistic insights into the dissociative steps that follow the initial cycloaddition

248 of the disorder, and a small but distinctly dissociative subgroup that composed 12% of individuals w

249 The molecularity of the dissociative substitution reaction varies, depending on

250 demiologic data documenting the value of the dissociative subtype in distinguishing a meaningful prop

251 Although the proposal for a dissociative subtype of posttraumatic stress disorder (P

252 at excessive or out-of-phase REM sleep fuels dissociative symptomatology.

253 In 'sudden onset' cases, panic (n=29, 59%), dissociative symptoms (n=19, 39%) and injury to the rele

254 mpared to active placebo, except for greater dissociative symptoms and transient blood pressure eleva

255 tly negatively correlated with psychotic and dissociative symptoms at 40 minutes.

256 Fewer dissociative symptoms in both patient groups were associ

257 of careful psychopathological assessment of dissociative symptoms in the entire range of mental diso

258 Dissociative symptoms occurred transiently and attenuate

259 c psychological distress were used to assess dissociative symptoms of depersonalization and derealiza

260 rceptual alterations (Clinician Administered Dissociative Symptoms Scale (CADSS)), and subjective eff

261 rceptual alterations (Clinician Administered Dissociative Symptoms Scale (CADSS)).

262 ve Syndrome Scale and Clinician-Administered Dissociative Symptoms Scale.

263 antly correlated with the psychosis-like and dissociative symptoms under ketamine.

264 ferences between PTSD with and without these dissociative symptoms were examined across a variety of

265 Dissociative symptoms were present in 14.4% of responden

266 posttraumatic stress disorder (PTSD), early dissociative symptoms, depression, and health care utili

267 Trauma-related dissociative symptoms, distinct from PTSD and childhood

268 y impairments in psychiatric conditions with dissociative symptoms, in which individuals feel detache

269 olerated; the most common adverse effect was dissociative symptoms, only at the 40-minute point.

270 The most common side effect was dissociative symptoms, which occurred only at the 40-min

271 ed without clinically significant persistent dissociative symptoms.

272 ed with patients' depressive, psychotic, and dissociative symptoms.

273 es of ketamine correlated with psychotic and dissociative symptoms.

274 The PT-Disk consisted of a dissociative thermoresponsive hydrogel-loaded clip unit

275 n activity as subjects were writing, in both dissociative trance and non-trance states.

276 on-state theory with an assumption of a late dissociative transition state (TS), in which the ligand

277 mplex can be largely accounted for by a late dissociative transition state and the rehydration of B a

278 lization of the native TTR tetramer over the dissociative transition state by small molecule binding

279 participation of the acetyl-lysine, and the dissociative transition state has a significant oxocarbe

280 tcome that is inconsistent with the expected dissociative transition state in which CO(2) forms along

281 ors selectively to the native state over the dissociative transition state or by the introduction of

282 tion of the tetrameric state of TTR over the dissociative transition state raises the kinetic barrier

283 the native tetrameric state of TTR over the dissociative transition state under amyloidogenic condit

284 This pathway proceeds via a dissociative transition state where the C-O bond cleavag

285 sis of MTA by E. coli MTAN involves a highly dissociative transition state with ribooxacarbenium ion

286 eds by a concerted mechanism that involves a dissociative transition state, although the negative cha

287 sis of phosphate monoesters through a loose, dissociative transition state, similar to that in soluti

288 tabilizing the native tetramer more than the dissociative transition state, thereby raising the kinet

289 In the proposed dissociative transition state, which occurs in the close

290 ity for inhibitors that are mimics of a late dissociative transition state.

291 iation, apparently by destabilization of the dissociative transition state.

292 19M) into heterotetramers to destabilize the dissociative transition state.

293 ooxacarbenium mimics, consistent with a more dissociative transition state.

294 piens (Hs) OPRTs are characterized by highly dissociative transition states with ribocation character

295 We have produced the Wigner-Huntington dissociative transition to atomic metallic hydrogen in t

296 t the relative height of the associative and dissociative TS is different in different systems.

297 the phosphorodithioate analogue into a more dissociative type, where the leaving group carries a lar

298 racter of the TS changes from associative to dissociative upon decrease in the pKa of the leaving gro

299 = 2) state that appears at low energy and is dissociative with respect to the Fe-NO bond.

300 racter gradually changes from associative to dissociative with the increasing acidity of the leaving