ライフサイエンスコーパス: dominant-positive

1 ed on fluorescence-activated cell sorting or dominant positive and negative drug selection, and appro

2 nists and antagonists of RhoA activation and dominant positive and negative plasmid constructs demons

3 mary hepatocytes, primary liver macrophages, dominant positive and negative transgenic mice of the C/

4 utinin-tagged plasmids expressing wild-type, dominant-positive, and dominant-negative forms of RhoA i

5 h between these alternatives, we expressed a dominant positive arrestin, arr2(R169E), that desensitiz

6 GRK3-/- neurons following transfection with dominant positive arrestin3-(R170E).

7 Dominant-positive Arrestin3 but not Arrestin2 was suffic

8 found that overexpression of a constitutive dominant positive Cdc42 itself was sufficient to produce

9 HD, approximately 320 amino acids long with dominant positive charge, and its interaction with sulfa

10 ilar to that of mice expressing an E protein dominant-positive construct, ET2, suggesting that the ba

11 h mannose/hybrid N-glycans functioned like a dominant positive displaying increased interaction with

12 e previously shown that an iron-insensitive, dominant-positive dtxR(E175K) mutant allele from Coryneb

13 ests of chimeric molecules revealed that the dominant-positive effect of SynCAM on synaptic function

14 nant-negative effect and gain-of-function (a dominant-positive effect).

15 abilization of the system state by a single, dominant positive feedback.

16 aneously function as a dominant negative and dominant positive for different pathways implies that ef

17 tested by transfecting arrestin3-(R170E), a dominant positive form of arrestin that does not require

18 owever, transfection of arrestin3-(R170E) (a dominant positive form of arrestin that does not require

19 Finally, a dominant positive form of MyoD, one which is tethered to

20 activated by nSREBPs (-1a, -1c, and -2) or a dominant positive form of the SREBP cleavage-activating

21 se a model in which FLT3(ITD/-) represents a dominant positive, gain-of-function mutation providing A

22 discharge of the LTP probe, He(2)(+) is the dominant positive ion when helium is used as the plasma

23 xpression of Munc18b wild-type and, more so, dominant-positive K314L/R315L mutant promoted the assemb

24 es overexpressing LdRab5a, LdRab5b, or their dominant-positive (LdRab5a:Q93L and LdRab5b:Q80L) or dom

25 Using dominant-positive (LdSar1:H74L) and dominant-negative (L

26 o(y)Mn(1-x-y)O(2) (0 < x, y < 1, NCM) is the dominant positive material for the state-of-the-art lith

27 ence, suggesting that the mutation acts by a dominant positive mechanism.

28 Rab1:WT, GFP-LdRab1:Q67L (a GTPase-deficient dominant positive mutant of Rab1), and GFP-LdRab1:S22N (

29 aR truncated at position Pro(379) acted as a dominant positive mutant that down-modulated surface exp

30 role of TR in metamorphosis by developing a dominant positive mutant thyroid hormone receptor (dpTR)

31 sistent with these findings, expression of a dominant-positive mutant of AtRac1 blocked the ABA-media

32 ic pathways is suggested by the facts that a dominant-positive mutant of PAK3 does not alone cause ne

33 Such a change in TPSC leads to the most dominant positive/negative anomalies of TPSC in the foll

34 duced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regula

35 Ectopic expression of Ahr and dominant-positive Nrf2 in Nrf2-/- MEFs also substantiall

36 struct with a variety of plasmids expressing dominant positive or dominant negative mutant proteins i

37 l activity mediated by wild type but not the dominant positive p65 mutant (S536D).

38 cal microscopy and functionally exhibited a "dominant-positive" phenotype, implying positive cooperat

39 Experiments with a dominant positive PKC1 gene showed that the two effects

40 The dominant positive polarity of hilar LFPs was only produc

41 ts are largely without unique effect, except dominant positive Rac1-Q61L, and rapidly cycling Rac1-F2

42 is response can be mimicked by expression of dominant-positive Rac1.

43 Expression in nonhairy cells of a dominant-positive Ras mutant activated the CD11c promote

44 The dominant positive regulator of TSST-1 is the SaeRS two-c

45 location were prevented by overexpression of dominant positive RhoA.

46 Src activation was observed in KSHV-infected dominant-positive RhoA cells compared to wild-type cells

47 Lastly, dominant-positive RhoA(V14) will block the ability of AF

48 trate that aberrant AEG-1 expression plays a dominant positive role in regulating oncogenic transform

49 Our findings elucidate the dominant positive role of RhoB in cancer.

50 In most cases, the dominant positive species is N(4)(+), whereas NO(2)(-) a

51 contrast with previously reported effects of dominant-positive SREBP-1a, which activated fatty acid s

52 We produced transgenic mice that express a dominant-positive truncated form of sterol regulatory el

53 ed in livers of transgenic mice that express dominant-positive versions of all three isoforms of SREB