ライフサイエンスコーパス: dopachrome

1 ct against proteasomal inhibition induced by dopachrome.

2 ctive-catalyzed oxidation of l/d-DOPA to l/d-dopachrome.

3 and (p-hydroxyphenyl)pyruvate and converts D-dopachrome, a stereoisomer of naturally occurring L-dopa

4 catalyzed oxidation to generate aminochrome, dopachrome, and furanoquinone, respectively.

5 rwent tyrosinase-catalyzed oxidation to form dopachrome, and similar to aminochrome, proteasomal inhi

6 The stoichiometric ratio of O(2) uptake to dopachrome formation was 1.5 +/- 0.2 for substrate l-tyr

7 en shown that formation of (HO)2IndCOOH from dopachrome is catalyzed by dopachrome tautomerase, that

8 eceptors, OR) and phenylpyruvate tautomerase/dopachrome isomerase activity (MIF and DDT genes).

9 oxidase, phenol oxidase, and interleukin 1, dopachrome isomerase and other, as of yet unidentified,

10 vity using either p-hydroxyphenylpyruvate or dopachrome methyl ester as substrate.

11 note, molecular modeling of the substrate L-dopachrome methyl ester into the active site of MIF sugg

12 monitoring the tautomerase activity using l-dopachrome methyl ester or 4-hydroxyphenyl pyruvic acid

13 n of the non-naturally occurring D-isomer of dopachrome, phenylpyruvate, and certain catecholamines,

14 and functional similarity, the MIF homolog D-dopachrome tautomerase (also called MIF-2) has low seque

15 r (MIF) protein family consists of MIF and D-dopachrome tautomerase (also known as MIF-2).

16 hage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT or MIF2) play key roles in

17 tic understanding of the MIF homolog MIF-2/d-dopachrome tautomerase (d-DT) and its clinical translati

18 be the protein encoded by the homologous, D-dopachrome tautomerase (D-DT) gene.

19 ally functionally redundant family member, D-dopachrome tautomerase (D-DT), also remains to be furthe

20 ation inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor

21 y factor (MIF) and its functional homolog, d-dopachrome tautomerase (d-DT), have protumorigenic funct

22 rine MIF and its only known family member, D-dopachrome tautomerase (D-DT), promote the expression of

23 For the immunomodulatory protein D-dopachrome tautomerase (D-DT), the mechanism of protein-

24 ew inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutro

25 Plant MIF/D-dopachrome tautomerase (D-DT)-like proteins (MDLs) can i

26 droxyphenylpyruvate dioxygenase (HPPD) and D-dopachrome tautomerase (D-DT); two additional enzymes th

27 iption of a second MIF superfamily member, D-dopachrome tautomerase (D-DT/MIF-2), prompted closer inv

28 Tyrosinase and dopachrome tautomerase (DCT) activities were found exclu

29 DOPAchrome tautomerase (Dct) functions downstream of tyr

30 The melanin synthesis enzyme dopachrome tautomerase (DCT) is involved in intracellula

31 carrying a tyrosinase minigene driven by the dopachrome tautomerase (Dct) promoter region.

32 cell development in transgenic mice from the dopachrome tautomerase (Dct) promoter.

33 inase, tyrosinase-related protein-1 (Tyrp1), dopachrome tautomerase (Dct), and LAMP1 and 3 localizati

34 essing neural precursor cells (line Ntva) or dopachrome tautomerase (DCT)-expressing melanoblasts (li

35 yrosinase-related protein-1 (TYRP1/gp75) and dopachrome tautomerase (DCT/TYRP2) belong to a family of

36 pression of members of the MIF family MIF, D-Dopachrome Tautomerase (DDT) and DDT-like (DDTL) in a lu

37 Recent work by others has described D-dopachrome tautomerase (DDT) as a functional homologue o

38 D-dopachrome tautomerase (DDT) is an enzyme that lacks phy

39 of the role of MIF (and its family member D-dopachrome tautomerase (DDT)) in genitourinary cancers a

40 l-Dopachrome tautomerase (l-DCT), also called tyrosinase-r

41 yrosinase, melanocortin receptor (MC1R), and dopachrome tautomerase (TRP-2).

42 melanocytes, Tyr, Tyr-related protein 1, and dopachrome tautomerase accumulated in enlarged granules

43 also has been described recently to exhibit dopachrome tautomerase activity and to be structurally h

44 yphenylalanine oxidation drop rapidly, while DOPAchrome tautomerase activity increases and dihydroxyi

45 ne is the same as the catalytic site for the dopachrome tautomerase activity of MIF.

46 methyl ester (ISO-1), an inhibitor of MIF d-dopachrome tautomerase activity, reveals that ISO-1 bind

47 igens gp100 and tyrosinase-related protein 2/dopachrome tautomerase and increased protection from a l

48 cell development and pigmentation, including dopachrome tautomerase and tyrosinase.

49 The expression of the dopachrome tautomerase gene (Dct) and its protein produc

50 lite resident within an intron of the bovine dopachrome tautomerase gene.

51 s and for physiological investigations (e.g. dopachrome tautomerase in melanogenesis).

52 nder the regulation of a melanocyte-specific dopachrome tautomerase promoter.

53 enic line with Grm1 expression driven by the dopachrome tautomerase promoter.

54 ge migration inhibitory factor-2 (MIF-2 or D-dopachrome tautomerase) is a recently characterized seco

55 nd of the melanogenic enzymes tyrosinase and dopachrome tautomerase, all major players in melanogenes

56 cy of an enhancer required for expression of dopachrome tautomerase, an enzyme that functions in mela

57 as tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, and Pmel17, are known, the funct

58 rophthalmia-associated transcription factor, dopachrome tautomerase, and tyrosinase promoters, leadin

59 n inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory

60 osinase or on the mRNA levels of tyrosinase, dopachrome tautomerase, Pmel17, or MITF mRNA levels.

61 (HO)2IndCOOH from dopachrome is catalyzed by dopachrome tautomerase, that the melanogenic protein tyr

62 Plants have orthologous MIF and D-dopachrome tautomerase-like (MDL) proteins that mimic so

63 racterized three MIF orthologs (termed MIF/d-dopachrome tautomerase-like proteins or MDLs) of the mod

64 on of an early zebrafish melanoblast marker, dopachrome tautomerase.

65 We identify D-dopachrome tautomerase/macrophage migration-inhibitory f

66 tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and

67 tion genes, tyrosinase-related protein 1 and Dopachrome-tautomerase have lower protein levels in NPC1

68 hat these basic residues are not involved in dopachrome tautomerization.

69 of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHI

70 ome, a stereoisomer of naturally occurring L-dopachrome, to 5,6-dihydroxyindole-2-carboxylic acid.

71 inhibition correlated with the presence of a dopachrome UV-visible spectrum.