ライフサイエンスコーパス: dorsal column

1 T) axons descends in the ventral part of the dorsal column.

2 ensory functions, associated with the spinal dorsal column.

3 t collaterals in Lissauer's tract and in the dorsal column.

4 ch express TRPV1 in Lissauer's tract and the dorsal column.

5 3 compared with the contralateral unlesioned dorsal column.

6 cal injections of S-AMPA or NMDA into lumbar dorsal columns.

7 3b after complete or partial lesions of the dorsal columns.

8 axonal loss in the corticospinal tracts and dorsal columns.

9 be explained by conduction delays within the dorsal columns.

10 neurons in the corticospinal tracts and the dorsal columns.

11 more similar to peripheral nerve than intact dorsal columns.

12 gray matter rather than in the degenerating dorsal columns.

13 illimeters rostral to a severe lesion of the dorsal columns.

14 ollowing the onset of anoxia in demyelinated dorsal columns.

15 ses in immunostaining in the gray matter and dorsal columns.

16 llum, brainstem, spinocerebellar tracts, and dorsal columns.

17 ining was also prominent along the ascending dorsal columns.

18 infused with vehicle for two weeks into the dorsal column, 3 mm rostral to the nerve graft, essentia

19 Following a partial section, the remaining dorsal column afferents continue to activate neurons wit

20 Here, we unilaterally sectioned dorsal column afferents in the cervical spinal cord (C4-

21 er large but incomplete lesions of ascending dorsal column afferents in the cervical spinal cord, the

22 It has long been thought that dorsal column afferents of the spinal cord represent the

23 ion-induced enhanced regeneration of injured dorsal column afferents.

24 macrophages in axonal retraction within the dorsal columns after spinal cord injury in vivo and foun

25 ter near the crush site and in the ascending dorsal column also exhibited increased Mac1 staining tha

26 ceptors to the brain through the spinal cord dorsal column and its brainstem target, the dorsal colum

27 spinal segments in Lissauer's tract and the dorsal column and regulate motor activity.

28 ion, including somatosensory inputs from the dorsal column and spinal trigeminal nuclei.

29 eptive fields of spinocervical, postsynaptic dorsal column and spinothalamic tract neurons was used t

30 nkeys with chronic unilateral lesions of the dorsal columns and expanded chin representation, connect

31 he injury, HO-1 was primarily induced in the dorsal columns and occasionally in the lateral white mat

32 lso severely affected, with shrinkage of the dorsal columns and reduction in the number of neurones i

33 f the main dorsal corticospinal tract in the dorsal columns and some damage to the adjacent medial pa

34 expressed in the synaptic terminations from dorsal columns and trigeminal brainstem nuclei, the effe

35 In 6 experiments, dorsal columns and ventrolateral funiculi were sequentia

36 rocesses were seen along fiber tracts in the dorsal columns and, after intracerebral injection, subja

37 important relays for indirect, postsynaptic dorsal column, and direct ascending pathways, respective

38 ns fail to cross the midline to the opposite dorsal column as normal.

39 ted into the superficial dorsal horn and the dorsal columns, as well as across the dorsal commissure.

40 lcium transients within Lissauer's tract and dorsal column at L5 segments when compared to the calciu

41 ipolar ball electrode was placed on the left dorsal column at lumbar spinal cord segments 2-3 in sodi

42 We found that stimulating the dorsal column at the L2 spinal segment at 0.6 mA at eith

43 ed to the calcium transients only within the dorsal column at the lumbar 2 (L2) segments, which were

44 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal cord segments (L2

45 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal cord segments (L2

46 ipolar ball electrode was placed on the left dorsal column at the lumbar 2-3 spinal segments in rats.

47 Lesions of the dorsal columns at a mid-cervical level render the hand r

48 dorsal hemisection promotes regeneration of dorsal column axons across and beyond the lesion site in

49 This same compound promotes regeneration of dorsal column axons after acute lesions and potentiates

50 hwann cell-mediated remyelination of central dorsal column axons and whether Nrg1 ablation influences

51 lted in the total failure in regeneration of dorsal column axons consequent on the lack of GAP43 upre

52 h wild-type DRG neurons, and regeneration of dorsal column axons does not occur after a conditioning

53 Furthermore, regeneration of dorsal column axons does not occur after a conditioning

54 ditioning lesion of the peripheral branch of dorsal column axons is a well-known paradigm enabling th

55 ing cells, suggesting that the retraction of dorsal column axons is not a secondary effect of increas

56 db-cAMP results in extensive regeneration of dorsal column axons lesioned 1 week later.

57 Dorsal column axons of the rat spinal cord are partially

58 sal column crush resulted in regeneration of dorsal column axons up to and beyond the injury site int

59 utcomes of previous studies, regeneration of dorsal column axons was compared following transplants o

60 leus of rats partially denervated of forepaw dorsal column axons was examined.

61 n and the electrophysiological properties of dorsal column axons were characterized after transplanta

62 cal doses, both in vivo and in vitro, to rat dorsal column axons which had been experimentally demyel

63 romote regeneration of subsequently lesioned dorsal column axons.

64 and functional remyelination of demyelinated dorsal column axons.

65 he spinal cord and profound demyelination of dorsal column axons.

66 n dorsal root ganglia after sciatic nerve or dorsal column axotomy.

67 yelinated central axons, particularly in the dorsal columns, become associated with peripheral myelin

68 thin 12 min of the onset of anoxia in normal dorsal columns, but was not abolished until 50 min follo

69 ating lesions were induced in the rat spinal dorsal column by microinjection of lipopolysaccharide, a

70 focal demyelination in the mouse spinal cord dorsal column by microinjection of lysophosphatidylcholi

71 We found that the dorsal column cerebrospinal-fluid-normalized magnetizati

72 12.2% of control amplitude) in demyelinated dorsal columns compared to controls (30.8 +/- 5.3%) foll

73 Attenuation of dorsal column compound action potentials was ameliorated

74 Our in vivo analysis of dorsal column crush lesions confirms the close associati

75 el of axonal dieback as well as an adult rat dorsal column crush model of spinal cord injury, we foun

76 Using either spinal cord dorsal column crush or contusion injury models, miR-155

77 to the sciatic nerve 1 week before bilateral dorsal column crush resulted in regeneration of dorsal c

78 In addition, a minor dorsal column CST projection was identified.

79 Specifically, we modeled the dorsal column (DC) axonal response, dorsal column nucleu

80 or spinal cord corticospinal tract (CST) and dorsal column (DC) axons in both monophasic (C57/BL6 mic

81 mation (MRF) neurons after acute and chronic dorsal column (DC) lesions of the T8 spinal cord and los

82 a visceral pain pathway that ascends in the dorsal column (DC) of the spinal cord.

83 ctal distension (CRD), whereas lesion in the dorsal column (DC) reverses this neuronal sensitization,

84 y by forming neuronal relays between injured dorsal column (DC) sensory axons and the denervated dors

85 Here, we show that the dorsal column (DC) somatosensory pathway contains projec

86 collaterals of dorsal root axons within the dorsal column (DC) was studied after neonatal spinal ove

87 The dorsal column (DC) white matter, for example, is the spi

88 atter (VGM), ventral white matter (VWM), and dorsal columns (DC) at levels ranging 15 mm rostral and

89 sneuronal atrophy occurred in neurons of the dorsal column (DCN) and ventral posterior lateral thalam

90 that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epile

91 Selective lesions of the spinal dorsal columns did not affect either of these types of r

92 In NG2 knock-out mice, sensory axons in the dorsal columns dieback further than their control counte

93 The transplanted dorsal columns displayed improved conduction velocity an

94 Here, we determined how transections of the dorsal columns done within a few days after birth affect

95 set blindness, cerebellar ataxia, nystagmus, dorsal column dysfuction, and spasticity with upper moto

96 rized by progressive spasticity, ataxia, and dorsal column dysfunction, and is considered a primary a

97 Thus, LTMR and PSDC subdivisions of the dorsal column encode different tactile features and diff

98 er spinal pathways do not substitute for the dorsal columns even after injury.

99 my, DTI revealed a lesion in the ipsilateral dorsal column extending from the lumbar to the cervical

100 However, tracing of ascending dorsal column fibres showed that few regenerated beyond

101 ere used to record field potentials from the dorsal columns following distal local surface stimulatio

102 hich the main contingent of CST axons in the dorsal column had been transected.

103 and behavioural consequences of cutting the dorsal column have been reported to range from mild and

104 l cord of adult rats or the injury site in a dorsal column hemisection model of spinal cord injury, a

105 ithin weeks after a unilateral lesion of the dorsal column in squirrel monkeys.

106 on reduced immunostaining of the ipsilateral dorsal columns in segments rostral to the lesion and in

107 Injections of BMP4 or BMP7 into the dorsal columns in the absence of demyelination led to in

108 ave re-examined this issue by sectioning the dorsal columns in the cervical region and recording the

109 that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in

110 ripheral nerve graft bridging the transected dorsal columns in the thoracic spinal cord resulted in a

111 d axons, we studied axonal conduction in rat dorsal columns in vitro following a 60-min period of ano

112 ed deafferentation lesion model (dorsal root/dorsal column) in male monkeys to remove sensory input f

113 o examine the spinal cord in rats with focal dorsal column inflammatory or demyelinating lesions to d

114 what extent this brain reorganization due to dorsal column injuries is related to axonal sprouting is

115 ndergo severe atrophy 4 weeks after thoracic dorsal column injury and that ChABC is neuroprotective f

116 onditioning lesion 1 or 2 weeks prior to the dorsal column injury results in growth into the spinal c

117 l pattern of callosal connections depends on dorsal column input and not on normal interhemsipheric i

118 d hemisection at C(2) (C(2) SH), sparing the dorsal column is widely used to investigate the effects

119 hese receptors 4-5 months following either a dorsal column lesion (DCL) or a combined dorsal root/dor

120 at following a combined cervical dorsal root/dorsal column lesion (DRL/DCL), both motor and S1 CSTs s

121 sal root lesion (DRL), (2) or a combined DRL/dorsal column lesion (DRL/DCL), or (3) a DRL/DCL where t

122 olumn lesion (DCL) or a combined dorsal root/dorsal column lesion (DRL/DCL), when functional recovery

123 , the relationship between the extent of the dorsal column lesion and the amount of cortical reactiva

124 luation of total soluble CSPGs 2 weeks after dorsal column lesion in the rat demonstrated that NG2 is

125 on across the monkeys shows that even if the dorsal column lesion is partial, preserving most of the

126 omoted by olfactory cell transplants after a dorsal column lesion.

127 ort bridging of corticospinal axons beyond a dorsal column lesion.

128 gracilis was blocked by dorsal rhizotomy or dorsal column lesion.

129 lls results in functional remyelination of a dorsal column lesion.

130 g and grasping function following a cervical dorsal column lesion.

131 to spontaneously regenerate in vivo after a dorsal column lesion.

132 ry cortex confirmed the effectiveness of the dorsal column lesion.

133 in the area 3b hand cortex of monkeys after dorsal column lesions (DCLs) in the cervical spinal cord

134 cortex were more widespread after incomplete dorsal column lesions (DCLs) than after a complete DCL.

135 ntly higher acutely than those of LINGO-1 in dorsal column lesions and reduced in models of dorsal ro

136 eorganization of digit representations after dorsal column lesions and reveals differences between fu

137 Dorsal column lesions at a high cervical level deprive t

138 mus are affected by long standing unilateral dorsal column lesions at cervical levels in macaque monk

139 cuneate nucleus that survives high cervical dorsal column lesions by traveling in the lateral funicu

140 In dorsal column lesions of adult rats treated with the Gel

141 itory protein, CD59 (hCD59), into transected dorsal column lesions of the spinal cord of the immunosu

142 the near-completeness of the more extensive dorsal column lesions we studied, we suggest that altern

143 Dorsal column lesions were placed at a spinal cord level

144 In three other squirrel monkeys, unilateral dorsal column lesions were placed at the cervical segmen

145 After dorsal column lesions, all fibers stop at the injury sit

146 nucleus through pathways that circumvent the dorsal column lesions, contributing to cortical reactiva

147 on and ethidium bromide-induced demyelinated dorsal column lesions, with or without co-transplantatio

148 f the brain reorganization immediately after dorsal column lesions.

149 ith dorsal hemisection lesions as opposed to dorsal column lesions.

150 ected in the larger size of both primary and dorsal column lesions.

151 ronal system with dendrites that embrace the dorsal columns like palisades is observed.

152 the few spared primary axon afferents in the dorsal columns, likely have a major role in the reactiva

153 white matter edema in L3-L5 localized to the dorsal column medial lemniscus area associated with loss

154 tly different at each of these levels of the dorsal column-medial lemniscal pathway.

155 are found: 1) ascending ipsilaterally in the dorsal column near the dorsal intermediate septum or the

156 that distinguish ventral, intermediate, and dorsal column neuroectoderm and neuroblasts, and a cell

157 nts have a transformation of intermediate to dorsal column neuroectoderm fate, and only 10% of the in

158 m dorsal root ganglions to a small number of dorsal column neurons, a caudal extension of nucleus gra

159 Following a complete section of the dorsal columns, neurons in area 3b become immediately an

160 The mammalian dorsal column nuclei (DCN) are principally composed of t

161 Tactile receptive fields (RFs) of brainstem dorsal column nuclei (DCN) neurons rapidly enlarge when

162 ance P receptor binding was localized in the dorsal column nuclei (DCN) of the rat, cat, monkey, and

163 sizes and plasticity of RFs in the brainstem dorsal column nuclei (DCN) when peripheral inputs were n

164 dorsal column and its brainstem target, the dorsal column nuclei (DCN)(1,2).

165 citatory inputs from the trigeminal complex, dorsal column nuclei (DCN), spinal cord and superior col

166 column (DC) sensory axons and the denervated dorsal column nuclei (DCN).

167 mn nuclei complex (DCN-complex) includes the dorsal column nuclei (DCN, referring to the gracile and

168 cluding excitatory projection neurons of the dorsal column nuclei and for vital components of the int

169 The dorsal column nuclei are large and distinct.

170 These results suggest that the dorsal column nuclei can participate in persistent pain

171 The dorsal column nuclei complex (DCN-complex) includes the

172 Lesions of the dorsal column nuclei did not affect the climbing fibre r

173 on of labeled neurons in the spinal cord and dorsal column nuclei following injections of Fluoro-Gold

174 Based on their anatomical connections, the dorsal column nuclei may contribute to thalamic changes

175 luded the effects of TEA and 4-AP in NTS and dorsal column nuclei neurones, but not in dorsal vagal n

176 or circular immunostained structures in the dorsal column nuclei of old cats.

177 axonal accumulation of neurofilaments in the dorsal column nuclei of the cat by using immunohistochem

178 Although the dorsal column nuclei receive both primary afferent input

179 t in mammals, involving projections from the dorsal column nuclei to the thalamus, and thence to soma

180 ed with somatosensory function, although the dorsal column nuclei were also labelled above control.

181 ory inputs from the somatosensory cortex and dorsal column nuclei were found to terminate almost excl

182 About half the neurons in the rat dorsal column nuclei were immunopositive for glycine or

183 s are PSDC neurons that project to brainstem dorsal column nuclei, and chemogenetic activation of Zic

184 ory pathways originating in the dorsal horn, dorsal column nuclei, and trigeminal nuclei, and the oth

185 in segments rostral to the lesion and in the dorsal column nuclei, presumably from the loss of ascend

186 uded neurons in sensory pathways such as the dorsal column nuclei, the area postrema, the spinal trig

187 ponses were not exclusively mediated via the dorsal column nuclei.

188 imary afferents that project directly to the dorsal column nuclei.

189 ine is an inhibitory neurotransmitter in the dorsal column nuclei.

190 r crest, in the solitary nucleus, and in the dorsal column nuclei.

191 terminate within discrete subdomains of the dorsal column nuclei.

192 eled the dorsal column (DC) axonal response, dorsal column nucleus (DCN) synaptic transmission, condu

193 n to examine the physiological properties of dorsal column nucleus neurons during persistent pain.

194 cord send long ascending projections to the dorsal column nucleus that are important in the transmis

195 bulbs, optic tectum, octavolateral area, and dorsal column nucleus, and it innervates, apart from the

196 and medial nuclei of the octavolateral area, dorsal column nucleus, solitary tract nucleus, motoneuro

197 (SpVi) and subnuclei caudalis (SpVc) and the dorsal column nucleus-based lemniscal and cortical pathw

198 leus, nucleus of the solitary tract, and the dorsal column nucleus.

199 tion potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating

200 progressive loss of myelin in the brain and dorsal column of the spinal cord associated with increas

201 vagus nerve, and in the motor neurons of the dorsal column of the spinal cord.

202 vented degeneration of sensory fibers in the dorsal column of the spinal cord.

203 that were originally designed to target the dorsal column of the spinal cord.

204 igalacto-cerebroside, are implanted into the dorsal columns of 4-8 d rat spinal cord, some of the mye

205 ult CNS, ES cells were transplanted into the dorsal columns of adult rat spinal cord 3 days after che

206 Dorsal columns of adult rat spinal cords were demyelinat

207 The dorsal columns of adult rats were injected with lysoleci

208 d chondroitinase ABC (ChABC) to the lesioned dorsal columns of adult rats.

209 in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous ge

210 d severely impaired axonal conduction in the dorsal columns of global Nrg1 mutants (where Schwann cel

211 the X-irradiation/ethidium bromide lesioned dorsal columns of immunosuppressed Wistar rat.

212 marker of axonal injury, in the spinal cord dorsal columns of mice with EAE.

213 are expressed in ventral, intermediate, and dorsal columns of neuroectoderm, respectively.

214 ound demyelinating phenotype observed in the dorsal columns of Nrg1 mutant mice is related to conduct

215 ins of adult monkeys with chronic lesions of dorsal columns of spinal cord at cervical levels undergo

216 To examine this issue, the dorsal columns of the adult rat spinal cord were demyeli

217 omatosensory afferents as they ascend in the dorsal columns of the cervical spinal cord.

218 cells were transplanted into the transected dorsal columns of the rat spinal cord to induce axonal r

219 Lesions of the dorsal columns of the spinal cord in adult macaque monke

220 the ascending afferents from the hand in the dorsal columns of the spinal cord in monkeys is followed

221 ucleus in adult monkeys after lesions of the dorsal columns of the spinal cord or therapeutic amputat

222 To address this possibility, the dorsal columns of the spinal cord were sectioned between

223 but the central branch, which courses in the dorsal columns of the spinal cord, does not.

224 after section of ascending afferents in the dorsal columns of the spinal cord, it reorganizes to ove

225 imb in monkeys because of transection of the dorsal columns of the spinal cord, therapeutic amputatio

226 educed, number of corticospinal axons in the dorsal columns of the spinal cord.

227 ns, with higher signal intensity than in the dorsal columns on axial rAMIRA images.

228 Lesions of dorsal column or lateral habenula (LHb) prevented the in

229 ty is achieved by ipsilateral lesions of the dorsal columns or lidocaine microinjection into the nucl

230 Rats with incomplete lesions that spared the dorsal column pathway on the left side but not the right

231 own that the gracile nucleus in postsynaptic dorsal column pathway plays an important role in conveyi

232 ns were normal along both the trigeminal and dorsal column pathways.

233 s achieved through a boosted growth state of dorsal column projecting sensory neurons.

234 Postsynaptic dorsal column (PSDC) neurons transmit noxious visceral i

235 However, postsynaptic dorsal column (PSDC) neurons within the spinal cord dors

236 les dynamic, flexible tuning of postsynaptic dorsal column (PSDC) output neurons and dictates how neu

237 neurons that contribute to the postsynaptic dorsal column (PSDC) pathway transmitting tactile inform

238 Bilateral lesions of the dorsal columns reduced the size of the brainstem nuclei

239 neurons, but not their central axons in the dorsal columns, regenerate after injury.

240 system axons of the corticospinal tract and dorsal columns, respectively.

241 on of long axons in corticospinal tracts and dorsal columns, resulting in spasticity and difficulty w

242 axons in mice with selective lesions of the dorsal column revealed that DLCST axons arborize extensi

243 sh motor output longitudinally after a C3/C4 dorsal column SCI that bilaterally ablated the dorsal co

244 After dorsal column SCI, miR-155 KO mouse spinal cord has redu

245 after severely disrupting afferent inputs by dorsal column section.

246 s includes methods for injury and tracing of dorsal column sensory and corticospinal axons; clearing

247 Previous studies have shown that injured dorsal column sensory axons extend across a spinal cord

248 infusions through a lumbar puncture rescued dorsal column sensory axons innervating the nucleus grac

249 s underwent C3 lesions to transect ascending dorsal column sensory axons, and autologous bone marrow

250 By in vivo two-photon imaging of spinal dorsal column sensory axons, we systematically examined

251 eration of several spinal systems, including dorsal column sensory, regionally projecting propriospin

252 etrated control fibroblast grafts, including dorsal column sensory, rubrospinal, and nociceptive axon

253 One to 3 months later, long-projecting dorsal-column sensory axons regenerated into and beyond

254 stepwise multiple regression showed that the dorsal column signal and diagnosis subtype alone explain

255 A complete unilateral lesion of the dorsal column somatosensory pathway in the upper cervica

256 Adult rats underwent bilateral dorsal column spinal cord lesions that remove the dorsal

257 ation, whereas their broad activation at the dorsal column still alleviated mechanical hypersensitivi

258 dorsal half, Ia fibers entering through the dorsal columns still grew ventrally within the host dors

259 Here, we propose a semi-invasive method, Dorsal Column Stimulation (DCS) as a tool for transferri

260 atest changes in cutaneous blood flow during dorsal column stimulation (DCS).

261 We propose that dorsal column stimulation might become an efficient and

262 In contrast, dorsal column subcortical paw representation areas that

263 sted in neurology to assess the state of the dorsal column system.

264 spinal cord lesion, even when <1% of labeled dorsal column terminations in the cuneate nucleus remain

265 he central branch of the same neurons in the dorsal column, these central axons will regenerate and,

266 A dorsal column transection between the C6-C7 dorsal root

267 al tract axons into spinal gray matter after dorsal column transection SCI.

268 s of axon injury and regeneration, including dorsal column transection, dorsal root rhizotomy and per

269 ory-evoked potentials that disappeared after dorsal column transection.

270 epicenter in spinal cord after a concomitant dorsal column transection.

271 c organization of the gracile nucleus of the dorsal column-trigeminal complex, neuroanatomical tracer

272 ascin-C-rich dorsal root entry zone into the dorsal column up to C1 level and above (>25 mm axon leng

273 jury from both sides including epicenter and dorsal column was microdissected and used for further st

274 ion, inflammatory cell infiltration into the dorsal columns was reduced in phenytoin-treated mice wit

275 border, preferentially including the ventral dorsal column watershed.

276 The dorsal columns were removed and maintained in an in vitr

277 The dorsal columns were removed and maintained in an in vitr

278 Dorsal columns were transected between the 3rd and 12th

279 phosphorylated NFs of the small axons in the dorsal columns were widely spaced, suggesting that phosp

280 ndary lesion extending rostrocaudally in the dorsal columns (where long ascending and descending fibe

281 increased radial diffusivity (+20.5%) in the dorsal column, while FA was lower in the lateral (-10.3%

282 of the graft had grown up to 0.5 mm into the dorsal column white matter, 30+/-2% up to 1 mm, 19+/-3%

283 d injury, sensory neurons that course in the dorsal columns will regenerate, presumably because their