ライフサイエンスコーパス: dosage form

1 , despite the differences in the formulation/dosage form.

2 payload from a small, portable and discreet dosage form.

3 elivery clearance controlled by the designed dosage form.

4 ine the impact of in vitro parameters on the dosage form.

5 om the body controlled by clearance from the dosage form.

6 on in vivo drug release mechanisms for this dosage form.

7 e the wider adoption of this patient-centric dosage form.

8 drugs in a children-friendly, flexible solid dosage form.

9 the area of this complex controlled release dosage form.

10 capsule content and design and the delivered dosage form.

11 nsions from microns to the size of the final dosage form.

12 s when developing an oral controlled release dosage form.

13 to the once-a-day injection of the solution dosage form.

14 felodipine at different locations within the dosage form.

15 strated via analysis of pharmaceutical solid dosage forms.

16 a acceptance criteria for different APIs and dosage forms.

17 countries, indications, subpopulations, and dosage forms.

18 n explored chiefly for oral extended-release dosage forms.

19 related factors influencing the use of these dosage forms.

20 e the investigated drugs in their commercial dosage forms.

21 al classification in spatially heterogeneous dosage forms.

22 ofiles that are typically achieved for these dosage forms.

23 lternative to conventional immediate-release dosage forms.

24 justing for drug shortages, market size, and dosage forms.

25 considerable potential for patient-specific dosage forms.

26 dominates the mechanical properties of solid dosage forms.

27 riate formulation design of the conventional dosage forms.

28 ioxidant activity that is present in various dosage forms.

29 f phage cocktails in specific pharmaceutical dosage forms.

30 ion in spiked human serum and pharmaceutical dosage forms.

31 re development of IVIVC for complex non-oral dosage forms.

32 m and expulsion of conventional soluble drug dosage forms.

33 rent manufacturers and formulated in various dosage forms.

34 readily amenable to the development of solid dosage forms.

35 ies may use DBP or DEP as excipients in oral dosage forms.

36 ated via an analysis of pharmaceutical solid dosage forms.

37 A single gastric resident dosage form achieves an AUC equivalent to 7 daily treatm

38 nous or NG route followed by the alternative dosage form after a 72-hr washout period.

39 t microparticles were also formulated in two dosage forms, an aqueous suspension and a dry tablet, to

40 , causing slowed dissolution of the marketed dosage form and compromising the oral bioavailability of

41 es those CQAs that are most pertinent to the dosage form and that will likely require bespoke test me

42 llent excipient for formulation of classical dosage forms and advanced drug delivery systems.

43 e dose frequencies, complicated by different dosage forms and instructions, and associated with subse

44 cts is important both for rational design of dosage forms and subsequent quality control during manuf

45 to satisfy regulatory requirements for nasal dosage forms and the polymer nanoparticles alone were fo

46 licability of the analysis to pharmaceutical dosage forms and urine sample were also investigated.

47 ity attributes (CQAs) are identified for the dosage form, and a prioritisation exercise identifies th

48 in its bulk powder, different pharmaceutical dosage forms, and biological fluids (plasma and urine) u

49 in its bulk powder, different pharmaceutical dosage forms, and biological fluids (plasma and urine).

50 there is limited in vivo data on 3D printed dosage forms, and no studies to date have been performed

51 cokinetic models were developed for both the dosage forms, and simulations were performed for differe

52 ably formulated as liquids, gels, solid-oral dosage forms, and so forth, could significantly enhance

53 ms present which result in poor retention of dosage forms, and the potential for irritation and other

54 Pharmaceutical drug dosage forms are critical for ensuring the effective and

55 Conventional adult dosage forms are often not suitable for the paediatric a

56 n the avocado pulp powder demonstrating both dosage forms as potential dietary sources of avocado PFA

57 n of distigmine bromide (DB) in its pure and dosage forms as well as its degradation kinetics by cont

58 peutic proteins are rarely available in oral dosage form because the hostile environment of the human

59 learance compounds, where clearance from the dosage form becomes the drug clearance from the patient.

60 predictive design of immediate-release solid dosage forms by tailoring microstructures, and could be

61 ulation development, as both oral and rectal dosage forms can encounter challenges if the colon's dis

62 velopments are crucial to meet demands where dosage forms cannot be manufactured rapidly or when a pe

63 esholds for the maximum number of oral solid dosage forms children at different ages can take.

64 olonic targeting, as they can be utilised as dosage form coatings that are selectively digested by th

65 The paper discusses classification of the dosage form (combination/medicinal product), the regulat

66 s for fast field screening of pharmaceutical dosage forms containing beta lactam antibiotics or combi

67 Additionally, for drug dosage forms containing multiple controlled-release pell

68 medicinal applications, mainly through oral dosage forms (decoctions and infusions).

69 Tomato purees supplemented with dosage forms derived from Nannochloropsis showed higher

70 wettability must be considered in practical dosage form design.

71 quality control (QC), and inspire innovative dosage-form design.

72 tion of crystal form impurities in the solid dosage forms development pipeline.

73 total MRCI score is composed of 3 subscores (dosage form, dose frequency, and specialized instruction

74 itical role in the characterization of solid dosage forms due to its capabilities of chemical identif

75 Among various LAI dosage forms (e.g., crystalline aqueous suspensions, imp

76 (API) and was analyzed in a tabulated solid dosage form, embedded within commonly used excipients.

77 The melt-processed polymeric cellular dosage forms enable predictive design of immediate-relea

78 f feasibility of developing solid and liquid dosage forms, first-pass metabolism, high dosing frequen

79 An oral dosage form for biologic medications is ideal; however,

80 that MNs are a potential minimally invasive dosage form for delivering FENR, offering a new approach

81 drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually

82 low for packing this gaseous molecule into a dosage form for the goal of "carbon monoxide in a pill."

83 d microbial therapeutics as a potential oral dosage form for the treatment of inflammatory bowel dise

84 provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

85 gnosis and monitoring, and gastric-retentive dosage forms for prolonged drug delivery-typically incor

86 prolong drug delivery, or enable alternative dosage forms for the management of diabetes.

87 rs and healthcare workers prefer oral liquid dosage forms for young children, and had similar thresho

88 rs ago, the instability of proteins in these dosage forms has prevented their clinical use.

89 Establishing an IVIVC for non-oral dosage forms has remained extremely challenging due to t

90 lung, colon and breast cancer in its liquid dosage form, has been selected to develop injectable nan

91 ance in in vitro and in vivo, and inhalation dosage forms, highlighting design strategies to overcome

92 e development of an effective and controlled dosage form, i.e., in situ nasal gel for brain targeting

93 rt channels can be adopted in the designs of dosage forms, implants or stents to enhance the release

94 ehicles, and highlight the importance of the dosage form in microbicide effectiveness.

95 ions of IVIVC for extended release (ER) oral dosage forms in 1997, IVIVC has been one of the most imp

96 e provides an exciting opportunity to tailor dosage forms in a single-step with minimal excipients an

97 n phase behavior of multicomponent amorphous dosage forms, in particular those containing poorly wate

98 However, these dosage forms, in particular, are poorly retained and tra

99 s that are particularly pertinent to the MAP dosage form include the specifications of the finished p

100 d delivery systems, yet dynamic structure of dosage form intrinsically plays an unknown role.

101 Conventional immediate release dosage forms involve compressing the powder with a disin

102 When the solid dosage form is encapsulated, for example by the porous w

103 inistration of protein therapeutics in solid dosage form is gaining popularity due to its benefits, s

104 ever the regulatory science of this emerging dosage form is immature and explicit regulatory guidance

105 nabinoid-derived products, available as oral dosage forms is a significant progress already.

106 inkjet printing to produce drug loaded solid dosage forms is demonstrated using a naturally derived F

107 e time of drug release, from as large as the dosage form itself to as small as the thickness of the c

108 with data being collected directly from the dosage form itself.

109 TDT 067 is a novel carrier-based dosage form (liquid spray) of 15 mg/ml of terbinafine in

110 critical in designing processes for powdered dosage form manufacturing, with high spatial variance po

111 Most of the 48 NDAs evaluated were for new dosage forms (n = 25 [52.1%]) or new formulations (n = 9

112 oods that are generally sold in medicinal or dosage forms not usually associated with food which is d

113 aggregation during the production of a solid dosage form of a single variable domain on a heavy chain

114 rams are underway for a new modified release dosage form of tacrolimus (MR-4), a new analog of leflun

115 rincipal matrix ingredient in the injectable dosage form of the drug, Cremophor EL (polyethoxylated c

116 contribute more insight on the impact of the dosage form of the photoautotrophic microalga Nannochlor

117 Three different dosage forms of Nannochloropsis were compared to commerc

118 f these challenges allowed emergence of oral dosage forms of peptide-based drugs in clinical settings

119 ay provide a generic format for once-a-month dosage forms of potent drugs.

120 However, the impact of the dosage form on the enrichment of food products with n-3

121 printing to manufacture a multi-active solid dosage form or so called polypill.

122 'Wrong Drug', 'Wrong Dosage Form or Technique or Route', and 'Improper Dose/D

123 utions (28 of 45 [62.2]%) involved different dosage forms or different strengths of the same drug and

124 niosomes can then be further processed into dosage forms or incorporated into functional foods.

125 4 errors, 12.1%), using the wrong drug name, dosage form, or abbreviation (total of 79 errors, 11.4%,

126 d nomenclature factors (incorrect drug name, dosage form, or abbreviation) (93 errors, 13.4%).

127 Among the various dosage forms, oral medicine has extensive benefits inclu

128 (IQR) counts for the subscores were 6 (4-7) dosage forms per patient, 7 (5-9) dose frequencies per p

129 inistered drugs is a critical factor guiding dosage form selection in drug development.

130 ll provide a platform for the development of dosage form specific guidance (from regulatory authoriti

131 h-resolution structures in small-dimensional dosage forms such as subcutaneous implantable drug deliv

132 he development of IVIVC for complex non-oral dosage forms (such as parenteral polymeric microspheres/

133 The mechanism of drug release from complex dosage forms, such as multivesicular liposomes (MVLs), i

134 The present immediate-release solid dosage forms, such as the oral tablets and capsules, com

135 l formulation of the active molecules into a dosage form suitable for the physiological environment.

136 of memantine hydrochloride is the first oral dosage form that achieves multi-day drug release with ne

137 oneedle Array Patches (MAPs) are an emerging dosage form that creates transient micron-sized disrupti

138 ent of a preclinical in situ-forming implant dosage form that provides sustained release of a novel c

139 The development of oral dosage forms that can be infrequently dosed, and therefo

140 In this article, we introduce cellular dosage forms that can be readily prepared from polymeric

141 n has been limited by the lack of convenient dosage forms that can quickly and stably deliver mAbs wi

142 n in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on

143 In contrast to oral dosage forms, there is currently no clear consensus on a

144 , in the long-acting subcutaneous injectable dosage form TLC-ART 101, lopinavir persisted in plasma f

145 etention requires physical resistance of the dosage form to gastric emptying forces, which are known

146 This is the first vaginal dosage form to provide sustained delivery of milligram q

147 This allows the cellular dosage forms to achieve drug release rates over an order

148 croscopy to produce chemical images of solid dosage forms, typically in troubleshooting roles.

149 cess development of orally delivered protein dosage forms, ultimately enhancing their efficacy and st

150 n significant advances in controlled release dosage forms used for contraception.

151 ion have hampered full capitalization of the dosage forms vast benefits.

152 o 20.5), and more likely to have one or more dosage forms voluntarily discontinued by the manufacture

153 Release of antibiotic from PCL-PVP dosage forms was shown over 5 days and was slower compar

154 sodium (EC-MPS) and sirolimus (SRL) in oral dosage forms was well-preserved.

155 Using a novel hydrogel dosage form, we demonstrate that the use of sub-micron g

156 cyclophosphamide, ifosfamide, and leucovorin dosage forms were collected both covertly and overtly fr

157 contraceptive use (37 012 [22.3%]), and oral dosage forms were the most common (27 069 [73.1%]).

158 251 samples of chemotherapy drugs (dosage forms) were collected between April 6, 2023, and

159 Swallowing oral solid dosage forms whole or crushing/dissolving them and mixin

160 ntegrated fiber microneedle devices, an oral dosage form with tunable geometries and material configu

161 ion in spiked human serum and pharmaceutical dosage forms with acceptable recovery values.

162 olume along with repeated submergence of the dosage form within the disintegration medium.