ライフサイエンスコーパス: dose-response

1 hich can operate to create an ultrasensitive dose response.

2 The effect showed a saturable dose response.

3 design principles for rationally tuning the dose response.

4 uppressed, both temporally and in an insulin dose response.

5 generally well tolerated and demonstrated a dose response across multiple end points in patients wit

6 -based sub-clinical CT pixel intensity-based dose response, all four models performed well.

7 In addition, dose-response analyses gave estimated HRs of 0.97 (95% C

8 continuous 21-day cycles using a model-based dose-response analysis (continuous reassessment method).

9 rom non-NETotic cells and vastly facilitated dose-response analysis and screening of the NETotic resp

10 A new version (version 2) of the genomic dose-response analysis software, BMDExpress, has been cr

11 unmet demand for easy-to-use transcriptomic dose-response analysis software.

12 In the dose-response analysis, we found little association betw

13 te association, to use for normalization and dose-response analysis.

14 the molecular underpinnings of this nutrient dose-response are largely unknown.

15 We show here that Lifeact induces dose-response artefacts at the cellular level, impacting

16 e enzymatic ADP-ribosyltransferase inhibitor dose-response assay.

17 coluzzii was detected across villages, with dose-response assays demonstrating extremely high resist

18 Results from dose-response assays suggest that different ARF proteins

19 In dose-response assays, a blend of the five components eli

20 for QMRA (both in exposure assessment and in dose response assessment) came from measurements using a

21 eview and meta-analysis aimed to examine the dose-response association between maternal body mass ind

22 milk consumption, we found no evidence of a dose-response association between milk consumption and m

23 There was a dose-response association between more steps, less SB an

24 PA and sitting times simultaneously showed a dose-response association between sitting time and NAFLD

25 A dose-response association was consistently apparent in t

26 This study sought to quantify dose-response associations between LTPA, BMI, and the ri

27 There were dose-response associations between steps, SB (inverse) a

28 Dose-response associations of sedentary time and bout du

29 FreeSurfer image analysis, we found negative dose-response associations with copy number on intracran

30 betes, and dyslipidemia have independent and dose-response associations with incident AS in an unsele

31 d with anti-infective agents in temporal and dose-response associations.

32 The UV dose-response behavior of PBCV-1 to monochromatic UV rad

33 n eSAC concentration in a cell to reveal the dose-response behavior of the core signaling cascade of

34 ying GluN2B-antagonist eliprodil, an evident dose-response behavior was observed with (R)- (11)C-Me-N

35 These data provide evidence of a dose response between magnitude of HCMV IgG with risk of

36 Additionally, to enable correlation of dose responses beyond those that can be measured by meta

37 hip between levels of resistance observed in dose-response bioassays and actual efficacy of formulate

38 ed in the US western Corn Belt by laboratory dose-response bioassays.

39 ication coupled with experimental trials for dose-response characterization.

40 Doubling time estimates, dose response curve regression, and comparison analyses

41 A dose response curve was generated for each treatment and

42 D63(+)/anti-FcepsilonRI], and area under the dose-response curve [AUC]) as biomarkers for the clinica

43 One can easily model the dose-response curve at each time point with Hill equatio

44 ssess the problem of predicting the complete dose-response curve based on genetic characterizations.

45 dule of reinforcement, shifted the oxycodone dose-response curve downward, and inhibited oxycodone ex

46 However, the single summary metric of a dose-response curve fails to provide the entire drug sen

47 Importantly, the dose-response curve for this action was right-shifted re

48 y predict the entire functional profile of a dose-response curve rather than a single summary metric.

49 uction that has been reported as a monotonic dose-response curve that plateaus at high TSH doses.

50 li at extreme ends of the circadian system's dose-response curve to light.

51 stematic review and, when possible, we fit a dose-response curve using a restricted cubic spline regr

52 npirole and other dopaminergic drugs, a full dose-response curve was established.

53 Our analysis shows that the dose-response curve with the FSS data clearly differs fr

54 HR activation exhibits an "inverted U-shaped dose-response curve" with increasing cAMP production at

55 Despite debate over this biphasic dose-response curve, hormesis is challenging central bel

56 f incremental LBNP demonstrated a non-linear dose-response curve, suggesting 20 mmHg LBNP as the opti

57 ified by a summary statistic from a best-fit dose-response curve, whilst neglecting the uncertainty o

58 ctivity often forms a U- or reverse J-shaped dose-response curve.

59 significant rightward shift in the morphine dose-response curve.

60 Dose response curves of ML385, an NRF2 inhibitor, showed

61 We show that bistability and biphasic dose response curves of the maximally modified phosphofo

62 Log[ET-1]-%maxCVC dose-response curves demonstrated reduced vasodilatory r

63 t be tested in further trials, because their dose-response curves did not plateau.

64 Dose-response curves for pure hemoglobin and for hemoglo

65 ese models are often applied to conventional dose-response curves in which a normalized parameter wit

66 on experiments that determine the antibiotic dose-response curves of Escherichia coli strains, and pr

67 From the dose-response curves of mortality data created as a func

68 Clinical studies often track dose-response curves of subjects over time.

69 nd GDSC show a higher accuracy in predicting dose-response curves of the proposed functional framewor

70 We derive a recursion relation for dose-response curves over time capturing the temporal ev

71 sultant joint model allows us to predict the dose-response curves over time for new individuals.

72 The dose-response curves show an analytical range between 5

73 We characterized individual-level dose-response curves to light-induced melatonin suppress

74 Dose-response curves were constructed with random-effect

75 0a, Or22a and Or35a) showed a shift in their dose-response curves when Orco was co-integrated, reflec

76 This is a novel use of dose-response curves with a mixture of phospholipid subs

77 m functional predictors i.e., estimating the dose-response curves with a model built on dose-dependen

78 oss most allergen concentrations, the AUC of dose-response curves, and basophil allergen threshold se

79 atform across multiple cells lines and using dose-response curves, to insure the fidelity and robustn

80 The biomarker results revealed multiphasic dose-response curves, which suggested toxicity mechanism

81 the free inhibitor, resulting in bell-shaped dose-response curves.

82 and produced the most striking nonmonotonic dose-response curves.

83 s in drug-target binding based on antibiotic dose-response curves.

84 al regression (surveys) to obtain summarised dose-response data (relative risk reduction [RRR]) and m

85 Published dose-response data for a multispecies AOP network were u

86 For this we used dose-response data from pharmacogenomic encyclopedias an

87 dresses the increasing use of transcriptomic dose-response data in toxicology, drug design, risk asse

88 In this dataset only two dose-response data points per drug pair and two data poi

89 and subsequent mathematical modeling of the dose-response data uncover two crucial properties of the

90 We fit the dose-response data within RadioGx to the linear-quadrati

91 Our method is applicable to any dose-response data without replicates, and improves biom

92 droxyl radical modification products and the dose-response data.

93 than 3.5 hours per day is associated with a dose-response decline in verbal memory over the followin

94 Here we sought to quantify and model the dose response, dynamics, and stability of bacterial colo

95 Many studies have explored the dose-response effect of different formulations of ICS th

96 ver, for z-drugs there was no evidence for a dose-response effect on DRP, and for gabapentinoids the

97 However, a dose-response effect was observed, with maximal benefit

98 .97 to 4.43], p < 0.001), with evidence of a dose-response effect, but showed little evidence of an a

99 livery has the largest increased risks and a dose-response effect, with adjusted odds ratios from 2.6

100 ort these findings, which also demonstrate a dose-response effect.

101 Dose response effects of Cd, As, and Cd/As(mix) in S. ac

102 The dose-response effects of the solid/liquid ratio on the e

103 data are fit to general equations (e.g. the dose response equation) to determine empirical drug para

104 tients is likely to have reduced the size of dose-response estimates.

105 Dose-response experiments are a mainstay of receptor bio

106 Escalating dose-response experiments on primary VS cells grown from

107 Dose-response experiments showed a greater sensitivity a

108 We also noted significant dose responses for decreased ESA resistance index and in

109 However, there is a lack of data on the dose-response for CAP to inhibit HFD-induced obesity.

110 ta sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, puta

111 script-1 expression, a leftward shift in the dose/response for a thrombin receptor-activating peptide

112 l significance of a sex-dependent inverted U dose-response function for OT's effects on social reward

113 the concentration of any odorant via a fixed dose-response function with a variable sensitivity.

114 data for each country, we estimate a common dose-response function, which we use to compute national

115 study illustrates the need for assessing the dose-response functional form and the use of NLME models

116 se variability and with consideration to ESA dose response, hepcidin, and high sensitivity C-reactive

117 The evidence of dose-response highlights the need for nuanced interventi

118 y, the Hill coefficient (HC) of the in vitro dose-response Hill equation provided a better prediction

119 Finally, we observed a dose-response in forest change rate to intervention enga

120 85644 may contribute to variation in 25(OH)D dose-response in healthy postmenopausal Caucasian women.

121 A linear dose-response in the probability of confirmed disability

122 the Yin/Yang doctrine embodies the hormetic dose-response, including the relationship between the op

123 of mean arterial blood pressure, there was a dose-response increase in probability of good neurologic

124 Dose-response increases in serum 25-hydroxyvitamin D con

125 quality end-of-life care, with evidence of a dose response indicating that inequality persists across

126 ir based on linear superposition of a single dose response, indicating the potential for prediction o

127 o predict synergistic drug combinations with dose-response information and drug-treated gene expressi

128 Dose-response inhibitor experiments were conducted with

129 y associated with hypertension in an inverse dose-response manner and partially mediated through body

130 ly predicted lung cancer incident cases in a dose-response manner in participants at a high genetic r

131 ted with both mortality outcomes in a nearly dose-response manner in the least active groups reportin

132 ong mean bout durations were associated in a dose-response manner with increased CVD risk in older wo

133 of incident CVD and all-cause mortality in a dose-response manner.

134 (SAOS-2) and preosteoblasts (MC3T3-E1), in a dose-response manner.

135 ith higher odds of muscle abnormalities in a dose-response manner.

136 ischarge disposition (1.46, 1.23-1.72), in a dose-response manner.

137 experimental evolution with high-throughput dose-response measurements, we measure phenotypic profil

138 curves were constructed with random-effects dose-response meta-analyses and a spline model.

139 A systematic review and dose-response meta-analyses of prospective studies was c

140 Linear and nonlinear dose-response meta-analyses were conducted using random

141 Random effects dose-response meta-analyses were used to estimate summar

142 uthors sought to fill this gap by conducting dose-response meta-analyses.

143 We used a random-effects, dose-response meta-analysis model with flexible splines

144 We did a systematic review and dose-response meta-analysis of double-blind, randomised

145 ased risk of all-cause mortality in a linear dose-response meta-analysis.

146 , adjusted odds ratios (ORs) were pooled and dose-response meta-regression performed.

147 Here, we introduce a workflow for dose-response metabolomics to evaluate chemicals that po

148 In this work, we primarily focus on applying dose-response metabolomics to find off-target effects of

149 Critical concentrations depended on the dose response model (infection vs clinical severity infe

150 ationship is modeled using pathogen specific dose response models (DRMs).

151 1) to ~10(3) CFU per L for infection and CSI dose response models, respectively.

152 ute walk test distance among the 5 different dose-response models (P = .05 for Emax; P = .18 for quad

153 rstanding of radiobiology and development of dose-response models in this unique therapeutic context.

154 rstanding of radiobiology and development of dose-response models in this unique therapeutic context.

155 A significant dose response of cardiac uptake to doxorubicin treatment

156 The dose response of N,N,H,-trimethyl-5-([tricyclo(3.3.1.13,

157 hould generate biomarkers useful for in vivo dose responses of beta-lapachone treatment in humans, av

158 (Dose-Response of Gonadal Steroids and Bone Turnover in M

159 There is no information on the dose-response of oxylipin concentrations after n-3 PUFA

160 n D3 concentrations were correlated, and the dose-response of vitamin D3 in adipose mirrored that in

161 that M1R stimulation produced an inverted-U dose response on cell firing and behavioral performance

162 is review discusses current knowledge of the dose-response, or lack thereof, of different formulation

163 oup, and 58.0% in the 1500 mg IW-3718 group (dose-response P = .02).

164 olic disease-free life expectancy followed a dose-response pattern and was observed in subgroups of p

165 At 20 mul, densitometry showed a linear dose-response pattern at concentrations up to 500 ng/ml;

166 The results followed a dose-response pattern with a higher risk of ischemic str

167 At 10 mul, densitometry showed a linear dose-response pattern.

168 examples, we demonstrate that each group of dose-response patterns identified by TOXcms signifies a

169 as R-package) for the quantification of the dose-response potency of a gene-signature as EC(50) and

170 patients, with reductions in per-mill imeter dose/response predicted with longer AL.

171 posed Recursive Hybrid model with individual dose-response predictive models at desired time points.

172 he curve, and decreased EC(50); 2) a uniform dose-response profile across genetically heterogeneous c

173 cule is identified that exhibits an improved dose-response profile in taxane-sensitive and taxane-res

174 and quadratic) was used to evaluate diverse dose-response profiles.

175 us cocaine self-administration (acquisition, dose-response, progressive ratio, extinction, cue-induce

176 We performed a double-blind, dose-response, randomized, cross-over nutritional interv

177 omarker approach in cohorts and high-quality dose-response RCTs.

178 ; 95% CI = 0.64-0.78]) was associated with a dose-response reduced risk of asthma onset.

179 sion trees with node costs modified based on dose/response region dependence methodologies and respon

180 d for analyzing multiple-stressor data using dose-response regression.

181 level, some evidence was noted of a positive dose-response relation between area deprivation and invo

182 e aims of this study were to investigate the dose-response relation between changes in dietary choles

183 This may reflect an overestimation of the dose-response relation between sodium reduction (SR) and

184 DBP)], there was strong evidence of a linear dose-response relation between SR and BP.

185 In addition, a dose-response relation between the number of MetS compon

186 For SBP, the dose-response relation was -7.7 mm Hg/100 mmol SR (95% C

187 Given that no clear dose-response relation was apparent, this result must be

188 d evidence and no analyses have examined the dose-response relation.

189 a-regression analysis sought to estimate the dose-response relations between SR and BP in study group

190 Dose-response relations were examined using fractional p

191 wo dogs developed food allergy, suggesting a dose-response relationship (each dog owned aOR 0.12 (CI

192 mall increase in risk, with no evidence of a dose-response relationship (for fourth vs. first quartil

193 cancer was near null, with no evidence of a dose-response relationship (for fourth vs. first quartil

194 A significant dose-response relationship (multiple comparison procedur

195 The associations fitted a dose-response relationship (p < .001) and remained signi

196 f this study was to investigate the absorbed dose-response relationship and its association with over

197 o the representation of the Western hormetic dose-response relationship and review the Yin/Yang histo

198 nges in cardiac output (CO); (2) a potential dose-response relationship between 3-OHB levels and CO;

199 There was an inverse U-shaped dose-response relationship between attained sphenopalati

200 r, further studies are needed to clarify the dose-response relationship between different subtypes an

201 We hypothesized a dose-response relationship between duration of football

202 there is uncertainty about the nature of the dose-response relationship between HFSS advertising and

203 There was a consistent dose-response relationship between higher proportional b

204 tients who had no complications, there was a dose-response relationship between mortality and the num

205 There was a significant dose-response relationship between pack-years of smoking

206 Nevertheless, there was a dose-response relationship between RNFL thinning and num

207 Describe the dose-response relationship between step count and intens

208 cubic spline method was used to estimate the dose-response relationship between SUA and fundus arteri

209 There is a dose-response relationship between the number of postope

210 ant agents suppress REM sleep and a time-and-dose-response relationship between total REM sleep suppr

211 ting that ribosomal biogenesis regulates the dose-response relationship between training volume and m

212 ses a much more pronounced left shift of the dose-response relationship by increasing its affinity to

213 Hormesis is a generalizable dose-response relationship characterized by low-dose sti

214 atients with HFpEF, there was no significant dose-response relationship detected for neladenoson with

215 hods for bone marrow dosimetry and study the dose-response relationship during treatment with (177)Lu

216 esviruses are also implicated, nor whether a dose-response relationship exists between tuberculosis r

217 There was no significant dose-response relationship for the change in 6-minute wa

218 These results confirm a significant absorbed dose-response relationship in (166)Ho radioembolization.

219 Conclusion: A significant dose-response relationship in CRC patients treated with

220 ay afford insights that clarify the hormetic dose-response relationship in toxicology and pharmacolog

221 ediated by oxytocin; and that in females the dose-response relationship is initiated at lower doses c

222 MDS in both males and females, and that this dose-response relationship is initiated at lower doses i

223 A dose-response relationship is suggested with respect to

224 CM-HIPK2 heterozygous mice exhibited a gene dose-response relationship of CM-HIPK2 on heart function

225 with the currently available evidence of the dose-response relationship of ICS in adult asthma.

226 review to establish an understanding of the dose-response relationship of intrathecal GBCAs and to c

227 e purpose of this study was to establish the dose-response relationship of selective internal radiati

228 Although we did not observe a dose-response relationship on absolute changes in [tissu

229 harmacological profile without a bell-shaped dose-response relationship or tachyphylaxis in preclinic

230 and the number of injections had a nonlinear dose-response relationship that became apparent after ap

231 maximal change, change magnitude, and gluten dose-response relationship varied.

232 The absorbed dose-response relationship was assessed using a linear m

233 A dose-response relationship was found between the IOP PRS

234 A dose-response relationship was identified between pack-y

235 rimental periodontitis, however, a potential dose-response relationship was not determined.

236 However, a dose-response relationship was not observed.

237 A dose-response relationship was observed between anthracy

238 A dose-response relationship was observed for upadacitinib

239 igned intent-to-treat patients at week 12, a dose-response relationship was observed; APR40 (n = 63),

240 The absence of a dose-response relationship weakens causal interpretation

241 There was a dose-response relationship with a significant CO increas

242 The risk of mental disorders increased in a dose-response relationship with the number of maternal i

243 A significant dose-response relationship with the prevalence and incid

244 iation, alternative explanations, cessation, dose-response relationship, animal experiments, analogy,

245 To study the dose-response relationship, we begin with the assumption

246 on and frequency, cg05575921 showed a strong dose-response relationship, while there was evidence for

247 ROS production but with an inverted U-shaped dose-response relationship.

248 : HR, 0.84 [95% CI, 0.71 to 0.99]) without a dose-response relationship.

249 ction, and handwashing; evidence suggested a dose-response relationship.

250 This constitutes a robust absorbed dose-response relationship.

251 ciation; 25 assessed and found evidence of a dose-response relationship.

252 ption of network organization, reflecting a "dose response" relationship and emphasize the role of ef

253 testing positive for SARS-CoV-2 with strong dose-response relationships between several forms of mov

254 tems, (b) improving environmentally relevant dose-response relationships for different organisms and

255 We performed NTCP-modeling and established dose-response relationships for visual acuity (VA) deter

256 For chlorophyll, there were better dose-response relationships in Chlorococcum sp., Chlamyd

257 tion, the complexity of exposure and dose in dose-response relationships is highlighted.

258 The dose-response relationships of antipsychotic drugs for s

259 Dose-response relationships of sodium, chloride, potassi

260 There were dose-response relationships such that a greater number o

261 Dose-response relationships were modeled with restricted

262 d cause-specific mortality and elucidate the dose-response relationships with better quantification o

263 Based on target analysis, potency and dose-response relationships, 5 compounds were subsequent

264 dings from current knowledge of radiological dose-response relationships, here mammal response in ter

265 f nose-to-brain oxytocin routes and possible dose-response relationships.

266 ricted cubic spline regression characterized dose-response relationships.

267 chemotherapy-associated SMN risk, including dose-response relationships.

268 stricted cubic spline models to evaluate the dose-response relationships.

269 SARS-CoV-2, including 21 drugs that exhibit dose-response relationships.

270 ) that can quantitatively predict antibiotic dose-response relationships.

271 ead to the same outcomes, and modeling of IR dose-response reveals that the CO-unfavorable center reg

272 d malignant cells can be utilized to perform dose-response screenings in vitro for individual targete

273 compared these data to three measures of ESA dose response, sex, and dialysis incidence versus dialys

274 Progenies were subjected to herbicide dose-response studies following drift selection.

275 x vivo autoradiography, PET experiments, and dose-response studies.

276 Whole plant dose response study indicated an increased level of 2,4-

277 ouble-blind, randomised, placebo-controlled, dose-response study at 107 epilepsy and neurology centre

278 The dose-response study showed that CAP, at doses above 0.00

279 Here we performed a dose-response study using fingolimod from 0.03 to 1 mg/k

280 Results: In a dose-response study with the beta-emitter 177Lu-DOTA-dar

281 Study 2: In a dose-response study, 8 HFrEF patients were examined at i

282 indings regarding a temporal association and dose-response suggest a causal relationship.

283 inations, high-throughput screens using full dose-response surface are desirable but require an impra

284 We performed dose-response, synergism, P-glycoprotein inhibition, and

285 We show that the dose-response systems properties of this complex substra

286 Using linear models, we identify distinct dose responses to either N-moles, W-volume, N-molarity (

287 hese changes include a leftward shift in the dose-response to a D1-like agonist that indicates a beha

288 called TOXcms, which statistically evaluates dose-response trends for each metabolomic signal accordi

289 A linear dose response was also demonstrated between anthracyclin

290 fusion were detected in some patients, and a dose response was identified with a reduction of RNP pro

291 The dose response was linear in shape for half of the associ

292 The dose response was measured in groups of 7 mice using 37,

293 ve rate [RR] 2.7; 95% CI, 1.1 to 6.5), and a dose response was observed between alkylating agents and

294 ses from baseline; no evidence of an antigen dose response was observed.

295 ses from baseline; no evidence of an antigen dose-response was observed.

296 To assess for dose response, we calculated the total days of PPS presc

297 Single dose responses were 1.7 [1.1, 2.5] mm (median [range]) w

298 Linear dose responses were seen between alkylating agents and S

299 d more PTB than SPI, and DDI showed a linear dose-response, whereas SPI did not.

300 It followed a hyperbolic dose response with maximal inhibition of ~50%, Hill coef