ライフサイエンスコーパス: dose-response curve

1 tion (significant change in the slope of the dose-response curve).

2 nts to determine IC(50) and the slope of the dose-response curve.

3 ctivity often forms a U- or reverse J-shaped dose-response curve.

4 uring in silico the mode of the experimental dose-response curve.

5 , as well as induced a vertical shift in the dose-response curve.

6 dose dependent, but exhibited a bell-shaped dose-response curve.

7 eduction of tumor burden followed a U-shaped dose-response curve.

8 ement of the spinal morphine antinociceptive dose-response curve.

9 In male voles, all 3 drugs had an inverted-U dose-response curve.

10 shut correlation, and single-channel P(open) dose-response curve.

11 jects, implying a right shifted but parallel dose-response curve.

12 significant rightward shift in the morphine dose-response curve.

13 hilin A (CypA) were essential for the unique dose-response curve.

14 06 to 1.5 x 106 IU/m2, in order to model the dose-response curve.

15 concentration-reactive oxygen species (ROS) dose-response curve.

16 evidence of nonlinearity was observed in the dose-response curve.

17 ormalized ATP levels and displayed drug-like dose response curves.

18 during primary screening and verified using dose-response curves.

19 and produced the most striking nonmonotonic dose-response curves.

20 RDA is equivalent to CA only for linear dose-response curves.

21 s in drug-target binding based on antibiotic dose-response curves.

22 nd upward (short-term) shifts in fixed ratio dose-response curves.

23 ge and the interpatient variability in their dose-response curves.

24 measured by a leftward shift in the morphine dose-response curves.

25 inhibition), data analysis and generation of dose-response curves.

26 between aggregate-based inhibition and steep dose-response curves.

27 or Co2+ ions generated bell-shaped activity dose-response curves.

28 the free inhibitor, resulting in bell-shaped dose-response curves.

29 be clustered into two groups based on their dose-response curves.

30 cancer cell viability screen involving 11650 dose-response curves.

31 subjects and those with POAG by constructing dose-response curves across a wide range of corneal irra

32 0.25, 0.5, 1.0 mg/kg/infusion) followed by a dose-response curve after acquisition of cocaine self-ad

33 upled receptors, normalization stretches the dose-response curve along the y-axis, thereby masking th

34 te-based inhibition is correlated with steep dose-response curves, although not absolutely.

35 pproaches involving the use of concentration/dose response curves and antagonists have been replaced

36 esult in both a shift of the midpoint of the dose-response curve and a change of the slope of the cur

37 /L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations.

38 er of operator sites together determined the dose-response curve and gene expression noise.

39 trate that there is no ascending limb of the dose-response curve and that the cocaine priming and sat

40 pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affiniti

41 Dose-response curves and heparin-Sepharose binding sugge

42 Dose-response curves and IC50 values were determined for

43 activity falls quickly for drugs with sharp dose-response curves and short half-lives, such as boost

44 The glycine dose-response curves and the effects of caffeine indicat

45 y of factors to modulate the position of the dose-response curve, and the partial agonist activity, o

46 oss most allergen concentrations, the AUC of dose-response curves, and basophil allergen threshold se

47 er pharmacology (and many other areas), most dose-response curves are satisfactorily described by a c

48 that Hap1 activity exhibits the same oxygen dose-response curves as Hap1-dependent aerobic genes and

49 Dopamine dose-response curves assaying intracellular calcium mobi

50 visual inspection or a global fit of ligand dose response curves at a series of inhibitor concentrat

51 One can easily model the dose-response curve at each time point with Hill equatio

52 We establish dose-response curves at realistic particle-concentration

53 D63(+)/anti-FcepsilonRI], and area under the dose-response curve [AUC]) as biomarkers for the clinica

54 ssess the problem of predicting the complete dose-response curve based on genetic characterizations.

55 " leads to a requirement that noninteractive dose-response curves be linear, whereas in toxicology, i

56 salivary gland swelling (P = 0.001, logistic dose-response curve) but not with dry mouth (P = 0.63),

57 ver, cause a left shift in the dexamethasone dose response curve by increasing intracellular dexameth

58 the newly derived rate equation to inhibitor dose- response curves can, in favorable cases, reveal wh

59 uired cocaine self-administration and showed dose-response curves characteristic of the schedule of r

60 id not cause a greater shift in the morphine dose-response curve compared to morphine pretreated alon

61 exhibited a rightward shift in the nicotine dose-response curve compared with WT littermates but tha

62 to the right of the THC self-administration dose-response curves, consistent with antagonism of the

63 The overall dose-response curves could be reconstructed by combining

64 Log[ET-1]-%maxCVC dose-response curves demonstrated reduced vasodilatory r

65 specific for the target, was used to obtain dose-response curves, demonstrating the potential for qu

66 Dose-response curves determined defibrillation threshold

67 t be tested in further trials, because their dose-response curves did not plateau.

68 As assayed by a dose-response curve, different concentrations of the poo

69 dule of reinforcement, shifted the oxycodone dose-response curve downward, and inhibited oxycodone ex

70 drug target, ALLINIs display steep antiviral dose-response curves ex vivo.

71 However, the single summary metric of a dose-response curve fails to provide the entire drug sen

72 se two questions: How can a first-order Hill dose-response curve (FHDC) arise from a multistep reacti

73 ty of quantification is shown by a sigmoidal dose-response curve fitting to analyze IL-6 protein.

74 Dose-response curves followed exponential pharmacodynami

75 Dose response curves for gemcitabine in the absence or p

76 Dose response curves for oxidant production, actin polym

77 peated exposure, and produced a shift in the dose-response curve for alcohol on BSR threshold without

78 uitability of the technique for generating a dose-response curve for an enzyme inhibition assay.

79 nto the vPAG caused a rightward shift in the dose-response curve for antinociception whether the glut

80 1 antagonist also eliminated the bell-shaped dose-response curve for buprenorphine-induced antinocice

81 xposure and produced a leftward shift in the dose-response curve for cocaine on BSR threshold without

82 gene transfer during maintenance shifted the dose-response curve for cocaine self-administration upwa

83 e alone but produced a leftward shift in the dose-response curve for cocaine-primed reinstatement.

84 A dose-response curve for detection of DNA hybridization b

85 ngle lectin super-microarray to generate the dose-response curve for each glycan-lectin pair, from wh

86 A dose-response curve for each of the suicide inhibitors w

87 rs is a multistep process characterized by a dose-response curve for gene product that follows a firs

88 pplicable and amenable to predictions if the dose-response curve for gene repression is non-cooperati

89 deletion resulted in a leftward shift in the dose-response curve for glucose-stimulated insulin secre

90 otropin-releasing hormone and a left-shifted dose-response curve for gonadotropin-releasing hormone a

91 The dose-response curve for immunocomplex formation of TNT o

92 , as exemplified by a rightward shift in the dose-response curve for insulin stimulated 2-deoxyglucos

93 x orders of magnitude) leftward shift in the dose-response curve for intraplantar capsaicin-induced i

94 en 6.7 and 670 mug/kg (i.v.) and shifted the dose-response curve for isoprenaline to higher agonist c

95 nges in tadpole behavior shifted the ethanol dose-response curve for loss of righting reflex to lower

96 As the dose-response curve for many receptors can be fit to a B

97 einforcing effects of nicotine, shifting the dose-response curve for nicotine to the left, (2) inhibi

98 In the other words, the slope of the dose-response curve for one stimulus is an intrinsic pro

99 dition, GDNF induced a downward shift in the dose-response curve for operant self-administration of a

100 In contrast to NHK cells, the dose-response curve for ouabain inhibition of Na,K-ATPas

101 We established a dose-response curve for rFVIIa that is useful to explain

102 Acidosis shifted the dose-response curve for suppression of proteolysis by in

103 e 72h after resuscitation revealed a complex dose-response curve for testosterone, such that low and

104 ace preference (CPP) paradigm to determine a dose-response curve for the behavioral effects of AMPH i

105 h its mechanism of action and to construct a dose-response curve for the effect of allopurinol.

106 lain this effect, and the first quantitative dose-response curve for the effect of profilin on Ac fac

107 HI-231 cells and displayed a marked biphasic dose-response curve for the induction.

108 Importantly, the dose-response curve for this action was right-shifted re

109 The CCK dose-response curve for TyrP for sites in each kinase wa

110 nal independent-action approach based on the dose-response curves for a single end point at a single

111 similar binding affinity and transactivation dose-response curves for both thyroid hormone receptor i

112 Dose-response curves for buprenorphine-induced antinocic

113 duced dose-dependent rightward shifts in the dose-response curves for cocaine self-administration and

114 ifies the mechanism and matches the measured dose-response curves for different concentrations of the

115 ties and inhibition by small-molecule drugs, dose-response curves for each enzyme were established fo

116 The EC50 dose-response curves for GCSF, GCSF-Fc and PEG-GCSF were

117 Dose-response curves for homopentameric alpha7 nicotinic

118 The dose-response curves for inhibition of gene transfer rev

119 A rightward-shift of cumulative dose-response curves for morphine analgesia upon chronic

120 Dose-response curves for muscimol in the presence of 3,3

121 We calculated dose-response curves for peptidoglycan-induced interleuk

122 Dose-response curves for pure hemoglobin and for hemoglo

123 Dose-response curves for several genotoxins were obtaine

124 Dose-response curves for smoking versus fetal growth par

125 ted with radiotherapy demonstrated different dose-response curves for specific SNs.

126 Ultraviolet radiation dose-response curves for sunburn/erythema and suppressio

127 To determine whether the insulin dose-response curves for suppression of endogenous gluco

128 These data indicate that the dose-response curves for suppression of glucose producti

129 here are assay-dependent complexities to the dose-response curves for the engineered resistant viruse

130 nalyte, run and batch of runs; (v) calculate dose-response curves for titrations; (vi) interpolate un

131 rapeutic approach and help establish optimal dose-response curves for training.

132 ional experiments were performed and yielded dose-response curves for two exposure parameters: number

133 conducted a systematic study of currents and dose-response curves for wild-type MscL in Escherichia c

134 Based on dose-response curves from in vivo fluorescence resonance

135 Our model compares favorably with dose-response curves from in vivo Forster resonance ener

136 Glutamate dose-response curves from NR1a/NR2D(T692A) receptor chan

137 Dose response curves generated in this manner were compa

138 were translated into health burdens using a dose-response curve generated from a systematic review a

139 Hap1-dependent aerobic genes and that these dose-response curves have a sharp break at approximately

140 ys given before the acquisition phase and no dose-response curves have ever been drawn up.

141 Despite debate over this biphasic dose-response curve, hormesis is challenging central bel

142 d cubic spline adiposity-residential density dose-response curve identified a turning point at a resi

143 neration of an unusual type of IFN-induction dose-response curve, (iii) the presence of IFPs that ind

144 tibiotics produced statistically significant dose response curves in which denitrification was stimul

145 The PCP site antagonist had a U-shaped dose-response curve in females, the opposite of that in

146 lipogenic genes also followed a nonmonotonic dose-response curve in response to BPA.

147 No differences were observed in the morphine dose-response curve in suppression of acute nociception

148 also suggest the existence of an inverted-U dose-response curve in the potential therapeutic effect

149 The dose-response curves in 10% PBS revealed a detection lim

150 for simultaneous acquisition of at least 32 dose-response curves in a single experiment, each curve

151 Most steep dose-response curves in screening may be due to this eff

152 rrent as a measure of P(o), and treatment of dose-response curves in the two-state approximation.

153 ese models are often applied to conventional dose-response curves in which a normalized parameter wit

154 eness, such as the slope of the methacholine dose-response curve, in clinical practice and research b

155 percentage of maximal SkBF-[BQ123] sigmoidal dose-response curve indicated a vasodilatory response as

156 Biphasic dose-response curves indicated that the occupancy of the

157 be predicted from IC(50) if the shape of the dose-response curve is also known.

158 Despite this drastic reduction, the glucose dose-response curve is only shifted by approximately 2 m

159 This dose-response curve is strikingly similar to that for ce

160 d that PD-1 ligation dramatically shifts the dose-response curve, making T cells much less sensitive

161 resistance to antiviral drugs show that the dose response curve may not be monotonic.

162 affected by ethanol with the midpoint of its dose-response curve moved to lower steroid concentration

163 Projection of the dose-response curves observed in this convenience sample

164 The dose-response curve obtained with benzo(a)pyrene incubat

165 behavior of previously reported experimental dose-response curves obtained for two different ligand-r

166 Tolerance measures the dose response curve of a host's health in reaction to a

167 Dose response curves of ML385, an NRF2 inhibitor, showed

168 We show that bistability and biphasic dose response curves of the maximally modified phosphofo

169 The dose-response curve of 17beta-estradiol was established

170 The position of the dose-response curve of agonist complexes of glucocortico

171 pace is 3-dimensional, and predicts that the dose-response curve of an odor receptor can be obtained,

172 The dose-response curve of each compound was fitted with a s

173 ibited a left and upward shift of the Ang II dose-response curve of hypertrophy compared with those e

174 As a result, the dose-response curve of myocyte contraction to betaAR ago

175 This work reveals that the dose-response curve of PF74 consists of two distinct inh

176 Here, we found that the dose-response curve of PF74 is triphasic, consisting of

177 obtained by a parallel line analysis of the dose-response curve of the test article in relation to t

178 on experiments that determine the antibiotic dose-response curves of Escherichia coli strains, and pr

179 itself as a shift towards lower doses in the dose-response curves of individual antiandrogens that be

180 From the dose-response curves of mortality data created as a func

181 Dose-response curves of mtDNA damage were produced for e

182 Our analysis of dose-response curves of multiple LuxN mutants pins these

183 odel with independent sensors, the different dose-response curves of open probability for one stimulu

184 Dose-response curves of racemic fluoxetine (IC50 = 39 mu

185 Clinical studies often track dose-response curves of subjects over time.

186 The dose-response curves of ternary complex formation reveal

187 ns, followed by construction and analysis of dose-response curves of the most promising hits.

188 Steep dose-response curves of the percentage of responding cel

189 nd GDSC show a higher accuracy in predicting dose-response curves of the proposed functional framewor

190 application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-dim

191 tor activation produced an inverted U-shaped dose-response curve on plasticity induced by both facili

192 We derive a recursion relation for dose-response curves over time capturing the temporal ev

193 sultant joint model allows us to predict the dose-response curves over time for new individuals.

194 Irreducible uncertainties regarding the dose-response curve prevent us from quantifying the mini

195 ononuclear cells and T cells, we constructed dose-response curves, profiled the secretory behavior of

196 y predict the entire functional profile of a dose-response curve rather than a single summary metric.

197 Doubling time estimates, dose response curve regression, and comparison analyses

198 al framework to study disease tolerance, the dose response curve relating health to microbe load; thi

199 Dose-response curves relating insulin secretion to gluco

200 g both BIR2 and BIR3 domains with a biphasic dose-response curve representing two binding sites with

201 o waves of activation differ in time course, dose-response curve, requirement for GRPr CTD, and sensi

202 Dose-response curves revealed dose-dependent profiles wi

203 The dose-response curves show an analytical range between 5

204 These data, with dose response curves, show that SEN304 is a powerful inh

205 Analysis of the dose-response curve showed that 12 dimeric gp12 complexe

206 A leptin dose-response curve showed that subcutaneous leptin impr

207 Norepinephrine dose-response curves showed no HTN-related difference in

208 5-HT tension dose-response curves showed that 5-HT-induced myometrial

209 Dose-response curves showed that max2 seeds are hyposens

210 The resulting oxygen dose-response curve shows that an in vitro system with F

211 OFA showed overlapping dose response curves similar to those for RTX in phagocy

212 Our results emphasize the importance of the dose-response curve slope in determining the inhibitory

213 ation of a previously ignored parameter, the dose-response curve slope.

214 itory quotient, neglect a key dimension, the dose-response curve slope.

215 b potency at therapeutic levels by analysing dose-response curve slopes, and show that slope is indep

216 mpleted in less than 3 min and the sigmoidal dose-response curve spanned an antibody concentration ra

217 f incremental LBNP demonstrated a non-linear dose-response curve, suggesting 20 mmHg LBNP as the opti

218 first signaling GOx enzyme and a far steeper dose-response curve than that observed for simple Michae

219 y, post-nicotine episodes showed a different dose-response curve than the pre-nicotine episodes: post

220 uction that has been reported as a monotonic dose-response curve that plateaus at high TSH doses.

221 ve voltammetry, yielded a sigmoidally shaped dose-response curve that was linear over eight orders of

222 They are characterized by highly cooperative dose-response curves that are not explained by current p

223 life cycle generates the highly cooperative dose-response curves that make these drugs uniquely effe

224 Dose-response curves that were generated within several

225 nistration according to an inverted U-shaped dose-response curve; this effect was specific to consoli

226 at 8 mmol/l glucose and shifted the glucose dose response curve to the left.

227 and expectedly right-shifted the terbutaline dose-response curve to 8 +/- 3 microM.

228 Reduced cholesterol did not change the MC4R dose-response curve to alpha-MSH, but it decreased the a

229 li at extreme ends of the circadian system's dose-response curve to light.

230 deficient mice have a rightward shift in the dose-response curve to morphine on the tail-flick test (

231 However, the morphine dose-response curve to suppress evoked viscerosomatic hy

232 sis and shifted its percent animals vomiting dose-response curve to the right.

233 eased potency of carbachol by a shift in the dose-response curve to the right.

234 isplaced the spinal morphine antinociceptive dose-response curve to the right.

235 essed in isolated and perfused rat livers by dose-response curves to acetylcholine (ACh) and methoxam

236 ses a cell viability assay to generate broad dose-response curves to assess the efficacy of individua

237 weight and eight overweight/obese adults the dose-response curves to bradykinin and sodium nitropruss

238 We characterized individual-level dose-response curves to light-induced melatonin suppress

239 tance is the assumption that mutations shift dose-response curves to the right without affecting the

240 atform across multiple cells lines and using dose-response curves, to insure the fidelity and robustn

241 Increasing pH(i) induced a shift in H(+) dose-response curve toward less acidic pH but a shift in

242 stematic review and, when possible, we fit a dose-response curve using a restricted cubic spline regr

243 The TTX dose-response curve, using the whole cell voltage-clamp

244 aE and deltaA, extracted from 29 independent dose-response curves, varied in a linearly correlated ma

245 dependent function (narrow inverted-U-shaped dose-response curves) versus classroom/overt behavior (b

246 T(7) receptors, may underlie the bell-shaped dose-response curve via a mechanism of 'cross-talk' inhi

247 A dose response curve was generated for each treatment and

248 using UV detection at 260 nm, while a final dose response curve was quantified using fluorescence de

249 A similar rightward shift in the morphine dose-response curve was caused by morphine tolerance.

250 Also, dose-response curve was constructed to calculate the IC5

251 es C to higher temperatures, and the menthol dose-response curve was displaced to lower concentration

252 A linear dose-response curve was elicited at the fAb-IONs concent

253 npirole and other dopaminergic drugs, a full dose-response curve was established.

254 A dose-response curve was generated, and the linear detect

255 this primary endpoint, a significant linear dose-response curve was observed: the higher the dose, t

256 An inverted U-shaped dose-response curve was obtained when animals self-admin

257 Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 communi

258 Dose response curves were generated in naive mice and mi

259 At these concentrations the dose response curves were strongly U shaped indicating a

260 Hill coefficients for the spermine dose-response curves were approximately 0.58, indicative

261 Dose-response curves were carried out using a portable r

262 Dose-response curves were compared with previous individ

263 Dose-response curves were constructed using logistic reg

264 Dose-response curves were constructed with random-effect

265 Dose-response curves were generated in which Y79 retinob

266 In addition, two narrow bell-shaped dose-response curves were identified with maxima in eith

267 Time-course and dose-response curves were linear, yielding a limit of qu

268 Parallel dose-response curves were obtained between the universal

269 in at least seven concentrations, such that dose-response curves were obtained for all molecules in

270 Dose-response curves were obtained for quipazine (nonsel

271 ral Antigen, Listeria sp., and Shigella sp., dose-response curves were obtained, and limits of detect

272 Dose-response curves were predicted using Emax models.

273 release, bradykinin and sodium nitroprusside dose-response curves were repeated in the presence of 17

274 Linear and logistic regression and dose-response curves were used to evaluate relations of

275 0a, Or22a and Or35a) showed a shift in their dose-response curves when Orco was co-integrated, reflec

276 tunes the system to the steepest part of the dose response curve, where the sensitivity to a given ty

277 OS' feedback loop leads to hysteresis in the dose-response curve, which can enable a capacity to sust

278 ny screening hits inhibit enzymes with steep dose-response curves, which are considered pathological.

279 ost of these studies assayed changes in GABA dose-response curves, which are macroscopic measures tha

280 The biomarker results revealed multiphasic dose-response curves, which suggested toxicity mechanism

281 ified by a summary statistic from a best-fit dose-response curve, whilst neglecting the uncertainty o

282 , the ssOPM system is also used to acquire a dose response curve with the concentration of glucose in

283 h-dose alcohol site show a saturable ethanol dose-response curve with a half-maximal enhancement at 1

284 vities, and the most sensitive peptide had a dose-response curve with an SC(50) (concentration of ana

285 A biological dose-response curve with concentration in a dynamic rang

286 h lower doses revealed a U-shaped (hormetic) dose-response curve with greater parasite suppression at

287 Our analysis shows that the dose-response curve with the FSS data clearly differs fr

288 Dose-response curves with 7-84-103 showed that the diffe

289 This is a novel use of dose-response curves with a mixture of phospholipid subs

290 m functional predictors i.e., estimating the dose-response curves with a model built on dose-dependen

291 and automated fitting procedure to describe dose-response curves with multiphasic features.

292 how our approach is successful in describing dose-response curves with multiphasic features.

293 Dose-response curves with the allergens in BAT allowed a

294 We thus provide a robust approach to fit dose-response curves with various degrees of complexity,

295 HR activation exhibits an "inverted U-shaped dose-response curve" with increasing cAMP production at

296 ml(-1) to 1.66 mg ml(-1)) produced a sigmoid dose response curve, with maximal sweating (measured as

297 de novo lipogenesis followed a nonmonotonic dose-response curve, with more important effects at lowe

298 The method has demonstrated near-linear dose-response curves within a wide range of ~3 decades,

299 nositide turnover by a leftward shift of the dose-response curve without changing the maximum.

300 Glutamate depressed the GABA dose-response curve without shifting the curve laterally