ライフサイエンスコーパス: dosing regimen

1 f the antiangiogenic agent sunitinib (a 2-wk dosing regimen).

2 as well as simplification of the medication dosing regimen.

3 ntly proposed optimal allometric miltefosine dosing regimen.

4 11.3 to 37.6), supporting a once-daily oral dosing regimen.

5 488 (0-50 mug) according to a within-subject dosing regimen.

6 time ever) by the FDA, based on a new, safer dosing regimen.

7 IGlar OD do not support a three-times-weekly dosing regimen.

8 had a good, similar safety profile with each dosing regimen.

9 s are therefore needed to define the optimal dosing regimen.

10 h lower costs compared with a fixed, monthly dosing regimen.

11 d FcgammaRI/FcgammaRIII, following a chronic dosing regimen.

12 at in vehicle-treated controls over the 2-wk dosing regimen.

13 titration, was the most effective and safest dosing regimen.

14 aimed to select the most favourable dose and dosing regimen.

15 farin and to ascertain an optimal tecarfarin dosing regimen.

16 response and three partial responses in each dosing regimen.

17 a an ex vivo binding assay following an oral dosing regimen.

18 noglobulin G antibodies, supporting a 3-week dosing regimen.

19 remained more symptomatic regardless of the dosing regimen.

20 tment keeping and > or =80% adherence to the dosing regimen.

21 set of GH deficiency, age of the patient and dosing regimen.

22 antages of oral bioavailability and flexible dosing regimen.

23 ression could be controlled by the rapamycin dosing regimen.

24 half-life of 10.5 h, suggesting a once-daily dosing regimen.

25 a dose of 0.5 mg in either a T&E or monthly dosing regimen.

26 the T&E regimen was noninferior to a monthly dosing regimen.

27 er (42%), were treated with this alternative dosing regimen.

28 pendent on strict patient adherence to daily dosing regimen.

29 to an individualized ranibizumab 0.5 mg PRN dosing regimen.

30 atient population, iron chelating agent, and dosing regimen.

31 und (SC-51322) to AGN 197727 in the systemic dosing regimen.

32 half-life, necessitating a three times daily dosing regimen.

33 es iron absorption and might be a preferable dosing regimen.

34 rit additional evaluation of the once-weekly dosing regimen.

35 ry function for 4-6 months during a 12 month dosing regimen.

36 to ranibizumab or bevacizumab and to 1 of 3 dosing regimens.

37 t-reducing strategies, including alternative dosing regimens.

38 s of ranibizumab or bevacizumab under 1 of 3 dosing regimens.

39 patients receiving once-daily vs twice-daily dosing regimens.

40 ly effective in vivo activity, even with low dosing regimens.

41 es and lack of patient adherence to frequent dosing regimens.

42 nt outcomes, drug deployment strategies, and dosing regimens.

43 ationale for clinical testing of alternative dosing regimens.

44 ect and toxicity with standard and alternate dosing regimens.

45 eater visual improvement and more convenient dosing regimens.

46 acokinetic effects between the two elinogrel dosing regimens.

47 treated with IL-21 by using three different dosing regimens.

48 the efficacy and effectiveness of different dosing regimens.

49 ial therapeutic benefit using well-tolerable dosing regimens.

50 in combination with each of the chemotherapy dosing regimens.

51 2-dose regimen and was inferior to all other dosing regimens.

52 ctiveness, and feasibility of individualized dosing regimens.

53 A receptor agonist binodenoson, using 1 of 4 dosing regimens.

54 at can then be used to design individualized dosing regimens.

55 vitro immunologic activity of the different dosing regimens.

56 suffer from rapid clearance requiring 3-day dosing regimens.

57 , 69.4] twice daily; p=0.33) between the two dosing regimens.

58 to ranibizumab or bevacizumab and to 1 of 3 dosing regimens.

59 Typical side effects also occurred at low dosing regimens.

60 received placebo or one of three ALS-008176 dosing regimens: 1 loading dose of 750 mg followed by 9

61 oth erythropoietin groups were futile (first dosing regimen: 17/35 [48.6%; 95% CI, 31.4% to 66.0%], P

62 6%; 95% CI, 31.4% to 66.0%], P = .13; second dosing regimen: 17/57 [29.8%; 95% CI, 18.4% to 43.4%], P

63 randomly assigned to one of three paclitaxel dosing regimens-175 mg/m(2), 210 mg/m(2), or 250 mg/m(2)

64 emurafenib outside of trials with individual dosing regimens (240-1920 mg/d; median treatment duratio

65 ol (hydrocortisone, HCT) using two different dosing regimens (25 mg/day over 4 days, 100 mg single do

66 Palifermin administered at the indicated dosing regimen (40 microg/kg for 3 consecutive days) bef

67 ntration profiles for different temozolomide dosing regimens (75-200 mg/m(2)/d).

68 After a daily dosing regimen, a shift to excitatory-inhibitory balance

69 Current dosing regimens achieved target concentrations for merop

70 ed the efficacy and safety of an alternative dosing regimen administered on an outpatient basis in ac

71 2-year study of three intravenous teplizumab dosing regimens, administered daily for 14 days at basel

72 Continuing standard dosing regimens after primary non-response was rarely he

73 data from clinical trials evaluating various dosing regimens against the patient's disease, lifestyle

74 sign of the next trial to determine a repeat dosing regimen aimed at establishing a steady-state Treg

75 s compared with a paediatric oral dabigatran dosing regimen (an age-adjusted and weight-adjusted nomo

76 ose who received placebo, with an infrequent dosing regimen and an acceptable safety profile.

77 and physician compliance by simplifying the dosing regimen and clarifying endocarditis risk.

78 ant further studies to establish the optimal dosing regimen and efficacy.

79 ed open-label pexacerfont following the same dosing regimen and had cerebrospinal fluid sampled to es

80 ment of pediatric uveitis, including optimal dosing regimen and long-term efficacy.

81 rug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady st

82 The length of treatment, dosing regimen and stage of disease, patient age, ethnic

83 ere scored (0-5) by a radiologist blinded to dosing regimen and time interval.

84 Exploration of alternative dosing regimens and combinatorial therapies with vaccine

85 Dosing regimens and consequent drug exposures that ampli

86 ed 5,000 Monte Carlo simulations for various dosing regimens and minimal inhibitory concentration and

87 elopment of biomarkers to define appropriate dosing regimens and predict which patients may benefit f

88 ion probabilities to alternative selepressin dosing regimens and to trigger transition to part 2, whi

89 , that opens new avenues for evaluating drug dosing regimens and understanding growing resistance of

90 dual patient data on SAEs, assigned drug and dosing regimen, and baseline prognostic factors were req

91 nd strong translational evidence, an optimal dosing regimen, and better tolerability.

92 the potential of metabolic imaging for dose, dosing regimen, and compound selection in early-phase tr

93 Drug, dosing regimen, and genotype had no statistically signif

94 paradigm in terms of the treatment goal and dosing regimen, and provides a method to address the unm

95 or with pharmacokinetic properties, flexible dosing regimen, and suite of target engagement biomarker

96 ly limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status amon

97 oxicology studies, selection of first in man dosing regimens, and PK/PD model development.

98 lied on an outpatient basis according to the dosing regimen approved for psoriasis vulgaris.

99 ermatology with ustekinumab according to the dosing regimen approved for psoriasis.

100 by the kidneys or can affect renal function, dosing regimens are dramatically different in the neonat

101 These dosing regimens are especially challenging in the develo

102 ductions to the lowest recommended pediatric dosing regimens are possible when using PET/MRI.

103 ues, no difference was found between the two dosing regimens at any point over the study period for s

104 of this study was to select an intramuscular dosing regimen based on a comparison of the antiviral ac

105 supports an alternative weekly (40 000 U/wk) dosing regimen, based on common clinical practice.

106 supports an alternative weekly (40,000 U/wk) dosing regimen, based on common clinical practice.

107 (diagnostic category, age, sex, ethnicity), dosing regimen, blinding status, duration, or publicatio

108 Using this individualised dosing regimen, both genders responded equally to GH rep

109 havior of each class of drug so that optimal dosing regimens can be designed.

110 tions about efficacy and safety of different dosing regimens can be made.

111 zation with CTB by any of several routes and dosing regimens can provide protection against live V. c

112 129 patients were treated at ten dosing regimens combining vemurafenib and cobimetinib: 6

113 Complex dosing regimens, costs, side effects, biodistribution li

114 The sCAR-T-cell dosing regimen could be tuned to provide efficacy compar

115 These findings suggest that dosing regimens could be individualised and tailored for

116 mechanisms elicited by different irradiation dosing regimens could improve radiotherapy selection for

117 The improved selinexor dosing regimen described herein is crucial to help reduc

118 sistance emergence and incorporating them in dosing regimen design.

119 effects or switch to the use of a once-daily dosing regimen due to compliance issues.

120 With the dosing regimens employed in the included studies, ESA th

121 axel and eribulin, we performed a 2-week MTD-dosing regimen, followed by a determination of drug phar

122 icacy of adalimumab double-blind maintenance dosing regimens following open-label induction for pedia

123 ) monotherapy using a consistent, comparable dosing regimen for 3 months after transplant.

124 suspension; for those younger than 6 months) dosing regimen for 30 days (or 7 days for those younger

125 The optimal induction dosing regimen for adalimumab in this study was 160 mg a

126 and the tumor microenvironment, the optimal dosing regimen for carrier-mediated agents, and the lack

127 The best route and dosing regimen for corticosteroid administration (oral v

128 provide critical information for optimizing dosing regimen for effectiveness and safety.

129 n this model of acute pancreatitis, the same dosing regimen for ethyl pyruvate also ameliorated bacte

130 ess efficacy, and to identify an appropriate dosing regimen for further development.

131 xic coordinates, we optimized the timing and dosing regimen for injection of mAb into the cortex.

132 Moreover, the use of a different dosing regimen for RTX and OBZ further complicates any i

133 ve allowed us to identify a linker, dose and dosing regimen for SN-38 conjugated to polyoxazoline-mod

134 As such, applying current (99m)Tc-sestamibi dosing regimens for 1- and 2-d protocols based on those

135 ndomized in a double-blind fashion to 1 of 5 dosing regimens for 12 weeks: placebo or 5, 20, 50, or 1

136 domly to ranibizumab or bevacizumab and to 3 dosing regimens for 2 years and was at the ophthalmologi

137 zumab or bevacizumab treatment and to 1 of 3 dosing regimens for 2 years.

138 nical trials will help determine the optimal dosing regimens for all of these agents, as well as the

139 linical trials demonstrate that the standard dosing regimens for each of these agents may be used to

140 ded to determine the most effective maternal dosing regimens for improving infant vitamin A status.

141 Effective dosing regimens for inadequately responding patients to

142 , in reducing risk of colectomy, (6) optimal dosing regimens for intravenous corticosteroids and infl

143 However, the optimal drug and dosing regimens for IPT remain to be determined.

144 de the design of optimal drug candidates and dosing regimens for minimizing the emergence of resistan

145 tems ranging from coagulation to therapeutic dosing regimens for monoclonal antibodies.

146 methods for choosing drugs and for selecting dosing regimens for narrow-therapeutic-index drugs.

147 We determined optimal dosing regimens for neutrophil depletion and evaluated t

148 cific recommendations can be made on optimal dosing regimens for reversal; maintenance; and preventio

149 d in the development of increased and serial dosing regimens for somatic gene editing in vivo.

150 ary embolism randomly assigned to 1 of 4 tPA dosing regimens for ultrasound-facilitated, catheter-dir

151 ated tPA (tissue-type plasminogen activator) dosing regimens for ultrasound-facilitated, catheter-dir

152 sponse or web-response system, to one of two dosing regimen groups (every 2 weeks, or every 2 weeks f

153 mbination of data from the two pembrolizumab dosing regimen groups was not protocol-specified.

154 However, daily dosing regimen has augmented non-adherence.

155 Moreover, appropriate dosing regimens have not been systematically evaluated t

156 Appropriate dose and dosing regimens, however, require further study.

157 ATION: Both the 2-week and 4-week ixekizumab dosing regimens improved the signs and symptoms of patie

158 Consistent with this mechanism, the repeat dosing regimen in a separate cohort of subjects led to i

159 The probabilities of each drug and dosing regimen in achieving pharmacodynamic targets were

160 with human IL-2 (Proleukin) in a therapeutic dosing regimen in chimpanzees, and found that although t

161 However, the optimal dosing regimen in settings in which human immunodeficien

162 es of the drug and to rationalize an optimal dosing regimen in the clinic, a method is needed to quan

163 ved with 480 mg vemurafenib, suggesting that dosing regimens in BRAF-driven cancers could warrant rea

164 investigate the efficacy of different BUP-XR dosing regimens in participants with opioid use disorder

165 armacodynamic effects of different prasugrel dosing regimens in patients on maintenance prasugrel the

166 he efficacy and tolerability of different GA dosing regimens in patients with a poor PS.

167 ity of two long-term intermittent vismodegib dosing regimens in patients with multiple basal-cell car

168 dosing, ultimately supporting less frequent dosing regimens in preclinical tumor models compared wit

169 Patients received one of three dosing regimens in which aliquots of Surfaxin were admin

170 known Pgp substrate, using steady-state PAC dosing regimens in wild-type and Pgp knockout (mdr1a -/-

171 exposures owing to our current non-optimized dosing regimens initiate a chain of evolution driven eve

172 h the higher dosage suggest that the optimal dosing regimen is <50 mg/h.

173 However, the most beneficial dosing regimen is not known.

174 The ideal dosing regimen is unknown.

175 n can be advantageous in achieving desirable dosing regimen, it must be well-directed in order to avo

176 arrhythmias [n=4]) were randomized to 1 of 3 dosing regimens (low, medium, or high: load plus 47-hour

177 as species/strain, route of administration, dosing regimen, lowest effect level, and test outcome, w

178 A simplified dosing regimen may improve drug compliance in kidney tra

179 Extended TMZ dosing regimens may be superior by delivering the drug c

180 Higher dosing regimens maybe required in critically ill patient

181 hs were available (85%) and adherence to the dosing regimen (mean >80%) also were remarkably high.

182 ned by drug (ranibizumab or bevacizumab) and dosing regimen (monthly or as needed).

183 61), or placebo administered in an identical dosing regimen (n = 161), for a total of 18 months.

184 Mice were put on the subacute dosing regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropy

185 on to clinically acquired image data using a dosing regimen of 3.7 MBq/kg, images from simulated low-

186 end points was observed with the therapeutic dosing regimen of BMS-345541, with use of the 100-mg/kg

187 The previously described interaction of dosing regimen of CAF with ErbB-2 was not dependent on p

188 cancer patients, further exploration of the dosing regimen of CDP860 is required to dissociate adver

189 ity was achieved in mice with a noncytotoxic dosing regimen of ethyl pyruvate shown previously to pro

190 The results show that a binge dosing regimen of METH to the rat increased plasma and b

191 important to more fully understand the best dosing regimen of MMF for induction versus maintenance t

192 f ranibizumab or bevacizumab and to a 2-year dosing regimen of monthly or pro re nata (PRN) or to mon

193 nversion to the same milligram-for-milligram dosing regimen of Neoral during period III (days 29-35).

194 apy regimens, leading to questions about the dosing regimen of prasugrel to administer if percutaneou

195 An individualized dosing regimen of ranibizumab 0.5 mg driven by stabiliza

196 the efficacy, long-term safety, and optimal dosing regimen of rituximab in this setting.

197 centration-dependent activity and once-daily dosing regimen of telavancin.

198 O(6)-BG when added to a 1-day dosing regimen of temozolomide was able to restore temoz

199 The safety and optimal dosing regimen of the most effective topical anti-inflam

200 t dose of vehicle or TNP-470, a steady-state dosing regimen of TMZ was administered with subsequent c

201 The same dosing regimen of topical BRAF inhibitor does not increa

202 in the morning and were maintained on an am dosing regimen of XL using the same therapeutic monitori

203 bone who had previously received a standard dosing regimen of zoledronic acid and/or pamidronate dis

204 In animal studies, different dosing regimens of AdE2F-1(RC) administered to flank xen

205 tered MPTP with varying subcutaneous or oral dosing regimens of AEOL11207.

206 istance would be of great value in tailoring dosing regimens of antibiotics so as to maximize the dur

207 re randomized in a double-blind fashion to 3 dosing regimens of atopaxar (50, 100, or 200 mg daily) o

208 t was the safety and tolerability of the two dosing regimens of benralizumab up to 68 weeks for adult

209 ients were randomly assigned to one of three dosing regimens of CAF.

210 antitative reporter to optimize sequence and dosing regimens of clinically relevant combination strat

211 dy determined the safety and efficacy of two dosing regimens of daclizumab compared with no antibody

212 we evaluated the efficacy and safety of five dosing regimens of denosumab in patients with breast can

213 ment interaction was observed between either dosing regimens of edoxaban and warfarin for the efficac

214 tion should be exercised on the extrapolated dosing regimens of ester drugs from other age groups.

215 Patients who received 1 of 6 dosing regimens of evolocumab in the parent studies and

216 ies enrolled 626 patients and used differing dosing regimens of fluconazole.

217 sought to evaluate the efficacy/safety of 4 dosing regimens of grass allergen peptides after a secon

218 is crucial to identify potentially effective dosing regimens of hydroxychloroquine.

219 Fixed-interval and variable dosing regimens of intravitreal bevacizumab improved vis

220 cokinetic and pharmacodynamic effects of two dosing regimens of IV followed by oral elinogrel (120 mg

221 tics (PK), efficacy, and safety of alternate dosing regimens of micafungin (MFG) for the treatment of

222 plant recipients should receive personalized dosing regimens of MMF, which would maximize efficacy an

223 d the activity and safety of three different dosing regimens of oral panobinostat in combination with

224 Three dosing regimens of RBX7455 were safe and effective at pr

225 Random assignment to 1 of 3 dosing regimens of selepressin (starting infusion rates

226 ents were randomized to receive one of seven dosing regimens of sibrafiban, ranging from 5 mg daily t

227 drugs and other biological treatments, both dosing regimens of sirukumab were well tolerated and sig

228 We aimed to compare two dosing regimens of tosedostat.

229 med to assess the efficacy and safety of two dosing regimens of tralokinumab in patients with severe

230 were given either saline (control) or 1 of 2 dosing regimens of Vitaxin (high dose, 5.0 mg/kg, and lo

231 vipiravir has demonstrated the importance of dosing regimen on the distribution and tissue uptake and

232 ent once-daily, prolonged-release tacrolimus dosing regimens on renal function after de novo liver tr

233 /d) mesalamine); (2) comparison of different dosing regimens (once-daily vs multiple times per day do

234 ons may be managed by modifying the levodopa dosing regimen or by adding several other medications, s

235 Further studies with different dosing regimens or second agents seem warranted.

236 ith regards to specific indications, optimal dosing regimens, or treatment efficacy.

237 n study design, participants, drugs used and dosing regimens, outcome measures, side-effects, and sou

238 anibizumab or bevacizumab and to 3 different dosing regimens over a 2-year period.

239 ranibizumab or bevacizumab with 3 different dosing regimens over a 2-year period.

240 did not differ by treatment group, drug, or dosing regimen (P > .01 for all).

241 ross diverse paradigms, varying the dose and dosing regimen, prion strain, treatment timepoint, and e

242 The 2 riboflavin dosing regimens produced equivalent reduction in the max

243 All three alternative dosing regimens produced HI, RBC transfusion independenc

244 mab administered as per a VA-guided flexible dosing regimen recommended in the European ranibizumab S

245 obability of target attainment of antibiotic dosing regimens regardless of pharmacodynamic target.

246 ability, and safety of the two intramuscular dosing regimens relative to oral cabotegravir plus abaca

247 plasma concentrations of fomepizole with the dosing regimen, residual illness or disability, and deat

248 Furthermore, weight-based dosing regimens resulted in lower overall doses in femal

249 going clinical trials with HCQ use different dosing regimens, resulting in various concentrations.

250 This ensures appropriate dosing regimen, route of administration and/or formulati

251 The new dosing regimen safely increased the efficacy of miltefos

252 erapy, as well as indications for their use, dosing regimens, safety, and efficacy.

253 These customized dosing regimens should also be given as soon as practica

254 nce the effect waned over time, intermittent dosing regimens should be considered for long-term eradi

255 Both benralizumab dosing regimens significantly improved prebronchodilator

256 The two benralizumab dosing regimens significantly reduced the median final o

257 per day Brd4 inhibitor JQ1 in a therapeutic dosing regimen substantially attenuated lung fibrosis in

258 sine administration at clinically meaningful dosing regimens suppressed P. aeruginosa pathogenicity i

259 This review focuses on a novel dosing regimen that has achieved significant clinical ac

260 with the FDA-approved drug ritonavir using a dosing regimen that resulted in plasma concentrations wi

261 lling 8-15 patients), and used agents and/or dosing regimens that are now less commonly used in clini

262 treatment, along with the study of modified dosing regimens that provide higher exposure, is warrant

263 ical models can be used to identify rational dosing regimens that suppress the amplification of the r

264 Furthermore, the simpler dosing regimen, the absence of neutropenia, and the lowe

265 atients treated overall with the recommended dosing regimen, the median number of prior systemic ther

266 Across all dosing regimens, the most common adverse events were dia

267 This permitted comparison of rituximab dosing regimens, the value of continuing immunosuppressi

268 able optimized dosing, the use of customized dosing regimens through either evidence-based dosing nom

269 ect may have been obscured by differences in dosing regimens, time off the filter, or altered pharmac

270 tion of Secukinumab vs. Etanercept Using Two Dosing Regimens to Determine Efficacy in Psoriasis), we

271 or racial origin, body-mass index, vitamin D dosing regimen, use of inhaled corticosteroids, or end-s

272 00 mg tedizolid phosphate per day in humans (dosing regimen used in phase 2 and 3 clinical trials).

273 The dosing regimen used in renal transplant recipients is mo

274 The dosing regimen used in the present study is considerably

275 With the dosing regimen used in this study, alteplase produces gr

276 ted the hypothesis that the patient-specific dosing regimen used with (131)I-tositumomab results in l

277 e marrow toxicity than does the weight-based dosing regimen used with (90)Y-ibritumomab tiuxetan.

278 case studies that investigated the different dosing regimens used for the 3 intravitreal anti-vascula

279 There is great variation in the drug dosing regimens used for thrombolysis and in the inciden

280 efficacy of 5 SAR236553/REGN727 (SAR236553) dosing regimens versus placebo at week 12 in patients wi

281 odynamic target attainment for antimicrobial dosing regimens vs. observed MIC distributions.

282 okinetic parameters with a convenient single-dosing regimen warrant further disease-directed evaluati

283 Adherence to the dosing regimen was 91.8% among subjects who completed th

284 inistration CYP activity; the St John's wort dosing regimen was continued for 48 hours.

285 Large variability in the micafungin dosing regimen was observed; 78 (75%) patients received

286 ies of toxicity studies of ligands 1- 3, the dosing regimen was shown to have a profound effect in an

287 An effective dosing regimen was then selected for testing in swine.

288 inferiority of T&E compared with the monthly dosing regimen was to be shown using a margin of 5 lette

289 valence for the treatment difference between dosing regimens was considered clinically relevant.

290 clinical allotransplantation, but using the dosing regimens we used, is not a tolerizing therapy in

291 Using a q4dx4 dosing regimen, we also found that POx/SB-T-1214 signifi

292 Intermittent and continuous dosing regimens were analysed.

293 proximately 40% of patients in both exercise dosing regimens were classified as VO(2)peak responders

294 The effects of these two dosing regimens were compared with our previous findings

295 Four PV701 intravenous dosing regimens were evaluated: (1) single dose: one dos

296 to ranibizumab or bevacizumab and to 1 of 3 dosing regimens were released from the clinical trial pr

297 ill patients treated with epoetin alfa, all dosing regimens were well tolerated and appeared to effe

298 elf-administering cocaine underwent a 6-week dosing regimen with fluoxetine designed to approximate s

299 Since then, various modified dosing regimens with the aim of lessening the treatment

300 aparin administration demonstrated that both dosing regimens would reach target 3-hour plasma concent