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1 utotetraploidization (that is, direct genome doubling).
2 39, 28 aquaporin-4 (AQP4)-Ab-seropositive, 3 double-Ab-seronegative, 4 myelin oligodendrocyte glycopr
3 eroid dimers were obtained by acid-catalyzed double acetalization of (20S)-5alpha-pregnan-3beta,16bet
4 soform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuro
5 pe (RNA or DNA), its strandedness (single or double), and its sequence (aside from the target adenine
7 rmed NTs containing Magneli phases through a double annealing route: oxygen (O(2)) annealing followed
15 essor pain tolerance before and 40-min after double-blind injection of .08 mg/kg morphine or placebo.
16 conducted a randomized, placebo-controlled, double-blind pharmacological study testing the impact of
23 this 12-week, single-center, parallel-group, double-blind RCT and randomized into 4 arms (n = 23): HP
24 NG, AND PARTICIPANTS: Multicenter randomized double-blind sequential trial conducted in France, with
25 ement initiation.SIGNIFICANCE STATEMENT This double-blind sham-controlled study suggested that neurof
27 no difference between treatment arms during double-blind treatment, but during the open-label period
32 reased Cardiovascular RisK) is a randomized, double-blind, multinational trial comparing monthly subc
33 , AND PARTICIPANTS: Multicenter, randomized, double-blind, parallel-group trial conducted at 74 inten
34 is phase 2, multicenter, placebo-controlled, double-blind, parallel-group trial, we randomly assigned
42 cally Manage Acute Coronary Syndromes) was a double-blind, placebo-controlled randomized trial conduc
46 DeltaNS2/Delta1313/I1314L was evaluated in a double-blind, placebo-controlled trial (vaccine-placebo
53 participants volunteered in this randomized double-blind, placebo-controlled, between-group study.
66 ers were analyzed as secondary outcomes of a double-blind, randomized, milk-based vitamin D intervent
71 focus on the use of un-bias patient cohorts, double-blinded index test and detection assays that do n
77 IGN, SETTING, AND PARTICIPANTS: Multicenter, double-blinded, randomized clinical trial at 20 trauma c
78 terpenes and terpenoids exhibiting a single double bond as the only functional group, such as alpha-
81 known as plasmalogens, harbor a vinyl ether double bond conferring special chemical and physical pro
84 mputational study suggest that, despite fast double bond migratory insertion into Ir-H, the reaction
85 enation of a 1,3-diene to a tetrasubstituted double bond, enzyme-catalyzed malonate desymmetrization,
86 t species with one localized N=P and one C=P double bond, whereas the heterocyclopentanediyl isomer r
89 d tandem-MS (MS(n)), the localization of C=C double bonds (DBs) requires specialized fragmentation an
90 id class with two additional CH(2) and three double bonds (Deltam/z = 0.0025) and the first isotopic
93 eveals the paramount role played by internal double bonds on the self-assembly of discrete large mole
94 cis addition of H(2) (or D(2)) across alkene double bonds, reminiscent of rhodium(I) catalysts but di
96 a submaximal concentration of enkephalin was doubled by application of all three peptidase inhibitors
98 increasing soil pH by liming, crop rotation, double-cropping, inter-season cover crops, no-tillage sy
101 nd protein were markedly reduced in Src-1/-2 double-deficient (Src-1/-2(d/d) ) fetal lungs, compared
104 n acyl-enzyme intermediate, Ac-Ser-216, by a double displacement bi-bi mechanism involving a Ser-His-
107 bm-Calpha-PNA with mixed sequences can form double duplexes by simultaneous binding to two complemen
108 of the costs and benefits of an illustrative double-duty intervention that addresses both stunting an
109 the Nt-amidase, arginyltransferase, and the double-E3 ubiquitin ligase UBR1-RAD6/UFD4-UBC4/5 are sho
110 eloped by an outer membrane that serves as a double-edged sword: On the one hand, it provides a layer
111 Site directed spin labeling EPR and DEER (double electron-electron resonance) studies of apo and h
112 FCDS platform employs water-in-oil-in-water double emulsion droplets serving as single-cell enzymati
114 ility of calcium and vitamin D(3), the W/O/W double emulsions were subjected to digestion in simulate
115 usions are fossilized, resin-in-sap-in-resin double emulsions, showing banding patterns with differen
117 al haploid induction (HI), which occurs when double fertilization precedes maternal (egg cell) genome
124 eracts with the surface of the triple-cation double-halide perovskite material via halogen bonding.
126 ting the shape of tetrahedral containers, of double helices, and, supreme wonder, of the Borromean ri
127 nzene-1,3,5-tricarboxamides (BTAs) that form double helices, fibers that were long thought to be chai
128 or the two consecutive reactions and the DNA double helix adopts drastically different structures.
136 rotocol, metal-containing anions and layered double hydroxides are employed to control the components
138 adult female (AF) seasonal ranges more than doubled in spring and summer and were significantly larg
140 den of pre-pregnancy hypertension has nearly doubled in the past decade and the rural-urban gap has p
143 hicle, relative risk = 2.21, p < 0.022), and doubled infarct volumes (p < 0.001) and worsened neurolo
144 roton-density/T2-weighted, as well as FLAIR, double inversion recovery and phase-sensitive inversion
146 X or ZNF711 reduced cell growth and that the double knockout cells have major defects in proliferatio
149 nderstanding of the formation of an electric double layer (EDL) at a liquid-solid interface in physic
150 he space-charge distribution in the electric double layer, which blocks the long-range migration of C
152 -source (SS) OCT angiography (OCTA) and the "double-layer sign" on structural spectral-domain OCT (SD
153 ft) single-Maddox rod values were similar to double-Maddox values (mean differences: -1.2 degrees and
156 Atg12, and Atg8-play in the formation of the double-membrane vesicle autophagosome, which is the func
158 with light microscopy, which correlates with double-membrane vesicles containing vacuoles observed wi
160 n is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored m
161 f cellular organelles and proteins, in which double-membraned vesicles (autophagosomes) sequester cyt
162 a, a small molecule inhibitor of MDM2 (mouse double minute 2 homolog) to upregulate and increase acti
163 ong and broad loss of neural APA in elav/fne double mutant CNS, the first genetic background to large
164 but chorions from eggs laid by larp6a;larp6b double mutant females were more defective than those fro
166 elX In line with this, a DeltapelX DeltapgnE double mutant was substantially impaired in its ability
167 aralog, and of trigenic interactions for the double mutant, provides insight into their roles and a q
173 developed normal spikelets, but ap2l2 ap2l5 double mutants generated spikelets with multiple empty b
175 Analysis of the lls1 sgl1 and lls1 palm1 double mutants revealed that SGL1 is epistatic to LLS1,
179 hymocytes to differentiate from CD4(-)CD8(-) double-negative (DN) cell to CD4(+)CD8(+) double-positiv
180 ts, we identify CD4(-)CD8(-)TCRalphabeta(+), double-negative (DN) T cells, in mouse secondary lymphoi
184 Treatment Diabetic Retinopathy Study lines (doubling of the visual angle) of uncorrected distance vi
185 of tucatinib to trastuzumab and capecitabine doubled ORR-IC, reduced risk of intracranial progression
186 essful ovulatory strategy would be to always double ovulate as an insurance against early fetal loss,
187 ; 95% confidence interval [CI]: 1.7, 6.9 per doubling; P = .001) and increasing GGO attenuation (OR,
188 ctive protein (OR, 2.1; 95% CI: 1.3, 3.4 per doubling; P = .004), history of heart failure (OR 1.3; 9
189 Graft assessment was performed using NMP via double perfusion of the hepatic artery and portal vein.
194 on with the TCGA database indicated a higher double-positive signal in basal-like breast cancer than
196 s also suggest that membrane binding of MreB double protofilaments induces a stable membrane curvatur
198 a bridged structure has been synthesized by double radical trans-hydroboration of benzo[3,4]cyclound
203 patterns two cytokinetic structures-a septin double ring and an actomyosin ring-and also defines the
206 es a structural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 ch
207 forded the enone (E, 70%; Z, 3%); subsequent double-ring cyclization of the E-enone (via Nazarov, ele
208 ymine, [P(4444)][Thy].2H(2)O, as well as the double salt cocrystal, [P(4444)](2)[Ad][Thy].3H(2)O.2HTh
209 dressed higher-priority topics, and included double-sequential defibrillation, intravenous versus int
210 by pressurized liquid extraction followed by double-shot microfurnace pyrolysis coupled to gas chroma
212 thermal ionization mass spectrometry (TIMS) double-spike method and produce unbiased seawater Pb iso
213 This finding not only exposes a fraught double standard, but also portends consequential behavio
216 y restore HR, whereas KAT5 depletion rewires double strand break repair by promoting 53BP1 binding to
217 to a large spectrum of DNA damage, including double strand breaks (DSBs) that interfere with replicat
219 xonuclease 5 (EXO5) gene in androgen-induced double strand breaks repair via homology-directed repair
220 gulatable CRISPR/Cas9 strategy to induce DNA double strand breaks specifically in the telomeres, ChIP
222 ibility that the minimal requirement for DNA double-strand break (DSB) formation is as low as even on
223 e evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chr
227 I3K pathway activation and also hindered DNA double-strand break repair, which both led to improved r
232 combination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic location
233 Mechanistically, BGL3 is recruited to DNA double-strand breaks (DSBs) by PARP1 at an early time po
234 t cancer cells to A3B-mediated mutations and double-strand breaks (DSBs) by perturbing canonical base
236 recombination were randomly distributed, the double-strand breaks (DSBs) that initiate recombination
237 omal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over m
238 se spo-11 mutants, which lack endogenous DNA double-strand breaks (DSBs), to induce a single DSB by M
239 way repairs psoralen-ICLs without generating double-strand breaks (DSBs), unlike the FA/BRCA pathway.
243 both DNA single-strand breaks (SSBs) and DNA double-strand breaks (DSBs); lesions that can trigger ne
248 stribution does not reflect the abundance of double-strand breaks, detected by proxy as RAD51 foci at
252 surface exhibiting a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA)
253 ethylation at meiotic hotspots, impaired DNA double-strand-break repair, and reduced crossover number
255 st SARS-CoV spike protein and nucleoprotein, double stranded RNA, and RNA probe for spike genes were
256 retrotransposition assay that identified the double-stranded break (DSB) repair and Fanconi anemia (F
258 rsaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unice
259 ng interface exclusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and
260 and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable n
263 During cell division, FtsK translocates double-stranded DNA until both dif recombination sites a
265 in which viral RNA genome is converted into double-stranded DNA, is that it is slow and non-processi
270 n GUVs provide significant protection of the double-stranded RNA (dsRNA) replication intermediate aga
271 IFN pathway, which comprises the sensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IF
273 Endogenous release of type I IFNs with the double-stranded RNA mimetic poly(I:C) likewise produces
274 ce (RNAi) is a natural process through which double-stranded RNA molecules can silence the gene carry
277 obust protein translocases and function with double the energetic efficiency of ClpAP variants with c
279 continuous veno-venous hemodiafiltration and doubled the percentage of patients using regional citrat
280 iver operating characteristic curve >= 0.9), doubles the estimated efficiency of population-based new
283 , and strongly synergizes with chemotherapy, doubling the duration of mouse survival over chemotherap
284 s of HC84.26.5D may also serve as a means of doubling the effective size of conventional Fab-protein
286 f isolates tested for drug susceptibility is doubled, this strategy could increase the effective life
287 strombine levels during the day were nearly double those at night, indicating sifnificant fermentati
288 ures of the cohort included short median PSA doubling time (2.3 mo) and extensive prior treatment, in
289 for Ng is challenged by the pathogen's slow doubling time and the lack of methods to quickly quantif
291 ge degree of GDGT cyclization increases with doubling time in continuous cultures of the thermoacidop
295 hensive Cancer Network stage, PSA level, PSA doubling time, PSA velocity, and time between initial tr
297 pted in the fast-growth regime, that is, for doubling times below 1 h, extension of these dogmas to t
299 Ts in marketed fish was performed by a novel double-vortex-ultrasonic assisted matrix solid-phase dis