ライフサイエンスコーパス: double helix

1 nfluenced by local environment (an adjoining double helix).

2 to U when paired with A, G, U or C inside a double helix.

3 nks have to facilitate strong bending of the double helix.

4 sive mode of action of Aga50D on the agarose double helix.

5 NA depend on the nanoscale properties of the double helix.

6 nario is realized in the alpha-helix and DNA double helix.

7 stabilizing influence of base-stacking in a double helix.

8 ngle site, inducing little distortion in the double helix.

9 ate between successive base pairs of the DNA double helix.

10 in a conformation similar to the B-form DNA double helix.

11 diversity of DNA well beyond the ubiquitous double helix.

12 he flanking base pairs and straightening the double helix.

13 thread back and forth repeatedly through the double helix.

14 equence specificity and strongly distort the double helix.

15 -bending protein can do when it binds to the double helix.

16 ention has been paid to proteins leaving the double helix.

17 When it binds to DNA, it bends the double helix.

18 ize how Twist and Rise generate the familiar double helix.

19 ed DNA sequences interact to assemble into a double helix.

20 s overlap and occur on opposite faces of the double helix.

21 t orientations--stretching/distortion of the double helix.

22 undergo Watson-Crick base pairing to form a double helix.

23 perative over more than two turns of the DNA double helix.

24 complementary oligonucleotides together in a double helix.

25 DNA within the nucleus or the opening of the double helix.

26 he probe and target first collided to form a double helix.

27 equence of the interwound strands of the DNA double helix.

28 he two damaged base pairs to flip out of the double helix.

29 ) positions of the deoxyribose sugars in the double helix.

30 a single chain of bases at the center of the double helix.

31 ng is the main stabilizing factor in the DNA double helix.

32 lding the nucleobases from damage within the double helix.

33 amino acid residues near one face of the DNA double helix.

34 dence of the stacking free energy of the DNA double helix.

35 the interstrand hydrogen bonding in the DNA double helix.

36 n part, by being bonded to the sugars of the double helix.

37 rce for self-assembling the fragments to the double helix.

38 r strand separation and unwinding of the DNA double helix.

39 nd generally lie on the same face of the DNA double helix.

40 fundamental gap in our knowledge of the DNA double helix.

41 ve to be located in the same side of the DNA double helix.

42 ns between adjacent base-pairs in intact DNA double helix.

43 en the RFC spiral and the grooves of the DNA double helix.

44 the direction-dependent unwindability of the double helix.

45 ures of a variety of adduct molecules in DNA double helix.

46 pair of electrons to the minor groove of the double helix.

47 e been shown to produce curvature in the DNA double helix.

48 two ligands occupy opposite faces of the DNA double helix.

49 half-century following the discovery of the double helix.

50 that an A-tract imparts curvature to the DNA double helix.

51 contributed directly to the discovery of the double helix.

52 binding to the major or minor groove of the double helix.

53 pective of those times and the impact of the double helix.

54 with DNA, using its arm to clamp around the double helix.

55 ed to unwind and separate the strands of the double helix.

56 lation complexes via the major groove of the double helix.

57 the removal of DNA adducts that distort the double helix.

58 ly collected for the atoms in a few turns of double helix.

59 ted by flipping of a DNA base out of the DNA double helix.

60 esion sites, with the local unwinding of the double helix.

61 quadruplex structure is joined to a standard double helix.

62 he DNA backbone as well as untwisting of the double helix.

63 erturb the aperiodic crystal seen in the DNA double helix.

64 structures beyond the canonical Watson-Crick double helix.

65 structural and dynamic perturbations in the double helix.

66 ylic acid (poly(rA)) parallel and continuous double helix.

67 even led to a stabilization of the parallel double helix.

68 of the four-letter nucleobase code to form a double helix.

69 s owing to its ability to locally unwind the double helix.

70 of all thermodynamic characteristics of the double helix.

71 s often corresponding to the turn of the DNA double-helix.

72 nds differing in modes of binding to the DNA double-helix.

73 r than the corresponding value of the intact double-helix.

74 NA structure that differs from the canonical double-helix.

75 n years elapsed between the discovery of the double helix (1953) and the first DNA sequencing (1968).

76 modalities-2D, astigmatic 3D, biplane 3D and double-helix 3D-and evaluated 36 participant packages ag

77 to adjacent major grooves on one face of the double helix; a second dimer then binds to another face

78 bula having the morphology of an intertwined double helix about 100 parsecs from the Galaxy's dynamic

79 cholesterol concentration, the antiparallel double helix (ADH) conformation was observed to be most

80 or the two consecutive reactions and the DNA double helix adopts drastically different structures.

81 he angles between adjacent base pairs of the double helix affects the cyclization efficiency.

82 a ring-shaped heterohexamer, unwinds the DNA double helix ahead of the other replication machinery.

83 he DNA is achieved by destabilization of the double helix along its length through multiple interacti

84 ions of the threading and translation of the double helix along multistation rods were monitored by (

85 motile elements which extrude loops from the double helix along which they translocate, while excludi

86 a thermodynamic stable structure, such as a double helix, although small structural changes can yiel

87 removal and renewal of proteins bound to the double helix, an effect that likely plays a major role i

88 o DNA was identifiable by the grooves of the double helix and exhibited sharp bends at points downstr

89 dimers clamp DNA from opposite faces of the double helix and form a topological trap of the bound DN

90 re sufficient to distort both strands of the double helix and generate an enzyme-mediated double-stra

91 topological stress-induced unpairing of the double helix and have critical roles in organizing large

92 ognizes its target site by unwinding the DNA double helix and hybridizing a 20-nucleotide section of

93 tation of a DNA or RNA nucleotide out of the double helix and into a protein pocket ('base flipping')

94 lieved to induce or stabilize bending of the double helix and mediate nucleoid compaction in vivo.

95 pends both on the intrinsic curvature of the double helix and on the thermal fluctuations of the angl

96 ll bending, i.e., persistence length, of the double helix and shows how known discrepancies in the me

97 model that accounts for the softening of the double helix and the presence of transient denaturation

98 e template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydroge

99 de, depending on the specific details of the double helix and the single nucleotide polymorphism.

100 en used to reveal physical properties of the double helix and to characterize structural dynamics and

101 translocate by three modes: unzipping of the double helix and--in two distinct orientations--stretchi

102 nontemplate strand are extruded from the DNA double-helix and captured by sigma.

103 ouble-stranded helixes, which resemble a DNA double helix, and the inner wall is a quadruple-stranded

104 zinc-fingers interact with the backbone of a double helix; and second, the zinc-fingers specifically

105 Three of the four extremities of each double helix are attached to two microscopic beads, and

106 of DNA lesions in which both strands of the double helix are covalently joined, precluding strand op

107 The obtained energy parameters of the DNA double helix are of paramount importance for understandi

108 tly link the Watson and Crick strands of the double helix, are repaired by a complex, replication-cou

109 mutation that oligomerizes as a right-handed double helix around microtubules, which are left-handed.

110 hich are thought to bind DNA by wrapping the double helix around the ring, are rigidly held in an ori

111 rs of N2-CEdG destabilized significantly the double helix as represented by a 4 kcal/mol increase in

112 sidue addresses the dynamic structure of the double helix at intermediate resolution, i.e., the mesos

113 a double cover of the graph and that the DNA double helix axes represent the designed graph.

114 nly responsible for the stability of the DNA double helix: base pairing between complementary strands

115 ecreases the overall stability of the B-form double helix, biasing toward non-B-form DNA helix confor

116 CRISPR RNA and target strands do not form a double helix but instead adopt an underwound ribbon-like

117 of two adjacently tethered cations into the double helix but not by a single cation: two adjacent am

118 nds to the minor groove of DNA and bends the double helix by 160 degrees.

119 We discovered that untwisting of the DNA double helix by bacterial non-specific DNA binding prote

120 The extension of a DNA double helix by one or two additional A:T base pairs is

121 nt of fixed charges near one face of the DNA double helix can induce DNA bending by a purely electros

122 eotides promoting strand invasion in the DNA double helix can significantly enhance gene repair frequ

123 -stable biological structures known, the DNA double helix, can be melted once inside the liquid dropl

124 metric polynitride Hf(2) N(11) that features double-helix catena-poly[tetraz-1-ene-1,4-diyl] nitrogen

125 protamine and mu appear to destabilize pDNA double helix character to similar extents, according to

126 does not induce any final transition in DNA double helix conformation, and eventually, DNA presents

127 The natural DNA double helix consists of two strands of nucleotides that

128 ent and crystallinity along with the loss of double helix content was supported by size exclusion chr

129 mall decreases in relative crystallinity and double helix content.

130 cated that the B15D fibril was composed of a double helix defined by the selection rule l = n + 7m (w

131 pecifically at regions of stress-induced DNA double helix destabilization (SIDD)(2-4).

132 y to G4 structures and high selectivity over double helix DNA.

133 A hereditary system that is based on double-helix DNA sequences provides a stable way to stor

134 SNP detection in large double-helix DNA strands (e.g., 47 nt) minimize false-po

135 hromosome (SMC)1-SMC3 heterodimer with naked double-helix DNA.

136 Aside from the well-known double helix, DNA can also adopt an alternative four-str

137 In addition to the canonical double helix, DNA can fold into various other inter- and

138 It contains one long, imperfect double helix (domain I), one branched domain (domain II)

139 free DNA is often crystallized as an A-form double helix, Dsx(A) was crystallized as B-DNA and thus

140 able secondary structures upon unwinding the double helix during DNA replication.

141 The iconic image of the DNA double helix embodies the central role that three-dimens

142 energy to one strand at a time in the B-form double helix, enabling repair using the undamaged strand

143 ity maps now accounting for nicks in the DNA double helix, entropic elasticity of single-stranded DNA

144 in DNA minicircles and small DNA loops, the double helix experiences local disruptions of its regula

145 , although some of the bonds do break as the double helix extends at room temperature.

146 Lowering pH destabilizes the double helix, facilitating DNA translocation at lower fi

147 ends and other structural distortions of the double helix find in currently available X-ray structure

148 mage due to local destabilisation of the DNA double helix, followed by recruitment of specific repair

149 Single mismatches in the DNA double helix form nucleation sites for bubbles.

150 Urea m-values determined for double helix formation by DNA dodecamers near 25 degrees

151 o the zipping mechanism of the non-enzymatic double helix formation.

152 uest molecules bound at the extremities of a double helix formed by the host, as shown by NMR and CD

153 The double helix forms in dilute CH(3)CN solution of the mic

154 Here we propose to build an artificial double helix from fragments of two strands connected by

155 in the A-form, fullerenes penetrate into the double helix from the end, form stable hybrids, and frus

156 ciated with the disruption in the unstressed double helix, G(d).

157 o more intricate secondary structures (e.g., double helix, G-quadruplex), a transition from planar to

158 rved to reduce the persistence length of the double helix, generating sharp DNA bends with an average

159 zation interface by interacting with the XPF double helix-hairpin-helix (HhH2) domain.

160 The discovery of the double helix half a century ago has so far been slow to

161 evidence that any anomalous behavior of the double helix happens when DNA fragments in the range of

162 t decade, the issue of strong bending of the double helix has attracted a lot of attention.

163 eriod close to the helical period of the DNA double helix has been associated with intrinsic DNA bend

164 The DNA double helix has been called one of life's most elegant

165 bases, but the fate of excited states in the double helix has been intensely debated.

166 The molecular structure of the DNA double helix has been known for 60 years, but we remain

167 tranded DNA surface exposed upon melting the double helix has been quantified for DNA samples of diff

168 nuclease site cleaves both DNA strands of a double helix has not been well understood.

169 Unfortunately the double helix has not, so far, revealed as much as one wo

170 between the two complementary strands of the double helix, have an important role in chemotherapy reg

171 Type I hydrogel is formed via the PNA/DNA double-helix hybridization.

172 Type I double-helix hydrogel exhibits larger pore sizes than ty

173 ermodynamically destabilize the Watson-Crick double helix in a manner that facilitates the flipping-o

174 RG binds to DNA and unwinds ~2 turns of the double helix in an ATP-independent fashion.

175 dimers bind to opposite faces of the mec DNA double helix in an up-and-down arrangement, whereas MecI

176 We succeed in building such a double helix in both solution and solid state, by using

177 the decay of excess electronic energy in the double helix in poorly understood ways.

178 with Hfq, but the RNAs are not released as a double helix in the absence of rim arginines.

179 air segment of the distorted nucleosomal DNA double helix, in a position predicted to exclude chromat

180 cluding plectoneme formation, melting of the double helix induced by torque, a highly overwound state

181 of the DNA replication machinery through the double helix induces acute positive supercoiling ahead o

182 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation

183 3 heterodimer is able to restructure the DNA double helix into a series of loops, with a preference f

184 DNA unzipping, the separation of its double helix into single strands, is crucial in modulati

185 t the dimer lesion is flipped out of the DNA double helix into the substrate binding pocket.

186 nd in damaged DNA sites implies that the DNA double helix intrinsically codes for excited state Hoogs

187 ction between the circumnuclear disk and the double helix is ambiguous, but the images show a possibl

188 The DNA double helix is among the stiffest of all biopolymers, b

189 The double helix is apparently very similar to the standard

190 ization of the information stored in the DNA double helix is compromised.

191 currence of such a sharp bend within the DNA double helix is confirmed and exploited through efficien

192 oreover, transient self-assembly of a chiral double helix is formed when ALP is present to consume AT

193 The double helix is idealized for its aesthetic elegant stru

194 l concentration of GB in the vicinity of the double helix is much less than its bulk concentration.

195 Yet, as we know now, the DNA double helix is neither ideal nor rigid.

196 especially at jubilee celebrations, and the double helix is no exception.

197 confirm that the global conformation of the double helix is not altered by the presence of these pol

198 Charge transport through the DNA double helix is of fundamental interest in chemistry and

199 in DNA, forming a gate through which another double helix is passed, and acts as a DNA dependent ATPa

200 The opening of a Watson-Crick double helix is required for crucial cellular processes,

201 , nucleic acid structures with a left-handed double helix, is poorly understood(1-3).

202 major contributions to the stability of the double helix: lateral pairing between the complementary

203 ntercalation of the bithiazole tail into the double helix likely brings the metal-bound complex close

204 This double helix macromolecule represents one of the most ri

205 scovery, 50 years ago, that RNA could form a double helix made possible a number of advances, includi

206 ering the perceived topological state of the double helix, making underwound DNA appear to be overwou

207 licase might trap a single DNA strand as the double helix melts, and before it is unwound.

208 The key finding in the DNA double helix model is the specific pairing or binding be

209 hey bear an interesting semblance to the DNA double helix model.

210 ility to recognize and cleave a deviated DNA double-helix near a nick or a strand-crossing site.

211 We show how double helix non-ideality and fluctuations broaden the d

212 Simulations associate the former with the double helix occupying the constriction and the latter w

213 nimal structural repeat of thin filaments: a double helix of actin subunits with each strand approxim

214 port remarkable chiral configurations with a double helix of disclination lines along the cylindrical

215 RNA is a single strand rather than the double helix of DNA.

216 science has reached the iconic status of the double helix of DNA.

217 ed the degree of order and the degree of the double helix of the NLS.

218 longated helical arrangement compared to the double helix of the porphyrin-DNA.

219 The resulting polymer consists of a double helix of two identical conjugated organic strands

220 re of the NsD7-PA complex reveals a striking double helix of two right-handed coiled oligomeric defen

221 dynamics (spontaneous local openings of the double helix) of double-stranded DNA, we simulated the d

222 comprehensive structural description of the double helix on a genome-wide scale.

223 exchange rates show that basepairs in a DNA double helix open on millisecond timescales.

224 participating in Watson-Crick pairing in the double helix, or the side chains contacting DNA in TALEN

225 at, in addition to the elastic moduli of the double helix, other factors contribute to loop formation

226 ls, H-DNA formation results in a kink in the double helix path.

227 dity, and an increased abundance of parallel double helix (PDH) and single-stranded head-to-head (SSH

228 trandedness and directional asymmetry of the double helix, play a defining role in CT efficiency.

229 r dual SECM/optical microscope, generating a double helix point spread function at the image plane, w

230 with a wide-field microscope that exhibits a double-helix point spread function (DH-PSF).

231 development of new techniques, including the double-helix point spread function (DHPSF), to accuratel

232 e used the dual-color three-dimensional (3D) double-helix point spread function microscope to study t

233 the bacterium Caulobacter crescentus using a double-helix point spread function microscope.

234 y inherent in the double-lobed nature of the Double-Helix Point Spread Function, we account for such

235 udding yeast cells using a microscope with a double-helix point spread function.

236 The double helix portion of the RNA triple helix is more sim

237 suggest that particular deformations of the double helix predicted by the V(step) algorithm can dist

238 ntertwine between the two strands of the DNA double helix provides a massive challenge to the cellula

239 n mimicking that of a single strand within a double helix, providing insight into a mechanism for hai

240 On one hand it disrupts the double helix, providing the necessary strand separation

241 isingly, some chain pairs form unanticipated double-helix regions that result from mutual twisting of

242 y the intrinsic mechanical properties of the double helix reported here.

243 6 bp and 41 bp (3.5 turns and 4 turns of DNA double helix, respectively).

244 ents that can restore broken ends of the DNA double helix, restart broken DNA replication forks, and

245 ng mode when the oligonucleotide threads the double helix results in a DNA kink that tends to occupy

246 t increased GC content accompanies increased double helix rigidity.

247 ouble crossed halogen bonding that makes the double helix stable.

248 use them to dock a DNA-binding protein on a double-helix stage that has user-programmable tilt and r

249 and CTGCAA) were then extended with the same double helix stem of four base pair DNA (GAAG to 5' end

250 sic sites and other lesions that distort the double helix stimulate topoisomerase II-mediated DNA cle

251 as well as determining the magnitude of the double helix structural deformations during the dynamic

252 DNA is renowned for its double helix structure and the base pairing that enables

253 a banner year for biological chemistry: The double helix structure of DNA was published by Watson an

254 nce-directed variations in the canonical DNA double helix structure that retain Watson-Crick base-pai

255 quence-related and thermal variations in the double helix structure.

256 te wormlike chain that includes the explicit double-helix structure of DNA and where the linking numb

257 953, Watson and Crick not only described the double-helix structure of DNA, but also embraced the ide

258 efect lines that wind around each other in a double-helix structure.

259 forming sugar-like coats in the hairpin-like double helix structures of pre-miRNAs.

260 t, including one-dimensional (1D) single and double helix structures, nanowires, and two-dimensional

261 iscriminate between the end-to-end dimer and double-helix structures of gramicidin A.

262 In addition to the double helix symmetry revealed by Watson and Crick, clas

263 Chiral gratings with double helix symmetry were produced by twisting glass op

264 The two DX components are connected by a double helix that contains the binding site for MutS; wh

265 which the exons are arranged in a continuous double helix that facilitates the second reaction.

266 each other, giving rise to the assembly of a double helix that is stabilized by intermolecular [C-H..

267 tion to the intrinsic periodicity of the DNA double helix, the free energy has an oscillatory compone

268 If sufficiently G + C rich, the double helix then propagated throughout the oligonucleot

269 e topological problems of DNA by passing one double helix through a transient break in another, in a

270 describes the coiling of the axis of the DNA double helix to accommodate the torsional stress injecte

271 rusion of the target nucleobase from the DNA double helix to an extrahelical position is an essential

272 ively, allows a head-to-head or head-to-tail double helix to be generated.

273 lly derived conformational parameters of the double helix to evaluate the role of structural paramete

274 ws that the enzyme redirects the path of the double helix to expose the nick termini for the strand-j

275 site of damage are translated across the DNA double helix to the active site of human topoisomerase I

276 ), which covalently link both strands of the double helix together resulting in cytotoxicity.

277 The local bending of the double helix, typically mediated by architectural transc

278 lity of DNA and observed the buckling of the double helix under high loads.

279 ay define the length of backtracked RNA; DNA double helix unwinding in advance of the polymerase acti

280 uanine residue on the opposing strand of the double helix was recently identified, but the chemical c

281 A single DNA double helix was unzipped in the presence of DNA-binding

282 nformation, and stability in DNA and DNA-RNA double helixes was studied.

283 In describing the DNA double helix, Watson and Crick suggested that "spontaneo

284 In the canonical DNA double helix, Watson-Crick (WC) base pairs (bps) exist i

285 of electrostatics on the rigidity of the DNA double helix, we define DNA*, the null isomer of DNA, as

286 helicase and DNA prior to the melting of the double helix, we determined the structure of an archaeal

287 s between major and minor grooves of the RNA double helix, we explain much of the asymmetry with a si

288 ring changes in torque upon unwinding of the double helix, we find that R-loop formation and collapse

289 gen bonds that lead to right- or left-handed double helix when the two alanine residues are of the sa

290 om modular hydrogen bonds in the core of the double helix, whereas in proteins, specificity arises la

291 ercoiling of DNA strands as it traverses the double helix, which could impede replication and comprom

292 Genetic information is encoded in the DNA double helix, which, in its physiological milieu, is cha

293 zation leads only to local distortion of the double helix while the overall structure of aps and ps D

294 ed to a decrease in the stability of the DNA double helix with decreasing salt concentration.

295 is revealed that DNA was ejected as a single double helix with ejection occurring at one vertex presu

296 equence crystallizes as a left-handed Z-form double helix with Watson-Crick base pairing.

297 usually present in the form of linear B-form double-helix with the base pairs of adenine (A) and thym

298 ompound 1, can spontaneously assemble into a double helix without the need for a covalently connected

299 of DNA conformations with one segment of the double helix wrapped around the enzyme were constructed.

300 lly make use of the two-fold symmetry of the double helix, zinc fingers can be linked linearly in tan