ライフサイエンスコーパス: double-knockout

1 enotype is not modified by Hic-5 deficiency (double knockout).

2 cidin knockout; and ceruloplasmin/hephaestin double knockout).

3 e-specific mice lacking both GSK-3 isoforms (double knockout).

4 n B mRNA editing enzyme catalytic, APOBEC-1 (double knockout).

5 ration, and these effects are nonadditive in double knockouts.

6 are viable, which permits the generation of double knockouts.

7 etic knockouts, including DNA ligase 3 and 4 double-knockouts.

8 erator activated receptor alpha (Ppara(-/-)) double knockout 129/SvJ mice for 12 weeks from weaning.

9 Our previous work produced double-knockout (2-KO) HEK293T human cell lines that lac

10 sensitivity in hair cells of mouse Tmc1:Tmc2 double knockouts; 3) there is so far no evidence that ex

11 was supported by the fact that Nlrp3/miR-155 double-knockout allo-HCT recipient mice had no increased

12 Although SAA1.1/2.1 double-knockout and SAA3 knockout mice had redundant att

13 In LRRK1 or LRRK2 single knockout, LRRK1/2 double knockout, and LRRK2 G2019S knockin, the postcross

14 In comparison with sperm from CAII and CAIV double knockout animals, pharmacological loss of CAIV in

15 rescued to a wild type identity in Moz;Bmi1 double knockout animals.

16 10 knockout does not alter sepsis mortality, double-knockout animals are highly protected.

17 traocular nor cardiac muscle was affected in double-knockout animals.

18 y led to massive muscle wasting and death in double-knockout animals.

19 -1 in chimeric Ldlr(-/-)Trem-1(-/-) mice and double knockout ApoE(-/-)Trem-1(-/-) mice, we pharmacolo

20 imental systems for measuring GIs (e.g. with double knockouts) as well as in defining computational m

21 CD80/CD86 double knockout (B7 KO) mice had enhanced adipose macrop

22 e examined the skeletal phenotype of BgnFmod double knockout (BgnFmod KO) mice and found they were sm

23 The Pkd1/Cdk1 double knockout blocked cyst cell proliferation that oth

24 The DNA-damage phenotype observed in double knockout brains was prevented by expression of a

25 Double-knockout cardiac myocytes showed cell cycle progr

26 The dcl2drb4 double knockouts caused a far smaller loss of antiviral

27 mary stem cell (MaSC)-specific Cbl and Cbl-b double knockout (Cbl/Cbl-b DKO) using Lgr5-EGFP-IRES-Cre

28 aneous viral infection, and lung Fabp4/Fabp5 double-knockout CD8(+) TRM cells generated by skin vacci

29 s; this increase was not seen in Fabp4/Fabp5 double-knockout CD8(+) TRM cells.

30 nic lethality, whereas conditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute l

31 Here we introduce a CRISPR-based double knockout (CDKO) system that improves the efficien

32 n CDK8 substrate, in a CDK8 and CDK19 CRISPR double-knockout cell line transfected with wild-type (WT

33 alysis using wild-type and AMPKalpha1/alpha2-double knockout cells and discovered 160 AMPK-dependent

34 X or ZNF711 reduced cell growth and that the double knockout cells have major defects in proliferatio

35 tative analysis of the proteome of tankyrase double knockout cells using isobaric tandem mass tags re

36 ly resistant to CDK4 inhibition, RB and p130 double knockout cells were significantly more resistant

37 enzymatic activity in vitro and in AKT1/AKT2 double knockout cells, but promoted growth factor indepe

38 17 cannot rescue ciliogenesis in Kif3a/Kif3b double-knockout cells or delay the loss of assembled cil

39 ckout cells nor between SLC35A2 knockout and double-knockout cells were observed.

40 trast to Dux, can no longer do so in Dppa2/4 double-knockout cells, suggesting that it may act to sta

41 s, SLC35A2 knockouts, SLC35A3 knockouts, and double-knockout cells.

42 sembly and Hedgehog signaling in Kif3a/Kif3b double-knockout cells.

43 promoting its focal erosion, as observed for double-knockout chimeras.

44 ds of genes showed altered expression in the double knockout clones, suggesting that these TFs are cr

45 sosome biogenesis, whereas a Stx16 and Stx17 double knockout completely blocked autophagic flux and d

46 Dot1l(AC) phenotypes were ameliorated in the double-knockout DE(AC) mice.

47 By contrast, a double knockout displayed an abnormal rate of barren sil

48 Constitutive Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality,

49 blasts from Megf10-/- mice and Megf10-/-/mdx double knockout (dko) mice also show impaired proliferat

50 Here, we show that global Fxr (-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight gain

51 (Cyp7a1) and sterol 27-hydroxylase (Cyp27a1) double knockout (DKO) mice by cross-breeding single knoc

52 We previously reported that FE65/FE65L1 double knockout (DKO) mice display disorganized laminin

53 Here, we find that Lin28a/b double knockout (dKO) mice display neural tube defects (

54 rved that multidrug-resistant 2 (Mdr2(-/-) ) double knockout (DKO) mice lacking tumor necrosis factor

55 amine this question, we generated Fmr1/beta4 double knockout (dKO) mice to genetically upregulate BK

56 tory carcinogenesis, we subjected single and double knockout (DKO) mice to the AOM/DSS protocol.

57 than murine MHC class II molecules, CD4 CD8 double knockout (DKO) mice transgenically expressing HLA

58 These double knockout (dKO) mice were able to form sarcomeres

59 -LTD is impaired in the hippocampus of MK2/3 double knockout (DKO) mice, an observation that is mirro

60 Using the first C2/C10 double knockout (DKO) mice, we report that C10 pathogene

61 rednisolone treatment in dystrophin/utrophin double knockout (dKO) mice, which exhibit a severe dystr

62 We then generated Ces1g (-/-) Ldlr (-/-) double knockout (DKO) mice, which were fed a Western die

63 ria and salt-wasting by generating SPAK/OSR1 double knockout (DKO) mice.

64 red the auditory function in Limk1 and Limk2 double knockout (DKO) mice.

65 auditory brainstem responses in K(Na)1.1/1.2 double knockout (DKO) mice.

66 em cell depletion in the dystrophin/utrophin double knockout (dKO) mouse model, which exhibits histop

67 We found that the double knockout (DKO) of Gcn5/PCAF inhibits expression o

68 Mice with enhanced cerebellar LTD, due to double knockout (DKO) of MHCI H2-K(b)/H2-D(b) (K(b)D(b-/

69 L is intrinsically inactive but only with a double knockout (DKO) of PKR and RNase L in A549 cells,

70 mouse embryonic stem cells (ESCs) carrying a double knockout (DKO) of the Tet1 and Tet2 dioxygenases.

71 ctroscopy to study the impact of a PDK2/PDK4 double knockout (DKO) on pyruvate metabolism in perfused

72 Here Mc3r and Mc4r single and double knockout (DKO) rats were generated using CRISPR-C

73 od 1 (Per1)/Per2 double deficient [Per1/Per2 double knockout (dKO)] and wild-type mice, respectively.

74 Disrupting the porcine GGTA1 and CMAH genes [double knockout (DKO)] that produce the gal-alpha(1,3)-g

75 The dystrophin-/-/utrophin-/-/ double knockout (dKO-Hom) mouse is a murine model of hum

76 t, we show that apolipoprotein E (apoE)-CD16 double knockout (DKO; apoE-CD16 DKO) mice have reduced a

77 th gene expression in wild-type and CBP/p300 double-knockout (dKO) fibroblasts.

78 ine in hematopoietic repopulating ability of double-knockout (dKO) HSCs.

79 Tet2-Tet3 double-knockout (DKO) iNKT cells displayed pronounced sk

80 The skeletal phenotype of JNK1 and JNK2 double-knockout (dKO) mice (JNK1(fl/fl)Col2-Cre/JNK2(-/-

81 We generated B cell-specific Shp-1 and Syk double-knockout (DKO) mice and compared them to the sing

82 These double-knockout (DKO) mice develop additional indication

83 Feeding Gsta4(-/-)/Ppara(-/-) double-knockout (dKO) mice liquid diets containing corn

84 24 clusters in skeletal muscle, we generated double-knockout (dKO) mice muscle-specifically lacking t

85 ast, platelets isolated from GLUT1 and GLUT3 double-knockout (DKO) mice, which lack the ability to us

86 sk the role of NDCBE, we generated Ndcbe/Ncc double-knockout (dKO) mice.

87 100% lethality in Ifnar1 (-/-) Ifngr1 (-/-) double-knockout (DKO) mice.

88 ous kidney failure, with that of Col4a3;Tsp1 double-knockout (DKO) mice.

89 Herein, we have created the nesprin-desmin double-knockout (DKO) mouse, eliminating a major fractio

90 ic endothelial cells (AEC) from a GGTA1/CMAH double-knockout (DKO) pig (and a GGTA1-KO pig) and immun

91 We obtained double-knockout (DKO) pigs lacking GAL and Neu5Gc.

92 we found a defect in trafficking of EVL/VASP double-knockout (dKO) T cells to the inflamed skin and s

93 O mice generated on an Lyl1-null background (double knockout [DKO] mice) had severe macrothrombocytop

94 (-/-), GzmB cluster(-/-), and GzmAxB cluster double knockout [DKO] mice) showed both delayed granulom

95 one or both isoforms (Epac1-KO, Epac2-KO, or double knockout, DKO) to assess isoform localization and

96 genetic inactivation of both B7.1 and B7.2 (double knockout; DKO) revealed aggravated obesity-relate

97 Characterization of single (Deltappx2) and double knockout (dkppx) strains of M. tuberculosis indic

98 Mouse embryonic fibroblasts (MEFs) from the double knockout embryos display an absence of the H3R17m

99 Using a BMF/BIM-double-knockout epithelial transplant model, we further

100 was supported both in Atp2b1(-/-)Tcf7l1(-/-) double-knockout ESCs passaged in defined media alone (no

101 The Wwox;p53(Deltaosx1) double knockout establishes a new osteosarcoma model wit

102 The double knockout Fanci-/- Fancd2-/- also showed epistatic

103 in primary betacyto- or beta/gammacyto-actin double-knockout fibroblasts.

104 To that end, we constructed all possible double knockouts for the S15, L33, and L36 ribosomal pro

105 o-expression of PIKE-A and CDK4 in TP53/PTEN double knockout GBM mouse model additively shortens the

106 trols, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had higher manganese levels in the bloo

107 kouts, Slc39a14 single and Slc30a10/Slc39a14 double knockouts had lower thyroid manganese levels and

108 al genes were increased in the alpha-catenin double knockout hearts indicating a less mature cardiac

109 iomyocyte proliferation in the alpha-catenin double knockout hearts.

110 e and promoted cardiomyocyte survival in the double knockout hearts.

111 Moreover, adult Meis1-Hoxb13 double-knockout hearts display widespread cardiomyocyte

112 that within 2 weeks of tamoxifen treatment, double-knockout hearts leads to excessive dilatative rem

113 regulators Klf1 and Epor, is upregulated in double-knockout hematopoietic stem cells (HSCs).

114 es: foxc1a-/- single homozygous and foxc1-/- double knockout homozygous embryos presented with simila

115 WT and Hsp70 double-knockout (Hsp70.1/.3(-/-)) mice were sensitized a

116 ncreased more than 100-fold when produced in double-knockout human CD4(+) T cells that lack both SERI

117 production is inefficient, we have generated double-knockout human cells lacking both Dicer and prote

118 We find that, in vitro, Yap/Taz double knockout impairs murine chondrocyte proliferation

119 adult cardiac myocytes and fibroblasts from double-knockout implicated cardiac myocytes intrinsic fa

120 By assessing the metastatic potential of the double knockouts in mice, we unveiled a quantitative lan

121 approach for combinatorial interrogation of double knockouts in vivo.

122 vidually generated the same phenotype as the double knockout, indicating that both pafR and pafP are

123 We generated Mmp7 and Pten double knockout (KO) (Mmp7(-/-)) mouse model and demonst

124 ted genome engineering to create single- and double knockout (KO) cell lines of TorA and TorB as well

125 hat hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iron accumulation in m

126 Double knockout (KO) mutants that are hemizygous for eit

127 1, a kinase-dead alpha2 AMPK (alpha2KD), and double knockout (KO) of beta1 and beta2 AMPK subunits (b

128 In this report, Cyp3a1/2 double knockout (KO) rats were generated by CRISPR-Cas9

129 prolin-deficient mice (WSX-1/tristetraprolin double knockout) leads to a reduction in cytotoxic T lym

130 An Arabidopsis double knockout line of both BASS6 and the glycolate/gly

131 sulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice.

132 ning adapter-inducing interferon-beta (TRIF) double knockout littermates, we define the role of toll-

133 By generating TDP1 and PARP1 double-knockout lymphoma chicken DT40 cells, we demonstr

134 hway were found to be shared between Id2/Id3 double-knockout lymphomas and human NKT tumors.

135 onse to IFN-alphabeta is lost in Stat1-Stat2 double-knockout macrophages suggest that Stat1 and Stat2

136 In consequence, transmigrated double-knockout macrophages were seen to accumulate in t

137 specifically in heart to generate myocardial double-knockout (MDKO) mice.

138 malignancy is accelerated, we show that the double-knockout methylome reflects regions of independen

139 Fxr/Tgr5 double knockout mice (DKO) were generated for metabolic

140 oduced Slc39a14 single and Slc30a10/Slc39a14 double knockout mice and compared their phenotypes with

141 olipoproteins worsened behaviour deficits of double knockout mice and their performance was undisting

142 ion of tumor growth and metastasis in NOX1/2 double knockout mice compared with WT mice.

143 In addition, the Wwox;p53(Deltaosx1) double knockout mice developed poorly differentiated ost

144 In addition, double knockout mice exhibit an impaired cardiac respons

145 pted in combination with RIP1, the resulting double knockout mice exhibit slightly prolonged survival

146 To answer this question, we produced double knockout mice for Bmp6 and beta2-microglobulin (a

147 Analyses of double knockout mice further revealed that IL-36alpha an

148 cently found that macrophages from RhoA/RhoB double knockout mice had increased motility of the cell

149 Double knockout mice have impaired oocyte development an

150 Reprogramming of SSC from Tet1 and Tet2 double knockout mice however lacked demethylation of H19

151 Double knockout mice lacking both receptors showed super

152 dine phosphorylase and uridine phosphorylase double knockout mice recapitulated several features of t

153 nd the expression of PKCbeta in PKCalphabeta double knockout mice rescues PTP.

154 Here we report that iRhom1/2(-/-) double knockout mice resemble Adam17(-/-) and Egfr(-/-)

155 P2rx7/HDAC3-double knockout mice show a partial rescue in DP cell nu

156 Electron micrographs of hearts from TPC1/2 double knockout mice showed that cardiomyocytes containe

157 Recent experiments on the double knockout mice showed, however, that their taste b

158 fibrosis was observed in PAI-1(-/-)/uPA(-/-) double knockout mice that was associated with reduced in

159 dx/utrn(+/-) heterozygotes and mdx/utrn(-/-) double knockout mice to investigate the role of these cy

160 severe salt-wasting, and generated SPAK/OSR1 double knockout mice to test this.

161 We also generated apoE(-/-)/As3mt(-/-) double knockout mice to test whether As3MT-mediated biot

162 In double knockout mice we show that (125)I-amyloid-beta mi

163 clerosis, hyperglycemic TSP-1(-/-)/ApoE(-/-) double knockout mice were compared with age-matched hype

164 Fmr1/BKbeta4 double knockout mice were generated to genetically upreg

165 Double knockout mice were protected against fasting-indu

166 function are restored upon treatment of the double knockout mice with antibiotics, implicating comme

167 ochondrial DNA instability, we have stressed double knockout mice with exogenous thymidine and deoxyu

168 ) binding protein null mice (Mttp-LKO, i.e., double knockout mice) hepatic steatosis was greatly dimi

169 genetic deletion of P2X2 and P2X3 receptors (double knockout mice) lack responses to all taste stimul

170 nesoid X receptor; Small Heterodimer Partner double knockout mice, a model for bile acid overload, di

171 a and total urinary iron was observed in the double knockout mice, and this was associated with compr

172 us model of oral staphylococcal infection in double knockout mice, deficient in the receptors for IL-

173 Administration of wild-type human LDLR to double knockout mice, expressing hPCSK9, led to diminish

174 By analyzing DUSP5(-/-), SerpinB2(-/-) double knockout mice, we demonstrate that deletion of Se

175 By generating miR-31 and Gprc5a double knockout mice, we show that miR-31 promotes the d

176 rogrammed death-ligand 1', whereas in NOD1/2 double knockout mice, which cannot recognize peptidoglyc

177 depletion, but also in WSX-1/tristetraprolin double knockout mice, with substantial reduction in the

178 d neuron-specific Bcl7a and Bcl7b single and double knockout mice.

179 y to account for the attenuated phenotype in double knockout mice.

180 tion in lungs, we generated Ifit2/IFNAR(-/-) double knockout mice.

181 ockout mice, and completely abolished in the double knockout mice.

182 everse the observed heart dysfunction in the double knockout mice.

183 l knockout mice (Dot1l(AC) ), Dot1l and Edn1 double-knockout mice (DE(AC) ), and Edn1 connecting tubu

184 We generated double-knockout mice (DKO) lacking the 2 cardiac CaMKII

185 of ANXA6 in the progression of NPC disease, double-knockout mice (Npc1(-/-)/Anxa6(-/-)) were generat

186 However, Nfil3/Rag1 double-knockout mice adoptively transferred with wild-ty

187 s have lower rate of neuritogenesis in vitro Double-knockout mice also have reduced levels of GM1 gan

188 axis, MI was induced in Cd36(-/-) Mertk(-/-) double-knockout mice and led to increases in myocardial

189 Tet1/Tet2 double-knockout mice are characterized by developmental

190 However, only double-knockout mice continued to exhibit low liver Hamp

191 Moreover, the double-knockout mice could potentially serve as models i

192 When placed on a high-fat diet, these double-knockout mice developed atherosclerosis at a much

193 ith Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associa

194 Compared with wild-type mice, the double-knockout mice displayed inhibited expression of p

195 g and defined that IL-4Ralpha(-/-)/IL-5(-/-) double-knockout mice displayed significant eosinophil de

196 C3(-/-);SRPX2(-/Y) double-knockout mice exhibit phenotypes associated with

197 In the periphery, Apoe/Apoa1 double-knockout mice exhibited substantial atheroscleros

198 Using Dnmt3a and Tet2 double-knockout mice in which the development of maligna

199 Double-knockout mice lacking both Kir4.1/Kir5.1 and Nedd

200 Pkd1 and Smyd2 double-knockout mice lived longer than Pkd1-knockout mic

201 ence of utrophin in the dystrophin-deficient double-knockout mice resulted in a higher MyHC-emb conte

202 In contrast,Tmprss2(-/-)Tmprss4(-/-)double-knockout mice showed a remarkably reduced virus s

203 r, NCC expression/activity was higher in the double-knockout mice than in Kir4.1 knockout mice.

204 Wild-type and Pkd2/Ift88 double-knockout mice that are protected from cyst growth

205 report rapid lymphoma development in Id2/Id3 double-knockout mice that is caused by unchecked expansi

206 We thus generated double-knockout mice to assess a potential genetic inter

207 n 'rescue' of muscular dystrophy, we created double-knockout mice to test the contributions of utroph

208 icits and dendritic morphology of Apoe/Apoa1 double-knockout mice were compared to APP/Abca1(ko), APP

209 re necessary for colitis, because Nfil3/Rag1 double-knockout mice were protected from disease.

210 Incubation of organoids derived from double-knockout mice with acetate or dichloroacetate res

211 We hypothesized that Apoe/Apoa1 double-knockout mice would mimic the phenotype of APP/Ab

212 with mice with disruptions in Vil1 and Gsn (double-knockout mice).

213 In double-knockout mice, constitutive phosphorylation of EI

214 In neuraminidase 3 and 4 double-knockout mice, GM3 ganglioside is stored in micro

215 In Cetn2 (-/-);Cetn3 (GT/GT) double-knockout mice, spermatogenesis-associated 7 (SPAT

216 ch more pronounced in Sdc4(-/-); Pecam1(-/-) double-knockout mice, which develop severe edema.

217 n over 3 days; hgd40 reduced colitis in TNFR double-knockout mice.

218 g order) by WT, STC1 knockout, and STC1/STC2 double-knockout mice.

219 d Apoa1 knockout mice to generate Apoe/Apoa1 double-knockout mice.

220 as shown by megakaryocyte-specific (Pf4-Cre) double-knockout mice.

221 inding lectin-A and mannose-binding lectin-C double-knockout mice.

222 and an overall delay in ossification in the double-knockout mice.

223 membrane fractions from the Sdr16c5/Sdr16c6 double-knockout mice.

224 ingle-knockout and Cetn2 (-/-);Cetn3 (GT/GT) double-knockout mice.

225 d retinoic acid signaling in the skin of the double-knockout mice.

226 sensitivity in muscle-specific APC- and TAZ-double-knockout mice.

227 ceptors serve complementary roles, such that double-knockout MIGIRKO mice displayed a marked reductio

228 A rod-specific Kif3/Kif17 double knockout mouse demonstrated that KIF17 and KIF3 d

229 circadian period in a Cry1 (-/-) Cry2 (-/-) double knockout mouse embryonic fibroblast cell line.

230 Differentiation assays reveal that Dppa2/4 double knockout mouse embryonic stem cells fail to exit

231 Rescue experiments in Dnmt3a/3b double knockout mouse embryonic stem cells show that the

232 Furthermore, by generating a TC10/Cdc42 double knockout mouse model, we found that TC10 can comp

233 We have developed a double knockout mouse model, which also shows reduced mu

234 The Sec63-Xbp1 double knockout mouse offers a novel genetic model of ch

235 ransduced into BAX/BCL2 agonist killer (BAK) double-knockout mouse embryonic fibroblasts, its locatio

236 yons as the genomic key feature of Tet1/Tet2 double-knockout mouse embryonic fibroblasts.

237 were also observed in a DeltapauA2DeltaphoU double knockout mutant and complemented by the wild-type

238 ned the wild-type S. aureus cell but not the double knockout mutant DeltatarM/S, which lacks both alp

239 ntitative cell-wall analytical assays of the double knockout mutant demonstrated reduced levels of pe

240 ere indispensable for seed development, as a double knockout mutant failed to make viable seeds.

241 tabolism, we generated two cyp71a12 cyp71a13 double knockout mutant lines.

242 Sperm of the double knockout mutant mice show responses to stimulus b

243 nes have markedly opposite phenotypes to the double knockout mutant, with increased cell-wall methyle

244 ed in wild type was lost in the LHY and CCA1 double knockout mutant.

245 nt human FH domains 6 and 7 fused to Fc than double knockout mutants prepared from two sensitive meni

246 Two constitutive double knockout mutants were generated (designated as dp

247 question, we generated dcl2drb4 and dcl4drb4 double knockout mutants, and subjected them to infection

248 In Munc13-1/2 double-knockout neurons, expression of a constitutively

249 cells and less mucin (Muc2) in Nod1 and Nod2 double-knockout (Nod DKO) mice after T. muris infection

250 obtained metabolomics data from a "chemical double" knockout (Oat3KO plus probenecid).

251 Here we show that a double knockout of ALA4/5 results in dwarfism, character

252 Previously, a double knockout of ALA6/7 was shown to result in pollen

253 It was shown that double knockout of Bax and Bak from proximal tubules att

254 paired retrograde organelle transport, while double knockout of betaII-spectrin and AnkB nearly elimi

255 knockouts, developmentally early conditional double knockout of both cerebellin-1 and neuroligin-3 se

256 d epithelium; cells fail to differentiate on double knockout of both HNF4 paralogs.

257 Double knockout of Csmd1 and C3 causes non-additive redu

258 the de novo methyltransferase DNMT3A or the double knockout of DNMT3A/3B that is further propagated

259 Furthermore, double knockout of FYN and PTPN23 via CRISPR/CAS9 also a

260 We show that double knockout of GRASP proteins disperses the Golgi st

261 Thus, we generated a novel model with double knockout of Mdr2(-/-) and NK1R(-/) (alias Tacr1(-

262 hylation, and the other carrying conditional double knockout of MLL3/4 enzymatic SET domain.

263 pogenesis, which was p66Shc independent, and double knockout of Osm and p66Shc completely rescued HSP

264 nder baseline conditions, although mice with double knockout of pendrin and the Na(+)/Cl(-) cotranspo

265 ional impairment of T(RM) cells in mice with double knockout of the T(RM)-cell-associated transcripti

266 Double knockout of the two miR-15/16 loci in mouse resul

267 members were identified by our approach, and double knockouts of each family demonstrated previously

268 ers to quantify this back-flux in single and double knockouts of genes relating to PEP synthetase and

269 Interestingly, double knockouts of HIF1alpha and HIF2alpha (HIF1alpha/2

270 NF4G did not affect maintenance of ISCs, but double-knockout of HNF4A and HNF4G resulted in ISC loss;

271 In the LRRK1/2 double knockout or LRRK2 G2019S knockin, the dopaminergi

272 os in wild-type and "taste blind" P2X2 /P2X3 double knockout (P2X-dbl KO) mice.

273 /-) pDC, as well as in Tlr7 (-/-) Tlr9 (-/-) double-knockout pDC, the IFN-alpha response to MHV68 was

274 Here, we rapidly generated RAG2/IL2RG double knockout pigs using direct injection of CRISPR/Ca

275 We generated double knockouts (PINK1(-/-)/NLRP3(-/-)), as well as cel

276 ination were investigated in mMDH1 and mMDH2 double knockout plants.

277 e and tapx single-knockout plants, 2cpa 2cpb double-knockout plants showed an impairment of photosynt

278 Dynamins 1 and 2 double-knockout podocytes showed dispersed acetylated al

279 After 12 weeks, Frmd6/Pten double knockouts presented high-grade prostatic intraepi

280 ked presenilin genes (presenilin conditional double knockout [PS cDKO]) after one-trial contextual fe

281 ticle, we demonstrate that Rab27a and Rab27b double-knockout (Rab27DKO) mice that are deficient in ex

282 Furthermore, Brca1/Cobra1 double knockout restores developmental transcription at

283 Early in tumorigenesis, the double knockout results in an additive reduction in angi

284 features of the Brn3b single- and Dlx1/Dlx2 double-knockout retinas, including near total RGC loss w

285 Analysis of single and double knockouts revealed no significant phenotypes at d

286 the graph for the acute kidney injury (AKI), double knockout (-/-), S-nitrosothiol (SNO) condition at

287 our optimized AsCas12a (opAsCas12a) through double knockout screening against epigenetic regulators.

288 Two double knockout seeds had approximately 3% of dry weight

289 Hepatocyte-specific double-knockout Smad1(fl/fl);Smad5(fl/fl);Cre(+) mice ex

290 Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5(dKO)) mice displayed growth ret

291 sis factor receptor (TNFR) 1 and TNFR2 (TNFR double knockouts); some mice were given a GATA3-specific

292 yl-ACP in vitro, and the DeltatesS DeltaplsX double knockout strain was a fatty acid auxotroph.

293 ice with Smpd1(-/-) mice, we also produced a double knockout strain, Smpd1(-/-)/Asah1(fl/fl)/Podo(Cre

294 However, both double-knockout strains displayed exacerbated muscle deg

295 By using double knockout strategies, we further prove that this p

296 ectin protein disappeared in T-cadherin/ApoE double-knockout (Tcad/ApoE-DKO) mice with significant el

297 mice, that have normal stomach, we obtained double knockout (TFF1 KO/DP KO).

298 trastructural analysis revealed that in this double knockout, the axoneme of the CC expanded radially

299 mouse was significantly higher in Apoe/Apoa1 double-knockout then in APP/Abca1(ko) mice.

300 Here we use an inducible double knockout to show that cells lacking both SCAR and