ライフサイエンスコーパス: double-strand

1 ific locations in complex genomes to cut DNA double-strands.

2 Mechanisms underlying increases in double-stranded Alu RNAs in MS are obscure.

3 Previously, XRN2 was implicated in DNA double strand break (DSB) repair and in resolving replic

4 Tracking DNA double strand break (DSB) repair is paramount for the un

5 the mosaic nature of editing outcomes after double strand break (DSB) repair.

6 le Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell.

7 ed end joining (HMEJ) at high frequency at a double strand break in the targeted gene.

8 ination (HR) is important for error-free DNA double strand break repair and maintenance of genomic st

9 y restore HR, whereas KAT5 depletion rewires double strand break repair by promoting 53BP1 binding to

10 ding of the mechanisms and regulation of DNA double strand break repair, we attempted to confirm that

11 nsive intrachromosomal mutations at a single double-strand break (DSB) and more frequent translocatio

12 Shot loss leads to double-strand break (DSB) DNA damage, and the apoptotic

13 dominant repair mechanism of any type of DNA double-strand break (DSB) during most of the cell cycle

14 uclear protein that negatively regulates DNA double-strand break (DSB) end resection and CCF formatio

15 y, HLTF-deficient cells also exhibit reduced double-strand break (DSB) formation and increased surviv

16 ibility that the minimal requirement for DNA double-strand break (DSB) formation is as low as even on

17 le telomeres in BLM-deficient cells involved double-strand break (DSB) formation, in this case by the

18 NA through the induction of an enzyme-linked double-strand break (DSB) in one DNA molecule and passag

19 e evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chr

20 To determine whether double-strand break (DSB) mobility enhances the physical

21 estimated to inflict fewer than a single DNA double-strand break (DSB) per hour per cell, they still

22 XRCC4 plus p53, a genotype that enhances DNA double-strand break (DSB) persistence to enhance detecti

23 Delays or failure of rDNA double-strand break (DSB) repair are deleterious, and ca

24 susceptibility protein (BRCA1) promotes DNA double-strand break (DSB) repair by homologous recombina

25 tional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombina

26 Chromatin responses during DNA double-strand break (DSB) repair have been studied with

27 The early steps of DNA double-strand break (DSB) repair in human cells involve

28 er) DNA damage factor to master regulator of double-strand break (DSB) repair pathway choice.

29 This perspective will highlight DNA double-strand break (DSB) repair pathways in human cells

30 n, DNA replication fork progression, and DNA double-strand break (DSB) repair.

31 d erroneously causes the accumulation of DNA double-strand break (DSB) response factors.

32 ylated histone H2A (gamma-H2AX) around a DNA double-strand break (DSB).

33 To repair a DNA double-strand break by homologous recombination, 5'-term

34 thality in tumors with loss of high-fidelity double-strand break homologous recombination.

35 DNA double-strand break repair by homologous recombination b

36 the function of 53BP1, a key factor for DNA double-strand break repair by non-homologous end joining

37 Efficient double-strand break repair in eukaryotes requires manipu

38 insic endonuclease activity and the cellular double-strand break repair machinery.

39 Among double-strand break repair mechanisms induced by oncogen

40 rotected forks are degraded by MRE11 homolog double-strand break repair nuclease (MRE11).

41 HMCES specifically enables DNA double-strand break repair through the microhomology-med

42 tudies indicating the role of R-loops in DNA double-strand break repair with an updated view of much-

43 (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair func

44 ors of DNA fidelity through diverse roles in double-strand break repair, replication stress, and meio

45 I3K pathway activation and also hindered DNA double-strand break repair, which both led to improved r

46 se excision repair, mismatch repair, and DNA double-strand break repair.

47 osphorylation causes DNA replication stress, double-strand break, and genomic instability.

48 that fbl17 mutants are hypersensitive to DNA double-strand break-induced genotoxic stress.

49 entral mediator of response for cellular DNA double-strand break.

50 retrotransposition assay that identified the double-stranded break (DSB) repair and Fanconi anemia (F

51 wn as CtIP), which regulates a DDR choice in double-stranded break (DSB) repair.

52 The distance between the Cas9-mediated double-stranded break (DSB) to the mutation site, rather

53 methyltransferase PRDM9 to ensure successful double-strand-break initiation and repair.

54 ethylation at meiotic hotspots, impaired DNA double-strand-break repair, and reduced crossover number

55 Analysis of CRISPR/Cas9-induced double strand breaks (DSBs) revealed that long-stem hair

56 The repair of DNA double strand breaks (DSBs) that arise from external mut

57 to a large spectrum of DNA damage, including double strand breaks (DSBs) that interfere with replicat

58 The virulent Mtb strain, Rv caused double strand breaks (DSBs), whereas the non-virulent Ra

59 homologous recombination (HR) repair of DNA double strand breaks (DSBs).

60 epresented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by re

61 xonuclease 5 (EXO5) gene in androgen-induced double strand breaks repair via homology-directed repair

62 gulatable CRISPR/Cas9 strategy to induce DNA double strand breaks specifically in the telomeres, ChIP

63 inhibitor, talazoparib led to increased DNA double strand breaks, as assessed by gamma-H2AX foci for

64 al carcinogen Helicobacter pylori causes DNA double strand breaks.

65 ic survival, and increases resolution of DNA double strand breaks.

66 DNA double-strand breaks (DSB) are the most deleterious type

67 Repair of DNA double-strand breaks (DSB) is performed by two major pat

68 ges the recruitment of DNA repair factors to double-strand breaks (DSBs) after genome editing with CR

69 -loops cause more telomeric and subtelomeric double-strand breaks (DSBs) and increase VSG switching r

70 mouse cells altered the repair of telomeric double-strand breaks (DSBs) and induced ALT-like phenoty

71 DNA double-strand breaks (DSBs) are common genome lesions th

72 DNA double-strand breaks (DSBs) are highly cytotoxic lesions

73 DNA double-strand breaks (DSBs) are implicated in various ph

74 e-coding as well as at intergenic areas when double-strand breaks (DSBs) are induced.

75 To generate a crossover, hundreds of DNA double-strand breaks (DSBs) are introduced in the genome

76 DNA double-strand breaks (DSBs) are toxic to mammalian cells

77 combination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic location

78 d to as very fast CRISPR (vfCRISPR), creates double-strand breaks (DSBs) at the submicrometer and sec

79 Mechanistically, BGL3 is recruited to DNA double-strand breaks (DSBs) by PARP1 at an early time po

80 t cancer cells to A3B-mediated mutations and double-strand breaks (DSBs) by perturbing canonical base

81 Exonucleolytic resection, critical to repair double-strand breaks (DSBs) by recombination, is not wel

82 ologous end joining (NHEJ) for the repair of double-strand breaks (DSBs) caused by reactive oxygen sp

83 During meiosis, DNA double-strand breaks (DSBs) enter interhomolog repair to

84 hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topois

85 In many vertebrates, double-strand breaks (DSBs) initiate recombination withi

86 The number of DNA double-strand breaks (DSBs) initiating meiotic recombina

87 Efficient repair of DNA double-strand breaks (DSBs) is of critical importance fo

88 ment of the repair protein RAD51 to sites of double-strand breaks (DSBs) or the abundance of proteins

89 DNA double-strand breaks (DSBs) pose an everyday threat to t

90 Chromosome movements and programmed DNA double-strand breaks (DSBs) promote homologue pairing an

91 Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA D

92 Here we demonstrate that DNA nicks or double-strand breaks (DSBs) targeted by CRISPR-Cas9 to b

93 recombination were randomly distributed, the double-strand breaks (DSBs) that initiate recombination

94 an efficient, scalable method for analyzing double-strand breaks (DSBs) that we apply in parallel to

95 ves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently

96 In this study, multiple DNA double-strand breaks (DSBs) were generated via the CRISP

97 single-strand breaks (SSBs), but not direct double-strand breaks (DSBs), in the genome during gene a

98 omal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over m

99 se spo-11 mutants, which lack endogenous DNA double-strand breaks (DSBs), to induce a single DSB by M

100 way repairs psoralen-ICLs without generating double-strand breaks (DSBs), unlike the FA/BRCA pathway.

101 most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethal

102 mic integrity is threatened by cytotoxic DNA double-strand breaks (DSBs), which must be resolved effi

103 R) and increases cellular sensitivity to DNA double-strand breaks (DSBs).

104 s on recombination initiation via programmed double-strand breaks (DSBs).

105 anized at multiple levels in response to DNA double-strand breaks (DSBs).

106 or of the cellular damage response after DNA double-strand breaks (DSBs).

107 recombination is initiated by SPO11-induced double-strand breaks (DSBs).

108 ponse to local DNA damage, specifically, DNA double-strand breaks (DSBs).

109 ombination-mediated repair of programmed DNA double-strand breaks (DSBs).

110 tein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs).

111 telomere addition (dnTA) is regulated at DNA double-strand breaks (DSBs).

112 result from homology-directed repair of DNA double-strand breaks (DSBs).

113 ologs at >200 sites originating from meiotic double-strand breaks (DSBs).

114 both DNA single-strand breaks (SSBs) and DNA double-strand breaks (DSBs); lesions that can trigger ne

115 ent and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in

116 ar level of FA can trigger mitochondrial DNA double-strand breaks and dysfunction.

117 inase that is recruited and activated by DNA double-strand breaks and functions as an important senso

118 Mre11-Rad50-Nbs1 complex that recognizes DNA double-strand breaks and has exonuclease and endonucleas

119 l of Il10 mRNA, and increased markers of DNA double-strand breaks and proliferation were observed in

120 ADP-ribosyl)ation in the germline, where DNA double-strand breaks are introduced by a regulated progr

121 In vertebrates, double-strand breaks are repaired predominantly by non-h

122 s with different isotypes by joining two DNA double-strand breaks at different switching regions via

123 nactive mutant blocked 53BP1 localization to double-strand breaks because (i) the mutant binding to T

124 terleukin (IL) 6 and IL8, and markers of DNA double-strand breaks but reduced markers of DNA repair,

125 dly respond to gamma-irradiation-induced DNA double-strand breaks by activating Ataxia Telangiectasia

126 Repair of DNA double-strand breaks by the nonhomologous end joining pa

127 In contrast, RAD51 loading at double-strand breaks does not require PrimPol.

128 Repair of DNA double-strand breaks have been shown to enable "shufflin

129 DNA double-strand breaks in cells of radionuclide-treated pa

130 that ASD-derived NPCs harbored elevated DNA double-strand breaks in replication stress-susceptible g

131 Similarly, double-strand breaks in the LPCAT3 and CD4 genes induced

132 us sequences and triggers DNA degradation at double-strand breaks in the target DNA.

133 is the predominant pathway that repairs DNA double-strand breaks in vertebrates.

134 cule microscopy measurements indicating that double-strand breaks induced by antibiotics strongly sti

135 written into target sites without requiring double-strand breaks or donor templates.

136 ich WRN protects MSI-associated cancers from double-strand breaks remains unclear.

137 n (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability.

138 stic increases in replication fork stalling, double-strand breaks, and apoptosis.

139 stribution does not reflect the abundance of double-strand breaks, detected by proxy as RAD51 foci at

140 accumulation of gammaH2AX, a marker for DNA double-strand breaks, in mammalian cells.

141 In response to DNA double-strand breaks, MAD2L2-containing shieldin complex

142 RNA-guided nuclease Cas9, we induced two DNA double-strand breaks, one each in the GAPDH and CD4 gene

143 tes 53BP1 stability and 53BP1 recruitment at double-strand breaks, providing yet another mechanism of

144 R) is a mechanism used to heal one-ended DNA double-strand breaks, such as those formed at collapsed

145 er of the DNA damage response (DDR) upon DNA double-strand breaks.

146 ited biomarkers of DNA replication stress or double-strand breaks.

147 -Jun activation show cell activation and DNA double-strand breaks.

148 d break repair by promoting 53BP1 binding to double-strand breaks.

149 of DNA damage, such as bulky lesions and DNA double-strand breaks.

150 ons in genomic target sites without inducing double-strand breaks.

151 cing small clusters or individual single- or double-strand breaks.

152 esponse to genotoxic stresses that cause DNA double-strand breaks.

153 , insufficient mismatch repair and increased double-strand breaks.

154 es created after formation of programmed DNA double-strand breaks.

155 ases in mammalian cells without donor DNA or double-strand breaks.

156 DNA double-stranded breaks (DSBs) are dangerous lesions thre

157 DNA double-stranded breaks (DSBs) are strongly associated wi

158 DNA double-stranded breaks (DSBs) trigger human genome insta

159 plex) are similarly deficient in joining DNA double-stranded breaks (DSBs) with hairpinned termini.

160 s recombination-mediated repair (HRR) of DNA double-stranded breaks (DSBs).

161 a DNA helicase protecting against G4 induced double-stranded breaks and concomitant loss of cohesion,

162 hromosomes of these bacteria was achieved by double-stranded breaks made by heterologous I-CeuI endon

163 ysis of germline transcripts, examination of double-stranded breaks using biotin-labeling DNA break a

164 HR-dependent repair of directly induced DNA double-stranded breaks.

165 uch as helical grooves, single-strand versus double-strand crossovers, backbone phosphate positions,

166 Even individual genome site-specific DNA double-strand cuts induced by CRISPR/Cas9, as well as in

167 Repair of double strand DNA breaks (DSBs) can result in gene disru

168 distal' face, three statistically disordered double stranded DNA molecules bind across the proximal f

169 Compared to double stranded DNA, PX DNA has dramatically enhanced (s

170 is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end j

171 Both ROS-induced single- and double-strand DNA breaks (SSBs and DSBs) contribute to R

172 mediated knockdown of ODC1, UC cells undergo double-strand DNA breaks and apoptosis.

173 ylation, induction of LINE-1 transcripts and double-strand DNA breaks and decreases viability in prim

174 We propose that DNA damage-elicited double-strand DNA breaks releases DNA fragments, which m

175 vate the aryl hydrocarbon receptor, increase double-strand DNA breaks, and increase the expression of

176 f neuroblastoma cell lines, directly causing double-strand DNA breaks.

177 revealing the initial step in the repair of double-strand DNA breaks.

178 orylation of histone H2AX, a known marker of double-strand DNA breaks.

179 NucC homohexamer competent for non-specific double-strand DNA cleavage.

180 Class-switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic

181 TSPV1 packages an 18.65-kb linear double-stranded DNA (dsDNA) genome with 31 open reading

182 This filament binds to a donor double-stranded DNA (dsDNA) to form synaptic filaments,

183 rsaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unice

184 d that SN1-type agents preferably mutagenize double-stranded DNA (dsDNA), and the mutation signature

185 ng interface exclusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and

186 quitinated, creating a channel that encloses double-stranded DNA (dsDNA).

187 iotic recombination intermediates by nicking double-stranded DNA adjacent to the junction points(9).

188 Formation of TLS was found in anti-double-stranded DNA antibody-positive mice, and the stru

189 with RNA (coacervates) to avid and specific double-stranded DNA binding.

190 t, independently of its nucleotide sequence, double-stranded DNA binds to a specific helix of the vWF

191 and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable n

192 predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial ind

193 esulted from nuclear entry by Dox, promoting double-stranded DNA breaks and apoptosis.

194 tion of the AIM2 inflammasome in response to double-stranded DNA damage triggers the production of cy

195 To initiate replication on a double-stranded DNA de novo, all organisms require prima

196 Following the detection of cytosolic double-stranded DNA from viral or bacterial infection in

197 ASFV has a large, double-stranded DNA genome that encodes over 150 protein

198 BKPyV has a circular, double-stranded DNA genome that is divided genetically i

199 endogenous reverse transcription to produce double-stranded DNA genomes, which sometimes looped out

200 modified mC residues in single-stranded and double-stranded DNA in vitro, while the extent of the re

201 lization microscopy (BALM) using fluorescent double-stranded DNA intercalators and optical astigmatis

202 ds, the resulting brightness of 2CNqA inside double-stranded DNA is the highest reported for a fluore

203 In comparison to spCas9, miCas9 enhances double-stranded DNA mediated large size gene knock-in ra

204 's input strands and the restriction-induced double-stranded DNA melting resets the systems.

205 he capture rate and translocation of 1-5 kbp double-stranded DNA molecules through solid-state nanopo

206 in resistance to 14 phylogenetically diverse double-stranded DNA phages using two model Escherichia c

207 Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that catalyses the synthesis

208 ominantly cleaves the non-target strand of a double-stranded DNA substrate.

209 uvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential fo

210 transient DNA melting that may occur during double-stranded DNA surveillance by CRISPR-Cas9.

211 E2 Y138.IMPORTANCE Papillomavirus (PV) is a double-stranded DNA tumor virus infecting the cutaneous

212 Merkel cell polyomavirus (MCPyV) is a human double-stranded DNA tumor virus.

213 During cell division, FtsK translocates double-stranded DNA until both dif recombination sites a

214 More recently, several oncogenic double-stranded DNA viruses have been found to encode ci

215 but recent evidence suggests that some large double-stranded DNA viruses may also endogenize into the

216 CrAss-like phages are double-stranded DNA viruses that are prevalent in human

217 The Nudiviridae are a family of large double-stranded DNA viruses that infects the cells of th

218 us expression of a cloned A* gene.IMPORTANCE Double-stranded DNA viruses typically package their geno

219 The assembly of double-stranded DNA viruses, from phages to herpesviruse

220 he portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly a

221 igner DNA nanoparticles are constructed from double-stranded DNA with cytosine-rich stick ends (C-mon

222 with the presence of pathogenic anti-dsDNA (double-stranded DNA) antibodies, and provided spontaneou

223 in which viral RNA genome is converted into double-stranded DNA, is that it is slow and non-processi

224 NPs finally results in the formation of long double-stranded DNA-RNA (HCR products) -AuNPs.

225 logously to the nucleosome's organization of double-stranded DNA.

226 sult in the formation of physical defects in double-stranded DNA.

227 le at joint molecule structures and adjacent double-stranded DNA.

228 uclease to introduce site-specific breaks in double-stranded DNA.

229 termined positions on the backbone of native double-stranded DNA.

230 omote extensive and reversible compaction of double-stranded DNA.

231 ment in HDR between a Cas9 DSB and a plasmid double stranded donor DNA (dsDonor).

232 Silencing is attributed to a 1:1 double stranded (ds) complex that does not fit and canno

233 Only one strand on a double-stranded (ds) DNA substrate was modified in the r

234 Being guided by an RNA to cleave double-stranded (ds) DNA targets near a short sequence t

235 st innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress an

236 FN responses result from increased levels of double-stranded endogenous Alu RNAs.

237 pendent protein kinase (DNA-PK) requires DNA double-stranded ends for enzymatic activation.

238 hesis protocol, we achieved an unprecedented double-stranded hexagonal cycloarene containing 108 sp(2

239 nd time-dependently colocalized with non-CpG double-stranded immunostimulatory DNA (ISD).

240 obilization strategy of probe strands with a double-stranded linker.

241 to insert sulfur into the DNA backbone as a double-stranded phosphorothioate (PT) modification, and

242 ligonucleotides to target PCR-derived linear double-stranded plasmid DNA.

243 aling how these RNases recognize and process double-stranded pre-rRNA.

244 m and Nterm-ACB with RNA hairpins containing double-stranded regions.

245 an ADAR2 comprising its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to a

246 st SARS-CoV spike protein and nucleoprotein, double stranded RNA, and RNA probe for spike genes were

247 e aflatoxin control by exogenous delivery of double-strand RNA (dsRNA) it is necessary to understand

248 surface exhibiting a preference for binding double-strand RNA (dsRNA) over single-strand RNA (ssRNA)

249 ol of siRNAs can be used to construct a long double-strand RNA and expressed through virus-induced ge

250 e gene I (RIG-I)-like receptors detect viral double-stranded RNA (dsRNA) and 5'-triphosphorylated RNA

251 of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor.

252 sortment is common in viruses with segmented double-stranded RNA (dsRNA) genomes.

253 NA (ADARs) convert adenosines to inosines in double-stranded RNA (dsRNA) in animals.

254 n GUVs provide significant protection of the double-stranded RNA (dsRNA) replication intermediate aga

255 The virus is bipartite, containing two double-stranded RNA (dsRNA) segments designated as dsRNA

256 ctivate protein kinase R (PKR), a known host double-stranded RNA (dsRNA) sensor.

257 gment of the DvSSJ1 gene, the formation of a double-stranded RNA (dsRNA) transcript and siRNAs in tra

258 tudy, we identified a taxon of monosegmented double-stranded RNA (dsRNA) viruses in five planarian sp

259 Partitiviruses are segmented, multipartite double-stranded RNA (dsRNA) viruses that until recently

260 cription of mitochondrial RNAs that may form double-stranded RNA (dsRNA), as has been observed in mam

261 sensing and binding to viral RNA, including double-stranded RNA (dsRNA), RIG-I and MDA5 undergo cyto

262 granules (avSGs) by regulating activation of double-stranded RNA (dsRNA)-dependent protein kinase R (

263 Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees reveal

264 s that lead to production of progeny genomic double-stranded RNA (dsRNA).

265 ced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] together with the endogenou

266 (EDIII) subunit antigen and two adjuvants, a double-stranded RNA (Poly (inosinic:cytidylic acid) (Pol

267 IFN pathway, which comprises the sensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IF

268 Functional relevance was demonstrated as double-stranded RNA and LL-37 promoted adhesion and tran

269 C of RdRps from three RNA viruses, i.e. the double-stranded RNA bacteriophage Phi6, and the positive

270 tly increased when larvae were injected with double-stranded RNA bound to CNTs (PAMAM-CNT-dsRNA), com

271 tected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may

272 The digestion of double-stranded RNA from keratinocytes exposed to UVB bl

273 nucleotide sensing receptor that recognizes double-stranded RNA from viral infection.

274 ound that ZBP1 constitutively bound cellular double-stranded RNA in a Zalpha-dependent manner.

275 The unwinding of double-stranded RNA intermediates is critical for the re

276 Endogenous release of type I IFNs with the double-stranded RNA mimetic poly(I:C) likewise produces

277 ce (RNAi) is a natural process through which double-stranded RNA molecules can silence the gene carry

278 l-like receptor 3 stimulation with poly(I.C) double-stranded RNA or infection with herpes simplex vir

279 ated siRNA loci were most often derived from double-stranded RNA precursors copied from spliced mRNAs

280 Here we show XPO5 pervasively binds to double-stranded RNA regions found in some clustered prim

281 ominant RNA-capsid interaction sites favored double-stranded RNA regions.

282 alvi can stably recolonize bees and produce double-stranded RNA to activate RNAi and repress host ge

283 rus (reovirus) is a nonenveloped, segmented, double-stranded RNA virus in the Reoviridae family.

284 In line with the double-stranded RNA-binding activity of EBP1 in human (H

285 This construct, the DGCR8 core, contains two double-stranded RNA-binding domains (dsRBDs) and a C-ter

286 t RAN translation is highly regulated by the double-stranded RNA-dependent protein kinase (PKR).

287 lated by PRKRA (protein interferon-inducible double-stranded RNA-dependent protein kinase activator A

288 RNA (ADARs) convert adenosine to inosine in double-stranded RNA.

289 nse, mediated by the formation of endogenous double-stranded RNAs (dsRNAs).

290 t an effective antiviral response.IMPORTANCE Double-stranded RNAs produced during viral infections se

291 ent RNA polymerase (RdRP), which synthesizes double-stranded RNAs that are sensed by melanoma differe

292 ting of RNA to prevent sensing of endogenous double-stranded RNAs.

293 teins bind to origins of replication at many double-stranded sites and also at AT-rich regions where

294 d is greatly stabilized in vitro by specific double-stranded sites of the origin.

295 plexes of the initiator with the single- and double-stranded sites.

296 , 23S and 5S pre-rRNAs, are catalyzed by the double-strand specific ribonucleases (RNases) Mini-RNase

297 structure that lacks single-stranded loops, double-stranded stems, or junctions.

298 single-stranded RNA substrate but not on the double-stranded substrate.

299 Integron integrases innovated from double-strand- toward single-strand-DNA recombination th

300 to the modularity of DNA nanotechnology, DNA double strands with different complementary overhang len