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1 termined positions on the backbone of native double-stranded DNA.
2 racellular innate immune sensor that detects double-stranded DNA.
3 ICP4 is a viral nucleoprotein which binds double-stranded DNA.
4 echanisms operate only when the damage is in double-stranded DNA.
5 n transfer through (or from) electrode-bound double-stranded DNA.
6 enables the translocation and processing of double-stranded DNA.
7 logously to the nucleosome's organization of double-stranded DNA.
8 4) complex formation immediately adjacent to double-stranded DNA.
9 ate hydrolysis-dependent translocation along double-stranded DNA.
10 ble an Mcm2-7 double-hexamer around adjacent double-stranded DNA.
11 f potato is further able to bind and distort double-stranded DNA.
12 y structure which appears capable of binding double-stranded DNA.
13 by ATP, which allows efficient processing of double-stranded DNA.
14 omote extensive and reversible compaction of double-stranded DNA.
15 sult in the formation of physical defects in double-stranded DNA.
16 le at joint molecule structures and adjacent double-stranded DNA.
17 uclease to introduce site-specific breaks in double-stranded DNA.
18 bqp)(2)](2+) with i-motif, G-quadruplex, and double-stranded DNA.
19 olocalizing with cGAS, which is activated by double-stranded DNA.
20 scence quenching to detect unpaired bases in double-stranded DNA.
21 ith similar efficiencies in both single- and double-stranded DNA, 1-methyladenine is preferentially r
22 iotic recombination intermediates by nicking double-stranded DNA adjacent to the junction points(9).
25 oprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D
28 terminal domain displays strong affinity for double-stranded DNA and is sufficient for the accumulati
29 dro-2'-deoxyguanine (8-oxoG) often occurs in double-stranded DNA and poses a threat to genomic integr
30 psid shell, must be reverse transcribed into double-stranded DNA and released from the capsid (in a p
32 stinguishable fluorescence upon binding with double-stranded DNA and single-stranded RNA in live cell
33 shishijimicin A binds to the minor groove of double-stranded DNA and that its beta-carboline moiety p
34 king and unstacking reactions in single- and double-stranded DNA and thus may help to define the mole
35 facilitation of primer strand invasion into double-stranded DNA, and a suppression of non-homologous
36 igher in single-stranded DNA (ssDNA) than in double-stranded DNA, and copying the resulting uracils c
37 ystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibitors within the enzymatic
38 with the presence of pathogenic anti-dsDNA (double-stranded DNA) antibodies, and provided spontaneou
41 n remodelers are ATP-driven motors that pump double-stranded DNA around the histone core of the nucle
42 fluorescence which was slightly enhanced in double-stranded DNA as compared to single-stranded oligo
43 ting such models have been reported that use double-stranded DNA as donors, but their efficiency is t
44 assembly of head-to-head CMGs that encircle double-stranded DNA at the origin, the two CMGs must pas
47 for the capsid shell assembly of many tailed double-stranded DNA bacteriophages, some archaeal viruse
48 hermore, our data indicate that the entry of double-stranded DNA beyond a short threshold distance fr
51 ed that both affect the dynamic features and double-stranded DNA binding properties of Mre11, but in
53 t, independently of its nucleotide sequence, double-stranded DNA binds to a specific helix of the vWF
55 al chromatin organization before and after a double-stranded DNA break (DSB), to estimate the level o
57 method, which predicts the extent to which a double-stranded DNA break site will utilize the microhom
59 ubiquitin ligase is activated in response to double stranded DNA breaks (DSBs) where it mono-ubiquiti
60 t during homologous recombination, repair of double stranded DNA breaks, and integron recombination.
62 are particularly susceptible to formation of double-stranded DNA breaks (DSBs) arising from physiolog
63 and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable n
64 Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-s
65 predictably and independent of Cas9-induced double-stranded DNA breaks (which causes substantial ind
68 pyogenes (SpCas9) is more active in creating double-stranded DNA breaks at 37 degrees C than at 22 de
69 tumours are often deficient in the repair of double-stranded DNA breaks by homologous recombination(8
70 of linked loci is limited as multiple nearby double-stranded DNA breaks created by Cas9 routinely res
74 cycle progression through mitosis following double-stranded DNA breaks leads to the formation of mic
75 antage that it does not require formation of double-stranded DNA breaks or provision of a donor DNA t
77 gly, CSR induced by staggered but not blunt, double-stranded DNA breaks was impaired by SAMHD1 deplet
78 BRCA1 has no equivalent role at chromosomal double-stranded DNA breaks, indicating that tandem dupli
79 parallel with CRISPRi/a, which do not induce double-stranded DNA breaks, revealed that a distinct set
85 se activity against both single-stranded and double-stranded DNA but not RNA under the conditions tes
86 Pfh1 from Schizosaccharomyces pombe, unwind double-stranded DNA by a branched mechanism with 2 modes
89 sembly and utilization of a surface-attached double-stranded DNA catenane composed of two intact inte
90 ersion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertio
93 how that its packaging series initiates with double-stranded DNA cleavages that are scattered across
95 resent the structure of CcrM in complex with double-stranded DNA containing the recognition sequence.
98 ranscribes its RNA genome and integrates the double-stranded DNA copy into a host cell chromosome.
100 a unique noncanonical role in regulating the double-stranded DNA damage response pathway through modu
101 tion of the AIM2 inflammasome in response to double-stranded DNA damage triggers the production of cy
104 nt depressants capable of rapidly denaturing double stranded DNA (dsDNA) linkers, and 8 compounds are
105 cal sensor for detection of acrylamide using double stranded DNA (dsDNA)/Hemoglobin (Hb)-modified scr
106 f single-stranded DNA (SSDNA, probe DNA) and double-stranded DNA (DSDNA) and that the ability of DSDN
109 uence homology, the major capsid proteins of double-stranded DNA (dsDNA) bacteriophages, some archaea
110 ently repressed to prevent the generation of double-stranded DNA (dsDNA) breaks in cycling large pre-
111 ing via homology-directed repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functio
113 cant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infecti
114 e-induced DNA adducts, can be converted to a double-stranded DNA (dsDNA) form by using appropriate tr
115 interferons (IFNs) and nucleosome-associated double-stranded DNA (dsDNA) fragments (nsDNA) are the ha
118 Each strain encodes a 9.8- to 9.9-kb linear double-stranded DNA (dsDNA) genome with large inverted t
121 ies of small single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) have been measured by capill
124 sport measurements through single 30-nm-long double-stranded DNA (dsDNA) molecules with an experiment
125 hannels to manipulate, stretch, sort and map double-stranded DNA (dsDNA) molecules, however nanochann
126 ectrochemical characteristics of immobilized double-stranded DNA (dsDNA) on a Au electrode were studi
127 l biosensor based on immobilized calf thymus double-stranded DNA (dsDNA) on the carbon-based screen-p
128 system to answer fundamental questions about double-stranded DNA (dsDNA) packaging by viruses that ha
130 ormation of infectious virions in the tailed double-stranded DNA (dsDNA) phages, herpesviruses, and a
132 onjugate accumulation was dependent upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP syntha
136 e can form a nucleoprotein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrappin
137 cryo-EM), we show that the binding of target double-stranded DNA (dsDNA) to a type I-F CRISPR system
138 tion releases granule proteins together with double-stranded DNA (dsDNA) to form extracellular fibers
140 ssDNA-RecA filament searches for homologous double-stranded DNA (dsDNA) to use as a template for the
141 rsaria chlorella virus-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unice
142 fever virus (ASFV) is a complex, cytoplasmic double-stranded DNA (dsDNA) virus that is currently expa
143 aneous quantitation of 10 transplant-related double-stranded DNA (dsDNA) viruses (adenovirus [ADV], B
144 ies to prevent active infection with certain double-stranded DNA (dsDNA) viruses after allogeneic hem
147 ntermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly sus
151 u magnetic nanoparticles functionalized with double-stranded DNA (dsDNA), a sequence of the breast ca
152 d that SN1-type agents preferably mutagenize double-stranded DNA (dsDNA), and the mutation signature
155 r on single-stranded DNA (ssDNA) compared to double-stranded DNA (dsDNA), raising a key conceptual qu
156 nsible for the sensing of aberrant cytosolic double-stranded DNA (dsDNA), which is a hallmark of canc
157 nsible for pairing the ssDNA with homologous double-stranded DNA (dsDNA), which serves as the templat
158 AcrVA4 and AcrVA5 inhibit recognition of double-stranded DNA (dsDNA), with AcrVA4 driving dimeriz
159 ng interface exclusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and
160 se in base editing requires the unwinding of double-stranded DNA (dsDNA)-for example by a CRISPR-Cas9
168 plex led to the release of the AuNPs-S2 from double-stranded DNA(dsDNA) and the recovery of the ECL s
169 robe (single stranded DNA-ssDNA) and hybrid (double stranded DNA-dsDNA) both via 3-NT reduction and g
171 NFalpha, human cytomegalovirus infection, or double-stranded DNA, eEF2 phosphorylation on Thr56, whic
177 ination events are associated with repair of double-stranded DNA gaps and/or involve Mlh1-independent
178 illus subtilis phage whose uracil-containing double-stranded DNA genome encodes distant homologs of b
179 or dissociation and release of SP during the double-stranded DNA genome packaging step accompanying p
183 edrovirus is an insect virus with a circular double-stranded DNA genome, which, among other multiple
184 ruses, which we denote magroviruses, possess double-stranded DNA genomes of 65 to 100 kilobases in si
185 endogenous reverse transcription to produce double-stranded DNA genomes, which sometimes looped out
186 g activities of aTFs for small molecules and double-stranded DNA, here we develop a simple, supersens
192 modified mC residues in single-stranded and double-stranded DNA in vitro, while the extent of the re
193 The latter allows MjAgo to process long double-stranded DNAs, including circular plasmid DNAs an
194 hich preferentially bind the minor groove of double-stranded DNA, inhibit vaccinia virus infection by
195 lization microscopy (BALM) using fluorescent double-stranded DNA intercalators and optical astigmatis
196 The topological state of covalently closed, double-stranded DNA is defined by the knot type $K$ and
197 ds, the resulting brightness of 2CNqA inside double-stranded DNA is the highest reported for a fluore
199 P-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory di
200 in which viral RNA genome is converted into double-stranded DNA, is that it is slow and non-processi
203 In comparison to spCas9, miCas9 enhances double-stranded DNA mediated large size gene knock-in ra
205 tes DNA topology by transiently breaking one double-stranded DNA molecule (cleavage), allowing a seco
206 distal' face, three statistically disordered double stranded DNA molecules bind across the proximal f
207 sitive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact wit
208 s (Cas) that utilize RNA to find and cut the double-stranded DNA molecules at specific locations.
209 ombination, in which the repair of breaks in double-stranded DNA molecules is taking place with a hel
210 he capture rate and translocation of 1-5 kbp double-stranded DNA molecules through solid-state nanopo
211 l plastid (chloroplast) genomes are circular double-stranded DNA molecules, typically between 100 and
214 linear HCR is a hairpin-free system in which double-stranded DNA monomers could dendritically assembl
216 ge polarization and charge transport through double-stranded DNA of various lengths and through doubl
217 e analyze smFRET data of structurally rigid, double-stranded DNA-oligonucleotides in aqueous buffer a
218 and chromosomal gene conversion with either double-stranded DNA or single-stranded oligonucleotide d
220 action of cauliflower mosaic virus (CaMV), a double-stranded DNA pararetrovirus, with the model plant
222 s for T4, we show how the energetic costs of double-stranded DNA phages scale with the capsid size, r
223 in resistance to 14 phylogenetically diverse double-stranded DNA phages using two model Escherichia c
224 clusively been found to match the genomes of double-stranded DNA phages(9,10), suggesting that Cas13
226 are studied as models for viruses containing double-stranded DNA (polymer) and condensing proteins (p
228 pesvirus infection to increase the levels of double-stranded DNA-reactive antibodies at the peak of v
229 specifically bound to cGAS independently of double-stranded DNA, resulting in a non-competitive inhi
232 ulator of interferon genes, a key adaptor in double-stranded DNA-sensing pathway, followed by its rap
235 PR)-associated 9 (Cas9) endonuclease cleaves double-stranded DNA sequences specified by guide RNA mol
237 ands of individual data points per minute on double-stranded DNA standard (dsDNA) samples containing
240 nt states of assembly with its guide RNA and double-stranded DNA substrates reveal an extensive RNA s
241 uvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential fo
242 orm programmable endonucleolytic cleavage of double-stranded DNA substrates, showing enhanced activit
245 es with a CRISPR RNA (crRNA) and cleaves the double-stranded DNA target complementary to the crRNA gu
248 The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets bearing a protospacer adjace
250 through single-stranded loops embedded in a double-stranded DNA template and is programmed by a set
251 t single-stranded RNA of the viral genome to double-stranded DNA that is then integrated into the DNA
252 genome of HIV-1 is reverse transcribed into double-stranded DNA that ultimately integrates into the
254 nome exists as a covalently closed circle of double-stranded DNA, topoisomerase 1 (Topo1) is thought
255 ation where a double-hexamer idly encircling double-stranded DNA transforms to single-hexamers that e
256 V E2.IMPORTANCE The papillomavirus (PV) is a double-stranded DNA tumor virus infecting cervix, mouth,
257 E2 Y138.IMPORTANCE Papillomavirus (PV) is a double-stranded DNA tumor virus infecting the cutaneous
259 During cell division, FtsK translocates double-stranded DNA until both dif recombination sites a
260 ngle-stranded-DNA, DNA is first converted to double-stranded-DNA via terminal-deoxynucleotidyl-transf
264 acmanvirus is a newly discovered icosahedral double-stranded DNA virus that was isolated from an envi
265 e fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cell
269 but recent evidence suggests that some large double-stranded DNA viruses may also endogenize into the
270 and complex genomes make evolution in these double-stranded DNA viruses more efficient than that in
276 simplex virus 1 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persiste
278 lve the atomic structures of two filamentous double-stranded DNA viruses that infect archaeal hosts l
280 s) are an ancient and heterogeneous group of double-stranded DNA viruses that preferentially infect t
281 g infection.IMPORTANCE Poxviruses are large, double-stranded DNA viruses that replicate entirely in t
282 us expression of a cloned A* gene.IMPORTANCE Double-stranded DNA viruses typically package their geno
284 e that Epstein-Barr virus and possible other double-stranded DNA viruses use TRIM29 to suppress local
285 ighlight the emergence of previously unknown double-stranded DNA viruses which delineate and extend t
288 he portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly a
290 ckaging is strongly conserved in the complex double-stranded DNA viruses, including the herpesviruses
294 ian on solvated nucleotide, and single-, and double-stranded DNA, we mimic hydrogen transfer reaction
295 only partial ketone formation in single- and double-stranded DNA, where the orientation of the base i
297 ity to telomeric DNA substrates comprised of double-stranded DNA with a 3' single-stranded extension.
298 igner DNA nanoparticles are constructed from double-stranded DNA with cytosine-rich stick ends (C-mon
300 the HRP3 PWWP domain in complex with various double-stranded DNAs with/without bound histone peptides