ライフサイエンスコーパス: double-stranded RNA

1 A molecules but displays limited activity on double stranded RNA.

2 ly recognize more complex structures such as double stranded RNA.

3 and C. maculate larvae treated with dietary double stranded RNA.

4 ble formation do not occur in overstretching double-stranded RNA.

5 nts, thus increasing intracellular levels of double-stranded RNA.

6 the eggs laid by females injected with Kr-h1 double-stranded RNA.

7 f defense against viral infection by sensing double-stranded RNA.

8 RNA (ADARs) convert adenosine to inosine in double-stranded RNA.

9 ircularly closed nanoobject made entirely of double-stranded RNA.

10 ependent on the formation of sense/antisense double-stranded RNA.

11 viral antigen 2B and mature virions but not double-stranded RNA.

12 tion initiation factor upon binding to viral double-stranded RNAs.

13 ting of RNA to prevent sensing of endogenous double-stranded RNAs.

14 mpanied by repetitive element expression and double-stranded RNA accumulation.

15 kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulate

16 Inhibition or deletion of double-stranded RNA-activated protein kinase (PKR) also

17 eased expression of the interferon-inducible double-stranded RNA-activated protein kinase (PKR) has b

18 previously unrecognized nuclear function of double-stranded RNA-activated protein kinase (PKR) in th

19 tol-requiring enzyme 1alpha (IRE1alpha), and double-stranded RNA-activated protein kinase (PKR)-like

20 odulated activator of the interferon-induced double-stranded RNA-activated protein kinase (PKR).

21 n of the ISR, by inhibiting the ISR-inducing double-stranded RNA-activated protein kinase or boosting

22 gh facilitating ATP efflux to potentiate the double-stranded RNA-activated protein kinase R (PKR)-dep

23 itical component of interferon-regulated and double-stranded-RNA-activated antiviral host responses.

24 Adenosine deaminases acting on double-stranded RNA (ADARs) catalyze the deamination of

25 novirus vector expressing haemagglutinin and double-stranded RNA adjuvant delivered orally by tablets

26 ory cytokine and type I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mo

27 feron-induced antiviral response that senses double-stranded RNA and activates endoribonuclease RNase

28 IFN pathway, which comprises the sensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IF

29 LR3 (Toll-like receptor 3) is a receptor for double-stranded RNA and has been recently implicated in

30 receptors 3 and 4 (TLR3, TLR4), which sense double-stranded RNA and high-mobility group protein B1 (

31 Functional relevance was demonstrated as double-stranded RNA and LL-37 promoted adhesion and tran

32 the capacity of UVB exposure to promote both double-stranded RNA and LL-37 was responsible for the en

33 Double-stranded RNA and the synthetic analog polyinosini

34 ryptic transcripts being more prone to cause double-stranded RNA and viral mimicry, we observe low DN

35 RDR2 converts Pol IV transcripts into double-stranded RNAs and then typically adds an extra un

36 st SARS-CoV spike protein and nucleoprotein, double stranded RNA, and RNA probe for spike genes were

37 ents of the genome replication complex (NS3, double-stranded RNA, and cellular lipids, including phos

38 House virus replication are dynamic, protect double-stranded RNA, and enhance RNA replication in gene

39 vation with poly(I:C), a synthetic analog of double-stranded RNA, and longitudinally imaged postsynap

40 C of RdRps from three RNA viruses, i.e. the double-stranded RNA bacteriophage Phi6, and the positive

41 an ADAR2 comprising its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to a

42 propose that bivalent interactions with the double stranded RNA binding domain and the basic region

43 NAs also activate PKR constructs lacking the double-stranded RNA binding domain and bind to a basic r

44 ADARs are modular enzymes with multiple double-stranded RNA binding domains (dsRBDs) and a catal

45 ng at the Q/R site of GRIA2 Furthermore, the double-stranded RNA binding domains of ADAR3 are require

46 ith pre-60S ribosomal particles requires the double-stranded RNA binding domains of NF90, while deple

47 non-catalytic factors containing one or more double-stranded RNA binding motif (dsRBM) that play impo

48 We have identified a cytoplasmic double-stranded RNA binding protein, Stau1, which is cru

49 we retrace the evolutionary history of plant double-stranded RNA binding proteins (DRBs), a group of

50 responsible for recognizing dsRNA is termed double-stranded RNA binding proteins (dsRBP).

51 In line with the double-stranded RNA-binding activity of EBP1 in human (H

52 This construct, the DGCR8 core, contains two double-stranded RNA-binding domains (dsRBDs) and a C-ter

53 Double-stranded RNA-binding domains (dsRBDs) are commonl

54 the nonsequence-specific protein TRBP, whose double-stranded RNA-binding domains (dsRBDs) interact wi

55 dividual, a homozygous variant in one of the double-stranded RNA-binding domains (dsRBDs) was identif

56 The double-stranded RNA-binding protein and RNA-editing enzy

57 The double-stranded RNA-binding protein DRB4 of Arabidopsis

58 uding those coding for Dicer, Argonaute, and double-stranded RNA-binding proteins (dsRBP) as well as

59 The RIG-I-like receptors (RLRs) are double-stranded RNA-binding proteins that play a role in

60 tly increased when larvae were injected with double-stranded RNA bound to CNTs (PAMAM-CNT-dsRNA), com

61 Classical activators of PKR are long viral double-stranded RNAs, but recently, PKR has been found t

62 factors activated by the detection of viral double-stranded RNA by pattern-recognition receptors (RI

63 cleaved precursor fragments are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (R

64 24-nt siRNAs are known to be processed from double-stranded RNAs by Dicer-like 3 (DCL3) and loaded i

65 two such single-stranded RNA circles into a double-stranded RNA circle, and this strand-annealing ac

66 er-235 phosphorylated NS5A co-localized with double-stranded RNA, consistent with its role in HCV rep

67 imic the in vivo situation and show that the double-stranded RNA-dependent protein kinase (PKR) is in

68 ough inhibiting eIF-2alpha kinases including double-stranded RNA-dependent protein kinase (PKR), whic

69 t RAN translation is highly regulated by the double-stranded RNA-dependent protein kinase (PKR).

70 lated by PRKRA (protein interferon-inducible double-stranded RNA-dependent protein kinase activator A

71 ich encodes an innate immune sensor of viral double-stranded RNA, depends on the interferon regulator

72 The sensor RIG-I detects double-stranded RNA derived from RNA viruses.

73 tected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may

74 We identified double-stranded RNA derived from tumour cells as an upst

75 d siRNA-directed pUG RNA biogenesis underlie double-stranded-RNA-directed transgenerational epigeneti

76 MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts a

77 lasmid for in planta transient expression of double stranded RNA (dsRNA) homologous to the acetylchol

78 Considerable double-stranded RNA (dsRNA) accumulation in Xrn1-deplete

79 essive steps in mRNA degradation and prevent double-stranded RNA (dsRNA) accumulation, whereas the vi

80 Double-stranded RNA (dsRNA) activates the innate immune

81 We also tested the effects of injecting double-stranded RNA (dsRNA) against XDH1, XDH2, or both.

82 e gene I (RIG-I)-like receptors detect viral double-stranded RNA (dsRNA) and 5'-triphosphorylated RNA

83 ions that fully separate the strands of long double-stranded RNA (dsRNA) and allow the released RNAs

84 RNaseIII enzymes catalyze the cleavage of double-stranded RNA (dsRNA) and have diverse functions i

85 (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in

86 nnate immune system detection of cytoplasmic double-stranded RNA (dsRNA) and promotion of host antivi

87 of interferon-inducible enzymes that require double-stranded RNA (dsRNA) as a cofactor.

88 Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material.

89 has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian imm

90 range expansion using three genotypes of the double-stranded RNA (dsRNA) bacteriophage phi6 (wild typ

91 on early in infection upon exposure to viral double-stranded RNA (dsRNA) before the induction of inte

92 ressed by ADARs beyond their RNA editing and double-stranded RNA (dsRNA) binding functions.

93 abundance 22-nucleotide siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respective

94 The strategy of directly targeting double-stranded RNA (dsRNA) by triplex-formation is rela

95 Long double-stranded RNA (dsRNA) can silence genes of matchin

96 er (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a type I interferon

97 Studies on double-stranded RNA (dsRNA) degradation by dsRNases and

98 Immunofluorescence assays (IFA) specific for double-stranded RNA (dsRNA) demonstrated the presence of

99 t to respond to the aberrant accumulation of double-stranded RNA (dsRNA) due to increased sensor leve

100 Viruses that generate double-stranded RNA (dsRNA) during replication must over

101 create enough space to accommodate and bind double-stranded RNA (dsRNA) during unwinding.

102 A protein hub that involves the double-stranded RNA (dsRNA) editing enzyme adenosine dea

103 Double-stranded RNA (dsRNA) exhibits a smooth transition

104 Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plan

105 Total RNA and double-stranded RNA (dsRNA) from mycelia and RNA from sa

106 em that assigns a genotype to each of the 11 double-stranded RNA (dsRNA) genome segments.

107 sed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome that replicate in dis

108 sortment is common in viruses with segmented double-stranded RNA (dsRNA) genomes.

109 the VP35-based inhibitory functions of viral double-stranded RNA (dsRNA) IFN-beta induction.

110 NA (ADARs) convert adenosines to inosines in double-stranded RNA (dsRNA) in animals.

111 Herein, we show increased levels of double-stranded RNA (dsRNA) in infected bone in a Staphy

112 e worm Caenorhabditis elegans, expression of double-stranded RNA (dsRNA) in neurons can result in the

113 Viruses induce double-stranded RNA (dsRNA) in the host cells.

114 entation machinery, mediated in part through double-stranded RNA (dsRNA) induction.

115 MDA5-mediated signaling by reducing the MDA5-double-stranded RNA (dsRNA) interaction.

116 are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replica

117 Delivery of double-stranded RNA (dsRNA) into animals can silence gen

118 to-specific genes was performed by injecting double-stranded RNA (dsRNA) into female Aedes aegypti mo

119 tinct Dicer-like (DCL) proteins that process double-stranded RNA (dsRNA) into small-interfering RNAs

120 Double-stranded RNA (dsRNA) is a common by-product of vi

121 Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for prog

122 Upon infection, viral double-stranded RNA (dsRNA) is detected, which results i

123 ses, but amplification of viral proteins and double-stranded RNA (dsRNA) is inhibited in infected neu

124 In support of this idea, when double-stranded RNA (dsRNA) is introduced into some anim

125 Double-stranded RNA (dsRNA) molecules are used as a nove

126 Endogenous double-stranded RNA (dsRNA) must be intricately regulate

127 port the discovery and characterization of a double-stranded RNA (dsRNA) mycovirus isolated from the

128 Here, we characterized a novel double-stranded RNA (dsRNA) mycovirus, Sclerotinia scler

129 the antiviral state induced by an analog of double-stranded RNA (dsRNA) or by IFN treatment.

130 RNAi-5x was applied either as double-stranded RNA (dsRNA) or RNAi plasmid DNA (dsDNA).

131 Double-stranded RNA (dsRNA) pesticides are a new generat

132 H3N2, viral RNA, a synthetic analog of viral double-stranded RNA (dsRNA) polyinosinic-polycytidylic a

133 that the biogenesis of viral siRNAs from IAV double-stranded RNA (dsRNA) precursors in infected cells

134 a signature of dsRNA sensing, including the double-stranded RNA (dsRNA) receptor DExD/H-Box Helicase

135 eviously, our group has shown that noncoding double-stranded RNA (dsRNA) released during wounding is

136 storically been used as a model to study the double-stranded RNA (dsRNA) Reoviridae family, the membe

137 n GUVs provide significant protection of the double-stranded RNA (dsRNA) replication intermediate aga

138 t encode an ExoN, which functions to degrade double-stranded RNA (dsRNA) replication intermediates.

139 ty is due, in part, to the activation of the double-stranded RNA (dsRNA) response pathway and the acc

140 The virus is bipartite, containing two double-stranded RNA (dsRNA) segments designated as dsRNA

141 aberrant innate immune responses through the double-stranded RNA (dsRNA) sensor MDA5, unleashing endo

142 ctivate protein kinase R (PKR), a known host double-stranded RNA (dsRNA) sensor.

143 worms bacteria carrying a plasmid expressing double-stranded RNA (dsRNA) targeting a gene of interest

144 only egress, cells were transfected with the double-stranded RNA (dsRNA) targeting an individual ESCR

145 Diet based insect feeding assays using double-stranded RNA (dsRNA) targeting dvssj1 and dvssj2

146 Injection of double-stranded RNA (dsRNA) targeting gene coding for in

147 ases had a modest binding affinity for their double-stranded RNA (dsRNA) targets.

148 innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon re

149 RIG-I detects double-stranded RNA (dsRNA) to trigger antiviral cytokin

150 gment of the DvSSJ1 gene, the formation of a double-stranded RNA (dsRNA) transcript and siRNAs in tra

151 ting the cascade of antiviral responses that double-stranded RNA (dsRNA) triggers in host cells.

152 and abuse of cellular pathways, and applied double-stranded RNA (dsRNA) virology.

153 ant and insect viruses, and between a fungal double-stranded RNA (dsRNA) virus and an insect virus, i

154 (GLV) is a small, nonenveloped, nonsegmented double-stranded RNA (dsRNA) virus infecting Giardia lamb

155 The endogenous double-stranded RNA (dsRNA) virus Leishmaniavirus (LRV1)

156 Rotavirus is a segmented double-stranded RNA (dsRNA) virus that causes severe gas

157 Most double-stranded RNA (dsRNA) viruses are transcribed and

158 tudy, we identified a taxon of monosegmented double-stranded RNA (dsRNA) viruses in five planarian sp

159 Endogenous RNA transcription characterizes double-stranded RNA (dsRNA) viruses in the Reoviridae, a

160 Partitiviruses are segmented, multipartite double-stranded RNA (dsRNA) viruses that until recently

161 Specifically, efficient synthesis of double-stranded RNA (dsRNA) within infected cells is req

162 Invertebrates rely on Dicer to cleave viral double-stranded RNA (dsRNA), and Drosophila Dicer-2 dist

163 cription of mitochondrial RNAs that may form double-stranded RNA (dsRNA), as has been observed in mam

164 , when the AKT gene (HdAKT) was inhibited by double-stranded RNA (dsRNA), expression levels of HdAKT

165 In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and

166 sensing and binding to viral RNA, including double-stranded RNA (dsRNA), RIG-I and MDA5 undergo cyto

167 AZA treatment generates self, double-stranded RNA (dsRNA), transcribed from hypomethyl

168 stimulation with IFN, but not intracellular double-stranded RNA (dsRNA), was inhibited by RV.

169 nting translational shutdown mediated by the double-stranded RNA (dsRNA)-activated kinase PKR and the

170 In particular, NP associates with the double-stranded RNA (dsRNA)-activated protein kinase (PK

171 to viral infection through the action of the double-stranded RNA (dsRNA)-activated protein kinase (PK

172 Double-stranded RNA (dsRNA)-activated protein kinase (PK

173 Double-stranded RNA (dsRNA)-activated protein kinase (PK

174 erfect RNA duplexes and act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PK

175 Injection of female mosquitoes with either double-stranded RNA (dsRNA)-ALAT1 or dsRNA ALAT2 signifi

176 y, a previously unidentified mutation in the double-stranded RNA (dsRNA)-binding domain (I64T) decrea

177 ny of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR.

178 ny of these transcripts bind and inhibit the double-stranded RNA (dsRNA)-dependent kinase PKR.

179 granules (avSGs) by regulating activation of double-stranded RNA (dsRNA)-dependent protein kinase R (

180 ble protein I (RIG-I)-like receptors (RLRs), double-stranded RNA (dsRNA)-dependent protein kinase rec

181 Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees reveal

182 n bluetongue virus (BTV), are multisegmented double-stranded RNA (dsRNA).

183 s that lead to production of progeny genomic double-stranded RNA (dsRNA).

184 mplex and the viral replication intermediate double-stranded RNA (dsRNA).

185 dsRBDs) interact with the A-form geometry of double-stranded RNA (dsRNA).

186 ication and the accompanying accumulation of double-stranded RNA (dsRNA).

187 g domain (RBD) that are required for binding double-stranded RNA (dsRNA).

188 ex with inosine-containing DNA/RNA hybrid or double-stranded RNA (dsRNA).

189 ced by ADARs [adenosine deaminases acting on double-stranded RNA (dsRNA)] together with the endogenou

190 Double-stranded RNAs (dsRNA) produced during human cytom

191 Double-stranded-RNA (dsRNA)-activated protein kinase R (

192 particles (DLPs), while genome replication (double-stranded RNA [dsRNA] synthesis) by VP1 occurs wit

193 catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly

194 In this study, we analyzed how non-coding double-stranded RNA (dsRNAs) act as a DAMP in the skin a

195 motifs that are required for p38 binding to double-stranded RNAs (dsRNAs) and interaction with RNA-i

196 Recent new studies demonstrate that spraying double-stranded RNAs (dsRNAs) and small RNAs (sRNAs) tha

197 silencing is triggered by the production of double-stranded RNAs (dsRNAs) by RNA-DEPENDENT RNA POLYM

198 rus (CPV), all package a genome of segmented double-stranded RNAs (dsRNAs) inside the viral capsid an

199 Detection of double-stranded RNAs (dsRNAs) is a central mechanism of

200 Feeding with SmedOB1 double-stranded RNAs (dsRNAs) led to homeostasis abnorma

201 It relies on plants stably expressing double-stranded RNAs (dsRNAs) that target essential gene

202 terize the AlucJHEH gene, three fragments of double-stranded RNAs (dsRNAs) were designed to target di

203 By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundan

204 ble elements that leads to the production of double-stranded RNAs (dsRNAs).

205 whereas Dicer-2 makes 21-nt siRNAs from long double-stranded RNAs (dsRNAs).

206 that Botrytis can take up external sRNAs and double-stranded RNAs (dsRNAs).

207 nse, mediated by the formation of endogenous double-stranded RNAs (dsRNAs).

208 inly attributed to MDA5 and RIG-I sensing of double-stranded RNAs (dsRNAs).

209 The extracted double-stranded RNA from 312 maize cobs was converted to

210 We conclude that the interaction of double-stranded RNA from injured cells with toll-like re

211 Oligoadenylate synthetase 1 (OAS1) binds double-stranded RNA from invading viruses and produces 2

212 The digestion of double-stranded RNA from keratinocytes exposed to UVB bl

213 nucleotide sensing receptor that recognizes double-stranded RNA from viral infection.

214 er RNA viruses.IMPORTANCE The rotavirus (RV) double-stranded RNA genome is replicated and packaged in

215 the process of reassortment, whereby the 11 double-stranded RNA genome segments are exchanged among

216 BTV possesses a ten-segmented double-stranded RNA genome, and NS3 proteins are encoded

217 etic manipulation of the rotavirus segmented double-stranded RNA genome.

218 CE, we discovered a novel plant virus with a double-stranded RNA genome.

219 tic homologous sequences, suggests a role of double stranded RNA in the production of de novo piRNAs.

220 hitefly genes by expressing their homologous double stranded RNAs in plants has great potential for m

221 These interactions are primarily with double-stranded RNA in a non-sequence specific fashion,

222 ound that ZBP1 constitutively bound cellular double-stranded RNA in a Zalpha-dependent manner.

223 Double-stranded RNA in bronchoalveolar lavage and serum

224 e of toll-like receptor 3 and the binding of double-stranded RNA in the pathogenesis of sterile injur

225 d region stem-loop structures, which contain double-stranded RNA, in vitro.

226 g with a monoclonal antibody that recognizes double-stranded RNA indicated that the released vesicles

227 The unwinding of double-stranded RNA intermediates is critical for the re

228 cts: the host RNAi machinery processes viral double-stranded RNA into small interfering RNAs (siRNAs)

229 ; however, sequence-selective recognition of double-stranded RNA is challenging.

230 ed processing indicate that the synthesis of double-stranded RNA is defective in the absence of G3BP

231 P binding confirmed that ATP binds only when double-stranded RNA is present.

232 element [KIL-d] alters killer activity of M double-stranded RNA killer virus and confers cell resist

233 ally, pretreatment with toll-like receptor 3/double-stranded RNA ligand inhibitor led to a reduction

234 A toll-like receptor 3/double-stranded RNA ligand inhibitor was injected into w

235 inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and MDA5; this

236 kness behavior, single-stranded RNA viruses, double-stranded RNA ligands, and IFNs shared pathways in

237 raphic data demonstrate a mechanism in which double-stranded RNA mediates enzyme dimerization.

238 Endogenous release of type I IFNs with the double-stranded RNA mimetic poly(I:C) likewise produces

239 Small double-stranded RNA molecules can efficiently trigger RN

240 ce (RNAi) is a natural process through which double-stranded RNA molecules can silence the gene carry

241 h broadly acting, because it is triggered by double-stranded RNA molecules derived from virtually any

242 r with cum1(+) sense mRNA, thereby producing double-stranded RNA molecules that could induce RNAi.

243 al, attenuating the cytosolic L-A and Killer double-stranded RNA mycoviruses and protecting meiotic p

244 Upon sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates

245 Toward this goal, we injected double-stranded RNA of ferritin2 and ferritin1 into newl

246 signaling pathways, either those that sense double-stranded RNA or cytoplasmic DNA that trigger IFN

247 l-like receptor 3 stimulation with poly(I.C) double-stranded RNA or infection with herpes simplex vir

248 (EDIII) subunit antigen and two adjuvants, a double-stranded RNA (Poly (inosinic:cytidylic acid) (Pol

249 ated siRNA loci were most often derived from double-stranded RNA precursors copied from spliced mRNAs

250 mary transcripts from which RDR2 synthesizes double-stranded RNA precursors for small interfering RNA

251 cessive TLR3-mediated cell death, induced by double-stranded RNA present in the skin of SHARPIN-defic

252 osinic-polycitidilic acid (PIC) (a mimick of double-stranded RNA produced during viral infection) sho

253 t an effective antiviral response.IMPORTANCE Double-stranded RNAs produced during viral infections se

254 ession is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that doub

255 ndothelial cells, confirming the role of the double-stranded RNA recognition pathways.

256 enosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activ

257 find that SMAD3 binds poorly to single- and double-stranded RNA, regardless of sequence.

258 Here we show XPO5 pervasively binds to double-stranded RNA regions found in some clustered prim

259 ominant RNA-capsid interaction sites favored double-stranded RNA regions.

260 (MAVS) by the antimicrobial peptide LL37 and double stranded-RNA released from necrotic cells.

261 eplication complexes revealed that the viral double-stranded RNA replication template is coiled insid

262 show that sigmaNS also binds to a partially double-stranded RNA, resulting in gradual helix unwindin

263 plex of VP1, VP4, and VP6 and a genome of 10 double-stranded RNA segments.

264 stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential appr

265 TLR3 knockdown promoted double-stranded RNA signaling via other intracellular RN

266 a RNA helicase Dhx9, Nlrp9b recognizes short double-stranded RNA stretches and forms inflammasome com

267 mmunity is independent of a 5' triphosphate, double-stranded RNA structure, or the primary sequence o

268 RNase III proteins recognize double-stranded RNA structures and catalyze endoribonucl

269 approximately 22 nt microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer

270 itro for efficient nuclease activity against double-stranded RNA substrates, particularly at lower te

271 of cellular functions that are controlled by double-stranded RNAs, such as RNA interference, RNA edit

272 gulation of AsFAR expression by injection of double-stranded RNA suppresses ovarian development and f

273 l RNA molecules prior to capsid assembly and double-stranded RNA synthesis within viral inclusion bod

274 notype was detected in insects injected with double-stranded RNA targeting HDAC1 (dsHDAC1).

275 As that form stable secondary structures and double-stranded RNA targets remains challenging as retro

276 chanism involving formation of a PRUNE2/PCA3 double-stranded RNA that undergoes adenosine deaminase a

277 ent RNA polymerase (RdRP), which synthesizes double-stranded RNAs that are sensed by melanoma differe

278 RNA polymerases (RDRs) catalyze synthesis of double-stranded RNAs that can serve to initiate or ampli

279 saRNAs are small double-stranded RNAs that enhance target gene expression

280 acting on RNA-1 (ADAR1), which catalyzes in double-stranded RNA the C-6 deamination of adenosine to

281 Double-stranded RNAs, the viral replication intermediate

282 alvi can stably recolonize bees and produce double-stranded RNA to activate RNAi and repress host ge

283 Using partially double-stranded RNAs, very efficient TATase activity was

284 ) was independently generated in single- and double-stranded RNA via photolysis of a ketone precursor

285 rus (reovirus) is a nonenveloped, segmented, double-stranded RNA virus in the Reoviridae family.

286 non-segmented, 4.5-5.5 kilo-base pair (kbp), double-stranded RNA virus infecting T. vaginalis.

287 ny Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1),

288 isolates of L. braziliensis (>25%) contain a double-stranded RNA virus named Leishmaniavirus 1 (LRV1)

289 The triennial International Double-Stranded RNA Virus Symposium, this year organized

290 Bluetongue virus (BTV), a nonenveloped double-stranded RNA virus, is a potent inducer of type I

291 Recently, we reported that a double-stranded RNA virus, Leishmania RNA virus 1 (LRV1)

292 cytotoxicity caused by reovirus, a prototype double-stranded RNA virus.

293 rthoreoviruses (reoviruses) are nonenveloped double-stranded RNA viruses that infect most mammalian s

294 Destabilization of the double stranded RNA was measured as a function of number

295 us by plaque assay even though intracellular double-stranded RNA was detected by immunofluorescence.

296 Finally, when synthetic double-stranded RNA was detected by OAS3 to induce RNase

297 ch targets minus-strand synthesis to produce double-stranded RNA) when mu1 is knocked down.

298 The endoribonuclease RNase III cleaves double stranded RNAs, which can be formed during the int

299 were found defective in degrading exogenous double-stranded RNAs, which may explain retention of vir

300 NV RNA replicates efficiently and generates double-stranded RNA without inducing a detectable IFN re