ライフサイエンスコーパス: doublecortin

1 topia-like phenotype, reminiscent of loss of doublecortin.

2 d for BrdU and a marker of immature neurons, doublecortin.

3 ole for phosphorylation in the regulation of Doublecortin.

4 codes a novel 40 kDa predicted protein named Doublecortin.

5 es, which can be rescued by the knockdown of doublecortin.

6 expression of the neuronal markers Tuj1 and doublecortin.

7 AT1 colocalizes on bundled microtubules with doublecortin.

8 These distinct properties combine to give doublecortin a unique function in microtubule regulation

9 dal but not stellate-cells co-localized with doublecortin - a marker of immature neurons - suggesting

10 After C cells, Doublecortin(+) A cells were the second-most common divi

11 Doublecortin, a component of the microtubule cytoskeleto

12 helin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were simila

13 murine piriform cortex express low levels of doublecortin, a marker for migratory and immature neuron

14 of DCN neurons in the adult rat that express doublecortin, a plasticity-related protein.

15 IS NF186 by impeding Lis1's interaction with doublecortin, a potent facilitator of NF186 endocytosis.

16 ed the immunocytochemical method to localize doublecortin, a protein associated with microtubules in

17 Subsets of BrdU+ precursors expressed Doublecortin, a protein found exclusively in migrating n

18 Doublecortin, along with the newly characterized mDab1,

19 Mutations in doublecortin also cause sporadic DC in females.

20 topathology and putative progenitor markers [doublecortin and calcium/calmodulin-dependent protein ki

21 These traits include enhanced expression of doublecortin and CaM kinase-like-1 (DCAMKL-1), Lgr5, CD1

22 ependent increases in progenitors expressing doublecortin and CaM kinase-like-1 (DCAMKL1), stem cells

23 Co-labelling with doublecortin and neuron-specific markers and BrdU in spi

24 arrest, induction of the neuroblastic marker doublecortin and of the neuron-specific intermediate fil

25 on of RhoA small GTPase and up-regulation of doublecortin and p35, which, in turn, modulate the actin

26 tors were unaffected, while raised levels of doublecortin and Proliferating Cell Nuclear Antigen (PCN

27 rd coexpressed the immature neuronal markers doublecortin and proliferating cell nuclear antigen but

28 Hippocampal neurogenesis, measured by doublecortin and proliferating cell nuclear antigen expr

29 dine-labeled) with various cellular markers; doublecortin and PSA-NCAM as the early neuronal marker,

30 (radial and horizontal) and three classes of doublecortin and PSA-NCAM-positive D cells (D1, D2, D3)

31 Expression of doublecortin and TUC-4 was associated with neurons in th

32 scopy to characterize microtubule binding by doublecortin and visualize its binding site.

33 mammary tumors had no effect on hippocampal doublecortin + and did not alter depressive-like behavio

34 oughout the dorsal hippocampus (positive for doublecortin) and expressed markers for astrocytes and f

35 nd microtubule-associated components such as doublecortin, and LIS1.

36 DF infusion also resulted in an induction of doublecortin- and Sox10 double-positive cells in the adu

37 (2 h) or Ki-67; immature neurons labeled by doublecortin; and adult-generated neurons labeled with B

38 Anti-doublecortin antibodies, such as the rabbit polyclonal A

39 onal nuclei protein (NeuN, a.k.a. Fox-3) and doublecortin antigens in the whole brain of chicks 2 day

40 cursor cells and young neurons, labeled with doublecortin, appeared to be lost equally from rostral a

41 nocytochemistry for newly born neurons using doublecortin, as well as double labeling using an additi

42 The finding that doublecortin associates with FIGQY-phosphorylated neurof

43 ncreased in old age, and the lower levels of doublecortin at old age in the hippocampus of Arg-61 mic

44 specificity was explained when we found that doublecortin binds between the protofilaments from which

45 Doublecortin binds selectively to 13 protofilament micro

46 AAV2/1-FGF2 injection enhances the number of doublecortin, BrdU/NeuN, and c-fos-positive cells in the

47 labeled with neuronal (beta-III-tubulin and doublecortin) but not RG markers [GFAP, vimentin, and BL

48 a microtubule-associated protein related to doublecortin, by Shu et al., Koizumi et al., and Deuel e

49 th a camelid antibody fragment show that the doublecortin C-terminal domain adopts the same well defi

50 ines and its regulation of the gene encoding doublecortin calmodulin-like kinase 1 (DCLK1), a marker

51 ed markers (glial fibrillary acidic protein, doublecortin, calretinin and calbindin).

52 Bax-knock-out, there was an accumulation of doublecortin, calretinin+, and neuronal-specific nuclear

53 ls were localized in the isthmus adjacent to doublecortin CaM kinase-like-1(+) putative progenitor ce

54 A mutation in LIS1 or doublecortin can lead to either classical lissencephaly

55 Mutations of doublecortin causing lissencephaly (R59H, D62N, and G253

56 of bromodeoxyuridine-positive, Ki-67(+), and doublecortin(+) cells in the subgranular zone of the den

57 in fibers in the cingular cortex and loss of doublecortin(+) cells in the subventricular zone and hip

58 Finally, phospho-FIGQY neurofascin and doublecortin colocalize in developing axon tracts and in

59 In the adult rostral migratory stream, doublecortin colocalizes in migrating neurons with a pho

60 des in RP1 diseases, and suggest that RP1, a doublecortin-containing microtubule associated protein,

61 Doublecortin contains a consensus Abl phosphorylation si

62 GluN2A subunit, unco-ordinated-5H3 (unc5H3), doublecortin, cyclo-oxygenase, sonic hedgehog and Disrup

63 erneuron marker Er81, the neuroblast markers doublecortin (DC) and Distalless-related homeobox (DLX),

64 A recently identified gene, doublecortin ( DCX ), is expressed in fetal brain and mu

65 Doublecortin (DCX) and doublecortin-like kinase (DCLK),

66 l-labeled for ERbeta and the new-cell marker doublecortin (DCX) and examined by electron microscopy.

67 AIE reduced immunoreactivity for doublecortin (DCX) and increased immunoreactivity for ac

68 nto neurons as assessed by the expression of doublecortin (Dcx) and other neuronal fate markers.

69 Doublecortin (DCX) and polysialylated neural cell adhesi

70 Mutations in doublecortin (DCX) are associated with intractable epile

71 Finally, we establish doublecortin (DCX) as a novel substrate of GSK3beta in t

72 rylation of the lissencephaly-linked protein doublecortin (DCX) by cdk5/p35, but the phosphorylation

73 phosphorylation of the lissencephaly-linked doublecortin (DCX) by cdk5/p35, but the phosphorylation

74 Doublecortin (Dcx) defines a growing family of microtubu

75 andidate for this role is TgDCX, which has a doublecortin (DCX) domain and a TPPP/P25-alpha domain, b

76 le-associated ciliary protein containing the doublecortin (DCX) domain.

77 d microtubules, indicating that the putative doublecortin (DCX) domains in RP1 are functional.

78 They can be induced to become Doublecortin (DCX) expressing migrating neuroblasts by R

79 ecortin-like kinases (DCLKs), members of the doublecortin (DCX) family expressed in adult retinal gan

80 Mutations in the doublecortin (DCX) gene in human or targeted disruption

81 We have also cloned the X-linked mouse doublecortin (Dcx) gene.

82 Doublecortin (DCX) has long been implicated in, and empl

83 Using doublecortin (DCX) immunocytochemistry, these growing de

84 Here we studied doublecortin (DCX) in cultured hippocampal and sympathet

85 Doublecortin (DCX) is a cytoskeletal protein that is pri

86 Doublecortin (DCX) is a microtubule (MT)-associated prot

87 Doublecortin (DCX) is a microtubule (MT)-associated prot

88 Doublecortin (DCX) is a microtubule-associated protein r

89 Doublecortin (DCX) is a microtubule-associated protein t

90 Doublecortin (Dcx) is a microtubule-associated protein t

91 Doublecortin (DCX) is a microtubule-associated protein t

92 Doublecortin (DCX) is an important microtubule-associate

93 Doublecortin (DCX) is one of the three genes found from

94 Doublecortin (DCX) is required for normal migration of n

95 Doublecortin (Dcx) is the causative gene for X-linked li

96 For example, doublecortin (Dcx) knockdown but not knockout shows a ne

97 Doublecortin (DCX) missense mutations are found in two c

98 2b (PHOX2B), tyrosine hydroxylase (TH), and doublecortin (DCX) mRNA in PB and BM of children enrolle

99 roximal enhancer of the neuron-specific gene doublecortin (Dcx) Once differentiation is induced, MEIS

100 een fluorescent protein under control of the doublecortin (DCX) or glial fibrillary acidic protein (G

101 ng a DsRed reporter under the control of the doublecortin (DCX) promoter (labeling immature neurons).

102 ptor (DTR) is expressed under control of the doublecortin (DCX) promoter, which allows for specific a

103 synthase kinase 3beta (GSK3beta) activity on doublecortin (DCX) revealing mechanistic details about t

104 onsible for the dephosphorylation of the MAP Doublecortin (Dcx) Ser 297 selectively at the "wrist" of

105 Immature neurons expressing doublecortin (DCX) were quantified in the hippocampus, c

106 SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integ

107 Mutations in the human doublecortin (DCX), a brain-specific putative signaling

108 ession of the microtubule-associated protein doublecortin (DCX), a marker of neurogenesis.

109 inase (TK) under control of the promoter for doublecortin (Dcx), a microtubule-associated protein exp

110 e measured the distribution of expression of doublecortin (DCX), a microtubule-associated protein, in

111 Doublecortin (DCX), a microtubule-associated protein, is

112 Doublecortin (DCX), a MT-associated protein (MAP) requir

113 Doublecortin (DCX), a widely accepted marker of newly ge

114 Here we show that doublecortin (DCX), a widely used marker for newly gener

115 We biochemically validated doublecortin (DCX), also an X-linked disease protein, an

116 tudy the expression of the neuroblast marker doublecortin (DCX), and compared its expression pattern

117 rogenitor cells such as Nestin, Musashi, and Doublecortin (DCX), and of the granule cell lineage such

118 The potential role of doublecortin (Dcx), encoding a microtubule-associated pr

119 llapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assesse

120 the expression of bromodeoxyuridine (BrdU), doublecortin (DCX), IGF-1 and IGF-1R at 7, 14 and 30 day

121 ic neurogenesis that is highly homologous to doublecortin (DCX), in the adult mouse brain.

122 rence to the microtubule-associated protein, doublecortin (DCX), that has been extensively used to id

123 these cells express the cytoskeletal protein Doublecortin (DCX), yet they are generated prenatally an

124 Glutamic acid decarboxylase 65 (GAD65)- and Doublecortin (Dcx)-expressing cells constitute major pro

125 was performed 14 days after distal MCAO and doublecortin (Dcx)-expressing cells in the subventricula

126 Doublecortin (DCX)-immunopositive cells (i.e. neuroblast

127 We reported previously that ablation of doublecortin (DCX)-immunopositive newborn neurons in mic

128 The morphology of doublecortin (DCX)-positive cells in fixed brain section

129 protein 2 (MAP2)-positive neurons (-24%) and doublecortin (Dcx)-positive neuroblasts (-21%), and incr

130 that resident astrocytes can be converted to doublecortin (DCX)-positive neuroblasts by a single tran

131 rosphere-derived cells to show that immature doublecortin (Dcx)-positive neurons are uniquely sensiti

132 e algorithms, we solved the 8 A structure of doublecortin (DCX)-stabilized MTs.

133 ses the X-linked lissencephaly gene encoding doublecortin (DCX).

134 K), a protein that shares high homology with doublecortin (DCX).

135 localized with the immature neuronal marker, doublecortin (Dcx).

136 vation of the microtubule-associated protein doublecortin (DCX).

137 red the volumetric changes and expression of doublecortin (DCX; an endogenous marker of the neuronal

138 dNoggin-treated R6/2 mice harbored migrating doublecortin-defined neuroblasts in their striata, and t

139 Although Doublecortin does not contain a kinase domain, it is hom

140 In addition, doublecortin does not itself oligomerise and does not bi

141 ntibody fragment specific for the C-terminal doublecortin domain affected microtubule binding, wherea

142 is suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrograph

143 binding and polymerization activities of the doublecortin domain, yet little is known regarding the e

144 oint mutation in DCDC2 (DCDC2a), a member of doublecortin domain-containing protein superfamily, caus

145 nase (Dclk), encodes a protein with similar "doublecortin domains" and microtubule stabilization prop

146 orders are located on a tandem repeat of two doublecortin domains.

147 terization of antibodies that bind to single doublecortin domains.

148 ion of non-centrosomal microtubules in these doublecortin-enriched distal zones.

149 o-fold elevation of endogenous MOR levels in doublecortin expressing (DCX(+)) NSC progenies in the ra

150 In this study, we quantified the number of doublecortin expressing (DCX+) immature neurons and Ki-6

151 he basal nuclear cluster and the presence of doublecortin expressing neurons in the shell division of

152 (SGZ) as well as their derivatives including doublecortin-expressing neuroblasts and immature granule

153 we observe adjacent but more differentiated doublecortin-expressing progenitors (type-2 cells) being

154 e, increased numbers of proliferating cells, doublecortin-expressing progenitors/neuroblasts, and ear

155 vated and result in increased numbers of the doublecortin-expressing type-2 cells.

156 e RA-dependent up-regulation of p21/Cip1 and doublecortin expression and RA-promoted neurite outgrowt

157 rofascin (186 kDa) coimmunoprecipitated with doublecortin from detergent extracts of embryonic brain

158 Mutations in the gene that impair doublecortin function and cause severe brain formation d

159 understand the role of individual domains in doublecortin function.

160 C-terminal domains, which can be related to doublecortin function.

161 Although mutations in the human doublecortin gene (DCX) cause profound defects in cortic

162 Mutations in the doublecortin gene (DCX) in humans cause malformation of

163 Mutations in the X-linked doublecortin gene appear in many sporadic cases of doubl

164 ermal and progenitor markers such as nestin, doublecortin, GFAP, neurofilament, and vimentin.

165 show here by video microscopy that purified doublecortin has no effect on the growth rate of microtu

166 ntig also contains two brain-specific genes, doublecortin (HGMW-approved symbol DCX), responsible for

167 Furthermore, doublecortin immunoelectron microscopy was used to exami

168 e (Ki-67 immunohistochemistry) and immature (doublecortin immunohistochemistry) cells within the dent

169 SA-WD and CSA-CONT resulted in more immature doublecortin-immunopositive (+) neurons in the posterior

170 ubventricular zone (SVZ), migrating neuronal doublecortin immunoreactive cells and VEGF and bFGF expr

171 BrdU and doublecortin-immunoreactive (BrdU+/DCX+) cells were seen

172 cked with an antibody, enhanced migration of doublecortin-immunoreactive neurons in 1 d differentiate

173 using bromodeoxyuridine, Ki-67, nestin, and doublecortin immunostaining in the ischemic brain, and d

174 ane and could be important for a function of doublecortin in directing neuronal migration.

175 d progressively from dorsal-to-ventral, (ii) doublecortin in layer-2 calbindin-positive-patches disap

176 a raise the possibility that the function of doublecortin in neurons is to drive assembly and stabili

177 This study describes a novel activity of doublecortin in recognition of the FIGQY-phosphotyrosine

178 at express the early neuronal marker protein doublecortin in the subventricular zone of mouse brain.

179 genitors expressing the neuronal marker Dcx (Doublecortin) in the SVZ and the DG.

180 tional adult neurogenesis markers, Ki-67 and doublecortin, in the hippocampus was evaluated by immuno

181 How doublecortin influences microtubule dynamics, and thereb

182 Doublecortin is a cytoplasmic protein mutated in the neu

183 We further show that doublecortin is a direct gene target of REST, and that i

184 Doublecortin is a microtubule-associated protein produce

185 Doublecortin is a neuronal microtubule-stabilising prote

186 lation of the microtubule-associated protein Doublecortin is controlled by protein phosphatase 1 and

187 In cells, doublecortin is enriched at the distal ends of neuronal

188 Mutation analysis for LIS1 and doublecortin is essential in determining the etiology of

189 The molecular mechanism of action of doublecortin is only incompletely understood.

190 le cortex, but because LIS1 is autosomal and doublecortin is X-linked (on the X chromosome), the dise

191 ions in the X-chromosomal gene DCX, encoding doublecortin, is the main cause of classical lissencepha

192 Doublecortin kinase-1 (DCK1) is a newly described multid

193 t on the identification of a protein kinase, doublecortin kinase-2 (DCK2), with a domain (DC) highly

194 he density of bromodeoxyuridine-, NeuN-, and doublecortin-labeled cells was compared between chicks 2

195 decreased both the number and complexity of doublecortin-labeled maturing newborn neurons in the den

196 lecortin was similar at all timepoints, with doublecortin-labeled profiles located throughout all for

197 In support of this, increased doublecortin labeling of immature neurons was detected i

198 However, doublecortin labeling was not detectable in any midbrain

199 Mutations in the X-linked gene doublecortin lead to "double cortex" syndrome (DC) in fe

200 We have characterized the expression of doublecortin-like (DCL), a microtubule-associated protei

201 Here, we report that the doublecortin-like kinase (Dclk) gene functions in a part

202 otubule-associated proteins (MAPs) including doublecortin-like kinase (DCLK), a protein that shares h

203 Doublecortin (DCX) and doublecortin-like kinase (DCLK), closely related family

204 A second locus, doublecortin-like kinase (Dclk), encodes a protein with

205 Doublecortin-like kinase 1 (DCLK1) is a central driver o

206 Doublecortin-like kinase 1 (DCLK1) is a proposed driver

207 Doublecortin-like kinase 1 (DCLK1) is a serine/threonine

208 Among them, Doublecortin-like kinase 1 (DCLK1), a microtubule bindin

209 Doublecortin-like kinase 1 (DCLK1), a tumor stem cell ma

210 he roles of SARS-CoV-2-induced host factors, doublecortin-like kinase 1 (DCLK1), and S100A9 in viral

211 or 10 (FZD10) and increases in beta-catenin, doublecortin-like kinase 1 (DCLK1), CD44 molecule (CD44)

212 and/or its structurally conserved paralogue, doublecortin-like kinase 1 (Dclk1), show impaired Kif1a-

213 or KLHL15-mediated ubiquitination of DCX and doublecortin-like kinase 1 and 2 and subsequent proteaso

214 (DCX), also an X-linked disease protein, and doublecortin-like kinase 1 and 2 as bona fide KLHL15 int

215 We show with that the phenotype of Dcx/Doublecortin-like kinase 1 deficiency is consistent with

216 Doublecortin-like kinase 1 protein (DCLK1) is a gastroin

217 interfering RNA (siRNA) screen and identify doublecortin-like kinase 2 (DCLK2) as a TBK1 regulator i

218 , we targeted one of the closest homologues, doublecortin-like kinase 2 (Dclk2).

219 its interaction with the upstream activator doublecortin-like kinase 2 (DCLK2).

220 Doublecortin-like kinase 3 (DCLK3), a member of this elu

221 al., and Deuel et al., provide evidence that doublecortin-like kinase is essential for proper neuroge

222 is issue of Neuron, three related studies on doublecortin-like kinase, a microtubule-associated prote

223 n depletion of the putative stem cell marker doublecortin-like kinase-1 (DCLK1) in the crypts.

224 Using genetic lineage tracing, we show that Doublecortin-like kinase-1 (Dclk1) labels a rare populat

225 Doublecortin-like kinase1 (DCLK1) has been demonstrated

226 We discovered that doublecortin-like kinases (DCLKs), members of the double

227 1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for

228 that other genetic loci or mosaicism at the doublecortin locus may be responsible for this diversity

229 Together with recent results showing that Doublecortin may play a role regulating the morphology o

230 euronal microtubule-associated protein (MAP) doublecortin, mediate the interaction between RP1 and mi

231 pal vascular endothelial growth factor mRNA, doublecortin mRNA, doublecortin protein, doublecortin-po

232 four groups: anterior biased/global DC with doublecortin mutation (16 of 30; 53%), anterior biased/g

233 dic DC patients had been found not to harbor doublecortin mutations and to determine whether clinical

234 their families, we found evidence for mosaic doublecortin mutations in 6 individuals.

235 To determine the incidence of doublecortin mutations in DC, we investigated a cohort o

236 Additionally, Doublecortin mutations in females lead to a more variabl

237 on deletions and point mutations, as well as Doublecortin mutations in males, lead to a very similar

238 adic double cortex patients show independent doublecortin mutations, at least one of them a de novo m

239 and XLIS are sporadic, representing de novo doublecortin mutations, we considered that some of these

240 istinguish between patients with and without doublecortin mutations.

241 gave rise to small numbers of immature, DCX (doublecortin)-negative neurons in the ventral forebrain,

242 e cells were grown as spheres that expressed doublecortin, nestin, and betaIII-tubulin, as well as th

243 n of neuronal cell markers (betaIII-tubulin, doublecortin, NeuN), the extent of dendritic arborizatio

244 ls that expressed markers of neurons (HuC/D, doublecortin), neural precursors (Sox10, nestin, Phox2b)

245 NA levels of four NeuroD downstream targets: doublecortin, Notch1, neurogenic differentiation 4, and

246 Doublecortin on the X-chromosome (DCX) is a neuronal mic

247 Doublecortin on X chromosome (DCX) is one of two major g

248 oradic patients with DC for mutations in the doublecortin open reading frame as assessed by single-st

249 effect on proliferation (Ki67), maturation (doublecortin) or survival (bromodeoxyuridine) of new adu

250 kers of neuronal and glial immaturity (Tuj1, doublecortin, or NG2).

251 racts of embryonic brain membranes, and this doublecortin-phospho-FIGQY neurofascin complex was disas

252 imer's brains showed increased expression of doublecortin, polysialylated nerve cell adhesion molecul

253 sesses human-equivalent postnatal streams of doublecortin positive (DCX+) young neurons.

254 Importantly, the absolute number of immature doublecortin positive neuroblasts was significantly incr

255 patch-clamp electrophysiology, we evaluated doublecortin-positive (DCX(+)) ABGCs as well as DCX(-) d

256 ing (n = 15) had lower densities of immature doublecortin-positive (DCX(+)) multipolar and bipolar ne

257 that ketamine accelerates differentiation of doublecortin-positive adult hippocampal neural progenito

258 ed that p38 MAP kinase (p38) is expressed in doublecortin-positive adult NPCs.

259 ntate gyrus colocalized more frequently with doublecortin-positive and Ki67 proliferating neural prog

260 , we show that bromodeoxyuridine-labeled and doublecortin-positive cells from the SVZ colocalize with

261 risingly, young Arg-61 mice had more mitotic doublecortin-positive cells in the subgranular zone; mRN

262 001 significantly decreases the migration of doublecortin-positive cells that extend from the SVZ int

263 ith sedentary animals, the highest number of doublecortin-positive hippocampal cells was observed in

264 cell proliferation and ectopically localized doublecortin-positive immature neurons and radial glia-l

265 Our results show that doublecortin-positive immature neurons displayed increas

266 ns experiencing UCMS had significantly fewer doublecortin-positive multipolar neurons (p < 0.001) and

267 rons and dramatically increased apoptosis of doublecortin-positive neural progenitor cells in the sub

268 sis, as shown by a decrease in the number of doublecortin-positive neuroblasts (-28%), and mature, mi

269 oreactivity, but did not alter the number of doublecortin-positive neuroblasts at the end of the trea

270 NA, doublecortin mRNA, doublecortin protein, doublecortin-positive neuron counts and neurite length i

271 ed the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of

272 e subgranular zone yet reduced the number of doublecortin-positive neurons.

273 adult TGF-beta1 mice had 60% fewer immature, doublecortin-positive, hippocampal neurons than wild-typ

274 of the intrinsic and synaptic parameters of doublecortin-positive, new granule cells in the hippocam

275 lon binds to the microtubule binding protein doublecortin preventing its degradation.

276 Rare Sox2(+) cells produce rapidly cycling doublecortin(+) progenitors that, together with their po

277 elial growth factor mRNA, doublecortin mRNA, doublecortin protein, doublecortin-positive neuron count

278 the cell biology of the LIS1 protein and the Doublecortin protein, potentially interacting pathways n

279 amino terminus has similarity to that of the doublecortin protein, whose gene (DCX) has been implicat

280 further understanding of LIS1 protein and of Doublecortin protein.

281 regions are critical for the function of the Doublecortin protein.

282 ed by neuronogenic cells in the SVZ, such as doublecortin, PSA-NCAM, beta-tubulin, Dlx2, or GFAP.

283 ventricle stained for the neuroblast marker doublecortin revealed normal formation of chains of migr

284 These data reveal the structural basis for doublecortin's binding selectivity and provide insight i

285 evels of four hallmark NPC proteins (nestin, doublecortin, sex-determining homeobox 2, and glial fibr

286 Doublecortin specifically recognized the phospho-FIGQY t

287 We show that doublecortin-stabilised microtubules are substrates for

288 Doublecortin stabilizes microtubules and stimulates thei

289 However, doublecortin staining did show large parts of the caudal

290 igrating neurons marked by Ki67, nestin, and doublecortin, such as those in the subventricular zone a

291 lar to those of both CaM kinases (CaMKs) and doublecortin, the product of the gene mutated in X-linke

292 used a marker of neurogenesis and migration, doublecortin, to further characterize the response of th

293 f new neurons, assessed by the expression of doublecortin, to HVC.

294 The distribution of doublecortin was similar at all timepoints, with doublec

295 d the lesion expressed the neuroblast marker doublecortin, whereas human cells at the lesion border e

296 f these cells stained for betaIII-tubulin or doublecortin, which are molecules expressed by migrating

297 Mutations in the X-linked gene doublecortin, which encodes a protein with no dear struc

298 , a pattern that resembles the expression of doublecortin, which is implicated in neuronal migration.

299 Reducing the expression of stathmin or doublecortin with an antisense oligonucleotide inhibited

300 neurofascin provides the first connection of doublecortin with the plasma membrane and could be impor