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1 t) and detect droplets containing two cells (doublets).
2 ly, rectifying the strong correlation in the doublet.
3 d, in which every major peak is split into a doublet.
4 riples interrupted by a C*G-C triple and C-G doublet.
5 array in a precise location on each axonemal doublet.
6 perceived as a Middle Miocene impact crater doublet.
7 in state having a ground-state "non-Kramers" doublet.
8 ecies, and an unassigned residual quadrupole doublet.
9 ations including imputation of the so-called doublets.
10 ith no significant mixing even in the higher doublets.
11 ositioning and number of ciliary microtubule doublets.
12 tra consisted of a sextet and two quadrupole doublets.
13 d 3D cell aggregates and micropatterned cell doublets.
14 ty associated with other targeted biological doublets.
15 otors concentrates at the distal tips of the doublets.
16 owed by oscillatory bending between pairs of doublets.
17 her ixabepilone or paclitaxel platinum-based doublets.
18 ks were variable among different microtubule doublets.
19 uces both the EPSP-AP coupling and evoked AP doublets.
20 etry break, and moreover it often involved 2 doublets.
21 asal bodies in contrast to the nine outer MT doublets.
22 tastatic gastric cancer and a third received doublets.
23 costs and identifying artifacts such as cell doublets.
24 1 +/- 0.01 s vs. -0.04 +/- 0.04 s, P < 0.05; doublets: -0.02 +/- 0.03 s vs. -0.05 +/- 0.04 s, P < 0.0
25 reduced in pregnant vs. non-pregnant women (doublets: 1.6 +/- 1.1 mmHg vs. 3.6 +/- 3.1 mmHg, P < 0.0
26 d to incorporate mixing of the two e orbital doublets (30%) that results from a lowering of the ideal
27 complexes physically connect to the axonemal doublets 4 and 8, positioning them perpendicular to the
28 .7% of patients received a carboplatin-based doublet, 64.9% and 31.3% received docetaxel, and 0% and
30 e kinocilia contain 9 peripheral microtubule doublets, a central microtubule pair, and 9 connecting r
32 devoid of ferritin but contained the central doublet and features arising from what appear to be Fe(I
33 spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms.
34 transition-metal systems, leaving a Kramers doublet and quartet with effective angular momentum of J
35 Here we report observations of the Na (I) doublet and the Wing-Ford molecular FeH band in the spec
42 etic effects drive the assembly of staggered doublets and triplets of nanorods that are moving in the
43 rapy (one or two lines, including a platinum doublet) and crizotinib and had subsequent disease progr
44 gnet relaxes via the second-excited Kramers' doublet, and, when doped into a diamagnetic matrix at th
46 dominantly at but not limited to pyrimidine doublets; and from multiple lamps recommended for UV sha
47 alable, competitive approach that allows for doublet annotation of datasets with thousands of cells i
48 pproaches to four datasets with experimental doublet annotations and find that our methods perform at
51 e-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-
52 quations of motion for the flagellum and its doublets are derived from mechanical equilibrium princip
53 wed that dendrogram-based I(X 1; X 2; Y) and doublets are helpless for discovering pair-wise gene int
54 cally account for FP and FN errors, and cell doublets are modeled by employing a Beta-binomial distri
56 Median overall survival was improved in the doublet arm to 28.0 months (95% CI, 23.5 to 31.5 months)
62 ed to mild proteolysis, we observed pairs of doublets associating with each other and forming bends w
63 , composed of three bands: one low intensity doublet at 440 and 455 nm; one strong band at 525 nm; an
66 identity of >99% of singlets and identifies doublets at rates consistent with previous estimates.
68 for single base substitutions (SBSs), 11 for doublet base substitutions (DBSs) and 16 for small inser
69 ome sequenced cancers reveals: (i) that most doublet base substitutions are not due to two adjacent s
70 e identified 49 single-base-substitution, 11 doublet-base-substitution, 4 clustered-base-substitution
71 gnificantly longer OS than those assigned to doublets + bevacizumab (median, 28.9 v 24.5 months; haza
73 h metastatic colorectal cancer compared with doublets + bevacizumab and provides advantage in PFS, OR
74 inotecan (FOLFOXIRI) plus bevacizumab versus doublets + bevacizumab is lacking because all trials tha
75 with the benzene molecule (C(6)H(6)) on the doublet C(7)H(7) surface under single collision conditio
76 of 1-propynyl to benzene forming a low-lying doublet C(9)H(9) intermediate that dissociates by hydrog
78 d at high levels, extra spikes (for example, doublets) can occur in response to a single light pulse,
79 ks at 737 and 754 cm(-1) assigned as a Fermi doublet centered at 746 cm(-1)(Delta(18)O = 31 cm(-1)).
80 lene; it should proceed for the ground state doublet CH through C2h-like trajectories, with no activa
81 (35 cycles) or investigator-choice platinum-doublet chemotherapy (4-6 cycles or until documented dis
83 py, most SqCLC patients who receive platinum-doublet chemotherapy as first-line treatment, which ofte
84 ival in patients who received platinum-based doublet chemotherapy as subsequent line of treatment.
85 ll patients also received the platinum-based doublet chemotherapy cisplatin 75 mg/m(2) plus pemetrexe
86 er the addition of pembrolizumab to platinum-doublet chemotherapy improves efficacy in patients with
87 o show that adding a third agent to platinum-doublet chemotherapy improves efficacy in the first-line
91 ad progressed during or after platinum-based doublet chemotherapy to receive nivolumab at a dose of 3
95 nsidered cost-effective when compared to the doublet cisplatin-5-fluorouracil from the British and It
96 emsirolimus, and bevacizumab administered in doublet combinations did not significantly improve media
99 ra integrating a monolithic metasurface lens doublet corrected for monochromatic aberrations, and an
100 In the ASD group, the presence of lactate doublets correlated significantly with age (P = .004) an
101 anthanide SMM in which all low-lying Kramers doublets correspond to a well-defined MJ value, with no
102 ass spectral peaks to single data points), 9 doublets corresponding to APAP metabolites were identifi
104 in slices, we determined that complex-spike doublets delivered 100-150 ms after PF stimulus onset we
105 hieves high accuracy on genotype clustering, doublet detection and ambient RNA estimation, as demonst
107 also exhibited an intense central quadrupole doublet due to S = 0 [Fe(4)S(4)](2+) clusters and low-sp
111 technical noise and minimizes unwanted cell doublet events in mass cytometry data, and it reduces we
112 his is unsurprising because the lifetimes of doublet excited states of neutral organic radicals are t
113 cies enables the population of higher-energy doublet excited states, leading to the observed potent p
115 the basis of CGA (CGA arm: carboplatin-based doublet for fit patients, docetaxel for vulnerable patie
116 3 helps generate a high-affinity site on the doublets for outer arm assembly, either through direct i
119 uter junction, crucial for the initiation of doublet formation, appears to be formed by close interac
121 s and mitochondria contained a low-intensity doublet from non-heme high-spin (NHHS) Fe(II) species.
123 The ureteric buds (UBs) in mutants emerge as doublets from the intermediate mesoderm (IM)-derived nep
124 inical benefit to the rituximab-lenalidomide doublet, further investigation of the regimen in this se
125 m-based I(X 1; X 2; Y) (mutual information), doublets (gene pairs) and MIC(X 1; X 2; Y) based on the
127 3] in an organic glass has a spin-frustrated doublet ground state and a thermally accessible quartet
128 riplet, while the quinoniminyl radical has a doublet ground state with a doublet-quartet splitting of
130 earches at the B3LYP level yield triplet and doublet ground states for the oxygen-rich neutral and an
132 16.0 months-compared with 10.3 months in the doublet group (hazard ratio, 0.66; P = 0.043); however,
133 1) in unprecedented detail, with full Lambda-doublet (hence total NO parity) resolution in both the i
134 monophosphonated TAM probe with the simplest doublet hfs pattern ideally suited for dual function ele
135 abundances, data quality is improved through doublet identification and recovery of cells with low RN
136 apply our methods and existing computational doublet identification approaches to four datasets with
137 we propose two new approaches for in silico doublet identification: Co-expression based doublet scor
138 PS and age (standard arm: carboplatin-based doublet if PS </= 1 and age </= 75 years; docetaxel if P
140 irst clinical data on a BTKi and PI3K-deltai doublet in B-cell malignancies, and the results suggest
143 ork including a strong correlation in the EG doublet in motif 1 of family 4 UDGa and in the QD double
144 suggest that the correlated mutations in the doublet in motif 1 position the catalytic H155 in motif
145 tarting with a platinum and fluoropyrimidine doublet in the first line; median survival is less than
146 arib with cisplatin and etoposide (CE; CE+V) doublet in untreated, extensive-stage SCLC (ES-SCLC).
147 etagenomics characterization of a geothermal doublet in which hydrous ferric oxide and hydrous mangan
148 well as higher energy first excited Kramers doublets in 4 and 6 leading to higher energy barriers fo
151 drc-mutant axonemes resulted in splaying of doublets in the distal region, followed by oscillatory b
153 in family 4 Thermus thermophilus UDGa to QD doublet increases the catalytic efficiency by over one h
156 reconstructions revealed that no particular doublet initiated the symmetry break, and moreover it of
160 single cells, and that a number of so-called doublets is present in the output of such experiments.
163 ear observed preference for OD Pi(A') Lambda-doublet levels is not consistent with a simple extrapola
165 mplex, and emission occurs from a long-lived doublet ligand-to-metal charge-transfer ((2)LMCT) state
166 e-specific structures, including novel inter-doublet linkages and microtubule inner proteins (MIPs).
169 a tether linking one I1 motor domain to the doublet microtubule and doublet-specific differences pot
171 the repeating structure of a native axonemal doublet microtubule, which reveals the identities, posit
174 sists of a 9-fold array of remarkably stable doublet microtubules (DMTs), along which motor proteins
175 rotubules (TMTs), the axoneme is composed of doublet microtubules (DMTs), meaning the cilium must con
179 yoelectron microscopy and modeling to define doublet microtubules at near-atomic resolution, revealin
180 and B-tubule singlets from nine ciliary A-B doublet microtubules in cephalic male (CEM) neurons.
182 ction of thousands of dynein motors bound to doublet microtubules into a single propulsive waveform.
183 FAP50 is tightly associated with the outer doublet microtubules of the axoneme and appears not to b
184 veal how mechanoregulatory complexes dock to doublet microtubules with regular 96-nm periodicity and
185 la functions as a linker between neighboring doublet microtubules, acts to stabilize the axonemal cor
186 d spoke bases that facilitate docking to the doublet microtubules, and that inner dyneins connect dir
187 motility require a radially arranged set of doublet microtubules, each decorated in repeating patter
188 roteins establish the unique architecture of doublet microtubules, maintain coherent periodicities al
189 le distinguishing each one of the nine outer doublet microtubules, we systematically collected and re
190 ar transport, and bound to specific sites on doublet microtubules, where their activity facilitates m
197 th d-wave pairing in a Majorana type Kramers Doublet (MTKD) state, it is important to lift both the s
199 MR features of the RPA derivatives include a doublet near 4 ppm in their (1)H NMR spectra and a tripl
200 a localizes strictly to a proximal region of doublet number 1, which completely lacks ODAs in Chlamyd
201 mal axonemal structures with loss of tubulin doublets occur in most Stamp(tm/tm) sperm tails in conju
202 l domain of the L-selectin tail as well as a doublet of aspartic acid residues ((369)DD(370)) in the
203 difficulty is seen in the preference for the doublet of the parent SiH (doublet-quartet energy differ
207 oma with AKI are fragile, and indication for doublet or triplet regimen should be adapted to frailty.
208 representation of phosphorylated peptides as doublets or triplets according to the number of phosphat
211 of these reagents provides a characteristic doublet pattern of DMDSSO cross-linked peptides, thus ai
214 It accounts for the experimental Lambda-doublet populations via explicit consideration of the st
217 rigin is quantum coherence between the lower doublet produced by the pump and probe fields, similar t
218 itio calculations predict specific NO Lambda doublet propensities (orientations of the unpaired elect
220 ry, the ground state of dysprosium(III) is a doublet quantized along the anisotropy axis with an angu
221 arbynes (silylynes) examined, whose range of doublet-quartet differences calculated is impressive, 12
222 reference for the doublet of the parent SiH (doublet-quartet energy difference approximately 39 kcal/
225 we present a method to calculate the Lambda-doublet ratio when concurrent potential energy surfaces
226 CPR were not superior to the alkylator-free doublet Rd, which was associated with lower toxicity.
231 r use of any chemotherapy and platinum-based doublet regimens with increasing age, comorbidity, and p
233 of the in vitro binding of ODAs to axonemal doublets reveal a role for the ODA5/ODA10 assembly compl
234 a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic tra
237 doublet identification: Co-expression based doublet scoring (cxds) and binary classification based d
239 ur distinct song types were identified: long doublet, short doublet, long triplet, and short triplet.
241 two samples is proportional to the ratios of doublet signals with a static 6 Da mass difference in MA
245 duration and 1.37 ps separation; and singlet+doublet soliton structures with 1.8 ps duration and 6 ps
246 motor domain to the doublet microtubule and doublet-specific differences potentially contributing to
247 calculations confirm that the complex has a doublet spin configuration in the ground state as a resu
251 ver the OD(X(2)Pi) fine-structure and Lambda-doublet states, diagnostic of electronic non-adiabaticit
252 own a clear preference for the Pi(A') Lambda-doublet states, in apparent contradiction with ab initio
254 of the endofullerene (3)He@C(60) displays a doublet structure due to a J-coupling of magnitude 77.5
256 bule structure consisting of nine peripheral doublets surrounding a central pair apparatus (CPA), whi
258 of orbital-nematic ordering of a non-Kramers doublet that an orthogonal strain or a perpendicular mag
259 donor of origin and identify cross-genotype doublets that may have highly similar transcriptional pr
260 protein molecules arrayed along microtubule doublets that span the length of axoneme (the flagellar
261 subunit Cdc11 or the normally central Cdc10 doublet, the combination of the PIP2-containing monolaye
262 d 26.7% of patients treated with triplet and doublet therapies, respectively, which were most commonl
263 riority of nonplatinum therapy over platinum doublet therapy for ERCC1-positive NSCLC as well as noni
264 s in the first-line setting include platinum-doublet therapy for those with PS 0 to 1 (bevacizumab ma
265 f grade 3/4 adverse events compared with the doublet therapy of dabrafenib, trametinib and placebo.
266 therapy was four or more cycles of platinum doublet therapy or 3 or more months of EGFR or ALK inhib
268 involves at least the fourth-excited Kramers doublet, thus demonstrating that prominent SMM behavior
269 agnetic axiality, even in the fourth Kramers doublet, thus demonstrating the potential of rigid diami
270 hese complexes expands up to the 3rd Kramers doublet, thus revealing for the first time the exception
271 -carbene ligands was found upon binding as a doublet to one side of the G-quadruplex, much larger tra
272 g combinatorial barcoding scheme allows cell doublets to be identified and removed from the analysis.
276 e number of bursts and non-bursts [singlets, doublets, triplets and quadruplet (four or more)] and me
277 ior muscles and changed in its morphology to doublets, triplets, and multiplets in the first dorsal i
279 ring renal recovery and tolerance profile of doublet versus triplet bortezomib-based regimens in pati
281 In contrast to teleseismic analysis of this doublet, we use regional seismic data providing robust t
282 let, with continuation as monotherapy if the doublet were discontinued, resulted in significant and d
283 th clear signs of advanced rediploidization, doublets were diploidized with ancestral tetraploidy alr
286 two systemic regimens, including a platinum doublet, were randomly assigned at a 1:1 ratio to receiv
287 toxin is a correlate of a C-terminal lysine doublet which likely augments catalytic activity by incr
288 r singlet microtubules are converted into BB doublets which subsequently grow asynchronously to templ
289 antibonding unpaired electron in an orbital doublet, which renders R(3)S(0) Jahn-Teller (JT)-active
290 activity causes relative sliding between the doublets, which generates propulsive bending of the flag
293 line of Gd(2)@C(79)N is due to the Kramer's doublet with a half-integer spin quantum number of S = 1
295 ned to receive a platinum-based chemotherapy doublet with or without bevacizumab 15 mg/kg given intra
296 ell lung cancers evaluating a platinum-based doublet with or without the programmed death 1 (PD-1) in
297 n vivo, sensory stimuli evoked complex-spike doublets with intervals <=150 ms in up to 50% of events.
298 ion of veliparib to a highly active platinum doublet, with continuation as monotherapy if the doublet
299 These forces slide adjacent microtubule doublets within the axoneme, the motile cytoskeletal str
300 transient tyrosyl-like radical with a narrow doublet X-band EPR signal is present during catalase tur