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1 utotetraploidization (that is, direct genome doubling).
2 ll culture passages (approximatively 10 cell doublings).
3 ents, with negligible impact of whole-genome doubling.
4 tro cellular tolerance to spontaneous genome doubling.
5 the TCGA breast cancer cohort precede genome doubling.
6 .015) were significantly associated with CNV doubling.
11 5 times, with an average of 5.99 population doublings after subculturing, and a lifespan from 21 to
12 sed to LIV maintained a 28% increase of cell doubling and a 39% reduction in senescence-associated be
14 of acetylcysteine treatment, defined as ALT doubling and peak ALT greater than 100 IU/L, indicating
15 ibit a simple doubling in response to genome doubling, and individual gene dosage responses are highl
20 segregation, and elimination within six cell doublings, consistent with a measured LRV1 copy number o
23 are based on bacterial growth in antibiotic doubling dilution series, which means that any error in
24 h microdilution MIC QC ranges spanned 3 to 4 doubling dilutions and contained 99.6% to 100.0% of obta
27 0 increased by a mean (+/-SD) of 1.73+/-0.60 doubling doses in the imatinib group, as compared with 1
30 daughter cells of many early embryonic cell-doubling events contribute asymmetrically to adult blood
31 ateau agrees closely with the mortality rate doubling exponent estimated at the cross-over age near t
32 in lethal infections, with the odds of death doubling for each additional 10 million years of evoluti
35 d plant growth under salt stress conditions, doubling fresh weight levels when compared to uninoculat
36 icient living area and durable construction) doubling from 11% (95% confidence interval, 10-12%) to 2
37 anscriptomic responses to genomic merger and doubling have been demonstrated in many allopolyploid sy
38 icle phase concentrations of which were both doubling in 1995 but were both decreasing in 2015, proba
39 d an increasing trend over the years, almost doubling in 2014 in comparison to 2003 (15.3% vs 7.7%).
40 d in mutants that grew significantly faster, doubling in approximately 2 h anaerobically, although th
41 hanical ventilation, doubling in creatinine, doubling in bilirubin to >= 2.0 mg/dL, decrease in plate
42 equal to 2.0 mmol/L, doubling in creatinine, doubling in bilirubin to greater than or equal to 2.0 mg
43 fferences in neurobehavioral outcomes with a doubling in BPA concentration and sex-specific associati
44 ice-anchored CQD:perovskite solid exhibits a doubling in charge carrier mobility as a result of a red
45 ction (vasopressors, mechanical ventilation, doubling in creatinine, doubling in bilirubin to >= 2.0
46 lactate greater than or equal to 2.0 mmol/L, doubling in creatinine, doubling in bilirubin to greater
49 ells execute binary division after each mass doubling in order to maintain size homeostasis by coordi
50 ment across all major trophic guilds, with a doubling in overall abundance and 50% greater species ri
51 ng cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds o
53 djusted differences in SRS-2 T-scores with a doubling in phthalate concentrations in 510 children wit
54 fidence interval (CI)] of blood %-5hmC for a doubling in prenatal RBC-Hg concentration was -0.013% (-
55 n the genomic ratio of %-5mC to %-5hmC for a doubling in prenatal RBC-Hg concentration was 4.70% (0.0
57 transcriptome size does not exhibit a simple doubling in response to genome doubling, and individual
61 increased; in turn, there has been an almost doubling in the number of people who live outside a 60-m
62 tion domain (p50-RARalpha model) exhibited a doubling in the rate of leukemia, with a reduced latency
64 ral-blood cells was associated with nearly a doubling in the risk of coronary heart disease in humans
66 uencing technologies have resulted in a near doubling, in under 10 years, of the number of causal gen
67 ead exposure among female infants (-4.3% per doubling increase in lead exposure; p=1.1x10-06), was an
68 ation with prenatal lead exposure (-1.4% per doubling increase in lead exposure; p=2.3x10-7) and was
70 IPCC range of ECS (1.5 to 4.5 degrees C per doubling) is unlikely to be appropriate for high-CO(2) w
74 tegories based on OCTA area measurement: CNV doubling, modest growth of less than 50%, and shrinkage.
76 Meta-analyses of real-world data suggested a doubling of 2- and 3-year survival in glioblastoma patie
83 fter bleomycin challenge, was accompanied by doubling of chemokine (C-C motif) ligand 21 in lung lymp
84 ncrease in log(2) hormone value (approximate doubling of circulating concentration) and LC were calcu
85 ncrease in log(2) hormone value (approximate doubling of circulating concentration) and liver cancer
86 with meals, was associated with more than a doubling of cirrhosis incidence (adjusted RR 2.47, 1.96-
87 global warming projections in response to a doubling of CO2-from 1.5 degrees C to 4.5 degrees C or g
90 g holographic optical tweezers and achieve a doubling of escape rates compared to unhindered Brownian
93 etween prenatal PFHxS and TGs z-score [for a doubling of exposure, beta=0.11; 95% confidence interval
95 to 1.42) and 1.06 (95% CI, 0.97 to 1.17) per doubling of FGF23, respectively (P=0.13 for interaction)
96 Moreover, the engineered enzymes enabled a doubling of GalOA yields when glucose was used as a co-s
103 ally in nude mice resulting in a more than a doubling of median life extension compared to RT alone.
105 ncides with fragmentation of the chondriome, doubling of mitochondrial number, and heterogeneous redi
108 S part III scores (increase in MDS-UPDRS per doubling of odds 0.52, 95% CI 0.31 to 0.72; p<0.001), wh
109 substantial progress, experiencing an almost doubling of per-capita gross domestic product by purchas
113 in FEV(1) (-15.5 mL; 95% CI: -27.6, -3.3 per doubling of pollen count) and FVC (-20.8 mL; -35.4, -6.1
114 yer counting uncertainty, our record shows a doubling of precipitation since 1840 CE, with recent val
115 ents with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, im
117 sis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a his
118 exercise capacity, displaying an approximate doubling of running distance compared with WT mice.
121 nce interval [CI]: 0.66 to 0.89; p < 0.001), doubling of serum creatinine (HR: 0.62; 95% CI: 0.40 to
122 The primary endpoint was a composite of doubling of serum creatinine (sustained for >=30 days) o
123 ; need for the neonatal intensive care unit; doubling of serum creatinine or increase in CKD stage.
124 tion in 1301 donors (111 had AKI, defined as doubling of serum creatinine) and ascertained outcomes i
125 14.8%, and 1.7% for >/=30% decline in eGFR, doubling of serum creatinine, AKI, and kidney failure, r
126 with lower risks of >/=30% decline in eGFR, doubling of serum creatinine, and AKI; however, apixaban
127 ia, new or worsening chronic kidney disease, doubling of serum creatinine, end-stage renal disease, r
128 f the nephrotic syndrome; and a composite of doubling of serum creatinine, ESRD, or death between 100
129 andomization, and on the clinical end point (doubling of serum creatinine, GFR<15 ml/min per 1.73 m(2
133 fic composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal ca
137 This combination of coatings results in doubling of the light utilization efficiency (LUE), whic
138 single to double valency, consistent with a doubling of the molecular brightness of mCherry-tagged b
139 f GM-CSF in a TLR5-dependent fashion and the doubling of the number of activated type 2 conventional
140 ic diseases is increasing, as reflected in a doubling of the number of annual articles focused on thi
141 n duplication of whisker representations and doubling of the number of barrels without changes in the
143 uring implementation followed by a sustained doubling of the number of out-of-hospital cardiac arrest
144 C incidence by 80% is estimated to require a doubling of the primary screening rate, increasing refer
146 Surprisingly, CHIP is also associated with a doubling of the risk of atherosclerotic cardiovascular d
147 renal causes, renal replacement therapy, or doubling of the serum creatinine level was 0.81 (95.8% C
148 estimated glomerular filtration rate (eGFR), doubling of the serum creatinine level, acute kidney inj
149 nset persistent macroalbuminuria, persistent doubling of the serum creatinine level, end-stage renal
150 d GFR of <15 ml per minute per 1.73 m(2)), a doubling of the serum creatinine level, or death from re
151 density result increased significantly upon doubling of the solvent volume (i.e., by adding the same
153 Treatment Diabetic Retinopathy Study lines (doubling of the visual angle) of uncorrected distance vi
154 pril to June 2015) with an ensuing sustained doubling of those rates over the next 2 years (mean, 34.
155 However, in contrast with expectations, a doubling of toenail As was associated with a 2.3% decrea
157 s well understood in humans, but recent near-doubling of twinning rates in many countries since 1980,
158 oidy resulting from hybridization and genome doubling of two divergent species can disrupt these fine
159 antibiotic use (adjusted risk ratio [RR] per doubling of urine culturing, 1.21; 95% confidence interv
161 uminuria and a composite of serum creatinine doubling or 40% estimated glomerular filtration rate dec
164 54, respectively, P=.0004), ALT (OR=3.13 per doubling, P=.003), hypertension (OR=10.93, P=.002), hype
165 ; 95% confidence interval [CI]: 1.7, 6.9 per doubling; P = .001) and increasing GGO attenuation (OR,
166 ctive protein (OR, 2.1; 95% CI: 1.3, 3.4 per doubling; P = .004), history of heart failure (OR 1.3; 9
168 d hazard ratio, 1.60 (95% CI, 1.10-2.34) per doubling; P=0.014), irrespective of cardiovascular risk
169 onths (odds ratio, 1.29 [1.02-1.65] per PENK doubling; P=0.038; defined as >25% decrease in estimated
170 port cell proliferation for 30-40 population doublings (PD), a point at which telomeres remain relati
171 se cells after defined numbers of population doublings permitted analysis of nascent mutation accumul
172 Anopheles stephensi mosquitoes, essentially doubling prevalence of infected midguts and oocyst densi
174 obal nutrition target will require more than doubling progress, involving both improved measurement a
176 played stem-like features with a slower cell doubling rate, increased sphere formation capability, an
177 emographic covariates and social mobility on doubling rates and case fatality rates through a time-va
178 s, organic kale demand has increased at near-doubling rates in the USA due to its perceived nutrition
180 remains high, and the probability of weekly doubling rates remains >20% throughout summer in the abs
181 workplace mobility is associated with lower doubling rates with a roughly 2 week delay, and case fat
182 tal benefits of Bonsucro standards under the doubling scenario could be achieved by targeting adoptio
183 atest achievements in the field of frequency doubling (SHG) and tripling (third-harmonic generation,
186 losses probably occurred before whole-genome doubling, that was found as a clonal event in 49% of tum
188 in cooking water and sodium in cooked pasta; doubling the concentration increased sodium by 243 mg/se
189 hat exponentially replicates a seed pattern, doubling the copies in each diurnal-like cycle of temper
190 ughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array.
191 provide valuable recommendations, sometimes doubling the current state of the art performance of ven
192 , and strongly synergizes with chemotherapy, doubling the duration of mouse survival over chemotherap
193 s of HC84.26.5D may also serve as a means of doubling the effective size of conventional Fab-protein
194 h adding salmeterol (50 mug twice a day) and doubling the fluticasone (to 100 mug twice a day), a sup
195 fluticasone and in 46% of the children with doubling the fluticasone and adding salmeterol (P = 0.99
197 (up to 10%) of the study population, we are doubling the frequency of measurements in order to estim
199 ly Pu(V) solution where it was observed that doubling the HDEHP loading in the film increased uptake
201 oma activity in two models of GBM, including doubling the lifespan of the mice in an aggressive ortho
202 , narrow-line Gd(III) complex, [Gd(tpatcn)], doubling the magic-angle-spinning DNP enhancement of the
204 ozoans and marine stramenopiles, effectively doubling the number of available samples of heterotrophi
207 ertebrate Genomes Project assemblies, nearly doubling the number of mammalian species with known D ge
208 exin-1 nanoclusters from 40-50% to ~80%, and doubling the number of neurexin-1 molecules per nanoclus
210 ative; 71% in PLHIV), with population growth doubling the number of people needing services (15.4 mil
211 th HIV; 71% in PLWH), with population growth doubling the number of people needing services (15.4 mil
212 assified into 2737 homologous superfamilies, doubling the number of predicted protein domains in the
213 ts; and three-sector centerpieces that allow doubling the number of samples in a single run while red
214 families from five fecal samples, more than doubling the number of small proteins predicted to exist
215 m 3,3-dimethyldicyclohexanone (6), more than doubling the overall yield of the first generation route
222 ods for ligand identification, in some cases doubling the recognition rates, while requiring signific
223 is with public summary statistics, more than doubling the sample size of previous meta-analyses.
226 rted number of subscribers and approximately doubling the transmission distance compared to the recen
227 d high-risk features (Gleason score > 7, PSA doubling time < 10 mo, or PSA > 1.0 ng/mL) with negative
228 gen [PSA] failure, PSA nadir >0.5 ng/mL, PSA doubling time <9 months, and interval to PSA failure <30
229 dynamically on the basis of two factors: PSA doubling time (</= 3 v > 3 months) and nodal versus non-
230 ynechococcus 2973) has the shortest reported doubling time (2.1 h) among cyanobacteria, making it a p
231 ures of the cohort included short median PSA doubling time (2.3 mo) and extensive prior treatment, in
232 ures of the cohort included short median PSA doubling time (2.3 months) and extensive prior treatment
233 e cancer and prostate-specific antigen (PSA) doubling time (DT) of less than 12 months were randomly
238 was stratified by prostate-specific antigen doubling time and baseline use of a bone-targeting agent
239 s pT58 levels, leading to an increase in the doubling time and impairment of cell cycle progression.
241 for Ng is challenged by the pathogen's slow doubling time and the lack of methods to quickly quantif
242 rapidly in rich medium at 37 degrees C, the doubling time can be as short as ~20 min and the average
247 ge degree of GDGT cyclization increases with doubling time in continuous cultures of the thermoacidop
250 aHR], 1.72; 95% CI, 1.17-2.52; P = .01), PSA doubling time less than 9 months (aHR, 2.06; 95% CI, 1.2
251 the basis of conventional imaging and a PSA doubling time of <=10 months) who were continuing to rec
253 importations from Hubei, corresponding to a doubling time of 2.8 days, combined with a slower growth
255 ting enzyme of the mevalonate pathway, had a doubling time of 4 h under anaerobic conditions, in cont
256 as characterised by fast exponential growth (doubling time of 5-7 days) and fast spatial expansion (4
257 study was a prostate-specific antigen (PSA) doubling time of less than 12 mo after initial treatment
258 ned as PSA level of 10 ng/mL or greater, PSA doubling time of less than 3 years, or upgrading (define
262 ys are fundamentally constrained in speed by doubling time of the pathogen, and genotypic assays are
264 state cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned
265 tic disease (rapid prostate-specific antigen doubling time or velocity) but otherwise is not suggeste
266 wth from glucose is feasible up to a minimum doubling time that is proportional to the OxPhos burden
268 stay-at-home orders, the median increase in doubling time was 60% (95% CI, 9.2-223.3), compared with
269 Gleason score, PSA level at imaging, and PSA doubling time were 8, 0.42 (interquartile range, 0.29-0.
273 ound occurs early relative to the viral load doubling time, a model with multiple successful reactiva
277 (18)F-DCFPyL PET/CT correlates with PSA, PSA doubling time, and PSA velocity, suggesting it may have
278 t, Gleason score, NCCN stage, PSA level, PSA doubling time, PSA velocity, and time between initial tr
279 hensive Cancer Network stage, PSA level, PSA doubling time, PSA velocity, and time between initial tr
283 th slow rates of disease progression (median doubling time: 84 days, 95% uncertainty range 62-104) an
285 Additionally, we provide measurements of doubling times and in-vivo metabolic fluxes through the
288 pted in the fast-growth regime, that is, for doubling times below 1 h, extension of these dogmas to t
289 st recent literature on volumetry and volume doubling times in lung nodule management, outlining thei
291 e diffusion of EF-Tu in E. coli growing with doubling times in the range 62-190 min at 37 degrees C d
293 bor null mutations in MELK exhibit wild-type doubling times, cytokinesis, and anchorage-independent g
294 sufficient for a cell to reproduce measured doubling times, that measured metabolic parameters are n
295 degrees above pre-industrial levels, almost doubling to 2.4 metres per degree of warming between 2 a
297 ver, among patients living without HIV, each doubling was associated with a 27% increased risk; this
299 em climate sensitivity is K (1sigma) per CO2 doubling, which is notably higher than fast-feedback est
300 alleles proliferated for over 400 population doublings without exhibiting chromosomal abnormalities.