ライフサイエンスコーパス: dramatic

1 d effects on microglial activation were less dramatic.

2 e putative lithium-binding site results in a dramatic 100-fold reduction in the inhibitory constant a

3 nge-emitting CPP-based fluorophore showing a dramatic 105 nm red-shift in emission and striking 237 n

4 A dramatic 16-128-fold increase in the activity of teixoba

5 he same working concentration demonstrated a dramatic 16-fold increase in sensitivity (0.262 OD.mL/ng

6 instead experiencing rapid progression with dramatic acceleration of disease trajectory, termed 'hyp

7 how that molecular vibrations can enable the dramatic acceleration of some electron transfer reaction

8 ose deprivation-induced cell death exhibited dramatic accumulation of intracellular l-cysteine and it

9 e model peptides, the past decade has seen a dramatic advancement of experimental techniques and data

10 Second, dramatic advances in molecular genetics have created new

11 the gating behavior of K(v) channels exhibit dramatic affinity differences in these membrane-mimetic

12 test in terrestrial environments, due to the dramatic and continuing increases in use of ammonia-base

13 Armed Forces of Colombia (FARC), we found a dramatic and highly significant increase in the deforest

14 ienced by genomes of eukaryotic cells can be dramatic and spans several orders of magnitude.

15 ate that subgroups of output neurons undergo dramatic and specific plasticity after peripheral injury

16 Our study also shows dramatic and unprecedented ATP-dependent DNA unwinding e

17 armacokinetic and toxicological profiles and dramatic antitumour efficacy in vivo.

18 Most dramatic are these effects, when the tQCUG gene is delet

19 These changes are particularly dramatic at 18 degrees C, a temperature synonymous with

20 tion of the p75 neurotrophin receptor causes dramatic axon guidance and branching deficits, leading t

21 Dramatic cases will see currently through-going rivers (

22 to localized H2O2 perturbations, eliciting a dramatic cell death response in comparison to similar cy

23 This requires dramatic cell shape changes and cell movements, powered

24 of sub-TAD genome architecture results in a dramatic, cell-type-specific blood disorder phenotype.

25 erlying protein stability changes that cause dramatic cellular phenotypes observed at nonpermissive t

26 The dramatic change in the activity of RA neurons during the

27 erse spin Hall effect measurement, we find a dramatic change in the spin pumping signal (decrease by

28 structure of a small molecule can lead to a dramatic change in the target profile of the molecule ev

29 The most dramatic change occurred in the Neoaves after the Cretac

30 Such a dramatic change to an asthenospheric contribution appear

31 al domains of epithelial cells often undergo dramatic changes during morphogenesis to form specialize

32 h transmission electron microscopy to reveal dramatic changes in dislocation structure and sub struct

33 rations of a material oftentimes bring about dramatic changes in functional properties as a result of

34 ase spirochete Borrelia burgdorferi exhibits dramatic changes in gene expression as it transits betwe

35 The dramatic changes in gene expression required for develop

36 Cellular transformation is associated with dramatic changes in gene expression, but it is difficult

37 itate chromosome segregation, accompanied by dramatic changes in gene expression.

38 Since most dramatic changes in genomic architectures are caused by

39 n cells triggers major imbalances in NSs and dramatic changes in glycolipids and glycoproteins, inclu

40 d enthalpies of different conformers undergo dramatic changes in magnitude and relative order to main

41 Priority effects also manifest as dramatic changes in microbiome development dynamics betw

42 or example, and red blood cells also undergo dramatic changes in morphology and receptor density as t

43 Because of dramatic changes in our understanding of human genetic v

44 ranscriptomic assessment of these EVs showed dramatic changes in protein and miRNA content long after

45 is a top concern for social well-being, and dramatic changes in the availability of freshwater have

46 , are associated with cardiomyocyte loss and dramatic changes in the cardiac extracellular matrix (EC

47 The miRNA-mRNA interactome showed dramatic changes in the Clk(jrk) flies.

48 f and Belding Scribner set in motion several dramatic changes in the epidemiology, economics and ethi

49 One of the most dramatic changes in the transcription program in Drosoph

50 in the axial coordinating linkers result in dramatic changes in the transport properties of the meta

51 Why metalloenzymes often show dramatic changes in their catalytic activity when subjec

52 can adapt to a broad spectrum of sudden and dramatic changes in their environment.

53 Remarkably, despite dramatic changes in tRNA isodecoder gene expression, the

54 rm line and Bmp10 in the right atrium led to dramatic changes in vascular tone and diminution of the

55 he brain and the immune system has undergone dramatic changes over the last two decades, with immense

56 Dramatic changes to NPIP gene structure and altered tiss

57 There have been dramatic changes worldwide in the attitudes toward and c

58 demonstrate that Apulia was not affected by dramatic climate oscillations during the MUPT.

59 V-positive mononucleosis that demonstrated a dramatic clinical response to immunosuppression.

60 ear to reshape network structure, leading to dramatic community changes, including loss of species an

61 on of capsule and O side chains, resulted in dramatic complement resistance reductions in all strains

62 During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling of their c

63 This method revealed dramatic compositional changes in exRNA population when

64 y dynamic molecular machinery that undergoes dramatic conformational and compositional rearrangements

65 DeCLIC in multiple conformations illustrate dramatic conformational state transitions and diverse re

66 tivity patterns, or phenology, may also have dramatic consequences for human exposure risk, local vec

67 Pneumocystis pneumonia has dramatic consequences in kidney transplant recipients an

68 inked genomes of host and endosymbiont, with dramatic consequences.

69 with recent experimental findings that show dramatic context-dependent changes of neurons' receptive

70 hampered by the challenge of accounting for dramatic contrast changes during the bolus and long exec

71 By showing such dramatic control over habits by DLS activity in a phasic

72 ngineering in perovskite oxides provides for dramatic control over material structure, phase, and pro

73 Dramatic coral loss has significantly altered many Carib

74 e, are already experiencing some of the most dramatic damage due to anthropogenic climate change, and

75 We argue that this event caused the dramatic decline of the Pearl River estuary coral commun

76 Recent reports of dramatic declines in insect abundance suggest grave cons

77 Unfortunately, due to dramatic declines this fauna is among the most threatene

78 PEMT-deficient embryonic stem cells showed a dramatic decrease in adipogenesis, and the resulting adi

79 A dramatic decrease in chlorophyllide was shown in the yel

80 er Rtn1 accumulated at late endosomes, and a dramatic decrease in ER packaging into autophagosomes wa

81 N) mice have myelination deficits along with dramatic decrease in mature oligodendrocytes and their p

82 refore, an increased ion charge results in a dramatic decrease in the sensor sensitivity.

83 Theory shows that the dramatic decrease of lifetime for core-vacancies paralle

84 te, in severe and critical patients showed a dramatic decrease.

85 the world have not adequately captured such dramatic decrease.

86 tion elongation and deletion of CTK-1 led to dramatic decreases of SET-2 recruitment and H3K36me3 mod

87 The human testis undergoes dramatic developmental and structural changes during pub

88 enormous transcriptome changes followed by a dramatic developmental transition.

89 Adolescence is a period of dramatic developmental transitions-from puberty-related

90 Slow loris bites often result in dramatic diagnostic wounds characterised by necrotic gas

91 proaches, and reveal causes behind sometimes dramatic difference in their respective powers.

92 The embryonic defects were accompanied by dramatic differences in vacuole morphology and distribut

93 ynthetic methodologies is underscored by the dramatic differences in yields from coupling reactions w

94 We observe dramatic distinctions in isodecoder expression and known

95 yl CPs at nanomolar concentrations promote a dramatic downregulation of KRAS and NRAS expression, but

96 l extinction event may have coincided with a dramatic drop in stratospheric ozone, possibly due to a

97 . difficile therapeutics but also highlights dramatic drug potency enhancement via halogen substituti

98 eral lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play

99 Administration of Delta9-THC caused a dramatic early upregulation of plasma IL-10 levels, redu

100 ed over a range of temperatures, showing the dramatic effect hydrogen bonding perturbation on polar s

101 fect in in vitro assays, opsonizing Ab had a dramatic effect in vivo on Y. pestis-neutrophil interact

102 methine cyanine scaffold and demonstrate the dramatic effect of restraint on the temperature sensitiv

103 Reducing ERalpha in the VTA had a more dramatic effect on binge-like drinking than reducing ERb

104 covery that the electrical stimulus can have dramatic effect on cell behavior.

105 associative or episodic memory, can exert a dramatic effect on functional network strength and effic

106 Moreover, Mdm30 does not have a dramatic effect on mitochondrial respiration/function, a

107 group on the opposite P2/P2' position had a dramatic effect on potency depending on the size and sha

108 k-irrelevant, images of visual objects had a dramatic effect on target selection, acting much like sp

109 n as loops, whose slight change will produce dramatic effect on the entire topology.

110 Dramatic effects are observed, including a stabilization

111 ing global impacts and will continue to have dramatic effects on public health for years to come.

112 Finally, RRF depletion has dramatic effects on the activity of ribosome rescue fact

113 Such dramatic effects were likely due to an essential role of

114 n coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10).

115 ive form of "identity management") can offer dramatic enhancements.

116 distinct advantage, alternate effects yield dramatic enhancements.

117 secretion, to splenic erythropoiesis and to dramatic erythrocytosis.

118 unately, only ~1 in 10 victims survives this dramatic event.

119 One of the most dramatic events in river environments is the natural div

120 While single dramatic events often excited onset, daily repetition of

121 A dramatic evolution of fruit size has accompanied the dom

122 cations (WGDs) represent yet another type of dramatic evolutionary events and inspire the reconstruct

123 Although eradication of dinosaurs is a dramatic example of extinction dynamics, similar applica

124 A dramatic example of such exchange is the annual emergenc

125 by lipid-derived TT3 nanoparticles trigger a dramatic expression of potential SARS-CoV-2 antigens.

126 results in substantial tumor regression or a dramatic extension in patient survival.

127 ate dynamical data, further underscoring the dramatic Fe metal-to-extended ligand CT character of ele

128 ack global expression of ERbeta, we observed dramatic, female-specific exacerbation of intestinal inf

129 the absence of this communication, there are dramatic fitness consequences for both partners.

130 ar aggregates, and this effect is especially dramatic for tau441 variants with disease-related mutati

131 ted and plausibly facilitated its subsequent dramatic geographic range expansion across most of tropi

132 system, protect injured axons by virtue of a dramatic glycolytic upregulation that arises in SCs as a

133 a favorable OXPHOG signature demonstrated a dramatic (>2fold) improvement in survival compared to th

134 ely populated South Asian nations could have dramatic health, social and economic consequences, and u

135 e delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genet

136 nce of the face-sharing octahedra can have a dramatic impact on magnetic properties of these compound

137 r, we know that the social environment has a dramatic impact on our sense of life satisfaction and we

138 w alternating potentials (2 V(pp,1Hz)) had a dramatic impact on scale formation, with the impact high

139 mping-a nonlocal damping effect-which have a dramatic impact on the amplitude and spectral distributi

140 We demonstrate that the molecule has a dramatic impact on the overall strong-field dynamics: it

141 inants, we showed that gO diversity can have dramatic impacts on cell-free and cell-to-cell spread as

142 Community diversity had dramatic impacts on the biomass, richness and traits of

143 The dramatic improvement in cancer has come at a cost of inc

144 improvement, with recovery of body weight, a dramatic improvement in pulmonary function, reduced lung

145 the program objectives, they can result in a dramatic improvement in the efficiency of locating infec

146 The dramatic improvement in the pool boiling performance occ

147 A dramatic improvement in the separation of fentanyl, alfe

148 omprising a silver salt and an acid led to a dramatic improvement in the way glycosyl halides are gly

149 dest improvement of the former activity, but dramatic improvement of the latter, which enables the tr

150 ficantly overcome these issues, resulting in dramatic improvements in organic photovoltaic performanc

151 ns such as 2'-OMe to the DNA gap resulted in dramatic improvements in therapeutic index.

152 Dramatic improvements in treatment and supportive care h

153 The improvement in recording is most dramatic in the hippocampus region, where the control gr

154 ission electron tomography (CSTET), namely a dramatic in-plane noise reduction and improved represent

155 pinocerebellar ataxia type 5 (SCA5) causes a dramatic increase in actin binding.

156 ous and evoked activity in PB neurons, and a dramatic increase in after-discharges, responses that fa

157 The past few years have seen a dramatic increase in applications of native mass and ion

158 Despite the dramatic increase in axonal territory available, oligode

159 At DSBs, depletion of POLQ caused a dramatic increase in IHR and in the fraction of recombin

160 In this Review, we summarize the dramatic increase in knowledge that informs adaptive mod

161 Comprehensive lipidomic analyses revealed a dramatic increase in membrane saturation in the fat1Delt

162 significantly reduced eNOS activity and to a dramatic increase in portal hypertension compared to BDL

163 Variants in the LOXL1 locus associate with a dramatic increase in risk of exfoliation syndrome (XFS),

164 d expanding economic activity resulting in a dramatic increase in shipping activity.

165 The past decade has witnessed a dramatic increase in the number of functional genomic st

166 samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils.

167 The number of currently known variants, and dramatic increase in the number of new variants being id

168 How to mitigate the dramatic increase in the number of self-inflicted deaths

169 In this regard, there has been a dramatic increase in the number of studies aimed at reco

170 2007 and 2016 may be explained in part by a dramatic increase in the proportion of high-volume catar

171 Fear conditioning produced an immediate and dramatic increase in the spontaneous firing of BLA neuro

172 e of collagen I in vertebrates resulted in a dramatic increase in the stiffness of the extracellular

173 and we showcase this approach to generate a dramatic increase in the yield of specific targets from

174 This analysis revealed a dramatic increase in tissue-specific gene expression, co

175 Despite the dramatic increase of structural complexity provided by t

176 al distribution early in charge and, also, a dramatic increase of the charge-discharge voltage hyster

177 of the vdW magnet Fe(3) GeTe(2) (FGT), and a dramatic increase of the coercive field (H(c) ) by more

178 in compression, and xylans contributing to a dramatic increase of the elongation at break under tensi

179 nt changes in ER stress levels, but rather a dramatic increase of the MEK/ERK/c-Jun pathway accompani

180 can destabilize the PbO(2(s)) and result in dramatic increases in aqueous lead concentrations.

181 which can bind each of these ligands, led to dramatic increases in both muscle and bone mass, with ef

182 cal and machine learning methods, as well as dramatic increases in computational speed and memory, ha

183 ring this time have been rapid, resulting in dramatic increases in sensitivity, mass range, resolutio

184 hospital discharge codes and have suggested dramatic increases in sepsis incidence and decreases in

185 he S1 CST sprouting response is particularly dramatic, indicating an important, if poorly understood,

186 increased during development, with the most dramatic induction occurring 2 wk postnatally.

187 n with the gammaherpesvirus MHV68 leads to a dramatic induction of a class of noncoding retrotranspos

188 Humans exert dramatic influences upon the environment, creating novel

189 ns is unknown, but they are accompanied by a dramatic interleukin-5 (IL-5)-dependent increase in eosi

190 not lyse during T-starvation, while both the dramatic killing and chromosomal DNA loss in the ECA-def

191 ble to memory misattributions in the form of dramatic levels of false remembering.

192 interactions in the TQ mutant explaining the dramatic loss of channel activity.

193 id shutoff of VEGFD expression, leading to a dramatic loss of dendritic structures.

194 Consistent with the dramatic loss of ER binding, the gene expression respons

195 uced performance vigor measures and caused a dramatic loss of habitual responding (i.e., animals quit

196 eration and cyst formation correlates with a dramatic loss of oriented cell division (OCD).

197 ymal BM cells and we specifically identify a dramatic loss of osteoblasts and alterations in endothel

198 3 cases expressing pAKT and all exhibited a dramatic loss of signal for the standard clinical workfl

199 P(tet)-cydDC or P(tet)-tcyP cells results in dramatic loss of survival, whereas catalase (katG) overe

200 removal of the antifungal drug can lead to a dramatic loss of the CNV and reversion to the progenitor

201 ido-1-(4-chlorophenyl)propenone (1c) exhibit dramatic mechanical effects by cracking or bending with

202 Dramatic methodological changes, designed to expand elig

203 alonolides in both live and fixed cells with dramatic microtubule colocalization.

204 se processing speed differences that lead to dramatic misperceptions of the distance and three-dimens

205 in immature mitochondria during a period of dramatic mitochondrial development that occurs after Dro

206 transformation with a 7% lattice change and dramatic modulation in chemical, electronic, magnetic an

207 th ultrasmall particle size (about 3 nm) and dramatic monodispersity.

208 ive spinal cord microglia response marked by dramatic morphologic changes, increased production of IL

209 he nanotransformer-based vaccine undergoes a dramatic morphological change from nanospheres (about 10

210 Nascent myotubes undergo a dramatic morphological transformation during myogenesis,

211 ctor begin to move in lock-step, presaging a dramatic move in the market.

212 is defence mechanism in offspring could have dramatic negative consequences (e.g. reduced Daphnia pop

213 ectively driven change (adaptation), despite dramatic nonadaptive genomic shifts (genetic drift) asso

214 We show that South African SRWs underwent a dramatic northward shift, and diversification, in foragi

215 with chain lengths from C6 to C11, exhibit a dramatic odd-even effect in helical propensity.

216 Here, using a dramatic one-shot perceptual learning paradigm, we obser

217 y structural tuning states in terms of their dramatic ordering and disordering far beyond the nearest

218 This creates dramatic out-of-equilibrium concentrations and depletion

219 H dehydrogenase) is far less efficient, with dramatic oversynthesis of numerous proteins, particularl

220 A dramatic pause of neuronal activity was recorded immedia

221 A dramatic peak in age at onset of vision loss was found a

222 cross all age groups, without any comparable dramatic peak of onset age.

223 cing larger declines in ozone displayed more dramatic pigmentation increases.

224 emic is a rapidly changing circumstance with dramatic policy changes and universal efforts to deal wi

225 entral Asia and Mongolia, but have undergone dramatic population declines and range constrictions; de

226 he onset of chronic pain is accompanied by a dramatic, previously unreported increase in the number o

227 Mitosis is a dramatic process that affects all parts of the cell.

228 It reveals a dramatic process whereby the lipid contents of the LD ca

229 This decade has seen dramatic progress in single-cell technologies establishi

230 A damage responses, the requirement for such dramatic protein stabilization in tumor suppression has

231 tween bacterial species has well-established dramatic public health implications, these genes can als

232 ns by relocating to favourable habitats, and dramatic range shifts of mobile marine species are among

233 and exchange, with bulkier thiolates causing dramatic rate retardations, as well as (2) the thermodyn

234 known as the diauxic shift, is reflected by dramatic rearrangements of mitochondrial function and st

235 Our results confirm dramatic redox imbalance, associated with impaired antio

236 Analysis of rats of both sexes revealed a dramatic reduction in brain size compared with WT (Pclo(

237 responsiveness to nutrition coincides with a dramatic reduction in gene expression plasticity.

238 e permitted rapid treatment scale-up, with a dramatic reduction in HCV infection burden and low reinf

239 A dramatic reduction in insulin requirements was observed

240 tion was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuro

241 olic acid fortification of dietary grains, a dramatic reduction in the incidence of NTDs was observed

242 mutant, synapsis is impaired and there is a dramatic reduction in the number of class I crossovers,

243 to continuous flow processing allowing for a dramatic reduction in the reaction time and simple scale

244 Bleaching caused a dramatic reduction of 'Ca.

245 poorly luteinized follicles, consistent with dramatic reduction of progesterone by 24 h after hCG adm

246 vements in NMR signal amplitudes, permitting dramatic reductions in acquisition times and thereby ena

247 esulted in depletion of mTEC progenitors and dramatic reductions in mTECs during fetal stages, consis

248 ent uptake in this particular patient group, dramatic reductions in new HCV infections can be achieve

249 Results reveal dramatic regional variations in material stiffness and s

250 Surprisingly, we observed a dramatic remodeling in the islet microenvironment, in wh

251 ization of ATAC-Seq profiling demonstrated a dramatic remodeling of DNA accessibility in the PVN foll

252 ng during preimplantation development is the dramatic remodelling of constitutive heterochromatin, al

253 The dramatic reorganization of the Asian climate system coin

254 pared to a diet high in carbohydrate, led to dramatic reprogramming of the liver transcriptional netw

255 Finally, R649W(+/-) cells exhibited a dramatic resistance to ER stress-dependent apoptosis.

256 of EBV positive mononucleosis that showed a dramatic response to immunosuppression.

257 These therapies often induce dramatic responses in susceptible tumors.

258 -CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral p

259 t generalist strains that coincided with the dramatic rise in cattle numbers in the 20th century.

260 The dramatic rise of data-intensive workloads has revived ap

261 As a result, we fear that there will be a dramatic rising tide of alcohol relapse, admissions for

262 Patient 3 experienced an immediate and dramatic seizure reduction with months of seizure freedo

263 c molecular etiologies that may underpin the dramatic sex differences in cancer incidence and outcome

264 zation of the membrane components as well as dramatic shape changes such as endocytosis, vesicular tr

265 We show that a dramatic shift in the frequency of genetic variants, cou

266 ion strain to a new host is accompanied by a dramatic shift in the selectivity of recruitment of PrPC

267 onses to elevated CO(2) that may result in a dramatic shift in their relative abundances in future oc

268 ain-body relationship that set the stage for dramatic shifts in early crown birds.

269 methyl, or methoxyl groups is known to cause dramatic shifts in reactivity and cleavage selectivity b

270 These abrupt transitions produce dramatic shifts in the composition and functioning of so

271 These findings suggest that even dramatic short-term declines need not necessarily result

272 Although there were dramatic species differences in several morphometric mea

273 Further evaluation of iPPO revealed its dramatic strain hardening afforded an UTS comparable to

274 alkaloid, as a synthetic starting point for dramatic structural alterations of its complex, fused ri

275 egrated crystals or PIX) which could undergo dramatic structural changes while maintaining crystallin

276 These dramatic structural differences are consistent with the

277 crotubules are highly dynamic filaments with dramatic structural rearrangements and length changes du

278 at the spike-interdomain interface displayed dramatic structural rearrangements and mediated RBD posi

279 A dramatic surge in fractures and related mortality is exp

280 Finally, narciclasine provides dramatic survival advantages to mice in two distinct mou

281 las in the entire male GSC lineage: the most dramatic switch occurs from early to late spermatocyte,

282 a significant gap in knowledge about how the dramatic switch to Big tau affects the properties of neu

283 months after a synaptopathic exposure, shows dramatic synaptic re-organization during the recovery pe

284 We show that AptA-MS provides a dramatic target enrichment and detection sensitivity in

285 roduced under different conditions were less dramatic than anticipated, and antigenicity analysis wit

286 n of IL-1alpha to oviduct pathology was more dramatic than observed in mice deficient for IL-1beta.

287 While this heavy tail is less dramatic than previous observations of methane in other

288 Much evidence points to a dramatic thinning of East Asian lithosphere during the M

289 ation, in the absence of which cells display dramatic transcriptome alterations.

290 We also observe a dramatic transcriptomic response to gamma-radiation that

291 eal that both PrP(106-126) and hIAPP induced dramatic transformations of the vesicles, specifically d

292 Earth's surface underwent a dramatic transition ~2.3 billion years ago when atmosphe

293 little is known about the cues driving this dramatic transition.

294 titutive, MDA5-dependent, and quantitatively dramatic upregulation of many ISGs, which confers broad

295 ersification, and fate of TEs, producing the dramatic variation in TE content observed across eukaryo

296 +) cells developed a fatal GI pathology with dramatic villus hypoplasia.

297 henotype of wild plants in an unexpected and dramatic way.

298 tor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like p

299 When over expressed, it causes dramatic weight reduction, suggesting a role in disease-

300 To explore the genomic basis underlying the dramatic yield increase in maize, we conducted a compreh