ライフサイエンスコーパス: drug-induced

1 eterogeneous aetiologies (eg, autoimmune and drug-induced).

2 ere hypertrophic, and 480 (11%) were alcohol/drug-induced.

3 All were drug-induced.

4 ere indeterminate (69.4%), non-acetaminophen drug-induced (26.1%), and viral hepatitis (2.5%).

5 Contrary to expectation, these drugs induced A3B expression and concomitant cellular cy

6 ated that these adverse outcomes result from drug-induced activating conformational changes in alphaI

7 lly, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response

8 Enforced ARHGEF1 expression or drug-induced activation of RhoA in the patients' cells c

9 ex optical urinalysis in the mouse models of drug-induced acute kidney injury (AKI) and chronic kidne

10 In drug-induced acute liver failure, plasma levels correlat

11 re thought to depend in part on long-lasting drug-induced adaptations in dendritic spine signaling an

12 rug use are thought to be the consequence of drug-induced adaptations in the neural mechanisms that e

13 ntial to improve outcomes and reduce risk of drug-induced adverse effects.

14 Drug-induced agranulocytosis is a potentially life-threa

15 an the tested clinical diagnostic methods in drug-induced AKI and CKD mice models, but also possesses

16 pted circadian genes to SU vulnerability and drug-induced alterations to these genes may augment drug

17 The causal relationships among drug-induced alterations, cocaine taking, and maladaptiv

18 tors constitute a biological brake to opioid drug-induced analgesia.

19 manipulating Ison@Man-Se NPs for synergistic drug-induced and phagolysosomal destruction of Mtb.

20 o categories: dilated, hypertrophic, alcohol/drug-induced, and other.

21 Thus, drug-induced AP can be leveraged to design evolutionary

22 RC2-NSD2/3-mediated MYC regulatory axis as a drug-induced AP pathway whose ability to confer resistan

23 e used for the quantification and imaging of drug-induced apoptosis in preclinical mouse models, thus

24 Drug-induced apoptosis was linked with enhanced levels o

25 directly repress pro-apoptotic BMF, limiting drug-induced apoptosis.

26 o chronic EGFR inhibition where it mitigates drug-induced apoptosis.

27 ine-70 (S70pBcl2) confers resistance against drug-induced apoptosis.

28 ted apoptosis priming and in protection from drug-induced apoptosis.

29 GNL1 protects colon cancer cells from chemo-drug-induced apoptosis.

30 cell survival and in promoting resistance to drug-induced apoptosis; we also identify TMPRSS13 as a p

31 ely induces both the intrinsic and extrinsic drug-induced apoptotic pathways in MM cells.

32 nowledge of distinct arrhythmias that may be drug-induced are essential for clinicians.

33 Some drug-induced arrhythmias (bradyarrhythmias, atrial tachy

34 oth experimentally and computationally, that drug-induced arrhythmias are dominated by the interplay

35 Management of drug-induced arrhythmias includes discontinuation of the

36 guidelines around preclinical screening for drug-induced arrhythmias require the measurement of the

37 For some drug-induced arrhythmias, particularly torsades de point

38 s a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.

39 is recruitment is required for inhibition of drug-induced ATR signaling by E4orf4 and for E4orf4-indu

40 tylase HDAC5 has a dynamic relationship with drug-induced behavioral neuroadaptations.

41 concerted action of both SPN populations on drug-induced behavioral responses, as these studies can

42 odeling was shown to be critical for several drug-induced behaviors, but its role in acquisition and

43 interface, which has a potential to disrupt drug-induced block of the channel.

44 y, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbi

45 the utility of this system for studying the drug-induced calcium signaling of human monocytes under

46 set to be standardized for the assessment of drug-induced cardiac toxicity.

47 hypertrophic cardiomyopathy, 61 had alcohol/drug-induced cardiomyopathy, and 509 had other forms.

48 iomyopathy, and 1.10 (1.06-1.13) for alcohol/drug-induced cardiomyopathy.

49 h tool holds great promise for understanding drug-induced cardiotoxicity of oncological drugs that ma

50 luated the longitudinal effect of natural or drug-induced CCR5 mutation and blockade on biomarkers of

51 anti-Notch4 were all capable of potentiating drug-induced cell death in B-ALL cells by upregulating i

52 shly isolated human-renal carcinoma cells to drug-induced cell death in xenograft models and ex vivo

53 Yet, a mode of drug-induced cell death, known as immunogenic cell death

54 sruption and their relative contributions to drug-induced cell death.

55 ed consequence of lobular-location-dependent drug-induced cellular damage and hepatocyte death.

56 ecreased bioactivity as reflected by reduced drug-induced cellular proliferation and STAT3 phosphoryl

57 e over the past several years in elucidating drug-induced changes at molecular, cellular, and physiol

58 an individual's vulnerability by amplifying drug-induced changes in gene expression that drive the t

59 However, drug-induced changes in gene expression underlying the s

60 n established fluorescence assay that senses drug-induced changes in lipid bilayer properties.

61 Although widespread drug-induced changes in neuronal excitability have been

62 Furthermore, drug-induced changes in the amount of electronic charge

63 Drug-induced changes of the J to T peak (JTp) and J to t

64 hrough simulations that the model reproduces drug-induced changes of willingness to work, as observed

65 and shell of NAc, BLA, and CeA, on cue- and drug-induced cocaine-seeking in the rat cocaine reinstat

66 ting revealed that garcinol had no effect on drug-induced cocaine-seeking, but was capable of blockin

67 to the NAc core and shell inhibited cue- and drug-induced cocaine-seeking, respectively.

68 Drug-induced compensatory signaling and subsequent rewir

69 -threatening arrhythmias (LTA) are potential drug induced complications previously reported with anti

70 Long QT syndrome (LQTS) is an inherited or drug induced condition associated with delayed repolariz

71 tic resonance spectroscopy, we show that the drug induced conformational changes in the IFN-gamma mol

72 Platinum drug-induced cross-link repair requires the concerted ac

73 ct expected and unexpected environmental and drug-induced crosslinks in biological samples.

74 tion in the nephrons of the kidney can cause drug-induced crystal nephropathy (DICN).

75 when cells are proficient in the removal of drug-induced damage.

76 o 53%) by genotype-guided dosing (P < .001); drug-induced death was reduced from 10% to 0%.

77 ues demonstrates the therapeutic efficacy of drug-induced degradation of transcription factors and ot

78 Drug-induced disruption of hERG channel function is a ma

79 Moreover, the magnitude of drug-induced disruptions in model-free learning was not

80 vator, FTY720, is accompanied by an enhanced drug-induced DNA damage and cell death in CLL primary ce

81 Naturally occurring or drug-induced DNA-protein crosslinks (DPCs) interfere wit

82 associated with side effects in the form of drug-induced dyskinesia and motor fluctuations and surgi

83 with which to assess detailed mechanisms of drug-induced effects on cardiac muscle contractility.

84 observed across lobes, the interpretation of drug-induced effects were consistent with biopsy-based c

85 However, antithyroid drug use can cause drug-induced embryopathy in pregnancy, radioiodine thera

86 Drug-induced enhanced dopamine (DA) signaling in the bra

87 These unexplored drug-induced environmental changes enhancing the target

88 Drug-induced exon skipping preferentially affects shorte

89 g Renshaw cells did not impact any aspect of drug-induced fictive locomotion in the neonatal mouse or

90 icited both flare-up reactions and real DHR, drug-induced flare-up reactions may be precursors of a p

91 Drug-induced formation of BCL6 filaments facilitates ubi

92 Using the large collection of drug-induced gene expression data from Connectivity Map,

93 ally, they are unable to predict whether the drug-induced gene expression or the topology of the netw

94 g transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectiv

95 we aimed to measure the main differences in drug-induced gene expression signatures across SLE patie

96 mic data from two cohorts were compared with drug-induced gene signatures from the CLUE database to c

97 We developed DIGREM (Drug-Induced Genomic Response models for identification

98 ozygosity and low oxygen- or anti-arrhythmic drug-induced gestational hypoxia, resulting in an increa

99 To reduce the risk of drug-induced haemolysis, all patients should be tested f

100 Cs and presumably higher predictive power of drug induced haemolytic risk.

101 nnels represents one of the major sources of drug-induced heart disturbances.

102 ture clinical pharmacology studies that show drug-induced heart rate changes of up to approximately 1

103 Drug-induced hepatocellular injury is identified interna

104 r (CFR) is synthesized for duplex imaging of drug-induced hepatotoxicity (DIH), a long-term medical c

105 resence of biothiols, for early detection of drug-induced hepatotoxicity in living mice.

106 ent study characterizes a novel mechanism of drug-induced hepatotoxicity in which mithramycin not onl

107 d identifying individuals who are at risk of drug-induced HL.

108 6559 was well tolerated, with no evidence of drug-induced hypercytokinemia or cytokine storm, and at

109 Our data point to an idiopathic, genetic, or drug-induced hyperglutamatergic state within the NAC as

110 -induced diabetes is the most common form of drug-induced hyperglycemia.

111 Drug-induced hypersensitivity syndrome/drug reaction wit

112 ibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E(2) block

113 uced thrombocytopenia is a relatively common drug-induced immune disorder that can have life-threaten

114 Drug-induced immunosuppression in kidney transplant reci

115 lyses of liver homogeneity demonstrated that drug-induced improvement in liver biopsy-assessed histop

116 There was a time dependent drug-induced increase in field potential duration in the

117 nts and the slope of an individual subject's drug-induced increase in heart rate-corrected QT (QTc) v

118 udy offers a single-cell resolved account of drug-induced injury of the mammalian liver and identifie

119 nical approach for simultaneously predicting drug-induced inotropic effect (sarcomere shortening) and

120 y experimentally testing the prediction that drug-induced interference with EZH2 function increases t

121 sibility that a patient's arrythmia could be drug-induced is important.

122 rations (e.g., hemodynamic, inflammatory, or drug induced) is key to a better understanding of clinic

123 Studies of drug-induced JTp/JT50 interval changes might therefore f

124 armacological therapy of both congenital and drug-induced K(v)11.1 trafficking defects.

125 Drug-induced kidney injury (DIKI) is a significant contr

126 nical, and histologic features of virus- and drug-induced lesions of the skin and changes to the vasc

127 alized adult patients with anti-tuberculosis drug induced liver injury (AT-DILI).

128 Drug induced liver injury (DILI) is a necro-inflammatory

129 Drug induced liver injury (DILI) is an important cause o

130 Two types of drug induced liver injury have been recognized: intrinsi

131 edominant pathological features were that of drug induced liver injury, although an abnormal amount o

132 Liver biology and function, drug-induced liver injury (DILI) and liver diseases are

133 blood biomarkers are suboptimal in detecting drug-induced liver injury (DILI) and predicting its outc

134 Drug-induced liver injury (DILI) developed in 26 (7.9%)

135 Patients with drug-induced liver injury (DILI) frequently have comorbi

136 We investigated the role of JNK in drug-induced liver injury (DILI) in liver tissue from pa

137 rition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of p

138 Drug-induced liver injury (DILI) is a leading cause of t

139 Drug-induced liver injury (DILI) is a patient-specific,

140 Idiosyncratic drug-induced liver injury (DILI) is a rare, often diffic

141 Drug-induced liver injury (DILI) is an adverse reaction

142 Drug-induced liver injury (DILI) is an important cause o

143 Drug-induced liver injury (DILI) is the leading cause of

144 Drug-induced liver injury (DILI) presents a significant

145 Drug-induced liver injury (DILI) remains a leading cause

146 ethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants as

147 or exposure to drug safety concerns, such as drug-induced liver injury (DILI).

148 RTs and anti-TBs are at an increased risk of drug-induced liver injury (DILI).

149 a hepatocyte-specific microRNA biomarker for drug-induced liver injury (DILI).

150 e associated with positive rechallenge after drug-induced liver injury (DILI): antimicrobials; and ce

151 Drug-induced liver injury caused by acetaminophen (acety

152 New onset or worsening drug-induced liver injury challenges coinfected patients

153 All cases of drug-induced liver injury enrolled into a prospective da

154 chaemia, viral and autoimmune hepatitis, and drug-induced liver injury from prescription drugs, and h

155 A role of FXR in drug-induced liver injury has also been hypothesized yet

156 Predicting drug-induced liver injury in a preclinical setting remai

157 Drug rechallenge following drug-induced liver injury is associated with up to 13% m

158 Bile duct loss during the course of drug-induced liver injury is uncommon, but can be an ind

159 However, the complexity of idiosyncratic drug-induced liver injury means that no current single-c

160 mortality) for 306 patients enrolled in the Drug-Induced Liver Injury Network prospective study at I

161 We analyzed patients in the US Drug-Induced Liver Injury Network prospective study havi

162 levels of alanine aminotransferase (ALT) for drug-induced liver injury often assume that the biomarke

163 There were no cases of drug-induced liver injury or clinically relevant hepatic

164 pon admission before the start of treatment, drug-induced liver injury should be taken into considera

165 clinical features, and outcomes of cases of drug-induced liver injury with histologically proven bil

166 restlessness, tendon disorder, and potential drug-induced liver injury) and one of four patients had

167 udy: hospitalization, colitis, and potential drug-induced liver injury) and one of four patients had

168 portant therapeutic target for patients with drug-induced liver injury.

169 tabolic dysfunction predisposing patients to drug-induced liver injury.

170 ontributes to disease, such as silicosis and drug-induced liver injury.

171 lates what is believed to occur during human drug-induced liver injury.

172 s can cause severe, chronic liver disease or drug-induced liver injury.

173 engineering because of the high frequency of drug-induced liver injury.

174 y these reactions, focusing on idiosyncratic drug-induced liver injury.

175 the frequency and decreased the amplitude of drug-induced locomotor bursting, effects that were depen

176 o the central pattern generator (CPG) during drug-induced locomotor-like activity.

177 In a drug-induced LQT3 model, acute interstitial edema exacer

178 Drug-induced maculopapular exanthemas (MPEs) are mediate

179 computational models to provide insight into drug-induced maladaptive decision making that may ultima

180 However, the mechanisms underlying these drug-induced metabolic perturbations remain poorly under

181 Finally, drug-induced mitochondrial priming measured by dynamic B

182 dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis.

183 ot promote mitotic slippage during prolonged drug-induced mitotic arrest.

184 s of addiction demonstrate that a variety of drug-induced molecular adaptations responsible for relap

185 Moreover, the protonated/neutral form of the drug induced more pronounced and/or distinct alterations

186 e, we also demonstrated that dose-dependent, drug-induced morphological change from different experim

187 e self-administration.SIGNIFICANCE STATEMENT Drug-induced morphological restructuring of dendritic sp

188 the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence.

189 Drug-induced movement disorders are disabling but are of

190 Prevention of the development of drug-induced movement disorders is an important consider

191 ave improved outcomes for many patients with drug-induced movement disorders.

192 tein-protein association responsible for the drug-induced multimerization of HIV-1 integrase (IN).

193 in mutations are remarkably resistant to the drug-induced multimerization.

194 To improve predictive understanding of drug-induced myelosuppression, we developed a quantitati

195 zing radiation, as well as BM recovery after drug-induced myelosuppression.

196 s of the nucleus accumbens in the control of drug-induced negative affect, a hallmark of continued dr

197 plays differential roles in the emergence of drug-induced negative affect.

198 which opens new perspectives for studies on drug-induced nephritis, nanocrystals, and local lipid or

199 into an OOC enabled dual-mode monitoring of drug-induced nephrotoxicity in situ.

200 e-dependent individuals are a consequence of drug-induced neural adaptations.

201 failure to properly encode states because of drug-induced neural alterations.

202 It is now critical to view drug-induced neuroadaptations from a circuit-level persp

203 These results, along with evidence for drug-induced neuroadaptations in glutamatergic neurons a

204 ve splicing, suggesting a novel function for drug-induced neuroepigenetic remodeling.

205 organoids represent a model system to study drug-induced neuroinflammation at single-cell resolution

206 methodology can detect the known effects of drug-induced neuronal inactivity and can be used to inve

207 chronic illness characterized by maladaptive drug-induced neuroplastic changes that confer lasting vu

208 observed in hepatocellular diseases (viral, drug induced, or metabolic) in which DR invaded the lobu

209 ansplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents.

210 There were no cases of incident drug-induced osteonecrosis and only 1 case of femoral sh

211 Here, we investigate the effect of drug-induced oxidative stress on NKA activity.

212 ne-70 functions as a redox sensor to prevent drug-induced oxidative stress-mediated DNA damage and ex

213 359 patients with idiopathic, heritable, and drug-induced PAH and 72 age- and sex-matched healthy vol

214 the use of dopamine transporter imaging for drug-induced parkinsonism, and treatment, with the appro

215 erent tardive syndromes and the treatment of drug-induced parkinsonism.

216 Our results imply that drug induced PD-L1 expression occurs in the broader cont

217 eutic strategy to protect against anticancer drug-induced peripheral neurotoxicity.

218 ized MRI as a sensitive technique to monitor drug-induced perturbation of the PI3K/mTOR pathway in sa

219 Moreover, drug-induced perturbations of cholesterol homeostasis ca

220 Therefore, assays that can measure drug-induced perturbations of defined functional tumor p

221 es in gramicidin dimerization free energy by drug-induced perturbations of lipid bilayer physical pro

222 rovide shared link between disease severity, drug-induced pharmacodynamic effects and response status

223 y be corrected when dynamic probabilities of drug-induced phenotypic events, i.e. induction of cell d

224 With the drug-induced phenotypic fitness defect of the deletion o

225 oven effective in drug discovery to evaluate drug-induced phenotypic variations.

226 level, in this case, on a cellular model of drug-induced phospholipidosis (DIPL).

227 -expressing neurons, indicating differential drug-induced plasticity between the variants.

228 ver, the effect of ZIP on reward seeking and drug-induced plasticity is unknown.

229 subpopulations, and consolidate findings of drug-induced plasticity of VTA DA neurons and highlight

230 hanisms in specific brain regions to control drug-induced plasticity.

231 Drug-induced proarrhythmia is so tightly associated with

232 tion were associated with decreased platinum drug-induced proliferating cell nuclear antigen (PCNA) a

233 of human leukocyte antigen risk alleles, and drug-induced proliferation of lymphocytes isolated from

234 rogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death.

235 Drug-induced proteome stress that involves protein aggre

236 s new VNTR AKT1 variant in schizophrenia and drug-induced psychoses.

237 pon BDNF genetic variation, illustrating how drug-induced psychosis may be modulated at the molecular

238 Drug-induced QT interval prolongation, a risk factor for

239 usly associated with baseline QT interval to drug-induced QT prolongation and arrhythmias is not know

240 significant proportion of the variability in drug-induced QT prolongation and is a significant predic

241 ptible to the lethal cardiac consequences of drug-induced QT prolongation because they have a substan

242 hich furthers our molecular understanding of drug-induced QT syndrome.

243 The genetic QT score was correlated with drug-induced QTc prolongation.

244 ic symptoms (DRESS) is a rare severe adverse drug-induced reaction with multiorgan involvement.

245 hly sensitive assay allows discrimination of drug-induced reactivation of productive HIV based on pro

246 Drug-induced readthrough over premature stop codons (PTC

247 We also revealed a previously unseen drug-induced rearrangement of nucleotides U2506 and U258

248 Drug-induced reduction of oxidative stress prevented dis

249 Drug-induced reduction of oxidative stress prevented HMG

250 bstinence facilitated extinction and blunted drug-induced reinstatement in female mice, it had the op

251 t responding during seeking, extinction, and drug-induced reinstatement of cocaine self-administratio

252 ic system distinctly contributes to cue- and drug-induced reinstatement of cocaine-seeking behavior.

253 ic system distinctly contributes to cue- and drug-induced reinstatement of cocaine-seeking behavior.

254 ach brain region immediately before cue- and drug-induced reinstatement of cocaine-seeking.

255 Drug-induced remission of JIA-U did not persist when ada

256 o predict kidney dysfunction, as a proxy for drug induced renal toxicity, in rats.

257 c single hit (epi) mutational transition, or drug-induced reprogramming, we found evidence for a hybr

258 ough the "lens" of intrinsic, extrinsic, and drug-induced resistance (also referred to as "tolerance"

259 m decreases in blood oxygen levels caused by drug-induced respiratory depression.

260 Drug-induced retained introns are typically shorter, dis

261 We also highlight the influence of drug-induced ribosome stalling, which causes bias at tra

262 ng and transmission electron microscopy in a drug-induced (sea anemone toxin, ATXII) Na(+) channel GO

263 Our simulations and empirical analysis of drug-induced selection on the HIV-1 genome show that the

264 Taken together, these findings suggest that drug-induced selective apoptosis of Mtb-infected macroph

265 our findings reveal a new mechanism by which drug-induced senescence is epigenetically regulated by m

266 ulation at the tumor region (inefficacy) and drug-induced severe side effects (toxicity).

267 In p53-wildtype cells, both drugs induced significant G2 cell cycle arrest and apopt

268 position (FTP) in patients with OSA through drug-induced sleep endoscopy (DISE).

269 Limited knowledge of baseline and drug-induced SMN levels in disease-relevant tissues hind

270 General anesthesia (GA) is a reversible drug-induced state of altered arousal required for more

271 , insulin, and free fatty acids), as well as drug-induced steatosis (i.e., amiodarone).

272 ion, in line with our previous findings that drug-induced stimulation of autophagy has anti-prion eff

273 mechanistic relevance of Nrf2 as a marker of drug-induced stress it is important to know if this adap

274 ence also suggests a requirement for direct, drug-induced stress, neoantigen formation, and stimulati

275 perturbations, including disease states and drug-induced stress, relies on tracing metabolic fluxes.

276 ing electrode to measure the release rate of drug-induced superoxides from C2C12 cells through a poro

277 isplayed discrete expression profiles during drug-induced T cell activation, and expression of each r

278 Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells.

279 Efforts at improving predictability of drug-induced tissue injury in humans include using stem

280 An increased awareness of drug-induced TMA is also essential because the key to th

281 TMA presentations in the critically ill, drug-induced TMA, cancer-associated TMA, and hematopoiet

282 etic QT score was a significant predictor of drug-induced torsade de pointes in an independent sample

283 olongation and is a significant predictor of drug-induced torsade de pointes.

284 ssfully used to build a predictive model for drug-induced torsadogenic and non-torsadogenic drugs bas

285 For example, drug-induced toxicities are not reported by the actual t

286 l lines, pinpointing a possible link between drug-induced toxicity and Golgi morphology alterations.

287 Its activation can be a critical factor in drug-induced toxicity and the development of diseases, i

288 Drug-induced toxicity is a significant problem in clinic

289 cell-cell interactions, and their effects on drug-induced toxicity.

290 tic protein Bcl-2, which protects cells from drug-induced toxicity.

291 lone, E4orf4 sensitized transformed cells to drug-induced toxicity.

292 We then projected drug-induced transcriptional profiles from in vitro canc

293 einforce arousal both against endogenous and drug-induced unconscious states.

294 nsitions between states of consciousness and drug-induced unconsciousness, or anesthesia.

295 P. univalens with ivermectin suggesting that drug-induced upregulation is not the mechanism of Pgp-me

296 of chemotherapy-mediated metastasis by which drug-induced upregulation of sEV secretion and PTX3 prot

297 of the Kv11.1 channel efficiently suppresses drug-induced ventricular arrhythmias in vitro by prevent

298 The network of genes with opposite drug-induced versus schizophrenia-associated expression

299 intensity of global neuronal activity during drug-induced wakefulness predicted the amount of subsequ

300 To investigate the range of drug-induced Wnt-activity within the dental pulp, RNA of