ライフサイエンスコーパス: dsDNA

1 dsDNA becomes longer ("stretched") in regions of high ne

2 dsDNA breaks (DSBs) are resected in a 5'->3' direction,

3 dsDNA phages require multiple lysis proteins, including

4 The SEED-R peak at f ~ 3.3 x 10(-4) (~270 dsDNA molecules) was (statistically) robust, correspondi

5 lex with several nucleases, including the 5' dsDNA exonuclease EXO1.

6 mily, we show that dsRNA viruses can adopt a dsDNA-like single-spooled genome organization.

7 Optimized 200 nm liposomes anchored to a dsDNA chain led to an improvement of the limit of detect

8 Cch2 additionally binds specifically to a dsDNA sequence downstream of its gene that is also a pre

9 Using a dsDNA ladder, we find a linear relationship between the

10 self double-stranded deoxyribonucleic acid (dsDNA) and induces apoptosis.

11 accelerates the overall catalytic activity, dsDNA length-dependent dimerization specifically acceler

12 s12a has multiple nicking activities against dsDNA substrates and that these activities vary among di

13 B could lead to a spiral translocation along dsDNA and DNA strand separation by the ThM motif, reveal

14 r Exo1 activation on not only ssDNA but also dsDNA.

15 Prior to analysis, dsDNA fragments and genomic DNA samples were first denat

16 owed cross-reactivity with TAF9(134-144) and dsDNA.

17 As a result, the SL-DNA/GE and dsDNA/GE were tested with the reduced 7ESTAC01, showing

18 the utility of combining synthetic gRNAs and dsDNA templates to perform homology directed repair and

19 over, the positive coupling between Mn2+ and dsDNA length-dependent activation requires the cognate A

20 to a nonnucleoside RT inhibitor (NNRTI) and dsDNA; a hyperextended thumb conformation helps to accom

21 In short, the ATPase, portal, and dsDNA work synergistically to promote genome packaging.

22 , the key component of R-loops, from RNA and dsDNA.

23 gate that enables transitions between ss and dsDNA.

24 Hence, ssDNA and dsDNA appear to interact in a similar manner with the io

25 The mobilities of both ssDNA and dsDNA decrease with increasing ionic strength until appr

26 ssessing RAD51 binding kinetics on ssDNA and dsDNA differing in length and flexibility using surface

27 o promote D-loop formation between ssDNA and dsDNA substrates.

28 f dsRNA over single-stranded RNA (ssRNA) and dsDNA regions at near-physiological conditions.

29 Anti-dsDNA Abs are considered a hallmark of SLE, and previous

30 erythematosus with childhood onset and anti-dsDNA reactivity.

31 ith corticosteroid treatment as well as anti-dsDNA, low serum complement, renal manifestations, and v

32 Subsequently, the attached anti-dsDNA AAbs are detected with a mixture of conventional H

33 have a drastic reduction in autoimmune anti-dsDNA Ab production.

34 s (NA-MBs) modified with a biotinylated-anti-dsDNA (b-dsDNA) as efficient magnetic microcarriers to s

35 ic microcarriers to selectively capture anti-dsDNA autoantibodies (IgG, IgA and IgM AAbs) present in

36 mL(-1) with a LOD of 0.3 IU mL(-1) for anti-dsDNA AAbs standards.

37 aptamer-based protein measurements from anti-dsDNA(pos) SLE blood samples and derived an IFN protein

38 ociated with the presence of pathogenic anti-dsDNA (double-stranded DNA) antibodies, and provided spo

39 the endosomal DNA sensor TLR9 promotes anti-dsDNA responses and SLE-like disease in Dnase1l3(-/-) mi

40 g secreted DNase DNASE1L3 develop rapid anti-dsDNA antibody responses and SLE-like disease.

41 iated T cell functions and reduce serum anti-dsDNA autoantibody levels; 2) differentially regulate au

42 ows performing the determination of the anti-dsDNA AAbs levels directly in 100-times diluted serum sa

43 Over 70% of RLFS-positive genomes are dsDNA viruses.

44 only TraB protein to transfer the plasmid as dsDNA.

45 e include several human pathogens as well as dsDNA bacteriophages-viruses that infect bacteria.

46 y reducing serum antinuclear autoantibodies, dsDNA titers, and the number of circulating plasma cells

47 ) modified with a biotinylated-anti-dsDNA (b-dsDNA) as efficient magnetic microcarriers to selectivel

48 nd IFN-gamma-inducible protein (IFI)16, bind dsDNA and form caspase-1-activating inflammasomes that a

49 ce, is flexible and disordered, but it binds dsDNA with micromolar affinity.

50 S) is the sensor protein that directly binds dsDNAs.

51 esents 80-nm-sized particles and a 44,924-bp dsDNA genome encoding for 74 predicted proteins.

52 DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite f

53 tection from methylation damage conferred by dsDNA relative to ssDNA has not been quantified.

54 affinity is further increased to 60-fold by dsDNA damage.

55 ependent ATPase that is highly stimulated by dsDNA substrates.

56 accessible to alkylating agents in canonical dsDNA and that Hoogsteen base pairs increase this access

57 rizing into the functionally active 2:2 cGAS-dsDNA state.

58 itively charged MB to the negatively charged dsDNA and carrageenan.

59 roduction of efficient nickases for a chosen dsDNA target sequence, without modification of the nucle

60 between adjacent layers of DNA, the circular dsDNA in SPV1 is fully covered with a viral protein form

61 R-Cas12f nucleases that recognize and cleave dsDNA in a PAM dependent manner.

62 , in specific complex with partially cleaved dsDNA, and in scanning complex with an RNA/DNA hybrid.

63 blocking the hybridization of complementary dsDNA to the CRISPR RNA, our results show that AcrIF9 bi

64 on-complementary and partially complementary dsDNA, and structures of RecA-D-loop complexes containin

65 l intermediate in the development of complex dsDNA viruses.

66 o recognize, package and cleave concatemeric dsDNA, ultimately giving rise to a pressurized, genome-c

67 In Ad5-wt unpacked cores, dsDNA associates in bundles interspersed with VII-DNA cl

68 Cas12a can bind and cut dsDNA targets with high specificity in vivo, making it a

69 ammalian cells utilize to detect cytoplasmic dsDNA from incoming viruses, bacteria, or self.

70 Sensing cytosolic dsDNA, mainly by the key DNA sensor cyclic GMP-AMP synth

71 The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the st

72 messenger produced in response to cytosolic dsDNA that activates the stimulator of interferon genes

73 8-yl)-2-acetylaminofluorene over non-damaged dsDNA.

74 the first observation of sequence-dependent dsDNA condensation by divalent alkaline earth metal cati

75 ls in the capsid spooled around a disordered dsDNA core.

76 are demonstrated to be capable of disrupting dsDNA while maintaining the integrity of protein binding

77 le-stranded RNA (dsRNA) or RNAi plasmid DNA (dsDNA).

78 -switched antibodies to double-stranded DNA (dsDNA) are prevalent and pathogenic in systemic lupus er

79 Tailed double-stranded DNA (dsDNA) bacteriophages, herpesviruses, and adenoviruses p

80 ajor capsid proteins of double-stranded DNA (dsDNA) bacteriophages, some archaeal viruses, and the he

81 , can be converted to a double-stranded DNA (dsDNA) form by using appropriate translesion DNA synthes

82 d nucleosome-associated double-stranded DNA (dsDNA) fragments (nsDNA) are the hallmark of this diseas

83 The simple 5.2-kbp double-stranded DNA (dsDNA) genome expresses just seven known proteins; thus,

84 ages an 18.65-kb linear double-stranded DNA (dsDNA) genome with 31 open reading frames (ORFs), whose

85 dating a tightly packed double-stranded DNA (dsDNA) genome(1-3).

86 and on-chip-hybridized double-stranded DNA (dsDNA) has been studied.

87 tranded DNA (ssDNA) and double-stranded DNA (dsDNA) have been measured by capillary electrophoresis i

88 The method relied on double stranded DNA (dsDNA) homology donors with ~1 kb homology arms.

89 demonstrate RNA-guided double-stranded DNA (dsDNA) interference activity.

90 e of rapidly denaturing double stranded DNA (dsDNA) linkers, and 8 compounds are demonstrated to be c

91 rough single 30-nm-long double-stranded DNA (dsDNA) molecules with an experimental set-up that enable

92 , stretch, sort and map double-stranded DNA (dsDNA) molecules, however nanochannels fail to stretch s

93 eristics of immobilized double-stranded DNA (dsDNA) on a Au electrode were studied as a function of c

94 immobilized calf thymus double-stranded DNA (dsDNA) on the carbon-based screen-printed electrode (SPE

95 amental questions about double-stranded DNA (dsDNA) packaging by viruses that have not been forthcomi

96 s, for immunity against double-stranded DNA (dsDNA) phages and plasmids.

97 s virions in the tailed double-stranded DNA (dsDNA) phages, herpesviruses, and adenoviruses and, as s

98 Double-stranded DNA (dsDNA) tailed phages and herpesviruses assemble their ca

99 ive class of mismatched double-stranded DNA (dsDNA) targets.

100 forms dye aggregates on double-stranded DNA (dsDNA) templates.

101 otein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrapping the nucleosomal DNA

102 lament binds to a donor double-stranded DNA (dsDNA) to form synaptic filaments, which search for homo

103 searches for homologous double-stranded DNA (dsDNA) to use as a template for the DNA synthesis needed

104 s-1 (PBCV-1) is a large double-stranded DNA (dsDNA) virus that infects the unicellular green alga Chl

105 a complex, cytoplasmic double-stranded DNA (dsDNA) virus that is currently expanding throughout the

106 f 10 transplant-related double-stranded DNA (dsDNA) viruses (adenovirus [ADV], BK virus [BKV], cytome

107 t to tailed icosahedral double-stranded DNA (dsDNA) viruses infecting bacteria and archaea, and herpe

108 s unclear whether large double-stranded DNA (dsDNA) viruses may be similarly susceptible to restricti

109 Some double-stranded DNA (dsDNA) viruses use an ATP-dependent motor to drive DNA i

110 lity to directly detect double-stranded DNA (dsDNA) without sequence-preference continues to be a maj

111 s preferably mutagenize double-stranded DNA (dsDNA), and the mutation signature characteristic of the

112 When incorporated into double-stranded DNA (dsDNA), it forms three hydrogen bonds with thymine.

113 Four duplexes: double-stranded DNA (dsDNA), PNA/DNA, dsRNA (modified RNA) and PNA/RNA, were

114 DNA (ssDNA) compared to double-stranded DNA (dsDNA), raising a key conceptual question: how does it d

115 g of aberrant cytosolic double-stranded DNA (dsDNA), which is a hallmark of cancer and viral infectio

116 inhibit recognition of double-stranded DNA (dsDNA), with AcrVA4 driving dimerization of Cas12a.

117 ely occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and sterically prevents c

118 quires the unwinding of double-stranded DNA (dsDNA)-for example by a CRISPR-Cas9 system.

119 We show that the double-stranded DNA (dsDNA)-induced conformational change in Cas8f exposes a

120 then translocate along double-stranded DNA (dsDNA).

121 strand (cDNA) to form a double-stranded DNA (dsDNA).

122 could have an effect on double-stranded DNA (dsDNA).

123 ts (~8-10 kilobases) of double-stranded DNA (dsDNA).

124 a channel that encloses double-stranded DNA (dsDNA).

125 ion of acrylamide using double stranded DNA (dsDNA)/Hemoglobin (Hb)-modified screen printed gold elec

126 iple, widely separated synapses on the donor dsDNA, which would increase the likelihood of encounteri

127 tructions across strands from the downstream dsDNA, and both activities are highly dependent on a str

128 or the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of a high

129 ensing of double-stranded RNA and DNA (dsRNA/dsDNA) followed by IFNalpha/beta secretion and transcrip

130 elts long blocks of dsDNA while it encircles dsDNA.

131 ts that the replication machinery encounters dsDNA and unique physical barriers such as structured ge

132 nonical activation mechanism of cGAS entails dsDNA-binding and dimerization.

133 ng of ssDNA to the secondary site, to extend dsDNA opening.

134 For dsDNA, the mobilities predicted by the Manning electroph

135 ning p44 and p62 enhances XPD's affinity for dsDNA 3-fold over p44 alone.

136 Serum was tested for dsDNA autoantibodies by Crithidia luciliae staining and

137 in complex with a symmetrical double forked dsDNA.

138 rdinate with each other to unwind the forked dsDNA.

139 t the mechanism by which Pif1 unwinds forked dsDNA remains elusive.

140 stability and preferentially unwinds forked dsDNA, but the mechanism by which Pif1 unwinds forked ds

141 We conclude that A-form dsDNA binding is a good predictor for RNA/DNA cleavage a

142 Caging confers complete suppression of gRNA:dsDNA-target hybridization and rapid restoration of CRIS

143 nthesis requires formation of a heteroduplex dsDNA that pairs >20 contiguous bases in the initiating

144 filament can then strand invade a homologous dsDNA to form the displacement loop (D-loop) structure l

145 cA nucleoprotein filament invades homologous dsDNA, pairing the ssDNA with the complementary strand i

146 can promote R-loop formation with homologous dsDNA.

147 sult of the released MB from the immobilized dsDNA, and attracted to the carrageenan can be monitored

148 icantly, three to fivefold, more abundant in dsDNA than dsRNA treatments.

149 ones mediate the long-distance conduction in dsDNA, contrary to the common wisdom in DNA electronics(

150 sed on base-pairing, namely forming a gap in dsDNA and creating protrusion sites in ssDNA for generat

151 llular DNA repair, as it fills short gaps in dsDNA that result from removal of damaged bases.

152 ve dye, methylene blue, that intercalates in dsDNA, leading to an R(max).

153 y, is strikingly similar to that observed in dsDNA viruses of the PRD1-adenovirus lineage, characteri

154 Watson-Crick base pairs in dsDNA exist in dynamic equilibrium with Hoogsteen base p

155 s in a bulge, Watson-Crick A-T base pairs in dsDNA only conferred ~130-fold protection against adenin

156 -Crick faces of nucleobases are protected in dsDNA, it is commonly assumed that deleterious alkylatio

157 n inhibitor led to significant reductions in dsDNA levels and improved survival.

158 ck faces of nucleobases has been reported in dsDNA in vitro through mechanisms that are not understoo

159 Although this process has been studied in dsDNA phages(6-9)-with which herpesviruses bear some sim

160 es that are positioned to intercept incoming dsDNA and promote strand separation during helicase tran

161 uld break tolerance to self dsDNA and induce dsDNA autoantibodies and end-organ damage.

162 B19V NS1-induced ApoBod inoculation induced dsDNA autoantibodies in a dose-dependent fashion.

163 in a collapse of replication forks, inducing dsDNA breaks, homologous recombination, and a PP2A-depen

164 cific incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthe

165 he primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second

166 ed whether they can protect against invading dsDNA in Escherichia coli and find that some but not all

167 as12f nucleases can protect against invading dsDNA like much larger class 2 CRISPR effectors and have

168 and facilitates translocation of an ~150-kb dsDNA genome, followed by acquisition of a pleomorphic t

169 DEP sorting of 1.0, 10.2, 19.5, and 48.5 kbp dsDNA analytes, including both plasmid and genomic DNA.

170 rsaria chlorella virus 1 (PBCV-1) is a large dsDNA virus that infects the microalga Chlorella variabi

171 Giant viruses have extraordinarily large dsDNA genomes, and exceptionally, they encode various co

172 Here, we show that the large dsDNA herpesvirus Epstein-Barr virus (EBV), which is the

173 ted on the surface of microbeads by ligating dsDNA fragments onto growing, surface-immobilised DNA, i

174 Utilizing synthetic gRNAs and linear dsDNA templates, we successfully performed knock-in of f

175 generic template cassettes to create linear dsDNA donors, termed PCR cassettes.

176 ifferent donor templates (synthesized linear dsDNA and cloned plasmid DNA constructs).

177 CI:FANCD2 forms filament-like arrays on long dsDNA.

178 were found to be polyreactive against LPSs, dsDNA, and ssDNA.

179 In many dsDNA viruses and phages, the portal protein acts as an

180 shells that encapsidate the genomes of many dsDNA phages and viruses.

181 n capsid that encapsulates a lipid membrane, dsDNA, and various internal proteins.

182 binding proteins and specifically methylates dsDNA.

183 bodies (ApoBods) containing virally modified dsDNA could induce autoimmunity in an animal model.

184 ple in an animal model that virally modified dsDNA in apoptotic bodies could break tolerance to self

185 of helicoid, double-stranded DNA molecules (dsDNA) could interact with H through electrostatic inter

186 wed significantly higher frequencies of nAg (dsDNA and nucleohistone) reactive IgA producing B cells

187 kinase is activated synergistically by naked dsDNA and the Mre11-Rad50-Xrs2(NBS1) complex (MRX).

188 g fractions than viruses encapsidating naked dsDNA.

189 flanking duplex DNA in a naturally occurring dsDNA-ssDNA telomere interface using polyamide (PA) and

190 Given the higher abundance of dsDNA relative to ssDNA, these results suggest that dsDN

191 esence of Mcm10 the CMG melts long blocks of dsDNA while it encircles dsDNA.

192 by an average filament length of ~180 bp of dsDNA and a Ctp1 tetramer footprint of ~15 bp.

193 t is likely conserved among these classes of dsDNA viruses.IMPORTANCE The existence of a single porta

194 ths because of the greater charge density of dsDNA.

195 or the direct, highly sensitive detection of dsDNA based on the strand replacement of dsDNA by peptid

196 these drive cyclic changes in the length of dsDNA as the phosphate groups respond to the protein's e

197 The mobility of dsDNA is greater than that of ssDNA at all ionic strengt

198 rther revealed robust nonspecific nicking of dsDNA when Cas12a is activated by binding to a target DN

199 that the canonical model for the packing of dsDNA can be extended to dsRNA viruses.

200 GAS cleavage was enhanced in the presence of dsDNA.

201 U.521 is applied to cells, the production of dsDNA-induced intracellular cGAMP is suppressed in a dos

202 mechanical and conformational properties of dsDNA.

203 The major coat proteins of dsDNA tailed phages (order Caudovirales) and herpesvirus

204 As opposed to dimeric recognition of dsDNA, GR-DBD binds to RNA as a monomer and confers high

205 of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ grow

206 stitution increases the flexural rigidity of dsDNA yet also facilitates conformational shifts, which

207 Sensitivity of dsDNA structure towards OH radicals as the pro-oxidants

208 ucleotides onto the end, using one strand of dsDNA as a template and displacing the other.

209 s can influence the damage susceptibility of dsDNA remains unknown.

210 ing to a responsivity of ~0.45 zeptomoles of dsDNA/spot.

211 n of CMG at origins and help preserve CMG on dsDNA during fork repair.

212 rprisingly, CMG undergoes rapid diffusion on dsDNA and can transition back onto ssDNA to nucleate a f

213 K21 aggregate formation on dsDNA is only weakly sequence dependent, providing a fle

214 tead stabilizes FANCI:FANCD2 heterodimers on dsDNA.

215 E1 endonuclease activity on ssDNA but not on dsDNA is compromised by a NEIL3 Zf-GRF repeat, whereas o

216 complexes revealing that Ctp1 polymerizes on dsDNA molecules and forms synaptic filaments that bridge

217 tly, both SA1 and SA2 localize to regions on dsDNA that contain RNA.

218 We carried out computational studies on dsDNA in the channels of viral portal proteins, and they

219 However, translocation on dsDNA is not required for CMG's removal from chromatin b

220 ce of RAD51 also blocks BLM translocation on dsDNA substrates.

221 this gate to traverse forked junctions onto dsDNA.

222 ation of pDCs by STING agonist 2'3' cGAMP or dsDNA, pDC-s produced type I, and type III IFN.

223 nflammatory cytokine, in response to HCMV or dsDNA in uninfected cells.

224 (PAH adsorption, immobilization of ssDNA or dsDNA molecules and on-chip hybridization of complementa

225 e portal vertex, genomic termini and ordered dsDNA coils in the capsid spooled around a disordered ds

226 matched bases in a strand from the original dsDNA.

227 portal protein, similarly to those of other dsDNA viruses, can act as an assembly nucleator.

228 In selecting ssDNA over dsDNA, the RAD51 DNA strand exchange protein has to over

229 Some viruses package dsDNA together with large amounts of positively charged

230 In terms of nucleic acid packing, dsDNA viruses, which lack genome segmentation and intra-

231 lecule regime estimated that the current per dsDNA molecule was ~4.1 fA.

232 Above the crossover transition, R(max), per dsDNA molecule dropped rapidly as f(-1/2) toward a plana

233 ary strand cleavage resulting in predominant dsDNA nicking.

234 t for up to 1200 bp, enabling us to quantify dsDNA length with up to 2 bp accuracy.

235 /or nucleolar activity unexpectedly regulate dsDNA-sensing to restrict virus reproduction and regulat

236 Remarkably, dsDNA allowed exclusive formation of H with right handed

237 X-ray structures in complex with HIV-1 RT/dsDNA showed binding of the conjugates at the polymerase

238 teins, CATCs, and the terminal end of KSHV's dsDNA genome.

239 optotic bodies could break tolerance to self dsDNA and induce dsDNA autoantibodies and end-organ dama

240 ococcal Cas9 homologs in complex with sgRNA, dsDNA, or the AcrIIC3 anti-CRISPR protein.

241 he opposite effect (in particular, for short dsDNA).

242 iversally conserved in all previously solved dsDNA phages.

243 omplex reveals a novel form of semi-specific dsDNA readout by a hexa-coordinated metal cation, most l

244 er and a single-stranded overhang domain (ss-dsDNA), can unlock dynamic DNA-based information storage

245 This simple but powerful ss-dsDNA architecture lays the foundation for information s

246 e purified enzyme specifically recognises ss-dsDNA junctions and possesses ssDNA-dependent ATPase, ss

247 BaPif1 bound to the 3' ss/dsDNA junction impacts duplex unwinding by stabilizing t

248 sDNA, and interact with the 5' arm and 3' ss/dsDNA respectively.

249 the 5' arm causes a sharp bend in the 5' ss/dsDNA junction, consequently breaking the first base-pai

250 ; is a multi-turnover enzyme; cleaves ssDNA, dsDNA and RNA targets in a single assay; and operates at

251 zinc-binding domain in PriA) near the ssDNA-dsDNA junction of the lagging strand in a PriA-DNA repli

252 per minute on double-stranded DNA standard (dsDNA) samples containing Forster resonance energy trans

253 Below f(T), dsDNA molecules behaved as individual single-molecule na

254 rface for the specific recognition of target dsDNA (dsDNA-T), which in turn leads to the formation of

255 merize, causing compaction of bound template dsDNA into a higher-ordered state less amenable to stran

256 ongly preferred in ssDNA regions rather than dsDNA, loop or bulge regions, with flanking bases influe

257 Here we demonstrate that dsDNA and MRX activate Tel1 synergistically.

258 elative to ssDNA, these results suggest that dsDNA could be a substantial source of cytotoxic damage.

259 The dsDNA in the AvaII complex is in the A-like form.

260 The interaction between the dsDNA and GEM was investigated by employing the modified

261 ty ('nick') in both strands that compose the dsDNA leads to complete suppression of the current, whic

262 Under optimum conditions, the dsDNA/GE biosensor exhibited excellent DPV response in t

263 This gating process may explain the dsDNA-to-ssDNA transition of CMG at origins and help pre

264 e ssDNA with the complementary strand in the dsDNA.

265 dye SYBR Green I (SG) was inserted into the dsDNA, generating enhanced fluorescence signals.

266 hanism that includes active packaging of the dsDNA genome into a precursor procapsid, followed by exp

267 reactions and coat protein structures of the dsDNA tailed phages and herpesviruses make phages ideal

268 al processes are recapitulated in all of the dsDNA viruses that package monomeric genomes from concat

269 revealed that GAL4-VVD randomly moved on the dsDNA using sliding and hopping to rapidly find specific

270 Herein, we present the dsDNA-packed and empty phage G capsid at 6.1 and 9 angst

271 nucleases of known structure that bind their dsDNA targets in the A-like form cluster into structural

272 e plant ssDNA viruses that replicate through dsDNA intermediates and form minichromosomes which carry

273 was examined by staining with antibodies to dsDNA, histones H1 and H4, and TATA-binding protein.

274 orm of ATPase-CW might cooperatively bind to dsDNA.

275 The C-terminal domain of RecA binds to dsDNA and directs it to the RecA L2 loop, which inserts

276 Purified recombinant YaaA binds to dsDNA, duplex DNA containing bubbles of unpaired nucleot

277 or-ligated oligonucleotides are converted to dsDNA with an appropriate translesion DNA synthesis (TLS

278 HIV-Nef induced Rac1 activation also led to dsDNA breaks in endothelial colony forming cells, thereb

279 iates a cell cycle checkpoint in response to dsDNA breaks (DSBs).

280 ulation regulates innate immune responses to dsDNA by controlling HMGB2 abundance.

281 ion assays performed in the presence of trap dsDNA disclosed that RHA enhances the processivity of HI

282 that a 5' T- or C-rich PAM sequence triggers dsDNA target cleavage.

283 NA polymerase mu (pol mu) may also align two dsDNA ends into close proximity for synthesis.

284 and forms synaptic filaments that bridge two dsDNA strands.

285 We then describe two dsDNA methods using cheap synthesized donors flanked by

286 ening will terminate and the as-yet-unopened dsDNA portion will bind to another C-terminal domain.

287 bound to each fork of the partially unwound dsDNA, and interact with the 5' arm and 3' ss/dsDNA resp

288 actor (ARF) transcription factors to various dsDNA targets, including the classical AuxRE motif and s

289 evolution of functional transitions in viral dsDNA packaging motors.

290 cludes a reverse transcription step, wherein dsDNA is synthesized from genomic RNA for subsequent ins

291 RNA competes for binding with dsDNA and occurs in a similar affinity range as dimer bi

292 th SLE, IRF5 hyperactivation correlated with dsDNA titers.

293 -mediated activation positively couples with dsDNA-dependent activation in a concerted manner.

294 omotes non-sequence-specific engagement with dsDNA, potentially sequestering the complex from target

295 leoprotein filaments probe and interact with dsDNA, forming the synaptic complex that is stabilized o

296 tic polyomaviruses and papillomaviruses with dsDNA genomes have evolved via parvoviruses from CRESS-D

297 -regulation of miR482 in leaves treated with dsDNA compared to the control.

298 ed proteins in uninfected cells treated with dsDNA was prevented by expressing the HCMV multifunction

299 atalyses the deamination of cytidines within dsDNA.

300 which Mn2+ activates monomeric cGAS without dsDNA.