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1 fluence of water shear forces on biofilms is dual.
2 Forty-eight patients were discharged on APT (dual: 31, single: 17) and 30 on OAC (direct anticoagulan
5 hibitors omapatrilat and sampatrilat possess dual activity against these enzymes by blocking the ACE-
6 al position among the CDK branch due to this dual activity and the dependence on two proteins for act
11 such as signal bias, allosteric modulation, dual agonism, polymorphic receptor variants, spatial com
12 yde-O-(3,4-dichlorobenzyl)oxime (CITCO) is a dual agonist for human constitutive androstane receptor
13 these genetic studies, we also identified a dual AIG1/ADTRP inhibitor, ABD-110207, which is active i
16 e scale and/or scope to faithfully model the dual and co-dependent nature of this relationship, limit
17 Methods: Phantom measurements with single-, dual- and triple-isotope combinations of (99m)Tc, (111)I
21 risk of major bleeding by 40% compared with dual antiplatelet therapy (1.97% versus 3.13%; hazard ra
22 f ticagrelor monotherapy following one-month dual antiplatelet therapy (DAPT) after percutaneous coro
23 current guidelines suggesting a benefit for dual antiplatelet therapy (DAPT) following peripheral va
25 discontinuation of the aspirin component of dual antiplatelet therapy after percutaneous coronary in
31 ate(OR 1.07, 95% C.I. 1.02-1.13, p<0.01) and dual antiviral therapy(OR 12.46, 95% C.I. 2.09-74.20, p<
32 tion, basal QTc values, basal heart rate and dual antiviral therapy, age(OR 1.06, 95% C.I. 1.00-1.13,
33 idic device for AB diagnosis utilizing a new dual aptamer assay was developed for point-of-care (POC)
38 s or CrossBeam) are routinely referred to as dual-beam microscopes, and they are equipped with a cryo
39 lectron microscopy who get basic training in dual-beam microscopy can complete the protocol within 2-
43 also report the discovery of first-in-class dual bromodomain-kinase inhibitors outside the bromodoma
44 yonic kidney 293 cells) cells, biochemistry, dual Ca(2+)/voltage optical mapping in intact hearts fro
47 the enhanced therapeutic potency of a novel Dual-CAR T cell product with the potential to effectivel
48 ents to the CAR T cell product, we developed Dual-CAR T cells that simultaneously expressed both 4-1B
54 flush (RFF) flow modulator and equipped with dual-channel detection using a quadrupole mass spectrome
55 est that BACS lung preservation protects the dual circulation inherent to the lungs, facilitating rob
56 c ensembles within the same mouse, we used a dual cocaine and sucrose self-administration protocol al
57 lyzed the editing patterns of three putative dual-coding genes, ribosomal protein S12 (RPS12), the 5'
59 membrane (PM), we performed state-of-the-art dual-color live-cell imaging at physiological and lowere
61 Improving the signal-to-noise ratio of the dual-comb photoacoustic spectrometer could enable high-s
62 te, however, no known PSCs have demonstrated dual competency for chimera formation and direct respons
63 show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell
65 llular interaction partner CsgF to produce a dual-constriction pore with improved signal and base-cal
66 e ratio offered by TMRET in combination with dual-contrast enhanced subtraction imaging provides new
67 method is first trained with the CT data and dual-contrast MRI data (two sets of MRI with different s
74 ucation interventions and research using the dual developmental science framework, and we discuss opp
76 vel Forster resonance energy transfer (FRET) dual DNA probes with the excimer-forming pyrene pair as
78 tes physiological angiogenesis, suggesting a dual effect on vascular repair upon FECH inhibition, wit
82 e thoroughly studied the chemistry involving dual-emission persistent luminescence nanoparticles (D-P
83 haring, which closely mimics the behavior of dual-ended readout, with the additional benefit of impro
87 corded on pancreatic parenchymal phase (PPP) dual-energy CT 70-keV, 52-keV, and iodine material densi
91 entional 120-kVp CT and 40-keV monoenergetic dual-energy CT images to record the presence of polyps a
94 se To quantify the diagnostic performance of dual-energy CT versus simulated single-energy CT in the
95 vity comparisons between conventional CT and dual-energy CT, and a Wilcoxon signed-rank test was used
96 using validated equations and compared with dual-energy x-ray absorptiometry measurements in a subgr
98 he three noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit
99 previously used gene editing to introduce a dual epitope tag into the endogenous allele of each of 1
100 ired with diverse CRISPR tools including our dual fluorescence CRISPRi/a cell lines, this system can
101 tion of mRNA and protein of a given gene via dual fluorescent reporters in single, live cells of the
105 o acid transporters (EAATs) are prototypical dual function proteins that function as coupled glutamat
106 ducted studies suggest that the demonstrated dual-function (lasing/EL) structures represent a promisi
111 linical study assessing the occupancy of the dual GCGR/glucagon like peptide-1 receptor agonist SAR42
115 nal pigment epithelial cells using a focused dual guide RNA library targeting 852 DDR-associated gene
120 Countries should consider incorporating dual HIV and syphilis rapid diagnostic tests as the firs
121 cal for skin homeostasis, and that IL-17 has dual homeostatic and inflammatory function in the skin.
125 ologically with chloroquine, synergizes with dual ICB therapy (anti-PD1 and anti-CTLA4 antibodies), a
126 the combination of autophagy inhibition and dual ICB therapy as a therapeutic strategy against PDAC.
127 studies, either IL-4 or IL-13 inhibition to dual IL-4/IL-13 inhibition, we demonstrate that blockade
130 ers are removed from the genome by concerted dual incisions bracketing the lesion, followed by gap fi
131 er observations, we speculate that Ocrl1 has dual, independent functions supporting proper RhoGTPase
132 fecting arbovirus, and whether patients with dual infection had a different disease spectrum or sever
135 ogression of CKD in type 2 diabetes, despite dual inhibition of sodium-glucose transporter-2 and the
136 ell factor (TCF)-mediated transcription, and dual inhibition of TEAD and Lats suppresses Wnt-uncouple
141 hibitors has provided the molecular basis of dual inhibitor recognition involving the catalytic site
146 itiation and used divergently in hundreds of dual-initiation promoters during maternal to zygotic tra
148 trometric data collection was conducted in a dual ion mode and chemical compositions were constructed
149 45 V and enable the operation of Zn/graphite dual-ion cells at 2.80 V with a long cycle life (92 % ca
151 the combinatorial treatment with lapatinib [dual kinase inhibitor of EGFR (ERBB1) and ERBB2] and thi
159 seq), bulk RNA sequencing, and an innovative dual lineage tracing mouse to understand the mechanism b
160 ysis of other fungal species shows that such dual-localization is also predicted to be common in the
161 single nuclear gene can be translated into a dual localized protein that distributes between the cyto
162 Numerous Cryptococcus mRNAs encode predicted dual-localized proteins, including many aminoacyl-tRNA s
163 tional activation effects of these ZFPs in a dual luciferase coincidence reporter system under the co
164 ay a foundation for developing more advanced dual Mcl-1/Bfl-1 inhibitors that have potential to provi
165 s and higher tissue remodeling, as well as a dual mechanical behavior, suggesting a critical function
168 mor suppressor in neuroblastoma and suggests dual MEK and YAP inhibition as a potential therapeutic s
170 ution and excellent temporal resolution, the dual-modal contrast agent is capable for high sensitivit
180 cribe the application of this mechanism to a dual nickel/photoredox catalytic protocol that enables t
187 r function) and rs269868-C/Ser1067 in DUOX2 (dual oxidase 2, related to thyroid function and innate i
188 droarylation of 1,1-disubstituted olefins by dual palladium and copper hydride catalysis as a conveni
191 ings pinpoint opposite effects of single and dual PARP-1 and PARP-2-deficiency in modulating the anti
192 Analysis of tumor-infiltrating cells in dual PARP-1/PARP-2-deficiency host-mice revealed a globa
194 ogical rationale and clinical development of dual-pathway inhibition strategies for the prevention of
195 Xa or thrombin, has renewed the interest in dual-pathway inhibition strategies that combine an antip
196 nce-based models, conflict-based models, and dual-pathway models-can be distinguished by the importan
197 erimental considerations for its utilization.Dual Perspectives Companion Paper: Integrating CRISPR En
198 tomography with intravenous contrast using a dual phase pancreatic protocol is typically the best met
199 the study were: 1) to compare two phases of dual-phase cone beam computed tomography (DP-CBCT) achie
200 es the controlled formation of an attractive dual-phase nanolaminate structure under ion irradiation
201 oci have previously been identified for this dual phenotype, and nine have previously been implicated
202 Thus, direct estrogen action in GHRH/Kiss1 dual-phenotype neurons modulates growth and puberty and
204 red the impact of a sanitation intervention (dual-pit latrines, sani-scoops, child potties delivered
207 oV-OC43 infection, we found that ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2), gamma-i
210 rophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment.
212 nths of treatment onset; for osteosarcoma, a dual primary endpoint of 6-month objective response and
213 we then examined its long-term effects using dual-probe in vivo dopamine and glutamate microdialysis
215 work that draws heavily on existing ideas of dual processes in memory in order to make predictions ab
216 the best compounds, 15au, showed a balanced dual profile (i.e., MOR agonism and sigma antagonism) an
217 iphilic nature and nano-size, they exhibited dual properties of surfactants and nanoparticles and red
218 wever, the molecular mechanisms behind their dual protease and ligase activities are still poorly und
222 ring an application for the evolved genes as dual-purpose selectable/counter-selectable markers.
224 late the sequence of events, controlling SAM dual reactivity and preventing unwanted radical-based ch
229 he N-terminal tail of GiKIN14a is a de facto dual regulator of motility and reinforce the notion of t
230 ic macrophages by ER stress, and VDR plays a dual regulatory role in macrophages by protecting agains
231 ctions into different NTS subdivisions, with dual retrograde tracing revealing that many afferent neu
232 the early day response of this circuit with dual rhythmic inputs is sensitive to the changes in dayl
236 lly engineered system capable of serving the dual role both as an effective PET imaging reporter and
240 t evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis
243 er these results indicate that NRARP plays a dual role in T-ALL pathogenesis, regulating both Notch a
244 e analyses provided evidence that GCN5 has a dual role in the regulation of H3K14ac levels in their 5
246 en wild and domestic traits corresponds with dual roles as companions and pest controllers, and with
247 Both basic and clinical evidence reveal dual roles for GJs, in tumor suppression, generally refe
248 actor in Saccharomyces cerevisiae that plays dual roles in activating RNA polymerase I (Pol I) transc
250 er, these findings provide insights into the dual roles of tumor-associated senescence and can potent
251 efrontal and parietal regions, we designed a dual route decision-making model that mimics the neural
255 a limited role in amino acid metabolism, and dual sets of the SUF pathway for FeS cluster assembly, o
260 cifically, the LrS induced the expression of dual specificity phosphatase 1 (DUSP1), activating trans
261 e activity is also observed for a eukaryotic dual-specificity Tyr phosphorylation-regulated kinase cl
262 sion electron microscopy, we directly show a dual-step twinning nucleation mechanism in HCP rhenium n
265 t one chlamydial SBP, OppA3 (Ct) , possessed dual substrate recognition properties and is capable of
271 worse gait performance, particularly during dual task conditions (ie, walking while performing an ad
275 l a previously unappreciated contribution of dual TCR cells to the immune repertoire and highlight th
277 o model and assess the cost-effectiveness of dual testing during antenatal care in four countries wit
280 1 year, high-certainty evidence showed that dual therapy was associated with reduced risk for major
283 yotic protein kinase substrate in vitro This dual Thr-Tyr kinase activity is also observed for a euka
284 variety of sample loading methods the novel dual-tip arrangement showed an increased product yield a
293 inty evidence showed inconclusive effects of dual versus triple therapy on risks for all-cause mortal
299 ith peak purity tests and response ratios at dual wavelengths for the individual vitamins in all test
300 pillars containing both the phases exhibited dual yielding behavior while the interface between L1(2)