ライフサイエンスコーパス: dual-specificity phosphatase

1 kinase (MEK) and dephosphorylation by DUSPs (dual specificity phosphatases).

2 entification and characterization of a novel dual specificity phosphatase.

3 PTEN) maps to chromosome 10q23 and encodes a dual specificity phosphatase.

4 e gene defective in ibr5 encodes an apparent dual-specificity phosphatase.

5 tions of protein tyrosine phosphatases and a dual-specificity phosphatase.

6 yrosine residues, indicating that P-TEN is a dual-specificity phosphatase.

7 P2 in combination with MSG5, which encodes a dual-specificity phosphatase.

8 f a subgroup of myristoylated VH1-like small dual specificity phosphatases.

9 nduced by T cell antigen receptor like other dual specificity phosphatases.

10 ymatic activity similar to that exhibited by dual specificity phosphatases.

11 ion of different MAP kinases by two distinct dual specificity phosphatases.

12 old selectivity across multiple tyrosine and dual specificity phosphatases.

13 activity in cells and evades inactivation by dual-specificity phosphatases.

14 phosphatases, Tyr-specific phosphatases, and dual-specificity phosphatases.

15 itical catalytic residues in Cdc25 and other dual-specificity phosphatases.

16 rabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1 (AtPFA-DSP1), herein unve

17 lls (VSMCs) indicate a role for induction of dual specificity phosphatase 1 (DUSP1) that decreases ER

18 cifically, the LrS induced the expression of dual specificity phosphatase 1 (DUSP1), activating trans

19 cyclooxygenase 2 (COX-2; inflammation), and dual specificity phosphatase 1 (DUSP1), DUSP5, and DUSP1

20 Here, we report the first such gene, dual specificity phosphatase 1 (dusp1).

21 encoding early growth response 1 (EGR1) and dual specificity phosphatase 1 (DUSP1); both known to be

22 cts as a direct transcriptional regulator of dual specificity phosphatase 1 (DUSP1; CL100), a threoni

23 These candidate genes are dual specificity phosphatase 1 DUSP1), Kelch domain cont

24 les produced during the early phase, such as Dual Specificity Phosphatase 1, and a modest effect on I

25 op, in which PGE2 augments the expression of dual specificity phosphatase 1, impairs the activity of

26 eta1, proteoglycan 2, the RhoB oncogene, and dual specificity phosphatase 1.

27 gen-activated protein kinase p38 inactivator dual specificity phosphatase 1.

28 Dual-specificity phosphatase 1 (DUSP-1) is a factor invo

29 ubiquitination and subsequent degradation of dual-specificity phosphatase 1 (DUSP1), an endogenous ne

30 activated protein kinase (MAPK) phosphatase, dual-specificity phosphatase 1 (DUSP1), in the dexametha

31 ative regulator of the hIL-10 feedback loop, dual-specificity phosphatase 1 (DUSP1), remained unchang

32 bit IFN-beta expression via the induction of dual-specificity phosphatase 1 (DUSP1), which dephosphor

33 terleukin-1beta (IL1B) induces expression of dual-specificity phosphatase 1 (DUSP1), ZFP36, and TNF.

34 sarcoma oncogene (c-FOS, encoded by Fos) and dual-specificity phosphatase 1 (DUSP1).

35 pression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1).

36 nosensitive manner through the modulation of dual-specificity phosphatase 1 expression to mediate MAP

37 expression but had normal IL-10 production, dual-specificity phosphatase 1 expression, and MAPK phos

38 vity occurred primarily through induction of dual-specificity phosphatase 1 expression.

39 sphorylation of the negative IL-10 regulator dual-specificity phosphatase 1.

40 ion of the master regulator of inflammation, dual-specificity phosphatase 1.

41 ive response by maintaining normal levels of dual-specificity phosphatases 1 and 5 in CD8(+) T cells.

42 ed 91 phosphatases (33 conventional PTPs, 31 dual specificity phosphatases, 1 Class III Cysteine-base

43 kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial

44 mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1).

45 MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a

46 Dual specificity phosphatase 10 (DUSP10), also known as

47 sites indicated that B cell CLL/lymphoma 6, dual specificity phosphatase 10, and suppressor of cytok

48 ngly increased in ILT3Fc-induced Ts, such as dual specificity phosphatase 10, B cell CLL/lymphoma 6,

49 encing role for the mammalian PIR-1 homolog (dual specificity phosphatase 11 [DUSP11]) was unexpected

50 e we demonstrate that the RNA triphosphatase dual-specificity phosphatase 11 (DUSP11) acts on both ho

51 Dual-specificity phosphatase 11 (DUSP11, also named as P

52 Human YVH1 (hYVH1), also known as dual specificity phosphatase 12 (DUSP12), is a poorly ch

53 Dual-specificity phosphatase 14 (DUSP14; also known as M

54 Mechanistically, dual-specificity phosphatase 16 (Dusp16) was a molecular

55 In addition, silencing of dual-specificity phosphatase 16 increased normoxic level

56 regulator of OPN-OB differentiation and that dual-specificity phosphatase 16, a JNK-specific phosphat

57 colo-rectal cancer (CRC) that implicates the dual specificity phosphatase 18 (DUSP18) in the establis

58 that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for t

59 sphatase of activated cells 1; also known as dual specificity phosphatase 2, DUSP2) is a dual threoni

60 y engineered pancreas-specific Kras-mutated, dual specificity phosphatase-2 (Dusp2) knockout mouse mo

61 evaluated the role and therapeutic value of dual-specificity phosphatase 26 (DUSP26) in CAVD.

62 AK2 forms a complex with dual-specificity phosphatase 26 (DUSP26) phosphatase and

63 investigated the expression and function of dual-specificity phosphatase 26 (DUSP26), also known as

64 The expression of 3 genes (dual specificity phosphatase 3 [DUSP3], guanylate-bindin

65 ich tags a gene with significant homology to Dual Specificity Phosphatase 3, maps within the CORD9 in

66 We identified dual-specificity phosphatase 3 (DUSP3) as a key KDM2A ta

67 This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signa

68 Dual-specificity phosphatase 3 (DUSP3) is a small phosph

69 s context, the present review focuses on the dual-specificity phosphatase 3 (DUSP3), also known as va

70 enes whose expression changed significantly, dual specificity phosphatase 4 (DUSP4), encoding an anta

71 Here we uncover a pathogenic role of dual specificity phosphatase 4 (Dusp4), which is transcr

72 Dual specificity phosphatase-4 (DUSP4) is a negative reg

73 Dual specificity phosphatase 5 (dusp5), cadherin 5 (cdh5

74 some of the vital host genes such as DUSP5 (dual specificity phosphatase 5), ICAM-1 (intercellular a

75 ertrophy via inhibition of the gene encoding dual-specificity phosphatase 5 (DUSP5) DUSP5, a nuclear

76 ative feedback (by Egr1-driven expression of dual-specificity phosphatase 5 (DUSP5)) both reduced inf

77 Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mit

78 eceptor (RDC1), cyclooxygenase-2 (COX-2) and dual-specificity phosphatase 5 (DUSP5).

79 ed by IL-2, IL-7, and IL-15 but not IL-4 was dual-specificity phosphatase 5 (DUSP5).

80 tory circuits: negative feedback mediated by dual-specificity phosphatase 5 and positive feedback by

81 Based on our previous work on dual specificity phosphatase-5 (DUSP5), and its role in

82 sequences identified contained exon 2 of the dual specificity phosphatase-5 gene (DUSP5).

83 nuclear phospho-ERK1/2-specific phosphatase, dual-specificity phosphatase-5.

84 f a light-activated protein phosphatase, the dual specificity phosphatase 6 (DUSP6 or MKP3).

85 nally regulates the ERK-specific phosphatase dual specificity phosphatase 6 (DUSP6) in a kinase depen

86 on of Ets-1, which inhibits its target gene, dual specificity phosphatase 6 (DUSP6), a negative regul

87 tion of NFkappaB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that

88 CCCTC-binding-factor-mediated expression of dual specificity phosphatase 6 (DUSP6), leading to react

89 eIF2a causes the translational repression of dual specificity phosphatase 6 (DUSP6), resulting in inc

90 enzyme NADPH oxidase 4 (NOX4), and increased dual specificity phosphatase 6 (DUSP6).

91 identified the Met62Ile substitution in the dual-specificity phosphatase 6 (Dusp6) gene from the DBA

92 ugh targeted disruption of the gene encoding dual-specificity phosphatase 6 (Dusp6) in the mouse.

93 Binding studies revealed PR-B interacts with dual-specificity phosphatase 6 (DUSP6) via the CD domain

94 ors lead to swift proteasomal degradation of dual-specificity phosphatase 6 (DUSP6).

95 Although inducible expression of dual-specificity phosphatase 6 in the heart eliminated E

96 RK1/2-inactivating phosphatase in the heart, dual-specificity phosphatase 6.

97 tivity through pharmacological inhibition of dual-specificity phosphatases 6 (DUSP6).

98 Here, we have identified the dual-specificity phosphatase 7 (DUSP7), known to display

99 Dual-specificity phosphatase 8 (DUSP8) is a MAPK phospha

100 ere downregulated, whereas the expression of dual-specificity phosphatase 8 (DUSP8) was upregulated.

101 lucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mi

102 PTEN maps to 10q23 and encodes a dual specificity phosphatase, a substrate of which is ph

103 og of Tim50, recombinant TbTim50 possesses a dual specificity phosphatase activity with a greater aff

104 Among them CL-100, a dual-specificity phosphatase also known as MAP kinase ph

105 l cells, DOX also inhibits the expression of dual-specificity phosphatases (also referred to as MAPK

106 designing inhibitors specific for the Cdc25 dual-specificity phosphatase, an important anticancer ta

107 MKP3 is a dual specificity phosphatase and a specific antagonist o

108 The dual specificity phosphatase and oncogene Cdc25B has bee

109 t regulate transformation and members of the dual specificity phosphatase and Sprouty gene families,

110 The dual specificity phosphatases and the low molecular weig

111 PTEN/MMAC1/TEP1 codes for a dual-specificity phosphatase and is likely a tumor suppr

112 The dual-specificity phosphatase and tensin homolog deleted

113 y of enzymes are differentially regulated by dual-specificity phosphatases and also indicate that the

114 structurally equivalent counterparts in the dual-specificity phosphatases and the low molecular weig

115 The dual-specificity phosphatases and the protein tyrosine p

116 Although the dual-specificity phosphatases and the PTPases appear to

117 as new protein phosphatase candidates: five dual-specificity phosphatases and three PP2Cs.

118 uppressor gene, PTEN/MMAC1, with homology to dual-specificity phosphatases and to the cytoskeletal pr

119 Cdc25A and Cdc25B dual-specificity phosphatases are key regulators of cell

120 ypertrophy and demonstrate the importance of dual-specificity phosphatases as counterbalancing regula

121 vestigate the cell division cycle 25 (Cdc25) dual-specificity phosphatases as potential upstream regu

122 These results propagate a role for dual specificity phosphatases at RNP particles and sugge

123 and can be inactivated by a unique family of dual specificity phosphatases, called MAP kinase phospha

124 one, these sites are dephosphorylated by the dual specificity phosphatase, Cdc25, leading to Cdc2-cyc

125 homologous in sequence or structure to other dual-specificity phosphatases, Cdc25 belongs to the clas

126 Like other dual-specificity phosphatases, Cdc25 contains an active

127 Like other dual-specificity phosphatases, Cdc25 exhibits a two-step

128 l-free conditions in vitro, particularly the dual specificity phosphatase Cdc25A.

129 The dual specificity phosphatases Cdc25a, Cdc25b and Cdc25c

130 types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A.

131 The dual specificity phosphatase Cdc25B is capable of inhibi

132 ver two other PTP enzymes (LAR and SHP-2), a dual specificity phosphatase (cdc25b), and a serine/thre

133 ct high-throughput screens for inhibitors of dual-specificity phosphatases: CDC25B, mitogen-activated

134 Chk1 phosphorylates the dual specificity phosphatase cdc25C on Ser-216, and this

135 e G(2)-M transition differently by targeting dual-specificity phosphatase Cdc25C activity.

136 into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which dephosphoryla

137 We show that the dual specificity phosphatases, Cdc25C and PP2Acalpha, wh

138 pro-influenza virus host gene identified was dual-specificity phosphatase cell division cycle 25 B (C

139 In addition, coexpression of a dual-specificity phosphatase, CL100/MKP-1, that is able

140 The Cdc25 dual specificity phosphatases coordinate cell cycle prog

141 Overexpression of the Cdc25A and Cdc25B dual-specificity phosphatases correlates with a wide var

142 95397 was more potent than any inhibitor of dual specificity phosphatases described previously and 1

143 CL100, a dual specificity phosphatase, displayed 10-25-fold highe

144 inding domain (CBD) at the N terminus or the dual specificity phosphatase domain (DSPD) at the C term

145 laforin carbohydrate-binding module and the dual specificity phosphatase domain generates an intimat

146 Moreover, we show that TgLaforin forms a dual specificity phosphatase domain-mediated dimer.

147 1) is an immediate-early gene comprised of a dual-specificity phosphatase domain and a noncatalytic N

148 re predicted to disrupt the protein tyrosine/dual-specificity phosphatase domain of this gene.

149 The recombinant dual specificity phosphatase (DSP) domain of LSF1 had no

150 virus gene H1, VH1, is the first identified dual specificity phosphatase (DSP).

151 , encoding myotubularin-related protein-2, a dual specificity phosphatase (DSP).

152 ere, we identify two members of the atypical dual specificity phosphatases (DSP), DSP18 and DSP21, th

153 ns a carbohydrate binding module (CBM) and a dual-specificity phosphatase (DSP) domain.

154 he carbohydrate-binding module (CBM) and the dual-specificity phosphatase (DSP) domain.

155 ases) dephosphorylate phosphotyrosines while dual-specificity phosphatases (DSPases) dephosphorylate

156 Dual specificity phosphatases (DSPs) are members of the

157 The involvement of dual specificity phosphatases (DSPs) in the mitogen-acti

158 Dual-specificity phosphatases (DSPs) belong to the large

159 a H1 related phosphatase) is a member of the dual-specificity phosphatases (DSPs) that often act on b

160 on of SAPK results from dephosphorylation by dual-specificity phosphatases (DSPs), we studied regulat

161 fic protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DSPs).

162 ive sequence similarity with myotubularin, a dual specificity phosphatase (dsPTPase) that is mutated

163 ily of proteins that display similarity with dual-specificity phosphatases (dsPTPases).

164 The dual specificity phosphatase (DUSP) family has catalytic

165 and show that despite belonging to the same dual specificity phosphatase (DUSP) family, its interact

166 ty is negatively regulated by members of the dual specificity phosphatase (Dusp) family, which differ

167 Dual-specificity phosphatase (DUSP) 1 dephosphorylates a

168 nscriptionally regulating two members of the dual-specificity phosphatase (DUSP) family.

169 biofilm formation A (TpbA) is a periplasmic dual-specificity phosphatase (DUSP) that controls biofil

170 otyrosyl (pY) library screening technique to dual-specificity phosphatase (DUSP) VH1 of vaccinia viru

171 tch1 through a mechanism involving RBPJkappa-dual-specificity phosphatase (DUSP)-p38 MAPK, indicating

172 teins physically interact with and stabilize dual-specificity phosphatases (Dusp) of ERK, resulting i

173 P2Ac was sufficient to elevate levels of the dual specificity phosphatase DUSP1, reduce p38 MAPK acti

174 ly shown that a KIM-containing MAPK-specific dual specificity phosphatase DUSP10 uses a unique bindin

175 decreased expression of the JNK-inactivating dual-specificity phosphatase Dusp10.

176 ike receptor agonists via suppression of the dual-specificity phosphatase, DUSP10/MKP5.

177 em-like cells and elevated expression of the dual specificity phosphatase DUSP4 by inhibiting NF-kapp

178 ind that a CpG island in the promoter of the dual-specificity phosphatase DUSP4 is aberrantly methyla

179 We report that a dual specificity phosphatase, Dusp4, is induced by AMPK

180 ssion of the nuclear phospho-ERK1/2-specific dual-specificity phosphatase, DUSP5.

181 Specifically, the dual-specificity phosphatase DUSP6/MKP3, which acts as a

182 Dual specificity phosphatases (DUSPs) are a family of ph

183 Ser/Thr and Tyr phosphatases and implicated dual specificity phosphatases (DUSPs) in the dephosphory

184 Dual specificity phosphatases (DUSPs) inactivate ERK 1/2

185 y members as well as MAPK pathway-regulating dual specificity phosphatases (DUSPs).

186 s), at least in part through upregulation of dual specificity phosphatases (DUSPs).

187 The dual-specificity phosphatases (DUSPs) are critical effec

188 A family of dual-specificity phosphatases (DUSPs) can regulate MAPK

189 A family of dual-specificity phosphatases (DUSPs) directly inactivat

190 X) is a catalytically inactive member of the dual-specificity phosphatases (DUSPs) family.

191 to Stx1 upregulate the expression of select dual-specificity phosphatases (DUSPs), enzymes that deph

192 MT-associated) transcription factors and the dual-specificity phosphatases (DUSPs).

193 tivation is counter-regulated by a family of dual-specificity phosphatases (DUSPs).

194 sphatase of the recently discovered atypical dual specificity phosphatase family as a physiological i

195 Cdc25C is a cell cycle protein of the dual specificity phosphatase family essential for activa

196 The Cdc25 dual specificity phosphatase family has a central role i

197 The CDC25 dual-specificity phosphatase family has been shown to pl

198 No genes other than members of the dual-specificity phosphatase family were induced in both

199 d phosphatase (VHR/DUSP3) is a member of the dual-specificity phosphatase family.

200 In mammalian cells the Cdc25 family of dual-specificity phosphatases has three distinct isoform

201 MKP-1, the founding member of this family of dual-specificity phosphatases, has been implicated in re

202 The Cdc25 dual specificity phosphatases have central roles in coor

203 Germline mutations in PTEN, which encode a dual-specificity phosphatase, have been implicated in at

204 We now show that the conserved dual-specificity phosphatase human cell-division cycle 1

205 n homologue deleted from chromosome 10) is a dual-specificity phosphatase implicated in embryonic dev

206 tein kinase phosphatase-1 (MKP-1), a nuclear dual-specificity phosphatase, in the transcriptional act

207 a first step in the development of selective dual-specificity phosphatase inhibitors, we have examine

208 rexpression of MAPK phosphatase-1 (MKP-1), a dual-specificity phosphatase, inhibits high NaCl-induced

209 Cdc25B is a dual specificity phosphatase involved in the control of

210 Human cdc25C is a dual-specificity phosphatase involved in the regulation

211 We have found that a dual-specificity phosphatase is essential for conveying

212 PTEN/MMAC1/TEP1, encoding a dual-specificity phosphatase, is a tumor suppressor gene

213 PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of

214 APKs are negatively regulated by a family of dual-specificity phosphatases known as the MAPK phosphat

215 essive mutations in either a gene encoding a dual-specificity phosphatase, known as laforin, or a rec

216 either the E3 ubiquitin ligase malin or the dual specificity phosphatase laforin.

217 novel tumor suppressor gene PTEN, encoding a dual specificity phosphatase, located at 10q23.3.

218 inhibited the cytokine-induced expression of dual specificity phosphatases, MAP kinase phosphatase-L,

219 nic mice overexpressing the p38-inactivating dual specificity phosphatase MAPK phosphatase-1 (MKP-1)

220 MAPK activity and enhances expression of the dual specificity phosphatase MAPK phosphatase-1 (MKP-1).

221 se (TMDP) and a novel DSP, muscle-restricted dual specificity phosphatase (MDSP).

222 TPase1 (SHP-1), SHP-2, and PTP1B but not the dual-specificity phosphatase mitogen-activated protein k

223 s study, we have also identified the nuclear dual-specificity phosphatase mitogen-activated protein k

224 In contrast to M3/6, the dual specificity phosphatase MKP-3 is selective for inac

225 resolubilization, was found with a distinct dual-specificity phosphatase MKP-1 but not with MKP-2.

226 lasses of PTPs, the receptor PTP LAR and the dual-specificity phosphatase MKP1.

227 Dual-specificity phosphatase MKP3 down-regulates mitogen

228 -tyrosine phosphatases, Ptp2 and Ptp3, and a dual specificity phosphatase, Msg5.

229 Conversely, cells lacking the dual-specificity phosphatase (msg5Delta) or that are def

230 The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of hum

231 RNAi of the dual-specificity phosphatase, Myotubularin, or the relat

232 Here we describe two new dual specificity phosphatases of the CL100/MKP-1 family

233 Cdk)-associated protein phosphatase KAP is a dual-specificity phosphatase of which the only known fun

234 Germline mutations in PTEN, encoding a dual-specificity phosphatase on 10q23.3, cause Cowden sy

235 ze to a P-loop active site characteristic of dual specificity phosphatases or to a non-catalytic site

236 d more selective for Cdc25A than VH1-related dual-specificity phosphatase or protein tyrosine phospha

237 The dual-specificity phosphatase, PAC1, which does not inhib

238 mine the roles played by PI-3 kinase and the dual-specificity phosphatase, phosphatase and tensin hom

239 The Cdc14 dual-specificity phosphatase plays a key role in the mit

240 DUSP6 is a broadly expressed dual-specificity phosphatase protein, which binds and de

241 maps to 10q23.3 and encodes a 403 amino acid dual specificity phosphatase (protein tyrosine phosphata

242 Here, we show that the dual specificity phosphatase PTEN, a gene almost univers

243 regulation of MAPK may occur via a family of dual specificity phosphatases referred to as mitogen-act

244 The Cdc14 dual-specificity phosphatases regulate key events in the

245 For example, Cdc25 dual-specificity phosphatases regulate mammalian cell cy

246 r example, DUSP6 has emerged as an important dual-specificity phosphatase regulating KRAS-MAPK signal

247 The dual-specificity phosphatases responsible for the inacti

248 lity to induce the expression of tyrosine or dual specificity phosphatase(s).

249 ochemical evidence that the stress-inducible dual specificity phosphatase, Sdp1, negatively regulates

250 Selective ablation by dual-specificity phosphatases should be a general method

251 racterization of PIR1, a novel member in the dual-specificity phosphatase subfamily of the protein ty

252 ine phosphatase domain fold, resembling many dual-specificity phosphatases such as phosphatase and te

253 studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated

254 Previous studies showed that PTEN, a dual specificity phosphatase that antagonizes phosphatid

255 Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a sin

256 tations in either EPM2A, encoding laforin, a dual specificity phosphatase that dephosphorylates glyco

257 he Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cel

258 ly regulated phosphatase (ERP or MKP-1) is a dual specificity phosphatase that has been implicated in

259 ed protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in ma

260 otein (MAP) kinase phosphatase-3 (MKP3) is a dual specificity phosphatase that specifically inactivat

261 Cdc25B and Cdc25C are closely related dual specificity phosphatases that activate cyclin-depen

262 Cdc25 phosphatases are dual specificity phosphatases that dephosphorylate and a

263 cle 25 (Cdc25) proteins are highly conserved dual specificity phosphatases that regulate cyclin-depen

264 Cdc25 is a dual-specificity phosphatase that catalyzes the activati

265 Cdc25 is a dual-specificity phosphatase that catalyzes the activati

266 CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activ

267 Cdc25, the dual-specificity phosphatase that dephosphorylates the C

268 ologue deleted on chromosome ten (PTEN) is a dual-specificity phosphatase that has activity toward bo

269 PTEN on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates t

270 ur suppressor gene PTEN/MMAC1/TEP1 encodes a dual-specificity phosphatase that recognizes phosphatidy

271 The tumour suppressor gene PTEN encodes a dual-specificity phosphatase that recognizes protein and

272 The tumour suppressor gene PTEN encodes a dual-specificity phosphatase that recognizes protein sub

273 DUSP1 is a dual-specificity phosphatase that regulates mitogen-acti

274 Human CDC14A is a dual-specificity phosphatase that shares sequence simila

275 Msg5p is a dual-specificity phosphatase that was previously demonst

276 Myotubularins are a family of dual-specificity phosphatases that act to modify phospho

277 ymes that include both tyrosine specific and dual-specificity phosphatases that hydrolyze pSer/Thr in

278 hosphatases (MKPs) constitute a family of 11 dual-specificity phosphatases that inactivate the MAPKs

279 tenuated at several levels, and one class of dual-specificity phosphatases, the MAPK phosphatases (MK

280 escribed testis and skeletal muscle-specific dual specificity phosphatase (TMDP) and a novel DSP, mus

281 he identification of authentic substrates of dual-specificity phosphatases utilizing affinity absorbe

282 e, topologically similar to the prototypical dual specificity phosphatase VH1.

283 codes two protein kinases (B1 and F10) and a dual-specificity phosphatase (VH1), suggesting that phos

284 he low microM range, whereas the Kis for the dual specificity phosphatase VHR is at least 10-fold hig

285 In this article we show that the small dual-specificity phosphatase VHR selectively dephosphory

286 f modest potency against PTP1B, SHP-1, and a dual-specificity phosphatase, VHR.

287 tive site substrate specificity of the human dual-specificity phosphatase, VHR.

288 PTEN is a tumour suppressor and dual-specificity phosphatase which affects apoptosis via

289 Cdc25 A and B are dual-specificity phosphatases which have been implicated

290 sidues of the TXY motif independently and by dual specificity phosphatases, which dephosphroylate bot

291 suppressed ERK activation by both protecting dual-specificity phosphatases, which was dependent on th

292 Therefore, we assayed levels of MKP-2, a dual specificity phosphatase whose substrates include ER

293 MAP kinase phosphatase (MKP) is a family of dual-specificity phosphatases whose function is evolutio

294 (DUSP12), is a poorly characterized atypical dual specificity phosphatase widely conserved throughout

295 ene at 10q 23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phos

296 The gene that encodes laforin, a dual-specificity phosphatase with a carbohydrate-binding

297 novel tumour suppressor gene that encodes a dual-specificity phosphatase with homology to adhesion m

298 jor new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to

299 t of other protein tyrosine phosphatases and dual specificity phosphatases, with the exception of the

300 In this study, we show that the dual-specificity phosphatase Yvh1 is required for the re