ライフサイエンスコーパス: ductular

1 urotransmitters, isolated HPCs, and immature ductular 603B cells were initially used to investigate S

2 norCDCA occurred, consistent with efficient ductular absorption (calculated to be 94%) and cholehepa

3 ular regeneration accompanied by marked bile ductular and septal duct hyperplasia.

4 rsity: focal hepatocytic differentiation and ductular areas (mixed-ICCs).

5 Cyclic AMP-induced ductular bicarbonate secretion depends on an autocrine s

6 lated bile ducts from these animals, whereas ductular bicarbonate secretion was examined in isolated

7 el in cholangiocytes, and loss of it impairs ductular bicarbonate secretion.

8 epithelial cells, which in turn may regulate ductular bile formation through the opening of Cl- chann

9 l cells (BECs) provide the driving force for ductular bile formation.

10 trosamine (DEN) hepatocarcinogenesis; 2) the ductular "bipolar" progenitor cell, which responds to ce

11 By contrast, no new ductular-canalicular junctions were observed in mouse mo

12 ntial target for the treatment of pancreatic ductular cancer that at present remains largely unrespon

13 ed with loss of parenchymal areas, increased ductular cell accumulation, and infiltration of immune c

14 rially located PDC-E2 and subsequent biliary ductular cell damage.

15 In AH patients, ductular cell expansion correlated with portal hypertens

16 LPS-TLR4 pathway role in ductular cell expansion was assessed in human and mouse

17 It is unknown whether LPS mediates ductular cell expansion.

18 s and identified keratin 23 (KRT23) as a new ductular cell marker.

19 xocrine degeneration, atrophy, inflammation, ductular cell proliferation, and/or observations in larg

20 There was no ductular cell replication in the fetal livers.

21 y hepatocyte, hepatocyte-like cell, atypical ductular cell, neocholangiole, etc., are used to describ

22 that Hh signaling promotes EMT in adult bile ductular cells (cholangiocytes).

23 essential for the hepatic differentiation of ductular cells after liver damage.

24 cyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS) levels.

25 nhances the viability and growth of residual ductular cells and promotes accumulation of inflammatory

26 Intra-acinar ductular cells and the scattered loss of myoepithelial c

27 ining for TARC was present on lacrimal gland ductular cells but not on the infiltrating lymphocytes,

28 Hh-mediated EMT in ductular cells contributes to the pathogenesis of cirrho

29 ildren with BA, both intra- and extrahepatic ductular cells demonstrated striking up-regulation of Hh

30 rgo a phenotypic switch (metaplasia) to form ductular cells during fetal development.

31 Ductular cells isolated from adult rats with and without

32 capacity to differentiate into OV-6 positive ductular cells or lobular hepatocytes.

33 otypic switch to ductules and replication of ductular cells play a role in the increase in the ductul

34 In other selective cholangiopathies, ductular cells positive for HAI-1 or HAI-2 also increase

35 Studies are revealing that ductular cells produce and respond to hedgehog (Hh) liga

36 iptional mechanisms modulate Hh signaling in ductular cells remains unclear.

37 Functional studies in ductular cells showed that KRT23 regulates collagen expr

38 During NASH, ductular cells strongly expressed OPN.

39 ers of Shh-producing cells and Hh-responsive ductular cells that expressed EMT markers increased in p

40 myoepithelial cells and ectopic intra-acinar ductular cells were also observed in dacryoadenosis.

41 In contrast, when the isolated bile ductular cells were cultured for 7 to 16 days in the pre

42 Immature ductular cells were exposed to Sonic hedgehog (Shh) in t

43 of the BA samples demonstrated that immature ductular cells with a mesenchymal phenotype were Hh-resp

44 enesis by promoting accumulation of immature ductular cells with a mesenchymal phenotype.

45 Treating immature ductular cells with Hh ligand-enriched medium induced me

46 and Hh-responsive MF progeny (i.e., HSCs and ductular cells).

47 remodeling, proliferation of hepatocytes and ductular cells, and restoration of liver mass.

48 xpanding ducts likely further converted into ductular cells, the incidence was rare.

49 ong Ihh expression was detected in most bile ductular cells.

50 cies that evolve from secretin receptor-rich ductular cells.

51 K1), in dysplastic and neoplastic pancreatic ductular cells.

52 le to differentiate into hepatocytes or bile ductular cells.

53 areas, with a distinct spatial proximity to ductular cells.

54 restricted to scarce expression in the bile ductular cells.

55 ling and blocked accumulation of both MF and ductular cells.

56 sly develop portal inflammation with biliary ductular damage and colitis with features similar to hum

57 pha(-/-) CD4(-/-) mice had increased biliary ductular damage but reduced inflammation in the colon.

58 and 2-AAF/PHx) as affected by previous bile ductular damage caused by 4,4'-methylene dianiline (4,4'

59 is an aromatic diamine, known to cause bile ductular damage in both humans and animals.

60 ols, develop portal inflammation and biliary ductular damage similar to human patients with PBC.

61 unction in mice, CD8 T cells mediate biliary ductular damage whereas CD4 T cells mediate induction of

62 inflammation but markedly attenuated biliary ductular damage.

63 f the MMTV promoter in transgenic mice, both ductular development in virgin mice and alveolar develop

64 n and AE1, indicative of both hepatocyte and ductular differentiation.

65 etaRII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary b

66 nTGFbetaRII) develop an inflammatory biliary ductular disease with elevated serum levels of interleuk

67 concentration gradient and a flow-augmented ductular domain, where regulated water influx creates un

68 iferation, only occasional and small foci of ductular dysplasia, and none of 16 rats developed CCAs.

69 racteristic changes in the morphology of the ductular epithelia including a loss of secondary membran

70 y cyst formation in kidney tubules and other ductular epithelia.

71 In addition, bile ductular epithelial (BDE) cells both in the AAF/PH model

72 at this gene is expressed in both acinar and ductular epithelial cell populations from the exocrine p

73 procedure to obtain and culture viable bile ductular epithelial cells in high numbers and with a hig

74 likely contributed by NAT1 expressed in the ductular epithelial cells of the mammary gland.

75 e readily established when the isolated bile ductular epithelial cells were cultured in plastic tissu

76 ne-arginine protein kinase 1 (SRPK1), to the ductular epithelial cells within human pancreas and have

77 smaller oval cell areas, fewer proliferating ductular epithelial cells, and lower cholestasis serum m

78 or vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively referred to as t

79 otypic features typical of hyperplastic bile ductular epithelium but did not show evidence of ductal

80 zation of CBP, SRC-1, and TTF-1 increased in ductular epithelium in association with type II cell dif

81 These results suggest that the bile ductular epithelium in the young rats responds to bile s

82 a that include beta cells proliferating from ductular epithelium, and by a six-fold increase in the n

83 tocytes and to the luminal side of the renal ductular epithelium.

84 tocytic (expressing AFP and albumin) or bile ductular (expressing only CK-19), had proliferated.

85 mature hepatocytes (HEPs), and 3) CK19+/AE1+ ductular hepatocyte (DH) cells lying at the interface be

86 A newly described lesion, isolated ductular hyperplasia (IDH) was found in patients with pr

87 normal, the liver still exhibits biliary and ductular hyperplasia along with varying degrees of hepat

88 d bile ductules formed in rat models of bile ductular hyperplasia and the cell types of normal adult

89 sociated with the SARS coronavirus, Isolated Ductular Hyperplasia in patients with liver function tes

90 ran is a unique animal model of massive bile ductular hyperplasia in which normal liver parenchyma is

91 iate into hepatocytes and underwent atypical ductular hyperplasia, exhibiting epithelial metaplasia a

92 patocytes and alternatively induced atypical ductular hyperplasia.

93 Acinar tissue destruction and ductular inflammation were common features, with less fr

94 g genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis.

95 apacity may contribute to the development of ductular injury in postischemic livers.

96 nsistent with differentiation along the bile ductular lineage.

97 In contrast, both bile ductular metaplasia and proliferation were observed in b

98 s that in BA excessive Hh activation impedes ductular morphogenesis and enhances fibrogenesis by prom

99 Although the control of biliary ductular morphogenesis has received some attention parti

100 n of factors that regulate hyperplastic bile ductular morphogenesis, cell proliferation, and polarize

101 ese findings indicate that for human biliary ductular morphogenesis, epithelial cell-cell interaction

102 ries of dacryops that implicate a failure of ductular "neuromuscular" contractility must therefore be

103 islets, eight of which showed intra-insular ductular or cyst formation as seen in the pancreas of ha

104 rrounding cytoplasmic EpCAM(+)/HNF-4alpha(-) ductular oval cells.

105 hepatocytes, biliary epithelial cells, and (ductular) oval cells.

106 obis (2-oxopropyl)amine (BOP)-induced ductal/ductular pancreatic cancers in the hamster model develop

107 ut in BDL mice resulted in decreased biliary ductular pathology associated with the reduced cholangio

108 The ductular progenitor cells are less numerous, may prolife

109 t genes, and markers of mesenchymal cells or ductular progenitors.

110 der and prepuberty were also associated with ductular proliferation (P < 0.05), increased numbers of

111 ase in biliary epithelial cells, evolving to ductular proliferation and a decrease in the density of

112 e injury, which is repaired through atypical ductular proliferation and oval cells and their subseque

113 Although mechanisms for bile ductular proliferation are unknown, recent evidence sugg

114 Ductular proliferation decreased in 92%.

115 Bile ductular proliferation in biliary atresia, however, was

116 -positive cells, indicating greater atypical ductular proliferation in KO, which coincided with incre

117 y may mediate pathologic alterations in bile ductular proliferation in other cholangiopathic conditio

118 , M70 ameliorated the hepatosplenomegaly and ductular proliferation that are associated with cholangi

119 Loss of NTPDase2 may mediate the bile ductular proliferation typical of obstructive cholestasi

120 Despite ductular proliferation vanishing and lobular zonation re

121 onclude that portal fibroblasts inhibit bile ductular proliferation via expression of NTPDase2 and bl

122 th interface hepatitis, portal fibrosis, and ductular proliferation without duct damage or loss.

123 came inflamed, with hepatocellular necrosis, ductular proliferation, and fibrosis; hepatocellular car

124 decreases in alkaline phosphatase, atypical ductular proliferation, and periportal inflammation comp

125 was associated with autoimmune markers, bile ductular proliferation, and portal infiltrates, which pr

126 portal fibrosis, lymphocytic infiltrates and ductular proliferation, lobular cholestasis, and acute l

127 Ductular proliferation, metabolic zonation, sinusoid cap

128 C) results in hepatobiliary injury, atypical ductular proliferation, oval cell appearance, and limite

129 giopathies" characterized by disordered bile ductular proliferation.

130 actors are up-regulated on BEC during active ductular proliferation.

131 r necrosis, inflammation, fibrosis, and bile ductular proliferation.

132 AT) (n = 4), CK-19 and HEA-125 immunostained ductular proliferative cells that tended to form finely

133 onalcoholic steatohepatitis (NASH), and bile ductular proliferative reactions in a number of liver di

134 primary bile acids ( R =0.41, p =0.004) and ductular reaction ( R =0.39, p =0.004).

135 Patients with NAFLD/NASH have increased ductular reaction (DR) and biliary senescence.

136 B6.Cg-Kit(W-sh) /HNihrJaeBsmJ [Kit(W-sh) ]), ductular reaction (DR) and liver fibrosis decrease compa

137 Inhibition of MC mediators decreases ductular reaction (DR) and liver fibrosis.

138 d profibrotic molecules closely connected to ductular reaction (DR) and prevailing after successful P

139 onic liver diseases it has been shown that a ductular reaction (DR) appears early, correlates with fi

140 ture cholangiocytes and by the appearance of ductular reaction (DR) as the results of hepatic progeni

141 seases are characterized by the expansion of ductular reaction (DR) cells and the expression of liver

142 We hypothesized that a bile acid-induced ductular reaction (DR) drives fibrogenesis.

143 Ductular reaction (DR) expands in chronic liver diseases

144 located mainly in the cytokeratin 19-labeled ductular reaction (DR) in human cirrhotic livers and in

145 Ductular reaction (DR) is characterized by the prolifera

146 Ductular reaction (DR) is observed in virtually all live

147 acultative liver stem cells that establish a ductular reaction (DR) to support liver regeneration fol

148 atory infiltrate and its relationship to the ductular reaction (DR), a second portal phenomenon impli

149 To address this issue, liver inflammation, ductular reaction (DR), and fibrosis were induced in C57

150 ate the liver during cholestasis and promote ductular reaction (DR), biliary senescence, and liver fi

151 elial cells, collectively referred to as the ductular reaction (DR).

152 to establish a regenerative process known as ductular reaction (DR).

153 direct target of miR-133b, is crucial in the ductular reaction (DR)/oval cell (OC) response for gener

154 001), hepatocyte ballooning (P = 0.004), the ductular reaction (i.e., numbers of gli2+/sox9+ cells; P

155 reduced hepatocyte proliferation and reduced ductular reaction 72 hours after BDL compared to wild ty

156 naling in WT mice also resulted in defective ductular reaction after BDL.

157 ibrosis stage, microvesicular steatosis, and ductular reaction among other findings, whereas eosinoph

158 RELB is required for the ductular reaction and development of biliary fibrosis in

159 able to restore PC2 expression and to reduce ductular reaction and fibrosis may represent a new thera

160 duced liver injury, with enhanced steatosis, ductular reaction and fibrosis.

161 y the progressive onset of liver injury with ductular reaction and fibrosis.

162 -specific miR-34a plays an important role in ductular reaction and fibrotic responses in a BDL mouse

163 receptor (Tr(-/-) ) display a more extensive ductular reaction and hepatic fibrosis compared to Mdr2(

164 Ghr treatment reduced ductular reaction and hepatic fibrosis in Mdr2KO mice, r

165 CCN1 induces cholangiocyte proliferation and ductular reaction and identify CCN1/alphavbeta5/NF-kappa

166 This is recognized histopathologically as a ductular reaction and leads to gradual distortion of the

167 Ductular reaction and liver fibrosis are typical liver c

168 on of the SR antagonist (SCT 5-27) decreased ductular reaction and liver fibrosis in bile duct ligate

169 c microRNA-34a in the cholestasis-associated ductular reaction and liver fibrosis.

170 atitis C and E, immunohistochemistry for the ductular reaction and malignant liver tumors and several

171 engagement of LIF signaling in BECs promoted ductular reaction and morphogenesis during cholestatic i

172 se findings indicate that biliary NIK drives ductular reaction and pathogenic cholangiokine secretion

173 One of the reasons for this is that both the ductular reaction and portal fibrosis have been primaril

174 Ductular reaction and portal inflammation were quantifie

175 Biliary atresia (BA) is notable for marked ductular reaction and rapid development of fibrosis.

176 ment of these mice with soluble JAG1 rescued ductular reaction and reduced hepatic necrosis and morta

177 om biliary epithelial cells constituting the ductular reaction and the regenerated peripheral IHBDs.

178 In chronic hepatitis C, the ductular reaction appears to be a major factor associate

179 Loss of hepatocytes and increased ductular reaction are tightly associated with monocyte-d

180 These results unveil a NIK/ductular reaction axis and a NIK/cholangiokine axis that

181 We found that ductular reaction cells in human cirrhotic livers expres

182 Cholangiocyte proliferation and ductular reaction contribute to the onset and progressio

183 could have beneficial effects by preventing ductular reaction development.

184 nf6(flox/flox)Rbpj(flox/flox) mice mounted a ductular reaction extending through the hepatic tissue a

185 Ductular reaction has been associated with chronic alcoh

186 ontained mainly collagen I associated with a ductular reaction in 6 cases, and delicate elastic stran

187 ort a role for LPS-TLR4 pathway in promoting ductular reaction in AH.

188 that describes the critical role of invasive ductular reaction in hepatocellular injury.

189 Both the ductular reaction in humans and hepatic progenitor cells

190 The ductular reaction in nonalcoholic steatohepatitis appear

191 The ductular reaction is a highly regulated response based o

192 in hepatocytes with liver injury triggered a ductular reaction of cholangiocyte origin, with approxim

193 landscapes indicative of their identities as ductular reaction progenitors (DRPs) and TICs.

194 ve stress-related changes, but had increased ductular reaction protoporphyrin-IX accumulation, and MD

195 on-skin type fibrotic lesions and pronounced ductular reaction starting from 4 weeks of age.

196 of HPCs also determines the appearance of a ductular reaction that has been correlated with progress

197 human diseased liver and mouse models of the ductular reaction that Notch and Wnt signaling direct sp

198 The ductular reaction to acute submassive necrosis was studi

199 ls to modulate virtually every aspect of the ductular reaction to injury.

200 er injury, hyperbilirubinemia, and increased ductular reaction under basal conditions.

201 The mechanisms mediating this so-called 'ductular reaction' need to be better understood to impro

202 Excessive cholangiocyte expansion (ductular reaction) promotes liver disease progression, b

203 icient mice develop focal liver necrosis and ductular reaction, accompanied by impaired Atg14L-linked

204 The HDC/histamine/histamine receptor axis, ductular reaction, and biliary senescence were evaluated

205 Fibrosis, ductular reaction, and ductopenia were significantly mor

206 Biliary/hepatocyte senescence, ductular reaction, and liver angiogenesis were evaluated

207 Biliary/hepatocyte senescence, ductular reaction, and liver angiogenesis were observed

208 ess hepatocyte proliferation, an exaggerated ductular reaction, and more advanced disease compared wi

209 There was a significant increase in ductular reaction, biliary senescence, liver inflammatio

210 PC2 expression and significantly reduced the ductular reaction, fibrosis, and phosphorylated ERK1/2.

211 ed in liver injury, steatosis, inflammation, ductular reaction, fibrosis, and tumor cell proliferatio

212 n of mTORC1 partially reversed hepatomegaly, ductular reaction, fibrosis, inflammatory cell infiltrat

213 holestatic mice, and excess leptin increases ductular reaction, hepatic fibrosis, and inflammation vi

214 her hepatic and serum bile acid levels, bile ductular reaction, increased pericellular fibrosis, and

215 ven placebo, as shown by serum biochemistry, ductular reaction, inflammation, and fibrosis.

216 ocyte TSC1 promotes liver cell repopulation, ductular reaction, inflammation, fibrosis, and liver inj

217 Cholestatic injuries are accompanied by ductular reaction, initiated by proliferation and activa

218 ind alphavbeta5/alphavbeta3 were impaired in ductular reaction, leading to massive hepatic necrosis a

219 Ductular reaction, LF, as well as the mRNA expression of

220 Decreased ductular reaction, liver fibrosis, biliary senescence, a

221 treatment similarly ameliorates DDC-induced ductular reaction, liver injury, and fibrosis.

222 DDC, ANIT, or BDL induces ductular reaction, liver injury, inflammation, and fibro

223 ty liver disease (eg, hepatocyte ballooning, ductular reaction, microsteatosis, pleomorphic nuclei, D

224 otype of Cyld(DeltaLPC) mice, which included ductular reaction, oval cell activation, and biliary fib

225 g the underpinning of hepatocellular injury, ductular reaction, pathologic vascular expansion, and fi

226 and other pathologic conditions that trigger ductular reaction, proliferating cholangiocytes acquire

227 lso mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholest

228 al tract but not the epithelial cells of the ductular reaction, which were instead encased by stellat

229 cholangiopathies) that are characterized by ductular reaction.

230 g fibrosis, Mallory body formation, and bile ductular reaction.

231 e models of liver disease characterized by a ductular reaction.

232 with a change in the liver parenchyma called ductular reaction.

233 ucing kinase (NIK) as a pivotal regulator of ductular reaction.

234 tensin homolog, which develops HCC involving ductular reaction.

235 KPE, elevated serum primary bile acids, and ductular reaction.

236 with hepatocyte ballooning degeneration and ductular reaction.

237 -13 in fibrosis, steatosis, cholestasis, and ductular reaction.

238 disease (NAFLD) with portal inflammation and ductular reaction.

239 compartment, Notch2 is capable of inducing a ductular reaction.

240 lmark of pathologic repair is the so-called "ductular reaction." This is a histologic abnormality cha

241 Ductular reactions (DRs) are observed in virtually all f

242 This induced ductular reactions (DRs) in healthy mice.

243 ctivation, which often occurs in the form of ductular reactions (DRs) when hepatocyte proliferation i

244 ar environment conducive to the formation of ductular reactions (DRs).

245 icantly fewer cytokeratin-19 (CK19)-positive ductular reactions (P = 0.0004) and significantly less p

246 ressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fi

247 At P30, Jag1(+/-) mice show widespread ductular reactions and ductopenia in liver and a mild, b

248 Ductular reactions are primarily composed of oval cells

249 Ductular reactions containing both hepatic progenitor ce

250 staining of hepatocytes, cholangiocytes, and ductular reactions in all tissues, to the exclusion of a

251 The 3-dimensional structure of ductular reactions in massive necrosis suggests that the

252 The miR-34a-mediated ductular reactions may be functioning through Sirt-1-med

253 We found more-active nuclear YAP in the bile ductular reactions of primary sclerosing cholangitis and

254 iver progenitor cell types of human atypical ductular reactions seen in chronic cholestasis, in regen

255 Because HAI-1 and -2 colocalized in ductular reactions sharing similar features to those obs

256 with overexpression of p27 and emergence of ductular reactions was detected.

257 cell marker, PROMININ-1 (PROM1), adjacent to ductular reactions within regions of periportal fibrosis

258 splantation, is associated with intrahepatic ductular reactions within regions of rapidly expanding p

259 a reservoir for the epithelial diversity of ductular reactions, appearance of hepatocytes in bile du

260 proliferation and aggravated alcohol-induced ductular reactions, fibrosis, inflammation, and liver in

261 Hepatic ductular reactions, pericellular fibrosis, and bridging

262 nic liver injury (CCl(4)-induced), or during ductular reactions.

263 and -2 were coexpressed in cells involved in ductular reactions.

264 /gp-80 systems in the early phases of type I ductular reactions.

265 d proliferation of liver progenitor cells or ductular reactions.

266 such as decay of bile canaliculi network and ductular reactions.

267 cells have been identified in human atypical ductular reactions: type I: primitive, has an oval shape

268 Ductular reactive (DR) cells exacerbate cholestatic live

269 In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic par

270 ere assessed for liver injury, fibrosis, and ductular reactive (DR) cells.

271 esponse; that is, a subpopulation acquires a ductular reactive and proliferative phenotype, while ano

272 Both ductular reactive cholangiocytes and senescent cholangio

273 o-regenerative microenvironment required for ductular regeneration, demonstrating that scarring and r

274 n to take place but inhibits efficiently the ductular response and extracellular matrix deposition.

275 chymal origin as the progenitor for the oval/ductular response in the rat.

276 tiple chronic liver disorders that display a ductular response such as alcoholic liver disease or scl

277 Chronic hepatic injury is accompanied by a ductular response that is strongly correlated with disea

278 her anti-inflammatory drugs can modulate the ductular response, we treated mice suffering from a stea

279 The formation of ductular scaring affects liver function; however, scar-g

280 most cases these diseases result in chronic ductular scarring, necessitating liver transplantation.

281 ile duct injury and promote the formation of ductular scars by upregulating pro-fibrogenic cytokines

282 (2+) release channel in Ca(2+) signaling and ductular secretion in animal models of cholestasis and i

283 i)(2+) is in part responsible for regulating ductular secretion, these findings also may have implica

284 owever can instead be induced to form acinar/ductular structures akin to bile ductules (in the presen

285 underwent organotypic morphogenesis forming ductular structures and cysts.

286 he formation and proliferation of dysplastic ductular structures are observed from the onset of the p

287 Similar acinar/ductular structures are seen in embryonic liver when HGF

288 epatocytic morphology appeared near EpCAM(+) ductular structures in the livers of mice fed 3,5-dietho

289 Proliferation of bile ductular structures is influenced by specific molecules

290 roduced grossly visible organoids containing ductular structures that stained for CK18, CK19, and AFP

291 -) cells provide luminal space near expanded ductular structures to prevent deterioration of the inju

292 tinal type" of ChC than in hyperplastic bile ductular structures within either cholangiofibrotic or b

293 The formation of ductular structures within islets was also demonstrated

294 On Matrigel, HBC-3 cells form elaborate ductular structures, which are positive for gamma-glutam

295 at pads of isogenic mice formed well defined ductular structures.

296 DDC diet, we found LacZ(+)Sox9(+) cells near ductular structures.

297 n the luminal areas of secretory alveoli and ductular tissue, indicating that much of the bacterial g

298 uccessfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile an

299 rowth to form a small, irregularly branched, ductular tree.

300 ithelial-to-mesenchymal transitions (EMT) in ductular-type progenitors.