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1 ic scaffold to recognize the shape of an RNA duplex.
2 gh covalent attachment of each strand of the duplex.
3 lty of separating the strands of the product duplex.
4 L2 loop, which inserts into and opens up the duplex.
5 ntroduction of mismatches within the initial duplex.
6 he C3'-endo conformation formed in canonical duplexes.
7 trands in the context of 3'-OH/5'-PO4 nicked duplexes.
8 oint the locations of the spin labels on the duplexes.
9 plexes are more stable than Cgamma(R)-bm-PNA duplexes.
10 s the canonical conformations of DNA and RNA duplexes.
11 NA, such structures were not observed in RNA duplexes.
12 HG base pairs for both naked B-DNA and A-RNA duplexes.
13 verted to parallel-stranded homo-base paired duplexes.
14 able in the polymerase relative to these DNA duplexes.
15 alters the hybridization kinetics in two RNA duplexes.
16 ymerase than in aqueous solution and the DNA duplexes.
17 ed, with few exceptions, in low stability of duplexes.
18 x reporter appended onto electrode-bound DNA duplexes.
19 ns while protecting the remainder in DNA-RNA duplexes.
20 ing honeycomb edges composed of six parallel duplexes.
21 bes and to construct closely packed parallel duplexes.
22 e edges that are composed only of one or two duplexes.
23 striction endonucleases naturally target DNA duplexes.
24 e stable than the corresponding DNA/RNA self-duplexes.
26 nces with 100% AT content, a poly(A)-poly(T) duplex (AA-TT) and a poly(AT)-poly(TA) duplex (AT-TA).
29 that introduces site-specific nicks into the duplex and a dynamic motor complex that rapidly transloc
30 the melting temperature of both an 8-mer DNA duplex and a hairpin with a stem of 6-nt depending on th
31 n between parallel-stranded homo-base paired duplex and antiparallel unimolecular hairpin in a pH-dep
32 study the kinetics and thermodynamics of DNA duplex and hairpin formation in crowded environments.
33 ns a regular C:G base pairing pattern in RNA duplex and has a relatively small effect on its base pai
34 including the influenza viral RNA panhandle duplex and HIV-1-1 ribosomal frameshift-inducing RNA hai
38 circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of double-stranded RNA (d
39 NS5B in ternary complex with template-primer duplexes and nucleotides, to address the question of rib
41 endent reductive charge transfer through RNA duplexes and through the non-Watson-Crick base-paired re
42 and expels fewer anions compared to the DNA duplex, and the RNA duplex interacts significantly stron
44 steen (HG) base pairing pattern in naked DNA duplexes, and estimated its relative stability and lifet
45 t better thermal stability than the isolated duplexes, and the Cgamma(S)-bm-PNA duplexes are more sta
46 n aqueous solution, in A-form and B-form DNA duplexes, and within the active site of a DNA polymerase
47 icular, the presence or absence of short RNA duplexes-and suggests that the equilibrium size of the c
50 zing both the flipped base and the distorted duplex are poorly conserved among McrB homologs, suggest
53 isolated duplexes, and the Cgamma(S)-bm-PNA duplexes are more stable than Cgamma(R)-bm-PNA duplexes.
58 from n = 14 human subjects using our mobile duplex assay, and showed excellent agreement with the go
63 on, triggered through the recognition of the duplex between the authentic pre-mRNA and U7 small nucle
65 ting strategy by conjugating highly specific duplex-binding molecules with potent quadruplex ligands.
67 lex composed of two bm-Calpha-PNA-C(5):dG(5) duplexes built on a core (bm-Calpha-PNA-T(7))(2):dA(8) t
68 be endoergic in aqueous solution and the DNA duplexes but slightly exoergic in the polymerase, with A
71 pha-PNA with mixed sequences can form double duplexes by simultaneous binding to two complementary DN
72 The G:G mismatch sites of the d(TTGGCGAA) duplex can also act as a hotspot for the formation of al
73 voltage across the nanopore facilitated the duplex capture inside the nanopore's vestibule against t
74 on-template DNA strand bonds with the hybrid duplex (collapsed R-loops, where the two DNA strands rem
75 hetic genetic information, relative to a DNA duplex consisting entirely of Watson-Crick base-pairs.
76 l basis of minor groove recognition of a DNA duplex containing synthetic genetic information by hairp
77 duce a higher melting stabilization of a DNA duplex containing the unnatural P.Z base-pair when an im
80 ed nanopore, polyarginine-conjugated DNA-PNA duplexes dehybridize faster than their DNA-PNA counterpa
81 tility of this workflow is demonstrated with duplexed detection of bacteria in a sample imitating a c
82 nally, the defect of an exo1-K185A mutant in duplex digestion was partially rescued by longer overhan
84 (6)A minimally impacts the rate constant for duplex dissociation, changing k(off) by ~1-fold but sign
86 er than its anisotropy decay in well-matched duplex DNA (theta = 20 ns), yet longer than the dynamic
87 strand separation, and show Csm3/Tof1 "grip" duplex DNA ahead of CMG via a network of interactions im
89 gnizes the symmetric sequence 5'-GCG C-3' in duplex DNA and cleaves (' ') to produce fragments with 2
90 resis results, the abundances of hairpin and duplex DNA are unaffected by the addition of netropsin.
91 contrast, fork-bound SSB loads PriA onto the duplex DNA arms of forks, suggesting a remodeling of Pri
94 homodimer that binds, unstacks, and sculpts duplex DNA at internal unpaired regions (bubbles) into s
95 together spirally encircle 10 base pairs of duplex DNA at the double-/single-stranded (ds-ss) juncti
96 that this model intercalator interacts with duplex DNA by a "displacement insertion intercalation" m
97 Purified recombinant YaaA binds to dsDNA, duplex DNA containing bubbles of unpaired nucleotides, a
98 targeting both G-quadruplex and its flanking duplex DNA in a naturally occurring dsDNA-ssDNA telomere
100 structure containing the single-stranded and duplex DNA junction with the allowed extension in the 5'
102 e has a quantum yield in single-stranded and duplex DNA ranging from 10% to 44% and 22% to 32%, respe
104 talytic sites, and cleave the two strands of duplex DNA simultaneously, in a single binding event.
108 rpin probes hybridized with T-DNAs to form a duplex DNA, and the ring of hairpin DNA was opened to ma
110 minimal activation was observed with 80-mer duplex DNA, the optimal effector for Tel1 activation is
111 ions that can migrate over long distances in duplex DNA, ultimately generating 8-oxo-7,8-dihydroguani
112 ntage of anti-parallel strand orientation of duplex DNA, within a given set of plausible premises.
118 und, UvrC forms high affinity complexes with duplexed DNA substrates; the apparent dissociation const
120 stalled due to interaction with the parental duplex, DNA rezipping-induced helicase backtracking rees
121 he absence of DNA and in complex with forked duplex DNAs before and after cleavage of the 5' single-s
123 utY excision rates with different A analogue duplexes do not correlate with the impact on overall Mut
126 To gain insight into the effect of Psi on duplex dynamics and hydration, we performed molecular dy
128 amic studies showed that AP destabilizes the duplex, enabling a structural transition of the sequence
131 oduce periodic kinks in the crRNA-target RNA duplex, facilitating cleavage of the target RNA with 6-n
133 Woods, which solves these challenges using a duplex-focused precursor detection method and stacked ra
134 more, the stability of the parallel-stranded duplex form can be altered by changing the 5'-nucleobase
135 , we study the hybridization kinetics of DNA duplex formation and the formation of hairpin stems, fin
136 e used to control the stereochemistry of the duplex formed in the templated oligomerization reaction
137 (11-CN-dppz)](2+) bound to d(TCGGCGCCGA), a duplex-forming sequence, and use both structural models
138 the DNA, a locally unwound and unpaired DNA duplex forms a zipper via alternating interstrand base s
139 shows that Dicer cleaves the modified siRNA duplex from the surface of the nanoparticle, and the lib
140 nd two different complementary DNAs, to form duplexes from both tert-amide side and Cgamma side.
141 se experimental results suggest that the RNA duplex generates a stronger electrostatic field than DNA
144 lex units, while another features an unusual duplex hairpin structure adjoined to two stacked paralle
145 ectly from synthetic RNA template/DNA primer duplexes having either a blunt end or a 3'-DNA overhang
151 stinct dissociation kinetic rates for a 7 bp duplex in which one G-C basepair is mutated to an A-T ba
153 roximal-face pore, whereas the remaining DNA duplexes interact with the rims and serve as bridges bet
154 ions compared to the DNA duplex, and the RNA duplex interacts significantly stronger with the divalen
160 tively sequence-independent quantum yield in duplexes makes 2CNqA promising as a nucleic acid label a
162 ystal structures of B-form spin-labelled DNA duplexes, molecular dynamics simulations and nuclear mag
163 s, from nanoscale optical isolators and full-duplex nanoantennas to topologically-protected networks.
164 can range from separation of strands within duplex nucleic acids to the physical remodeling or remov
166 PNA 1 forms a higher order pentameric double duplex of a triplex composed of two bm-Calpha-PNA-C(5):d
171 tep, there is a roughly 20% probability that duplex opening will terminate and the as-yet-unopened ds
174 ofile of the nucleotide analogues into a DNA duplex overhang using recently evolved XNA polymerases i
175 th UNA at the T(15) position and LNAs in the duplex part possess the highest value of melting tempera
178 tion pathway from initial recognition of the duplex promoter in a closed complex to the final RPo.
180 led with GAA and TTC strands; the two hybrid duplexes [r(GAA):d(TTC) and d(GAA):r(UUC)] in an R-loop;
181 d and confirmed using a previously published duplex real-time PCR (capable of detecting E. histolytic
183 he digestion strand of the substrate DNA for duplex recognition, critical for Exo1 activation on not
189 enzymes that convert adenosine to inosine in duplex RNA, a modification that exhibits a multitude of
191 nisms in which an RNA transcript forms a DNA duplex.RNA triple helix with a gene or one of its regula
193 -care duplex ultrasound test (podiatry ankle duplex scan; PAD-scan) against commonly used bedside tes
196 ation between mutation induction measured by duplex sequencing and the gold-standard transgenic roden
198 cacies of germline de novo mutagenesis using duplex sequencing directly in oocytes, which provided un
204 -end sequencing and in the case of combining duplex sequencing with target enrichment, lengthy hybrid
205 er-nucleotide frequencies <=1 x 10(-7) Using duplex sequencing, an extremely accurate error-corrected
207 with modified small interfering RNA (siRNA) duplexes, SNAs act as single-entity transfection and gen
209 extracorporeal membrane oxygenation weaning, duplex sonography or CT was conducted to detect cannula-
214 fects of oligomeric state, DNA geometry, and duplex stability on wtRep and RepDelta2B unwinding activ
215 the C:G pair and significantly decreases the duplex stability through a conformational shift of nativ
217 e low carbon steel by cladding it with super duplex stainless steel using laser powder bed fusion pro
220 he formation of a metallo-base pair within a duplexed strand and is therefore attractive for screenin
221 merases change both $K$ and $\Delta Lk$ by a duplex-strand-passage mechanism and have been shown to s
222 However, the manner in which modified siRNA duplex strands that comprise the SNA lead to gene silenc
224 e data report on charge transfer through RNA duplex structures mainly composed of homonucleotide sequ
227 iation constants to well-matched and damaged duplex substrates are 100 +/- 20 nM and 80 +/- 30 nM, re
230 has not been observed for 5'- and 3'-tailed duplexes, suggesting that it is the fork structure that
235 tro transcribed Cas9 mRNA and crRNA:tracrRNA duplex that can effectively generate indels in four gene
236 sgRNA molecule or a synthetic crRNA:tracrRNA duplex that perfectly matches the protospacer target sit
237 bit translation of target mRNAs by forming a duplex that sequesters the Shine-Dalgarno (SD) sequence
239 erted Alu repeats capable of forming RNA:RNA duplexes that bring splice sites together for backsplici
240 th transition in contrast to the other three duplexes that show sawtooth patterns, the latter being a
241 d (ANA) within small interfering RNA (siRNA) duplexes that were otherwise fully modified with the 2'-
242 ment of a single base pair in the miRNA-mRNA duplex-that elongates a weak five-base-pair seed to a co
243 re, and can displace the hemi-methylated DNA duplex, the native substrate of DNMT1, off the protein o
244 aphy, and the structure explains the loss in duplex thermal stability for the (R) isomer compared wit
245 o backbone ester bonds generally promote RNA duplex thermal stability to a greater magnitude than do
248 e RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DN
250 production, indicating that 340R binds siRNA duplexes to prevent RNA-induced silencing complex assemb
252 by making a double-stranded break in one DNA duplex, transporting another DNA segment through this br
254 nous thrombosis after ICU admission with 102 duplex ultrasound examinations, with 12 cases (16.7%) of
257 gnostic performance of a novel point-of-care duplex ultrasound test (podiatry ankle duplex scan; PAD-
259 volumetric measures of cerebral blood flow (duplex ultrasound) to quantify resting cerebral metaboli
261 s (28 +/- 7 years; 23 +/- 2 kg m(-2) ), FMD (Duplex ultrasound), arterial blood gases, Hct and [Hb],
264 ple protocol, which enabled the retrieval of duplex UMI in multiplex PCR based enrichment and sequenc
265 equencing method offers the benefit of using duplex UMI to remove NGS artifacts in a much more simpli
268 ides a mechanistic basis for relatively slow duplex unwinding by replicative helicases and explains h
269 f1 bound to the 3' ss/dsDNA junction impacts duplex unwinding by stabilizing the unpaired first base-
272 dy identifies key particularities of DNA-PNA duplex unzipping as it takes place inside the nanopore a
274 DNA-PNA and polyarginine-conjugated DNA-PNA duplexes unzipping inside the alpha-hemolysin nanopore (
275 step toward understanding the nucleic acids duplexes unzipping kinetics variability, in confined, va
277 ipheral arterial disease not recognized with duplex US and was more predictive than duplex US of the
278 oxytol-enhanced MR angiography compared with duplex US for vascular mapping before upper limb AVF cre
280 with duplex US and was more predictive than duplex US of the outcome of arteriovenous fistula surger
281 as the dependent variable and age, sex, and duplex US or ferumoxytol-enhanced MR angiography finding
284 Sense and antisense strands of the parent duplex were synthesized with single ANA residues at each
285 e foundation for future applications, 20 DNA duplexes, where the bases facing and neighboring (th)G w
286 differences in thermal stability of the DNA duplex, which require extensive optimization of the reac
287 imers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates
288 e helicases alternate between strands of the duplex-which does not require the 2B subdomain, contrary
289 n therefore replace any G residue in matched duplexes, while always maintaining similar photophysical
290 -base pairs stabilize a parallel A-form-like duplex with a 5' adenine-rich pocket, which binds a meta
293 d molecular dynamics (MD) simulations of RNA duplexes with 5'-GPsiC/3'-CAG, 5'-CPsiG/3'-GAC, 5'-APsiU
294 template switching are optimal from starter duplexes with a single nucleotide 3'-DNA overhang comple
296 es in this study is composed of two parallel duplexes with crossovers on both ends, and three, four,
297 The protein complex binds two short DNA duplexes with high affinity and bridges DNA molecules in
299 t is established that LC8 forms parallel IDP duplexes with some partners, such as nucleoporin Nup159