ライフサイエンスコーパス: dural

1 ) had a potentially causal cranial or spinal dural abnormality, 5 (11%) had an alternative cause, and

2 ways reveals a potential cause, most often a dural abnormality.

3 rtance of inflammatory mediator (IM)-induced dural afferent sensitization to this pain syndrome, the

4 trigeminal ganglion from 40 mechanosensitive dural afferents (conduction velocitity: 0.3-6.6 m s(-1))

5 6 m s(-1)) and nine mechanically insensitive dural afferents (MIAs) (conduction velocitity: 0.3-2.8 m

6 sistent pronociceptive neural adaptations in dural afferents and enhanced responses to an established

7 lays a dominant role in the sensitization of dural afferents because of the combination of the densit

8 asting increase in identified rat trigeminal dural afferents labelled for neuronal nitric oxide synth

9 d labeling for CGRP in identified trigeminal dural afferents that persisted long after discontinuatio

10 IMs modulated a number of currents in dural afferents, including those both expected and/or pr

11 appear to contribute to the sensitization of dural afferents, the Cl(-) current is the primary mechan

12 ression of neuronal nitric oxide synthase in dural afferents, which is critical for enhanced sensitiv

13 of the dura and subsequent sensitization of dural afferents.

14 ic neurotransmitter expression in identified dural afferents.

15 belling of neuronal nitric oxide synthase in dural afferents.

16 resented with severe tumoral calcinosis with dural and carotid artery calcifications.

17 can activate trigeminal nociceptors, produce dural and cortical inflammation, and induce trigeminal p

18 firing and hypersensitivity to intracranial-dural and extracranial-cutaneous (noxious and innocuous)

19 sioning of the A11 significantly facilitated dural and noxious pinch and innocuous brush evoked firin

20 antly inhibited peri-middle meningeal artery dural and noxious pinch evoked firing of neurons in the

21 M) to measure the diameter changes of single dural and pial vessels in the awake mouse during volunta

22 are involved in the descending modulation of dural and/or cutaneous facial trigeminovascular nocicept

23 okine expression, neutrophil recruitment and dural antimicrobial defences.

24 Dural application of interleukin-6 causes acute response

25 A similar sensitization was elicited by dural application of NTG and SNAP.

26 After dural application with MO, mechanical thresholds of the

27 he transverse sinus partially overlapped the dural area that shows the greatest density of mast cells

28 eurons that are responsive to stimulation of dural areas in the anterior 2/3 of the cranium and the p

29 on of pial arteries, prolonged dilatation of dural arteries and PPE are all unaffected by fremanezuma

30 of abnormal connections between branches of dural arteries and venous sinuses or veins.

31 sion gave rise to the expected dilatation of dural arteries, which was effectively blocked by fremane

32 morrhage, cerebrovascular malformations, and dural arteriovenous fistula affecting the basal ganglia,

33 ntracerebral haemorrhage due to intracranial dural arteriovenous fistula and presented our personal e

34 Dural arteriovenous fistula is a very rare cause of myel

35 retrospective analysis of the Consortium for Dural Arteriovenous Fistula Outcomes Research and the In

36 sistant pulsatile tinnitus caused by a small dural arteriovenous fistula revealed in computed tomogra

37 ssa dural sinus anatomy in two patients with dural arteriovenous fistula.

38 r center demonstrating right T7 to T8 spinal dural arteriovenous fistula.

39 haemorrhagic risk of intracranial low-grade dural arteriovenous fistulas (dAVFs), the benefits of ro

40 Rare causes of tinnitus include cranial dural arteriovenous fistulas (DAVFs), which are usually

41 reflux (CVR) in patients with lateral sinus dural arteriovenous fistulas (DAVFs).

42 with a complete cure in most cases of spinal dural arteriovenous fistulas (SDAVF), there has been an

43 lly excised if accessible, while hemorrhagic dural arteriovenous fistulas and distal/mycotic aneurysm

44 sentation, both symptomatic and asymptomatic dural arteriovenous fistulas deserve clinical attention,

45 the follow-up clinically and radiologically, dural arteriovenous fistulas should be kept in mind in t

46 r 2016 was reviewed, and 25 patients with 28 dural arteriovenous fistulas were identified.

47 on and rupture, arteriovenous malformations, dural arteriovenous fistulas, and cerebral cavernous mal

48 In arteriovenous malformations and dural arteriovenous fistulas, ASL is very sensitive to d

49 of intracranial haemorrhage in patients with dural arteriovenous fistulas.

50 ude idiopathic intracranial hypertension and dural arteriovenous fistulas.

51 onal experience in endovascular treatment of dural arteriovenous fistulas.

52 a new study by Fitzpatrick et al. describes dural-associated lymphoid tissue (DALT) and its contribu

53 The most elaborate of these dural-associated lymphoid tissues (DALT) surrounded the

54 the basis of the difference in the origin of dural attachment and patterns of growth, the PCMs were c

55 In cases of severe dural AV fistula in the cavernous sinus, the pituitary g

56 in 21 patients with angiographically proved dural AV fistula of the cavernous sinus were retrospecti

57 mmary, dynamic changes in the brain, LM, and dural B cells are associated with age-dependent disease

58 Characteristic cystic lesions with a broad dural base on the exiting nerve root sleeve were identif

59 hree of the 38 children presented with large dural-based lesions, manifesting as epilepsia partialis

60 that typically presents as a meningioma-like dural-based mass.

61 -to-male ratio, 4:1), with 93% presenting as dural-based masses mimicking meningioma.

62 with laser-Doppler flowmetry measurements of dural blood flow (DBF), we examined whether CGRP and men

63 as headaches, but little is known about the dural blood flow regulation during behavior.

64 ion of CGRP caused a significant increase in dural blood flow; however, neither method of CGRP admini

65 of mice migrate along perivascular spaces of dural blood vessels and then travel through hundreds of

66 Leakage of plasma proteins from dural blood vessels was first detected 4 h after GTN inf

67 nner arachnoid, outer arachnoid barrier, and dural border layer; and contrast them to a sixth fibrobl

68 ; the entire spine must be scrutinised for a dural breach often the size of a pin.

69 CGRP dilated dural, but not pial, vessels and significantly reduced s

70 inical application of OCTA in a patient with dural carotid-cavernous sinus fistula (CCF), which was c

71 normal episcleral venous plexus secondary to dural CCF.

72 Dural cerebral veins (CV) are required for cerebrospinal

73 ales but only causes priming to subthreshold dural CGRP (0.1 pg) in females.

74 and females but only priming to subthreshold dural CGRP (0.1 pg) in females.

75 this response was observed only in females; dural CGRP at doses from 1 pg to 3.8 mug produce no resp

76 In females, dural CGRP causes priming to a pH 7.0 solution after ani

77 These data further implicate dural CGRP signaling in the pathophysiology of migraine

78 Finally, the sexually dimorphic responses to dural CGRP were not specific to rats as similar female-s

79 iology of migraine and propose a model where dural CGRP-based mechanisms contribute to the sexual dis

80 r sodium nitroprusside (0.1 mg/kg) following dural CGRP.

81 s longest among patients with parenchymal or dural CNS disease only (3.57 years; 95% CI, 2.10-5.63 ye

82 origin at the orbital apex, continuous with dural connections extending into the skull base.

83 muscles, their course into the orbit and the dural connections of the common tendinous origin with th

84 The orbital apex and its dural connections were photographed.

85 n our overall sample, the odds of successful dural culture was almost two-fold compared with scalp (O

86 lecular and cellular processes that regulate dural CV development in mammals and describe venous malf

87 SF) leak occurs when there is an osseous and dural defect at the skull base, with direct communicatio

88 ncidence of Chiari I malformation (6.4%) and dural ectasia (42.6%); and physical examination findings

89 ogic lesions, such as optic pathway gliomas, dural ectasia and aqueduct stenosis.

90 ome include scoliosis, chest wall deformity, dural ectasia, joint hypermobility, and acetabular protr

91 ur findings suggest that the accumulation of dural ELS varies according to age, brain pathology, and

92 Dural enhancement was seen on 96 of 97 (99%) postoperati

93 the surgical margin and for the presence of dural enhancement, fluid, and air.

94 receptor activation in the vlPAG attenuated dural-evoked Adelta-fiber neurons (maximally by 19%) and

95 Some dural fibers issued collateral branches to the pia at th

96 VFOs were generated from postmortem dural fibroblast-derived iPSCs of four individuals with

97 cortex, other brain regions, dura mater, and dural fibroblasts of a single neurotypical individual, d

98 Multiple dural fistulas occurred in 12% of patients.

99 such as pial arteriovenous malformations and dural fistulas.

100 ly less hypersensitive than the WT following dural IL-6 and did not prime to pH 7.0 or sodium nitropr

101 WT mice prevented hypersensitivity caused by dural IL-6 or pH 7.0.

102 Dural IMs produced long-lasting generalized cutaneous al

103 ine release selectively in rats treated with dural IMs.

104 pamine release selectively in rats receiving dural IMs; CPP was blocked by intra-NAc alpha-flupenthix

105 d not expand; neuronal response threshold to dural indentation and skin stimulation did not decrease;

106 ous firing rates and mechanical responses to dural indentation with von Frey filaments were recorded

107 er treatment; neuronal response threshold to dural indentation, which initially decreased after IS, i

108 th compounds potently blocked the neurogenic dural inflammation following trigeminal ganglion stimula

109 -HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extr

110 -HT(1F) receptor agonists inhibit neurogenic dural inflammation, a model of migraine headache, indica

111 subjected to repeated restraint stress or a dural injection of interleukin-6 (IL-6) and tested for p

112 ously injected with IL-6 were given a second dural injection of pH 7.0 to test for hyperalgesic primi

113 well as the axonal size distribution of the dural innervation.

114 of the GON (20 s to 5 min) enhanced afferent dural input in 8/20 neurones.

115 dache, where it is believed that an enhanced dural input to the Vc may generate central sensitisation

116 is unlikely when there is an extensive local dural invasion and given that the molecular mechanisms r

117 ve therapeutic targets for the control of PA dural invasion.

118 arachnoid layers), and the outmost meningeal dural layer and calvaria (via the so-called arachnoid cu

119 al cells directly contact macrophages in the dural layer of the meninges to suppress pro-inflammatory

120 site of CSF leakage as either (1) a ventral dural leak, (2) a leaking spinal nerve root diverticulum

121 er confirmed CYC is a target of miR-34a by a dural luciferase reporter gene assay in vitro.

122 s also discussed, as are methods for imaging dural lymphatic channels involved with CSF efflux.

123 w into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the

124 Here we show dural lymphatic structures along the dural venous sinuse

125 e present study to visualize the major human dural lymphatic structures.

126 We show that dural lymphatic vessels absorb CSF from the adjacent sub

127 Dural lymphatic vessels transport fluid into deep cervic

128 trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from th

129 homatosis cerebri, intravascular lymphoma or dural lymphoma.

130 at 2 and 6 h and increased interleukin 6 in dural macrophages and in rat cerebrospinal fluid at 6 h

131 14 after clodronate liposome, although both dural macrophages and MLVs had recovered, leptomeningeal

132 Because iNOS was expressed in dural macrophages following topical GTN, and in the sple

133 However, whether leptomeningeal and dural macrophages play the same or distinct roles in mai

134 eptomeningeal macrophages, distinct from the dural macrophages, are essential for CSF drainage to the

135 Dural margin treatment (Simpson grade 1/2) prolonged PFS

136 Treatment of the tumor and dural margin with surgery and sometimes radiation are co

137 These findings reveal dural mast cells as central players in modulating CSF fl

138 Mice lacking dural mast cells exhibit impaired immune responses and h

139 ion and oedema formation after GTN infusion, dural mast cells exhibited granular changes consistent w

140 Here, we show that dural mast cells regulate CSF dynamics at ACE points.

141 ate the cAMP-PKA cascade in sensitization of dural mechanonociceptors and suggest that this cascade m

142 ioadhesive for intraoperative sealing of the dural membrane in rodent, porcine, and human central ner

143 system tissue and cerebrospinal fluid by the dural membrane is fundamental to maintaining homeostasis

144 ges in the dendritic cell compartment of the dural meninges that may support this process.

145 2 conventional dendritic cells (cDC) in the dural meninges.

146 phenotypes and effector functions within the dural meninges.

147 metastasis, leptomeningeal disease (LMD), or dural metastasis, who were treated between August 2010 a

148 , the present authors name it the 'Occipital-Dural Muscle'.

149 t type 2 leaks are actually due to a lateral dural nerve root sleeve tear through which the arachnoid

150 pression of these hormones in TG neurons and dural nerves; and showed GH expression in subsets of TRP

151 eminovascular neuronal tone and Adelta-fiber dural-nociceptive responses, which differs from the way

152 f the NO donor sodium nitroprusside (SNP) or dural pH 7.0, respectively.

153 priming to SNP, with no effect on priming to dural pH 7.0.

154 ve in two models of migraine: the neurogenic dural plasma protein extravasation model and the nucleus

155 We studied the dural plasma protein extravasation response after unilat

156 nding the dural sinuses, or the parasagittal dural (PSD) space.

157 ey points in the management of unintentional dural puncture and of PDPH.

158 approach to the management of unintentional dural puncture and PDPH.

159 an intrathecal catheter as it avoids further dural puncture and seals the hole during the time it is

160 ated spinal anesthesia as well as unintended dural puncture during epidural anesthesia.

161 ure headache (PDPH) can follow unintentional dural puncture during epidural techniques or intentional

162 re during epidural techniques or intentional dural puncture during neuraxial procedures, such as a lu

163 is associated with a lower incidence of post-dural puncture headaches.

164 The incidence following accidental dural puncture is not as high as previously thought--app

165 tch should not be performed until 24 h after dural puncture to increase its success; however, it shou

166 aumatic and conventional needles in which no dural puncture was done (epidural injections) or without

167 esia; it has not been studied for accidental dural puncture with a large bore needle.

168 subsequent epidural replacement, inadvertent dural puncture, and cesarean section with difficult intu

169 Dural-puncture epidural (DPE) and standard epidural are

170 istration of inflammatory mediators to their dural receptive field, sensitize their responses to stim

171 cted to be induced 2 h after IS application: dural receptive fields did not expand; neuronal response

172 Chemical stimulation of their dural receptive fields with inflammatory mediators both

173 racted two aspects of central sensitization: dural receptive fields, which initially expanded by IS,

174 the GON induced an increased excitability of dural responses in 8/12 and 9/10 neurones, respectively.

175 ity of patients, pointing to weakness of the dural sac as one of the etiological factors.

176 SCM type II includes cases without a divided dural sac but with a fibrous septum present.

177 yodural bridges are thought to stabilize the dural sac during head and neck movements and promote cer

178 he dynamic aspect of the myodural bridges as dural sac stabilizers.

179 ludes cases with a bony septum and a divided dural sac, while SCM type II includes cases without a di

180 nal and the presence or absence of a divided dural sac.

181 ion of a division within the spinal cord and dural sac.

182 n-coated collagen fleece (TachoSil) versus a dural sealant (DuraSeal) to prevent postoperative CSF le

183 patient and poorly depicted posterior fossa dural sinus anatomy in two patients with dural arteriove

184 tion of MacTel2 and/or increased right-sided dural sinus drainage related to normal anatomical variat

185 patients with skull fractures extending to a dural sinus or jugular bulb.

186 patients with skull fractures extending to a dural sinus or jugular bulb.

187 g of the optic disc [p=0.881], and bilateral dural sinus stenosis [p=0.837], Mann-Whitney U test).

188 Some theories - such as the dural sinus stenosis theory - seem to ignore the relatio

189 acute intracranial hemorrhage due to delayed dural sinus thrombosis after endovascular treatment of h

190 t is a rapid, useful method for diagnosis of dural sinus thrombosis and for preoperative mapping of v

191 Dural sinus thrombosis was diagnosed in seven patients,

192 Dural sinus thrombosis was found in four patients.

193 Eighteen patients had suspected dural sinus thrombosis.

194 the International Study on Cerebral Vein and Dural Sinus Thrombosis.

195 e are few reported cases of SAH secondary to dural sinus thrombosis; however most of these are convex

196 ingeal macrophages, a selective reduction in dural sinus-associated macrophages, a decreased density

197 = 0.83, 1.0), presence of retrograde flow in dural sinuses (kappa = 1), presence of retrograde cortic

198 inating from lymphatic vasculature along the dural sinuses and the middle meningeal artery.

199 hese findings highlight the critical role of dural sinuses as a neuroimmune interface, where brain an

200 surrounding large veins draining toward the dural sinuses on fluid-attenuated inversion recovery in

201 ctor CT venography depicted thrombosis of 98 dural sinuses or jugular bulbs in 57 (40.7%) of the 140

202 Thrombosed dural sinuses were found in 24/31 (77.4%) cases, thrombo

203 meninges, though are concentrated around the dural sinuses, and have a unique transcriptional profile

204 ebrospinal fluid (CSF) accumulate around the dural sinuses, are captured by local antigen-presenting

205 and function of the tissues surrounding the dural sinuses, or the parasagittal dural (PSD) space.

206 rospinal fluid barrier situated close to the dural sinuses, the site of recently discovered CNS lymph

207 ered functional lymphatic vessels lining the dural sinuses.

208 We investigated if noxious dural stimulation evokes sensitization of second-order n

209 al activation in the rat showed that noxious dural stimulation induced a 3- to 4-fold increase in the

210 acial and hind-paw allodynia associated with dural stimulation is a useful surrogate of pain associat

211 he facilitatory effect of GON stimulation on dural stimulation suggests a central mechanism at the se

212 The responses to dural stimulation were analysed before and after stimula

213 3 consecutive days of restraint stress or to dural stimulation with the proinflammatory cytokine inte

214 ould also not be observed at any time during dural stimulation.

215 al nerve (GON) were studied before and after dural stimulation.

216 Topical application on the dural surface of the auditory midbrain in mouse suppress

217 two of 25 patients (8%; 95% CI: 0, 19) had a dural tear only, and none had an underlying ruptured men

218 included patients with SIH due to a ventral dural tear who underwent epidural patching.

219 oid outpouching herniating through a lateral dural tear, distinct from a meningeal diverticulum, whic

220 Reoperation, operative time, dural tears, and PROMs did not differ significantly.

221 ntraoperative data were reviewed for lateral dural tears, arachnoid outpouching, and ruptured spinal

222 owever, its effectiveness in sealing ventral dural tears, particularly in chronic cases with organize

223 cal parameters (e.g., overall complications; dural tears, surgical site infections, reoperation), per

224 raditional patching for treatment of ventral dural tears.

225 Specifically, no dural thickening or intracranial enhancing lesion was id

226 Additionally, the extent of dural thrombosis was overestimated at 2D MR venography i

227 al context was evaluated in postmortem human dural tissue.

228 Tensile testing demonstrated that this dural tough adhesive (DTA) exhibited greater toughness w

229 siologically analgesic, are known to inhibit dural trigeminovascular nociceptive responses.

230 Dural vascular malformations are often elusive on all cr

231 Our knowledge of the dural vasculature has been limited to pathological condi

232 dilatation in pial arteries, pial veins, or dural veins.

233 This paradigm is exemplified by the dural venous sinus IgA defense system, where the antibod

234 raniosynostosis and mutations in TWIST1 have dural venous sinus malformations.

235 T owing to the presence of a fracture near a dural venous sinus or jugular bulb or a high index of cl

236 d only if there is a fracture extending to a dural venous sinus or jugular bulb.

237 eutic approach for a subset of IIH patients: dural venous sinus stenting.

238 e astronauts, but the impact on intracranial dural venous sinus structures remains unknown.

239 iffuse subarachnoid hemorrhage and extensive dural venous sinus thrombosis involving the superior sag

240 No dural venous sinus thrombosis was detected for any astro

241 Dural venous sinus volumes before and after spaceflight.

242 'Partial forms' lack significant shared dural venous sinuses (SDVS) and 'Total forms' with SDVS

243 of MLVs in mice and humans that aligned with dural venous sinuses but not with nasal CSF outflow, and

244 we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial

245 pography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lympha

246 hatic vessels in close anatomic proximity to dural venous sinuses, required for a functional meningea

247 d, as a consequence of thrombosis within the dural venous sinuses.

248 e rat trigeminal ganglion that innervate the dural venous sinuses.

249 transporting cerebrospinal fluid (CSF) into dural venous sinuses.

250 These cells are positioned adjacent to dural venous sinuses: regions of slow blood flow with fe

251 ure (ICP) during locomotion, indicating that dural vessel constriction was not caused passively by co

252 Dural vessel constrictions did not mirror the large incr

253 that, in the awake animal, the diameters of dural vessels are regulated dynamically during behavior

254 To better understand the dynamics of dural vessels during behavior, we used two-photon laser

255 To study how behaviorally driven dynamics of dural vessels might be altered in pathological states, w

256 luntary locomotion drove the constriction of dural vessels, and the dynamics of these constrictions c

257 ot block locomotion-induced constrictions in dural vessels.

258 Immunostaining for CGRP in dural wholemounts revealed a network of fibers extending

259 mplanting a synthetic, flexible, transparent dural window for chronic optical access to the neocortex