ライフサイエンスコーパス: early childhood

1 nt of autoantibodies against (pro)insulin in early childhood.

2 involved particularly in top-down control in early childhood.

3 e evaluated, especially if symptoms occur in early childhood.

4 Thus, prevention efforts should start in early childhood.

5 is a unique clonal hematopoietic disorder of early childhood.

6 xposures based on viruses circulating during early childhood.

7 er care intervention or care-as-usual during early childhood.

8 Epilepsy is common in early childhood.

9 the peak incidence of cerebellar tumours in early childhood.

10 rs among young adults treated for PCG during early childhood.

11 of morbidity after traumatic brain injury in early childhood.

12 and epilepsy, ultimately leading to death in early childhood.

13 urodevelopmental impairment and four died in early childhood.

14 t in a life-threatening disease phenotype in early childhood.

15 ted smoking in childhood and, especially, in early childhood.

16 racterized by neurodegeneration and death in early childhood.

17 mothers beyond the perinatal period and into early childhood.

18 n intact epithelial/epidermal barrier during early childhood.

19 is the most common cause of food allergy in early childhood.

20 th egg allergy, which had been present since early childhood.

21 utism-like symptoms that affect girls during early childhood.

22 stigate the stability of associations across early childhood.

23 most severe form of inherited retinopathy in early childhood.

24 r; 1.5%) and late (<3 yr; 4.1%) onset during early childhood.

25 odds for late respiratory morbidities during early childhood.

26 cal signs of late respiratory disease during early childhood.

27 YKL-40 levels) are associated with asthma in early childhood.

28 that this phenomenon has already matured by early childhood.

29 lower cognitive test scores measured during early childhood.

30 th increased risk of harm to the fetus or in early childhood.

31 s a rare and aggressive stem cell disease of early childhood.

32 chanisms could promote science engagement in early childhood.

33 to a broad array of allergenic molecules in early childhood.

34 ith adiposity gain and risk of overweight in early childhood.

35 health and well-being of HEU children during early childhood.

36 CS and infection-related hospitalisation in early childhood.

37 n 4 had a history of asthma-like symptoms in early childhood.

38 lopmental changes in sleep and memory during early childhood.

39 s that modify AD incidence and prevalence in early childhood.

40 ted diseases of adulthood often originate in early childhood.

41 lar dystrophy and affects boys in infancy or early childhood.

42 ring abdominal adiposity (AA) in infancy and early childhood.

43 f GM and white matter were slower throughout early childhood.

44 s (IHs) are the most common benign tumors in early childhood.

45 om a process of intuitive theory-building in early childhood.

46 ease mechanisms with asthma-like symptoms in early childhood.

47 fication is common after IOL implantation in early childhood.

48 rovirus infections in children from birth to early childhood.

49 posure was associated with delayed growth in early childhood.

50 What maximizes instructional impact in early childhood?

51 on showed no association with asthma through early childhood (0-6 years) when analyzed as any sensiti

52 seroclearance occurred predominantly in the early childhood, 20-24 and 35-39 year age groups.

53 n with CMT1A progressed consistently through early childhood (3-10 years) and adolescence (11-20 year

54 ional light on why sleep is important during early childhood, a period of substantial brain developme

55 anics (aOR = 6.42, 95% CI = 1.93-21.41) with early childhood AD were more likely to have persistent A

56 We observed null associations for boys and early-childhood adiposity measures.

57 e of healthy adults (n=30) with a history of early childhood adversity, and a control group (n=30) wi

58 c conditions experienced in utero and during early childhood affect educational attainment at ages 12

59 splasia (BPD) and respiratory disease during early childhood after preterm birth, we performed a pros

60 to identify shunt-related differences during early childhood after staged surgical palliations using

61 nt a role after transplant as it once did in early childhood, allowing a more complete restoration of

62 levels were in the lowest tertile, a higher early-childhood alpha-T level was associated with better

63 ult acute myeloid leukemia (AML) but rare in early childhood AML.

64 ifferent age groups including fetus, infant, early childhood and adult.

65 ICE measures during early childhood and adulthood approximated racial/ethnic

66 We assessed whether early childhood and adulthood experiences of neighborhoo

67 Findings support independent effects of early childhood and adulthood neighborhood privilege on

68 is disorder, leading to abnormal function in early childhood and adulthood.

69 The human gut microbiome develops over early childhood and aids in food digestion and immunomod

70 equality was greater among men and peaked in early childhood and at age 40-49 years.

71 associations between H. pylori infection in early childhood and atopy and reported allergic disorder

72 =3 mo may be associated with rapid growth in early childhood and body composition in young adulthood.

73 ences in the communication of the science of early childhood and brain development and our recommenda

74 -tissue sarcomas were diagnosed beginning in early childhood and continued well into adulthood, reach

75 severe hypomyelination present in infancy or early childhood and develop severe neurological deficits

76 define phenotypes of atopic sensitization in early childhood and examine their association with aller

77 ndemic areas, initial infection can occur in early childhood and following a recurrent episodes, it p

78 Despite initiation of ART in early childhood and good viral suppression at the time o

79 y and its associated anemia in pregnancy and early childhood and in characterizing states of iron rep

80 an herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodefic

81 tively associated with children's BMI during early childhood and particularly with higher fat mass.

82 ng disorder that often starts manifesting in early childhood and peaks in onset during adolescence.

83 justed odds ratios (aORs) of AD incidence at early childhood and persistence at mid-childhood.

84 ciles, but a significant gradient emerged in early childhood and reached 12 kg by 18 years of age.

85 Humans are leanest during early childhood and regain body fat in later childhood.

86 hereas girls start foraging wild plants from early childhood and spend more time in domestic activiti

87 od pressure among preterm children emerge in early childhood and that neighborhood SES accounts for a

88 identify different rhinitis trajectories in early childhood and their predictors and allergic associ

89 he frequency of physical aggression peaks in early childhood and then decreases until old age.

90 n 25,000 births, has an onset of symptoms in early childhood and typically is fatal by 20-30 years of

91 Paraoxonase 1 gene (PON1) that persisted in early childhood and was attenuated in mid-childhood bloo

92 arthritis and inflammatory bowel disease in early childhood, and a common genetic variant increases

93 ongest evidence is available for infancy and early childhood, and additional studies in older childre

94 n with the seasonal influenza vaccine during early childhood, and identify potential molecular correl

95 lated DNAmAge and age acceleration at birth, early childhood, and midchildhood based on the IlluminaH

96 topic eczema onset is described primarily in early childhood, and the frequency and characteristics o

97 ioural and emotional problems often start in early childhood, and this might be particularly importan

98 structure and function from infancy through early childhood, and this significantly influences cogni

99 ed to different temperatures in utero and in early childhood, and we estimate flexible regression mod

100 or adolescent remission or the correction of early childhood anomalies with a convergence toward typi

101 Early childhood antibiotic exposure induces changes in g

102 Very early childhood appears to be a sensitive period when ex

103 results suggest that learning systems during early childhood are constructed to permit modification b

104 financial losses due to growth faltering in early childhood are not available.

105 owth and neurobehavioural development during early childhood are often assumed to have common causes

106 nfections, enteropathy and undernutrition in early childhood are preventable risk factors for child d

107 However, data on dietary taste patterns in early childhood are scarce.

108 ntal milestones and associated behaviours in early childhood are, therefore, likely innate and univer

109 y-old transgender children (n = 317) who, in early childhood, are identifying and living as a gender

110 Our results further underscore early childhood as an important developmental period for

111 fined condition that manifests in infancy or early childhood as deficits in communication skills and

112 These findings suggest that poverty in early childhood, as assessed by at least one measure, ma

113 that the microbiota's link to JIA begins in early childhood, as early life events that influence the

114 d the hypothesis that poverty experienced in early childhood, as measured by income-to-needs ratio, h

115 These results suggest a novel mechanism of early childhood asthma and demonstrates the importance o

116 Most children vaccinated during early childhood available for sampling maintained seropo

117 Interestingly, it is not until early childhood (before 5 years of age) that the two exp

118 dy mass index (BMI) peak characteristics and early childhood BMI are emerging markers of future obesi

119 infancy BMI peak characteristics and higher early childhood BMI.

120 oid/rhabdoid tumor (AT/RT) is an aggressive, early-childhood brain tumor without standard effective t

121 l disorders such as ADHD, typically onset in early childhood but can persist into adult life; the sam

122 D); that is, they were diagnosed with ASD in early childhood but have no current ASD symptoms.

123 e surviving not only through their Fontan in early childhood, but also into adolescence and young adu

124 Celiac disease is often diagnosed in early childhood, but some patients receive a diagnosis l

125 shared environmental factors was greatest in early childhood, but these effects remained present unti

126 ition (BI) is a temperament characterized in early childhood by distress to novelty and avoidance of

127 Visual impairment (VI) in early childhood can significantly impair development.

128 ietary patterns from ages 6 to 12 months and early childhood caries (ECC) at age 2 to 3-years.

129 in preschool children in the United States, early childhood caries (ECC) has a profound impact on a

130 Early childhood caries (ECC) is a chronic disease affect

131 Early childhood caries (ECC) is a largely preventable co

132 queried electronic dental records to assess early childhood caries (ECC) status using highest decaye

133 tionship between prolonged breastfeeding and early childhood caries (ECC), but the evidence to date i

134 nt and outcome prediction, as they relate to early childhood caries (ECC)-a common complex disease wi

135 merica suffer from a higher degree of severe early childhood caries (S-ECC) than the general populati

136 one of the highest reported rates of severe early childhood caries (S-ECC).

137 e relationship between dietary practices and early childhood caries in a birth cohort of Australian p

138 To reduce the prevalence of early childhood caries, improved efforts are needed to l

139 In early childhood caries, Streptococcus mutans and Candida

140 s is often detected with Candida albicans in early childhood caries.

141 plaque-biofilms from children affected with early-childhood caries, a prevalent and costly oral dise

142 ive neurodegenerative disorder presenting in early childhood, caused by an inherited deficiency of th

143 urodegenerative lysosomal storage disease of early childhood, caused by mutations in the CLN1 gene, w

144 ex structure and function, such that without early childhood cochlear-implant, profoundly deaf childr

145 reased the risk of wheeze or food allergy in early childhood compared with vaginal delivery and wheth

146 uential allergy and respiratory disorders in early childhood contributes enormously to the burden of

147 Rapid-growth patterns in early childhood could be a mediating link between infant

148 ailable for recall on influenza challenge in early childhood could possibly contribute to early impri

149 did not identify a protective association of early childhood cow's milk volume or fat consumption wit

150 gut microbiome development using integrated early childhood data sets collected in the DIABIMMUNE st

151 e brain and the heart, eventually leading to early childhood death.

152 Early childhood depression is associated with anhedonia

153 Early childhood deprivation is associated with higher ra

154 Early childhood development (ECD) programmes can help ad

155 Despite progress, early childhood development (ECD) remains a neglected is

156 of this Series) and increasing commitment to early childhood development (Paper 1 of this Series), sc

157 Services and interventions to support early childhood development are essential to realising t

158 nition of the damaging effects of poverty on early childhood development has fueled an interest in in

159 ough the evidence base for the importance of early childhood development has grown, the research is d

160 provide a comprehensive updated analysis of early childhood development interventions across the fiv

161 nship between maternal age at childbirth and early childhood development outcomes in Indigenous and n

162 We aimed to integrate an early childhood development programme into government cl

163 Early childhood development programmes vary in coordinat

164 years of age, thereby supporting its role in early childhood development, and policy change toward MM

165 s paper, the first in a three part Series on early childhood development, we examine recent scientifi

166 mplement interventions, at scale, to promote early childhood development.

167 cientific progress and global commitments to early childhood development.

168 d apply this rationale to other phenomena in early childhood development.

169 nd disadvantaged families, could also reduce early childhood developmental inequalities.

170 esence of specific sensitization patterns in early childhood differentially associated with developme

171 tput occurs in utero, during infancy, and in early childhood, diminishing throughout life.

172 places recent neurodevelopmental research on early childhood disruptive behavior within the historica

173 its anatomy has not yet been well studied in early childhood due to the lack of available imaging dat

174 trong contribution to theory and practice in early childhood education, and a strong contribution to

175 er siblings in education, and she focused on early childhood education.

176 nding of long-term metabolic consequences of early childhood enteric infections.

177 ated high myopia phenotype is important, and early childhood examination with additional close follow

178 Adversity in early childhood exerts an enduring impact on mental and

179 lems in adulthood may be rooted partially in early childhood exposure to unpredictable events and env

180 th correlated early-life exposures including early childhood farm animal contact and raw milk consump

181 linear increase in arterial growth rates in early childhood, followed by plateauing to adult sizes i

182 We focus on two key populations: children in early childhood (from birth to age 6) and parents in ear

183 In the lowest tertile of early-childhood gamma-T, children with a higher alpha-T

184 ternal body size, birth size, and infant and early childhood growth during 3 time periods (0-4 months

185 pregnancy BMI, GWG, and percentile change in early childhood growth with BMI in daughters at midlife.

186 sults support potential associations between early-childhood gut microbiome and social behaviors.

187 e to the farming environment in utero and in early childhood had little or no association with asthma

188 Poor growth in early childhood has been associated with increased risk

189 Early childhood has emerged as a critical period when th

190 its caused by mismatched binocular vision in early childhood has predominantly focused on circuits in

191 fects of prenatal and postnatal exposures in early childhood have been limited.

192 els during the initiation phase of asthma in early childhood have not been reported.

193 Allergic skin inflammation often presents in early childhood; however, little is known about the even

194 From infancy to early childhood, hunter-gatherer children learn mainly b

195 accumbens, while depression severity during early childhood (i.e., preschool) was associated with mo

196 e most important viral cause of pneumonia in early childhood (ie, younger than 2 years), responsible

197 actors may also influence H3N2 VE, including early childhood imprinting and repeated vaccination, but

198 rences in blood pressure trajectories across early childhood in a sample of African-American and Euro

199 ts who were exposed to severe deprivation in early childhood in the Romanian orphanages of the Ceause

200 study on incident physician-diagnosed AD in early childhood including 451 cases and 451 controls.

201 Respiratory viral infection in early childhood, including that from respiratory syncyti

202 on to common food allergens and allergies in early childhood independent of eczema severity.

203 ion is believed to play in important role in early childhood infection with Kaposi sarcoma-associated

204 Early childhood infection with parainfluenza virus or re

205 wever, there is little known about how these early childhood influenza exposures shape CD4 T cell rea

206 tudies of the B cell repertoire suggest that early childhood influenza infections profoundly shape la

207 extends evidence of LOC specialization from early childhood into infancy and earlier than developmen

208 Early childhood is a critical period for development, an

209 Accelerated growth in early childhood is an established risk factor for later

210 25(OH)D deficiency in early childhood is associated with increased risk for pe

211 Undernutrition during intrauterine life and early childhood is hypothesised to increase the risk of

212 Here, we show that emotion understanding in early childhood is more sophisticated than previously be

213 and subsequent otitis media (OM) episodes in early childhood is unclear.

214 icits.SIGNIFICANCE STATEMENT Hearing loss in early childhood leads to impairments in auditory percept

215 From early childhood, learning occurs mainly in playgroups an

216 The median early-childhood level was 25 muM (interquartile range =

217 raeli-born controls or those arriving during early childhood, likely because of environmental and lif

218 The causes of early childhood linear growth faltering (known as stunti

219 ho were born in 2001 and participated in the Early Childhood Longitudinal Study-Birth Cohort.

220 Early childhood malnutrition affects 113 million childre

221 Early childhood malnutrition entails long-lasting epigen

222 Our aim was to identify the early childhood manifestations of this liability in a UK

223 findings demonstrate a significant effect of early childhood maternal support on hippocampal volume g

224 to examine associations of protein intake in early childhood (median 3.2 y) with height, IGF-I, and m

225 l and central adiposity in 1,006 children in early childhood (median, 3.2 years) and 876 in mid-child

226 Mutations in POLG can cause early childhood mitochondrial DNA (mtDNA) depletion synd

227 Malaria causes tremendous early childhood morbidity and mortality, providing an ur

228 onchopulmonary dysplasia that best predicted early childhood morbidity categorized disease severity a

229 cination in pregnancy increases the risk for early childhood morbidity in offspring.

230 We detected no increased risk for early childhood morbidity.

231 heal disease and an important contributor to early childhood mortality, malnutrition, and growth falt

232 oeal disease and an important contributor to early childhood mortality.

233 heal disease and an important contributor to early-childhood mortality.

234 e most severe forms of PID are identified in early childhood, most patients present in adulthood, typ

235 content in blood collected at birth (n=306), early childhood (n=68; 2.9 to 4.9 y), and midchildhood (

236 trategies such as for treatment of inherited early childhood neurodegenerative diseases.

237 ncentrations were negatively associated with early childhood neurodevelopment scores in our study.

238 es of survival among these infants relate to early childhood neurodevelopmental outcomes.

239 ears is associated with an increased risk of early childhood obesity.

240 irst Plasmodium falciparum infections during early childhood on the induction of innate and adaptive

241 eatment and should be mainstream practice in early childhood onset epilepsy.

242 FAHN/SPG35 manifests with early childhood onset predominantly lower limb spastic t

243 mia, and optic atrophy (PEHO) syndrome is an early childhood onset, severe autosomal recessive enceph

244 ciated with chronic isolated proteinuria and early childhood onset.

245 We present a case of early childhood-onset pork-cat syndrome possibly due to

246 l in nature and should be reclassified as an early-childhood-onset neurodevelopmental condition in DS

247 Such a roadmap is particularly relevant for early-childhood-onset neurodevelopmental conditions, whi

248 gamma-tocopherol (gamma-T) isoform levels in early childhood or in utero are associated with childhoo

249 Equitable early childhood policies and programmes are crucial for

250 Moreover, chemoprevention during early childhood prevented the development of dysfunction

251 Early childhood protein intake may contribute to program

252 We hypothesized that early childhood protein intake programs later growth.

253 ed by child sex and examined associations of early childhood protein intake with mid-childhood and ea

254 ession of exercise-induced cardiac arrest in early childhood refractory to conventional therapy.

255 was associated with preterm delivery in both early childhood (relative risk (RR) = 1.12, 95% confiden

256 onship with late respiratory outcomes during early childhood remains uncertain.

257 Early childhood represents a dynamic period for the inte

258 Early childhood represents a pivotal period amenable to

259 mosome gene FIGF (c.352 G>A) associated with early childhood respiratory deficiency.

260 ool age and early adolescence and suggest an early childhood sensitive period for these effects.

261 Individuals with music training in early childhood show enhanced processing of musical soun

262 nd supporting the relative importance of the early childhood social environment.

263 This article looks at both nutrition and early childhood stimulation interventions as part of an

264 mortality worldwide, continued high rates of early childhood stunting have put the global applicabili

265 eas CMT2A appeared to progress faster during early childhood than adolescence (mean difference, 10.0;

266 r were not more likely to be hospitalized in early childhood than unexposed children (hospitalization

267 r were not more likely to be hospitalized in early childhood than unexposed children (hospitalization

268 ted as part of a large longitudinal study of early childhood, the Effective Early Education Experienc

269 e track the development of this ability from early childhood through adolescence and adulthood.

270 etabolic risks may be established already in early childhood; thus, our data provide a further basis

271 The neurocranium changes rapidly in early childhood to accommodate the growing brain.

272 valences of nut sensitizations decrease from early childhood to adolescence.

273 group comprising different age classes, from early childhood to adult, with a majority of children.

274 arget reducing maternal PTSD symptoms during early childhood to enhance very preterm children's intel

275 s utilizing randomized enhancement trials in early childhood to inform public health strategies on pr

276 and cysts (LCC), presenting at any age from early childhood to late adulthood.

277 to complex intention-based reciprocity from early childhood to young adulthood.

278 g practices on changes in dental caries from early childhood to young adulthood.

279 aimed to evaluate dietary taste patterns in early childhood, to examine their tracking between the a

280 Among boys, however, each 10-g increase in early childhood total protein intake was associated with

281 Vertical (mother-to-child) and horizontal early childhood transmission are the main routes of HBV

282 Rate ratios of hospitalization in early childhood until 5 years of age.

283 ed subgroups of distinct BMI trajectories in early childhood using latent class trajectory modeling.

284 Mean protein intake in early childhood was 58.3 g/d.

285 first transition into income poverty during early childhood was associated with an increase in the r

286 ty of MMc to predict malaria outcomes during early childhood was evaluated in longitudinal models.

287 s recorded in the year after delivery and in early childhood was then assessed using multivariable Co

288 PFNA) concentrations in children assessed in early childhood were 5.6 (4.1-7.7), 24.8 (18.4-33.9), 2.

289 Asthma-like symptoms in early childhood were also associated with a reduced FEV(

290 DNAmAge and age acceleration at birth and early childhood were not associated with midchildhood al

291 Although early childhood wheeze is common, persistent asthma is l

292 f childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response.

293 Symptoms of ASD typically occur during early childhood, whereas most symptoms characteristic of

294 ic inflammatory disease and vasculitis since early childhood, which were refractory to classical trea

295 re were no associations of protein intake in early childhood with any of the mid-childhood outcomes.

296 The three patients presented from early childhood with combined immunodeficiency and sever

297 omal dominant optic atrophy (ADOA) starts in early childhood with loss of visual acuity and color vis

298 ing principles of adaptation to adversity in early childhood with molecular, cellular, and whole orga

299 es FF and liking for vegetables and fruit in early childhood with the use of a twin design.

300 utcomes and neurodevelopmental impairment in early childhood, with a resultant secular trend away fro