ライフサイエンスコーパス: early endosome

1 docytosis and low-pH-triggered fusion in the early endosome.

2 alization of the receptor was found with the early endosome.

3 found that both of them are localized in the early endosome.

4 ulting in an accumulation of the TfR1 in the early endosome.

5 nding of PE molecules in the membrane of the early endosome.

6 ggesting an important role for TSPAN9 in the early endosome.

7 g cells, and were delivered to DOPr-positive early endosomes.

8 egulating the formation of branched actin on early endosomes.

9 ork, whereas others suggested an origin from early endosomes.

10 PN-1 greatly reduced Lifeact accumulation on early endosomes.

11 tive trafficking between plasma membrane and early endosomes.

12 s, and LPS is released into the cytosol from early endosomes.

13 cking to Rab7-labeled late endosomes but not early endosomes.

14 lays long lifetimes, all features typical of early endosomes.

15 b5-GTP, and its recruitment to Rab5-positive early endosomes.

16 33 deubiquitinate agonist-activated GCGRs at early endosomes.

17 tine, unlike retromer components that act on early endosomes.

18 the cytoplasmic domain of beta1 integrin in early endosomes.

19 -operate to support bi-directional motion of early endosomes.

20 traffic of HAS3 from the plasma membrane to early endosomes.

21 ng Hook protein as general motor adapters on early endosomes.

22 periphery and reduced virion localization to early endosomes.

23 zed with both NOD1 and RIP2 in EEA1-positive early endosomes.

24 s essential for in vitro homotypic fusion of early endosomes.

25 sosomes because of a failure to recycle from early endosomes.

26 microtubule-based long-distance motility of early endosomes.

27 t the MHC-II-Ii complex away from March-I(+) early endosomes.

28 AP3 localized to the trans-Golgi network and early endosomes.

29 te receptor to become trapped in clusters of early endosomes.

30 sorted into recycling tubules emerging from early endosomes.

31 lysosomes while *0402 molecules traffic into early endosomes.

32 in-dependent endocytosis and accumulation of early endosomes.

33 responsible for terminating Ras activity on early endosomes.

34 olymers colocalized with transferrin-labeled early endosomes.

35 of early endosome antigen 1 (EEA1)-positive early endosomes.

36 cropinosomes often interacting with EEA-1(+) early endosomes.

37 d to only partially inhibit ASLV fusion with early endosomes.

38 of the synaptobrevin-like v-SNARE Snc1 from early endosomes.

39 crotubules, but were generally distinct from early endosomes.

40 ondrial quality control mediated by Rab5 and early endosomes.

41 leading to its accumulation in EEA1-positive early endosomes.

42 upports the formation of F-actin networks on early endosomes.

43 ion of DISLL enhances the exit of BACE1 from early endosomes, a pathway mediated by GGA1 and retromer

44 d that retrograde cargo TGN-38 is trapped in early endosomes after depletion of SNX-3 (a retromer com

45 APPL1, but not early endosome Ag 1, deficiency impairs IRF3 target gene

46 lmitoylated peptide also passed rapidly from early endosome Ag-1-positive endosomes to RAS-related GT

47 cipates in the trafficking and tubulation of early endosomes along microtubules.

48 here that peroxisomes move by hitchhiking on early endosomes, an organelle that directly recruits the

49 was also detected in the trans-Golgi network/early endosome and at the plasma membrane.

50 both an increased stability at the pH of the early endosome and efficient degradation at lower pH in

51 enin also prolonged TNF association with the early endosome and enhanced caspase-8 activation in apop

52 w glucose variation-induced stress regulated early endosome and lysosome formation via endocytosis of

53 s accumulate abnormal endosomes positive for early endosome and recycling endosome markers that are n

54 mannose-phosphate receptor-positive tubular early endosomes and a reduction in Notch signaling capac

55 iptional regulator RNF11, which localizes to early endosomes and appears additionally in the cell nuc

56 USP2a localizes to early endosomes and associates with EGFR, stabilizing th

57 ermal growth factor receptor (EGFR) from the early endosomes and degradation of EGFR after EGF stimul

58 ARRDC3 primarily localizes to EEA1-positive early endosomes and directly interacts with the beta2AR

59 by finding that F13 was largely confined to early endosomes and failed to colocalize with B5 in the

60 by tubular-vesicular carriers that bud from early endosomes and fuse with a corresponding acceptor c

61 transport in which peroxisomes hitchhike on early endosomes and identify PxdA as the novel linker pr

62 rs from the TGN, perinuclear accumulation of early endosomes and impaired transferrin endocytosis.

63 overexpression reduced NTR1 localization in early endosomes and increased expression of proteins rel

64 tination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decrea

65 ation-induced stress-stimulated formation of early endosomes and lysosomes.

66 new tools to quantify peripherally localized early endosomes and measure the rapid recycling of integ

67 e proteins, IFITMs), on the pH regulation in early endosomes and on the efficiency of acid-dependent

68 PACS-2 co-localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recyc

69 osphate (PIP3) on B cell receptor-containing early endosomes and proper sorting into the MHC class II

70 ted GCGR endocytic trafficking through Rab5a early endosomes and Rab4a recycling endosomes, but also

71 mine/siRNA polyplexes initially appearing in early endosomes and rapidly moving to other compartments

72 nonical Wnt signaling proteins are housed on early endosomes and recruit nucleation sites to branch p

73 RNAs are internalized by a specific class of early endosomes and show preferential association with e

74 2A, whereupon it quickly translocates to the early endosomes and subsequently routes to the lysosomes

75 PTH) stimulation, the PTHR internalizes into early endosomes and subsequently traffics to the retrome

76 hat KIF13A and KIF13B bind preferentially to early endosomes and that KIF1A and KIF1Bbeta bind prefer

77 ed that Leu-725 enhances PC7 localization to early endosomes and that, together with Glu-719 and Glu-

78 We localized AFTPH to early endosomes and the trans-Golgi network (TGN) in uns

79 now show that HCMV is initially retained in early endosomes and then moves sequentially to the trans

80 cits in the Rab5/EEA1 dependent formation of early endosomes and thus the recycling of SVs.

81 d activation of Rab5 to cause enlargement of early endosomes and to disrupt retrograde axonal traffic

82 ), suggesting brief receptor localization in early endosomes and transfer to late endosomes.

83 pathway used, all these viruses converge in early endosomes and use multivesicular bodies for cell e

84 resent in all endocytic compartments between early endosomes and vacuoles, shares features of Vam3p a

85 ation by two Sec1/Munc-18 proteins, Vps45 in early endosomes and Vps33 in early and late endosomes/va

86 ssemblies of clathrin and caveolin, Rab5a in early endosomes, and alpha-actinin, often in relationshi

87 due to delayed transit time of EGFR through early endosomes, and cells preferentially proliferate.

88 Both FhipA and FtsA associate with early endosomes, and interestingly, while FtsA-early end

89 beta1 integrin is internalized, traffics to early endosomes, and is returned to the plasma membrane

90 the Golgi/trans-Golgi network (TGN), in the early endosomes, and on the plasma membrane, yet the cel

91 rins, attenuates integrin translocation into early endosomes, and reduces delayed mitogen-activated p

92 ed NTR1 traffics from the plasma membrane to early endosomes, and then recycles.

93 At CCVs, CvpB binding to early endosome- and autophagy-derived PI(3)P and the con

94 t complex after stimulation with EGF, as was early endosome antigen 1 (EEA1), a factor responsible fo

95 n HSP, Mecp2 KO neurons have lower levels of early endosome antigen 1 (EEA1), a protein involved in A

96 ed colocalization of G. bethesdensis with an early endosome antigen 1 (EEA1)-positive compartment, fo

97 ripheral Rab5 puncta and a reduced number of early endosome antigen 1 (EEA1)-positive early endosomes

98 27a), and, to some extent, early endosomes (early endosome antigen 1), indicating a lack of integrit

99 or in early endosomes associated with EEA-1 (early endosome antigen 1).

100 es transient oxidation on or close to RAB5+/ early endosome antigen 1- endosomes.

101 ero-oligomers including Bax, Troponin C, and Early Endosome Antigen 1.

102 ed, the transit time of EGF receptor through early endosomes are accelerated, mitogenic MAPK-ERK1/2 s

103 Early endosomes are essential for regulating cell signal

104 Early endosomes are transported bidirectionally by cytop

105 fficking of plasma membrane receptors to the early endosomes as well as inhibit phagocytosis of the b

106 subcellular localization of the receptor in early endosomes associated with EEA-1 (early endosome an

107 imultaneous time-lapse imaging, we find that early endosome-associated PxdA localizes to the leading

108 A (A. nidulans FTS homologue) disrupts HookA-early endosome association and inhibits early endosome m

109 association requires FhipA and HookA, FhipA-early endosome association is independent of HookA and F

110 ith early endosomes, thus differing from the early endosome association of the cargo adapter HookA (H

111 rly endosomes, and interestingly, while FtsA-early endosome association requires FhipA and HookA, Fhi

112 in endothelial cells, possibly by fusing in early endosomes at higher pH or by other, unknown mechan

113 s of vezA causes an abnormal accumulation of early endosomes at the hyphal tip, where microtubule plu

114 early endosome clustering, and Rab5-positive early endosomes become smaller and scattered.

115 interaction between dynein-dynactin and the early-endosome-bound HookA is significantly decreased.

116 P21 dynamically localizes with EEA1-positive early endosomes but is also found in EEA1-negative endos

117 with the model that VSV initiates fusion in early endosomes but releases its core into the cytosol a

118 ansports various cellular cargoes, including early endosomes, but how dynein binds to its cargo remai

119 osome-related organelles obtain cargoes from early endosomes, but the fusion machinery involved and i

120 loss of VezA, HookA associates normally with early endosomes, but the interaction between dynein-dyna

121 EGFR-AMSH was efficiently internalized into early endosomes, but, importantly, the rates of ligand-i

122 t a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in

123 some maturation appears to control a pool of early endosomes capable of fusing with autophagosomes wh

124 nein is able to physically interact with the early endosome cargo, but dynein-mediated early endosome

125 Strip knockdown disturbs the early endosome clustering, and Rab5-positive early endos

126 Our data suggest that TSPAN9 modulates the early endosome compartment to make it more permissive fo

127 ed in the accumulation of EEA1/Rab5-positive early endosomes concomitant with a decrease in Rab7-posi

128 X, an increased amount of ZAP70 localized to early endosomes consistent with the role of monoubiquiti

129 TSPAN9 was localized to early endosomes containing internalized alphavirus, and

130 cells resulted in prolonged EGFR activity in early endosomes, delayed EGFR degradation, increased EGF

131 hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog

132 In endocytosis and early endosome development, net VPS34CII-catalyzed PI3P

133 This defective transit from the early endosome disrupts eventual recycling of beta1 inte

134 pergillus nidulans, as a factor critical for early endosome distribution.

135 rom a genetic screen for mutations affecting early-endosome distribution in Aspergillus nidulans, we

136 genome-wide screen for mutants defective in early-endosome distribution.

137 d binding protein 27a), and, to some extent, early endosomes (early endosome antigen 1), indicating a

138 ssociated with the trans-Golgi network (TGN)/early endosome (EE) and tracked along filamentous actin,

139 s required for maturation of TLR3 containing early endosome (EE) into LE, the compartment that fuses

140 ssential for kinesin-3- and dynein-dependent early endosome (EE) motility in the fungus Ustilago mayd

141 rt between the trans-Golgi network (TGN) and early endosome (EE) requires Drs2, a phospholipid transl

142 Unlike B2AR, which traffics to early endosomes (EE), LHR internalizes to distinct pre-e

143 n caused significant accumulation of ASOs in early endosomes (EEs) and reduced localization in LEs an

144 , and the endoplasmic reticulum (ER) rely on early endosomes (EEs) for intracellular movement in a fu

145 ow that long-distance retrograde motility of early endosomes (EEs) is necessary to trigger transcript

146 Early endosomes (EEs) mediate protein sorting, and their

147 PS-ASOs exited early endosomes (EEs) rapidly after internalization and

148 enetic ablation of the Hook complex adapting early endosomes (EEs) to dynein but absolutely requires

149 hereas a Rab5a DN that blocks trafficking at early endosomes eliminated agonist-induced GCGR deubiqui

150 tein implicated in translocation of Hsc70 to early endosomes for clathrin removal during retrograde t

151 Hook homologues were found to link dynein to early endosomes for their transport.

152 n of the protein from the plasma membrane to early endosomes, for tubule formation, and for CaMV infe

153 ither for membrane scission (shibire) or for early endosome formation (Rab5, Vps45, and Rabenosyn-5).

154 lasma membrane to the lysosomal membrane via early endosome formation.

155 ly binds to and activates Rabex-5, promoting early-endosome formation.

156 l imaging suggests that MoVps17 can regulate early endosome fusion and budding as well as endocytosis

157 Phagosome-early endosome fusion required PI(3)P, yet did not depen

158 lized endosomal compartments, beginning with early endosomes harboring Rab5 and its effector EEA1.

159 that form at the PM and trans-Golgi network/early endosomes have emerged as the prominent vesicle ty

160 brane, although the TGN also functions as an early endosome in plants.

161 t from the Golgi and the trans-Golgi network/early endosome in the seed coat epidermis.

162 elevation of external pH can raise the pH in early endosomes in a cell type-dependent manner and ther

163 nd dissociation of signalling molecules from early endosomes in a dense cytoplasm with single-molecul

164 have demonstrated that RME-8 associates with early endosomes in a phosphatidylinositol 3-phosphate (P

165 t SNX27 binds several beta integrin tails in early endosomes in a PI3 (phosphatidylinositide 3)-kinas

166 n organelle distribution: Golgi outposts and early endosomes in distal dendritic branches are reduced

167 8aa transmembrane smORF peptide localised to early endosomes in Drosophila macrophages.

168 ndosomal trafficking through somatodendritic early endosomes in L1-mediated axon growth.

169 er, we discovered a second pool of syt-17 on early endosomes in neurites.

170 llular calcium rapidly decreases the size of early endosomes in primary human fibroblasts.

171 nteraction between dynein and the Hook-bound early endosomes in vivo.

172 le in cargo sorting and vesicle budding from early endosomes, in most cases leading to cargo fusion w

173 y showed a dissociation of payloads from the early endosome indicating translocation of the chimeric

174 e interaction occurs independently of dynein-early endosome interaction and requires the C-terminal d

175 h dynein and dynactin independently of HookA-early endosome interaction but dependent on the N-termin

176 HookA is a novel linker important for dynein-early endosome interaction in vivo.

177 HookA-early endosome interaction occurs independently of dynei

178 d loss of HookA significantly weakens dynein-early endosome interaction, causing a virtually complete

179 bility of RME-8 to associate with PI(3)P and early endosomes is largely abolished when residues Lys(1

180 ors of beta1/beta2-integrin recycling in the early endosome, is decreased in Klf5(Delta/Delta) haemat

181 t pHs characteristic of the plasma membrane, early endosome, late endosome, and lysosome.

182 ires sequential fusion of the phagosome with early endosomes, late endosomes, and lysosomes.

183 nto phagolysosomes by sequential fusion with early endosomes, late endosomes, and lysosomes.

184 argos, including mitochondria, Rab5-positive early endosomes, late endosomes/lysosomes, and TrkA-, Tr

185 r bacterium Ehrlichia chaffeensis resides in early endosome-like vacuoles and circumvents lysosomal f

186 in PxdA that is necessary and sufficient for early endosome localization and peroxisome distribution

187 cted contribution of the trans-Golgi network/early endosome-localized V-ATPase to vacuolar pH.

188 an cells without affecting other organelles (early endosomes, lysosomes, the Golgi apparatus, the end

189 we observed that C5b-9 colocalizes with the early endosome marker EEA1 and that, in the presence of

190 ian cells, mCherry-RavD colocalized with the early endosome marker EGFP-Rab5 as well as the PI(3)P bi

191 ized GPRC6A was mainly co-localized with the early endosome marker Rab5 and the long loop recycling e

192 RUS colocalized with the trans-Golgi network/early endosome markers.

193 We identify a specific stage of early endosome maturation that is regulated by beclin 1,

194 As early endosomes mature, the SAND-1/CCZ-1 complex acts as

195 plasma membrane as expected, but also in the early endosome membrane, and that internalized receptors

196 s and colocalizes with the Golgi membrane or early endosome membrane.

197 on of TSPAN9 inhibited virus fusion with the early endosome membrane.

198 AVE/SCAR and Arp2/3 regulate endocytosis and early endosome morphology in diverse tissues of C. elega

199 ements require ATP and involve bidirectional early endosome motility, indicating that microtubule-ass

200 he early endosome cargo, but dynein-mediated early endosome movement away from the hyphal tip occurs

201 kA, as a factor required for dynein-mediated early endosome movement in the filamentous fungus Asperg

202 equency but not the speed of dynein-mediated early endosome movement.

203 pA complex are important for dynein-mediated early endosome movement.

204 ion, causing a virtually complete absence of early endosome movement.

205 ookA-early endosome association and inhibits early endosome movement.

206 ions are amphisomes formed through fusion of early endosomes, multivesicular bodies, and early autoph

207 inding of SNX31 with beta1 integrin tails in early endosomes occurs between the FERM domain and the m

208 f function, thus affecting actin dynamics in early endosomes of BLOC-1-deficient cells.

209 RA, zfyve9) has been classically observed in early endosomes of different cells types where it regula

210 pletion did not alter the delivery of SFV to early endosomes or change their pH or protease activity.

211 ome-edited cells with nanobodies tethered to early endosomes or mitochondria changes the subcellular

212 long-range movement of peroxisomes, but not early endosomes or nuclei.

213 , Strip acts as a molecular platform for the early endosome organization that has important roles in

214 tely 5,000-fold, whereas transferrin uptake, early endosome organization, and dynein-dependent moveme

215 the phosphatidylinositol-3-phosphate pool in early endosomes; phosphatidylinositol-3,4-biphosphate an

216 somes (EE), LHR internalizes to distinct pre-early endosomes (pre-EEs) for its recycling.

217 ediated fusion between Golgi-derived SGs and early endosomes precedes the maturation of the SGs, as r

218 tion of UBAP1 leads to dysregulation of both early endosome processing and ubiquitinated protein sort

219 internalizing surface pMHC-II in March-I(+) early endosomes promotes degradation of "old" pMHC-II an

220 (a) detection of the enzyme in EEA1-positive early endosomes, Rab7-positive late endosomes/multivesic

221 ure has ever been identified at the level of early endosomes, raising a question about their role.

222 The bidirectional movement of early endosomes randomly distributes polysomes, which ma

223 ex and uncovered a new function for Vps13 in early endosome recycling and Neo1 localization.

224 We further show that the early-endosome recycling route and its control though th

225 In MDCK 3D cultures, CLIC4 is expressed on early endosome, recycling endosome and apical transport

226 that once internalized, M1 mAChRs traffic to early endosomes, recycling endosomes and late endosomes.

227 1 was recruited to the cell surface from the early endosome-recycling complex pathway, its knockdown

228 - and branched actin-mediated trafficking on early endosome regulates apical delivery during early lu

229 and alters the subcellular enrichment of the early endosome regulator RAB-5.

230 lised into early endosomes, where the master early endosome regulator Rab5b promotes STAT5 phosphoryl

231 , IFITM2 and IFITM3 localize to the late and early endosomes, respectively, as well as the lysosome.

232 Membrane microcompartments of the early endosomes serve as a sorting and signaling platfor

233 ed infection by several viruses that fuse in early endosomes (SFV, SINV, CHIKV, and vesicular stomati

234 Mutant neurons also increased Rab5+ early endosome size.

235 n and caused prolonged TLR4 retention at the early endosome, suggesting that TLR4 transport from earl

236 port than ClC-5:S244L, but co-localized with early endosomes, suggesting decreased ClC-5:R345W membra

237 Apm2 and Apm1 colocalize at Golgi/early endosomes, suggesting that they do not associate w

238 oplasmic reticulum and cis-Golgi, but not in early endosomes, suggesting the nonsense mutation affect

239 suggested that TRAM and TLR2 co-localize in early endosomes, supporting the hypothesis that signalin

240 The dynamic trans-Golgi network/early endosome (TGN/EE) facilitates cargo sorting and tr

241 NG gene, which encodes a trans-Golgi network/early endosome (TGN/EE)-localized E3 ubiquitin ligase.

242 ole required neither the trans-Golgi network/early endosome (TGN/EE)-localized vacuolar H(+)-ATPase a

243 r its recognition at the trans-Golgi network/early endosomes (TGN/EE) for vacuolar targeting.

244 Thus FhipA is more directly linked to early endosomes than HookA and FtsA.

245 Within the small group of early endosomes that move away from the hyphal tip in th

246 the retromer complex, a sorting platform on early endosomes that promotes recycling of surface recep

247 ow demonstrate that polysomes associate with early endosomes that undergo kinesin 3- and dynein-depen

248 a) antibody to be localized to Rab5-positive early endosomes, the trans-Golgi network, and subsequent

249 ch shortens the transit time of EGFR through early endosomes, thereby limiting mitogenic MAPK signals

250 ings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autoph

251 Although Rab5 is known to work on early endosomes, this study showed that Rab5B plays a ro

252 venger receptors and subsequently escape the early endosome through a pH-triggered disassembly mechan

253 In contrast, if antigens were delivered to early endosomes through CD40 or CD11c, BDCA1(+) DCs were

254 manner but are not obviously associated with early endosomes, thus differing from the early endosome

255 trafficking vesicles that dock and fuse with early endosomes, thus overriding the default pathway to

256 OC-1 to -3, mediate protein sorting from the early endosome to lysosomes and lysosome-related organel

257 he exocytosis (not endocytosis) of NHE3 from early endosome to plasma membrane.

258 in-3 complex, which transports TLRs from the early endosome to the late endolysosomal compartments.

259 mal acid hydrolases requires traffic through early endosomes to late endosomes followed by transient

260 lts is that ArfGAP3 regulates transport from early endosomes to late endosomes.

261 own about the regulators of Ag delivery from early endosomes to lysosomal compartments where the prop

262 ticipates in the conversion of Rab5-positive early endosomes to Rab7-positive late endosomes.

263 Rab14 and PI(3)P to direct the maturation of early endosomes to Rab9/CD63-containing late endosomes.

264 r trafficking via the retrograde route, from early endosomes to the Golgi apparatus.

265 h enhanced recycling of VE-cadherin-positive early endosomes to the IEJ.

266 all Rab GTPase mediating fast recycling from early endosomes to the plasma membrane, and enhanced the

267 ided evidence that retrograde transport from early endosomes to the trans-Golgi network is required f

268 cifically blocking retrograde transport from early endosomes to the trans-Golgi network.

269 x2 and found that depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosoma

270 To identify host factors required for early endosome-to-Golgi trafficking of STx2, we performe

271 Early endosome-to-Golgi transport allows the toxins to e

272 A new study investigates why directed early endosome trafficking is so frequently interrupted,

273 onstrated that the IRT1 protein localizes to early endosomes/trans-Golgi network (EE/TGN) and is cons

274 ociated mutant CHMP2B toxicity and implicate early endosome transport as a potential contributing pat

275 Here we develop a mathematical model of early endosome transport in Ustilago maydis.

276 When early endosome transport is abolished, POs and LDs drift

277 light chain, and Hook, an adaptor protein in early endosome transport.

278 s exhibit similar defects in dynein-mediated early-endosome transport and nuclear distribution.

279 equency but not the speed of dynein-mediated early-endosome transport is decreased, which correlates

280 enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response,

281 CvpB association to early endosome triggers vacuolation and clustering, lead

282 Early endosomes undergo retrograde transport (clustering

283 We show that DTX3L localizes to early endosomes upon CXCR4 activation and interacts dire

284 ed with TLR4, CD14, and dynamin into Rab5(+) early endosomes upon LPS treatment.

285 ant having decreased colocalization with the early endosome versus the Cys23 allele.

286 tive intracellular staining of lysosomes and early endosomes via subtle changes in fluorescence emiss

287 n-dependent sequestration into Rab5-positive early endosomes via the ESCRT machinery.

288 RIN3 recruited CD2AP to RAB5a-positive early endosomes via these interaction sites.

289 irmed that while VP2 is shed from virions in early endosomes, virus particles still consisting of VP5

290 The rapid transit of BACE1 S498D from early endosomes was coupled with reduced levels of amylo

291 Albumin accumulation in early endosomes was independent of FcRn-binding affinity

292 activity of Rab5, the key GTPase regulating early endosomes, was required for p75 death signaling.

293 SNX17 localizes to early endosomes where it directly binds NPX(Y/F) motifs

294 Y1 and LjVPY2 within the trans-Golgi network/early endosome, where they might function to regulate en

295 Prolactin is internalised into early endosomes, where the master early endosome regulat

296 internalize polymersomes by endocytosis into early endosomes, where they are disassembled by the low

297 of PIPKIgammai5 blocks Rab7a recruitment to early endosomes, which prevents the maturation of early

298 However, 5-NT altered the distribution of early endosomes with a concomitant impairment of reoviru

299 lipid membrane composition mimicking that of early endosomes, with PI(3)P enhancing membrane recruitm

300 arance of large TrkA puncta in enlarged Rab5-early endosomes within the cytoplasm, suggesting delayed