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1 1 inhibits expression of the major immediate-early protein.
2 ated herpesvirus (KSHV) encodes an immediate-early protein.
3 activates expression of the other immediate-early protein.
4 nd in a bovine herpesvirus 4 major immediate-early protein.
5 r BRLF1 (in epithelial cells only) immediate-early protein.
6 eleted for various combinations of immediate-early proteins.
7 ed prolonged synthesis of cellular and viral early proteins.
8 s at ND10 before the production of immediate-early proteins.
9 of virion input proteins or viral immediate early proteins.
10 and in the synthesis of immediate-early and early proteins.
11 of tumors as the result of the action of its early proteins.
12 onal activation by cytomegalovirus immediate-early proteins.
13 prolonged expression of the viral immediate early proteins.
14 early unexplored, especially against the HPV early proteins.
15 overcome by viral tegument and/or immediate-early proteins.
16 ease severity, and Th2-like responses to HPV early proteins.
17 dentified immunogenic peptides within HPV-11 early proteins.
18 ), phosphoprotein 150 (pp150), and immediate early protein 1 (IE1) immunodominant antigens into the v
20 l responses to the pp65 (UL83) and immediate early protein 1 (IE1; UL123) gene products in 16 HCMV-in
22 stratified by their baseline CMV (immediate-early protein 1)-specific CMI risk, were randomized to r
23 ized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major target
24 CMV phosphoprotein 65 (pp65)- and immediate early protein 1-specific multifunctional T-cell response
26 erized the mechanisms by which the immediate early protein 2 (IE2 or IE86), a master transcriptional
29 A family members target the UL122 (immediate early protein 2) 3' untranslated region, resulting in re
30 ervical cancers and produce the oncoprotein, early protein 6 (E6), which binds to p53 and mediates it
31 c activity is facilitated in part by the HPV early protein 6 (E6), which interacts with the E3-ligase
32 require VZV replication; the viral immediate-early protein 62 (IE62) alone was sufficient to produce
35 by the abundant expression of the immediate early protein 63 (IE63), whereas other viral proteins ha
36 lish a new feedback mechanism between IE and early proteins, a new mechanism of promoter control via
37 f CaMKK has a negligible impact on immediate-early-protein accumulation yet severely attenuates produ
38 anscriptional activators, and each immediate-early protein activates expression of the other immediat
41 cting conserved regions from each of the six early proteins and generating consensus sequences to rep
42 and initiation by isoleucine anticodon CAU; early proteins and nucleozymes were all membrane-attache
43 T) fused in frame to MmuPV1 E6 (mE6) and mE7 early proteins and residues 11 to 200 of the late protei
44 code the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural prot
45 igation and puncture to sham-operated mice ("early proteins") and 24-hr post-cecal ligation and punct
47 n evolutionary resource for the emergence of early proteins, and that ornithine, together with its po
48 the initial accumulation of IE1 72 and viral early proteins, and viral DNA replication proceeds norma
49 totoxic T lymphocytes specific for immediate-early protein are present in seropositive individuals, a
52 egulate class I, indicating that one or more early proteins are responsible for the down-regulation o
53 ly demonstrated that ORF45, a KSHV immediate-early protein as well as a tegument protein of virions,
54 domain that included the Arabidopsis ALWAYS EARLY proteins AtALY2 and AtALY3, and two telomere bindi
56 ntion over the last 25 yr, the importance of early protein breakdown products to plant nitrogen (N) n
57 only the acquisition of organic nitrogen as early protein breakdown products, but also as non-protei
58 ctor Oct-1 cooperates with the EBV immediate-early protein BRLF1 (R, Rta) to induce lytic viral react
61 tedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an ep
63 resulted in similar levels of VZV immediate-early proteins but reduced levels of glycoprotein E comp
64 and some expressed HSV-1 immediate early and early proteins, but did not produce HSV-1 late proteins
69 of either Epstein-Barr virus (EBV) immediate-early protein BZLF1 (Z) or BRLF1 (R) is sufficient to co
75 that the Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-alpha activation of tar
78 ction is mediated by the two viral immediate-early proteins BZLF1 (Z) and BRLF1 (R), which are not ex
80 ty of rAd vectors encoding the EBV immediate-early proteins BZLF1 and BRLF1 to induce the lytic form
81 ection, expression of either viral immediate-early protein (BZLF1 or BRLF1) is sufficient to convert
82 encing, yet the Epstein-Barr virus immediate-early protein, BZLF1 (Z), converts the virus from the la
85 that the Epstein-Barr virus (EBV) immediate-early protein, BZLF1, inhibits the IFN-gamma signaling p
86 that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the swit
87 affect the ability of the two EBV immediate-early proteins, BZLF1 (Z) and BRLF1 (R), to induce the l
88 r, expression of either of the EBV immediate-early proteins, BZLF1 and BRLF1, is sufficient to induce
90 mmunohistochemical analysis of the immediate early protein c-Fos was performed as a marker for cellul
91 s from mammalian cells containing only viral early proteins, concordant with previous in vivo transfe
95 Herpes-simplex virus 1 (HSV-1) immediate early proteins directly induce expression of DUX4 and it
97 d through the pro-inflammatory action of the early protein dUTPase that is produced even during incom
99 imilarity between MAGE-11 and the adenovirus early protein E1A, we determined whether MAGE-11 contrib
101 had suggested a potential role for the viral early protein E2, we found that E2 protein expression di
106 experiment, expression of a second immediate early protein, egr-1, was blocked as well, suggesting th
107 e of COX-2 inhibitors, but expression of the early protein EP0 was not affected by COX inhibition.
109 protocell membranes played a crucial role in early protein evolution and show translation started wit
110 sly attempted to simulate domain creation in early protein evolution by recombining polypeptide segme
113 ity of an HDAC inhibitor to activate IE1 and early protein expression during infection with a laborat
114 ring reactivation and enhances Rta-dependent early protein expression induced by multiple signals, as
115 ich results in accumulation of the immediate-early protein, failed to down-regulate class I, indicati
118 with a virus that does not express immediate-early proteins, followed by superinfection with various
123 ata suggest that the TTP and TIS11 immediate early proteins have similar but distinct effects on grow
124 minor capsid protein homolog), or ORF 57 (an early protein homolog), in association with increases in
125 pt K3 and K5 (bovine herpesvirus-4 immediate-early protein homologues), K7 (nut-1), and K12 (Kaposin)
126 ction between the C-USP7 and HSV-1 immediate-early protein ICP0 (infected cell protein 0), which is e
128 e viral proteins gE and gD and the immediate-early protein ICP0 but did not have discernible effects
129 ssed in the infected cell, the HSV immediate-early protein ICP0 has E3 ubiquitin ligase activity and
130 nts that fail to express the viral immediate-early protein ICP0 have a pronounced defect in viral gen
132 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 interacts with several cellular prote
133 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP0 is a general activator of viral gene
135 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 is required for efficient lytic infec
136 Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to cellular structures know
140 The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions during infect
141 simplex virus type 1 (HSV-1), the immediate-early protein ICP0 serves as a counterdefense through de
142 nt viruses, we determined that the immediate-early protein ICP0 was necessary for the inhibition of I
145 ith herpes simplex virus 1 (HSV-1) immediate early protein ICP0, which stimulates lytic HSV-1 infecti
148 bsence of the "nonessential" viral immediate-early protein, ICP0, HSV-1 is severely impaired in its a
150 d gC, and increased amounts of two immediate-early proteins, ICP0 and ICP4, as well as protein specie
151 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP22 alters the phosphorylation of the ho
152 The herpes simplex virus 1 (HSV-1) immediate early protein ICP22 plays several roles in the virus lif
156 In addition, synthesis of the immediate early protein ICP27 causes partial inhibition of pre-mRN
157 ere, we demonstrate that the HSV-1 immediate early protein ICP27 induces DoTT by directly binding to
158 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an RNA-binding protein that perfo
159 erpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is required posttranscriptionally fo
160 V genome, we provide evidence that immediate-early protein ICP4 is involved in the process of convert
161 ith DeltaU(L)31, expression of the immediate-early protein ICP4, early protein ICP8, and late protein
162 DNA sequence, OriS, and the viral immediate-early proteins ICP4 and ICP27 are sufficient for a repor
164 nt, granzyme B, degrades the HSV-1 immediate early protein, ICP4, which is essential for further vira
165 The herpes simplex virus (HSV) immediate early protein ICP47 inhibits the transporter associated
167 us serotype 1 (HSV-1) expresses an immediate-early protein, ICP47, that effectively blocks the major
168 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibits the huma
169 ression of the immediate-early protein ICP4, early protein ICP8, and late protein glycoprotein C (gC)
172 Human cytomegalovirus (HCMV) major immediate-early protein IE1 is an abundant 72-kDa nuclear phosphop
175 We also demonstrate that the HCMV immediate-early protein IE1-72 complexes in vivo with the p107 pro
176 individual expression of the viral immediate-early protein IE1-72, mimicking full virus infection.
180 nsactivator plasmid expressing the immediate early protein (IE1) from the Bombyx mori nuclear polyhed
181 icapsid nuclear polyhedrosis virus immediate-early protein, IE1, is a 582-amino-acid phosphoprotein t
185 human cytomegalovirus (HCMV) major immediate-early protein IE2 is a nuclear phosphoprotein that is be
186 ified as a binding element for the immediate-early protein IE2, was essential for oriLyt(PM) activity
188 s corresponding to residues of the immediate early protein, IE62, of varicella-zoster virus (VZV) wer
189 tibody (rec-MAb 63P4) that detects immediate-early protein IE63 encoded by varicella-zoster virus (VZ
190 r immediate promoter (MIEP) by its immediate-early protein IE72 (determined by cotransfection of an I
191 ther HCMV tegument protein pp65 or immediate-early protein IE72 are found in both CD45RO(high) cells
194 ion of this promoter by the 86-kDa immediate-early protein (IE86) is controlled by sequences between
195 (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcr
199 istry indicated high level production of JCV early protein in the tumor tissue, but not in any other
200 vestigate the oncogenic potential of the JCV early protein in vivo, transgenic mice expressing JCV T-
202 d thereby define in vivo activities of these early proteins, including gene-specific regulation and i
205 The herpes simplex virus 1 (HSV-1) immediate-early protein, infected cell protein 22 (ICP22), is requ
210 provide a more complete understanding of how early protein interactions involving virus-encoded tegum
212 Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early ge
213 Thus, degradation of Tip60 by the adenoviral early proteins is important for efficient viral early ge
214 translation, the presence of viral immediate-early proteins is sufficient to establish a state permis
215 cription factor, the 72K principal immediate-early protein, is abundantly expressed before this block
216 ICP0, a herpes simplex virus (HSV) immediate-early protein, is necessary and sufficient to dissociate
217 CE HSV-1 ICP0 is a multifunctional immediate early protein key to effective replication in the HSV-1
218 eted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral g
219 -gamma inhibited the expression of the viral early protein large tumor antigen (TAg) and the late pro
222 rminant of myofibroblast differentiation and early protein marker for stromal cell response to tissue
223 These data suggest that the R immediate-early protein may activate a key early EBV promoter (pol
224 human cytomegalovirus (HCMV) major immediate-early proteins (MIEPs) can rescue the transcription defe
225 sed, production of HSV-1 immediate early and early proteins might activate CD8(+) T cells aborting vi
226 viously, we showed that the bacteriophage T4 early protein MotB binds to DNA, co-purifies with H-NS/D
228 Translocation of a Gag epitope into the early protein Nef markedly increased the activity of CTL
238 ctions between ICP4 and ICP27, two immediate-early proteins of HSV-1 that are essential for virus rep
240 es indicated that Rosco caused the immediate-early proteins ORF4 and IE62 to abnormally localize in i
241 tic proteins demonstrated that the immediate early proteins ORF45 and replication and transcription a
242 ion was also mediated by the viral immediate-early protein Orf50/Rta, suggesting that the K15 gene is
243 eactivate latent VZV or target the immediate-early protein ORF62p to the nucleus in cultured guinea p
245 n the redox imbalance in post-mortem muscle, early protein oxidation and the onset of pale, soft and
246 8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regul
247 e herpes simplex virus (HSV) ICP27 immediate-early protein plays an essential role in the expression
251 ORF59 binds to oriLyt through an immediate early protein, replication and transcription activator (
252 including repression of the viral immediate-early protein Rta and a cellular factor, Rbl2, that regu
255 rease in OBP phosphorylation is dependent on early protein synthesis and is independent of viral DNA
258 ells requires the participation of the viral early protein T antigen, cellular replication factors, a
260 lly and functionally interact with the viral early protein, T antigen, and downregulate viral gene ex
261 JCV and the transforming ability of the JCV early protein, T antigen, we investigated the associatio
267 CP22P) of Equine herpesvirus 1 (EHV-1) is an early protein that functions synergistically with other
268 One of the genes, ORF4, encodes an immediate-early protein that is present in the virion tegument.
269 escribed here, we conclude that EBV PK is an early protein that requires viral-DNA replication for ma
270 erpes simplex virus type 1 (HSV-1) immediate-early protein that stimulates viral mRNA expression from
271 (80 kDa) are expressed as several species of early proteins that are first detected at 3 to 4 h posti
274 0, and M141 gene products were identified as early proteins that localize to both the nucleus and cyt
275 ne of two Epstein-Barr virus (EBV) immediate-early proteins that mediate the switch from the latent t
276 virus replication proceeds normally through early protein translation and uncoating but stalls at re
279 vents in the conventional pathway, including early protein tyrosine phosphorylation, were unimpeded b
281 infection revealed that the viral immediate-early protein Vmw110 (also known as ICP0) formed discret
283 erpes simplex virus type 1 (HSV-1) immediate-early protein Vmw110 stimulates the onset of virus infec
287 interact with the mammalian TIS21 immediate-early protein, was then shown to have protein arginine m
289 ilar patterns of metabolically labeled viral early proteins were detected at permissive and nonpermis
291 70% homology to the well characterized SV40 early protein which has established oncogenic properties
293 nd TRS1 open reading frames encode immediate-early proteins with identical N-terminal domains and div
294 cation function of the EBV-encoded immediate-early protein Zta (also referred to as ZEBRA, EB1, and B