ライフサイエンスコーパス: edema factor

1 protective antigen (PA), lethal factor, and edema factor.

2 protective antigen, lethal factor (LF), and edema factor.

3 -protective antigen (PA), lethal factor, and edema factor.

4 ive antigen (PA) with lethal factor (LF) and edema factor.

5 protective antigen (PA), lethal factor, and edema factor.

6 rate proteins, called lethal factor (LF) and edema factor.

7 nated protective Ag (PA), lethal factor, and edema factor.

8 nergic effects provided by lethal factor and edema factor.

9 rves as a scaffold for binding of lethal and edema factors.

10 tance of LeTx, very recent studies show that edema factor, a potent adenyl cyclase, has the ability t

11 In addition, we found that edema factor, a potent adenylate cyclase, inhibits the h

12 o other enzyme components, lethal factor and edema factor, across the plasma membrane and into the cy

13 The edema factor also enhanced immunity to the binding PA su

14 aired in pore formation and in translocating edema factor and lethal factor across the endosomal memb

15 a purified vaccine free of bacterial toxins edema factor and lethal factor from 1 acre of land.

16 ce plasmid pXO1 at a locus distinct from the edema factor and lethal factor genes.

17 igen (PA) moiety of anthrax toxin transports edema factor and lethal factor to the cytosol of mammali

18 slocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell m

19 y binds the enzymatic moieties of the toxin, edema factor and lethal factor, and translocates them ac

20 f assembles at the cell surface from anthrax edema factor and protective antigen (PA).

21 lasmid-encoded A/B-type toxins, edema toxin (edema factor and protective antigen) and lethal toxin (l

22 ted channel, which unfolds lethal factor and edema factor and translocates them into the host cytosol

23 protective antigen (PA), lethal factor, and edema factor and virulence plasmid pXO2 that encodes cap

24 ur MAb react with three different domains of edema factor, and all were able to detect purified edema

25 ther toxin components, the lethal factor and edema factor, and domain 4, the receptor binding domain

26 Edema factor, another component of anthrax toxin, is an

27 iphtheria toxin that is conserved in anthrax edema factor, anthrax lethal factor, and botulinum neuro

28 g domain (RBD or domain 4) or the lethal and edema factor binding domain (LEF or domain 1') were engi

29 sule operon (capBCADE), lethal factor (lef), edema factor (cya), or protective antigen (pagA).

30 nts deficient in lethal factor, DeltaLF, and edema factor, DeltaEF.

31 A third component of anthrax toxin, edema factor, did not induce leakage alone or with PA.

32 i.e., protective antigen, lethal factor, and edema factor, disseminated from the lung to the spleen a

33 Edema factor (EF) and CyaA are adenylyl cyclase toxins s

34 Edema factor (EF) and CyaA are calmodulin (CaM)-activate

35 Entry of anthrax edema factor (EF) and lethal factor (LF) into the cytoso

36 surface involves competitive binding of the edema factor (EF) and lethal factor (LF) to heptameric o

37 membranes that leads to the translocation of edema factor (EF) and lethal factor (LF) to the cytosol.

38 To investigate the diffusion of edema factor (EF) and lethal factor (LF), we use sensiti

39 l, protective antigen (PA), and two enzymes, edema factor (EF) and lethal factor (LF), which are tran

40 ich binds to ANTXR2, and the protein cargoes edema factor (EF) and lethal factor (LF).

41 actors and consists of the adenylate cyclase edema factor (EF) and protective antigen (PA).

42 he anthrax toxins that act by binding to the edema factor (EF) and/or lethal factor (LF) components.

43 mammalian cell surface, competitively binds edema factor (EF) and/or lethal factor (LF).

44 rough which catalytic lethal factor (LF) and edema factor (EF) are believed to translocate to the cyt

45 PA(63)), translocates lethal factor (LF) and edema factor (EF) from endosomes into the cytosol of the

46 ective antigen (PA), lethal factor (LF), and edema factor (EF) in a growth phase-dependent manner whe

47 -terminal segments of lethal factor (LF) and edema factor (EF) in anthrax toxin, we asked whether LF

48 sport the two enzymes lethal factor (LF) and edema factor (EF) into the cell.

49 ranslocates either its lethal factor (LF) or edema factor (EF) into the host cell.

50 Edema factor (EF) is a component of an anthrax toxin tha

51 tective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclas

52 The lethal factor (LF) and edema factor (EF) of anthrax toxin bind by means of thei

53 tein of anthrax toxin that mediates entry of edema factor (EF) or lethal factor (LF) into cells.

54 (63) oligomerizes into heptamers, which bind edema factor (EF) or lethal factor (LF) to form the toxi

55 Anthrax edema factor (EF) raises host intracellular cAMP to path

56 mediates the entry of lethal factor (LF) or edema factor (EF) through a membranal pore into target c

57 ly) form by binding of lethal factor (LF) or edema factor (EF) to the pore-forming moiety protective

58 Edema factor (EF), a key anthrax exotoxin, has an anthra

59 Edema factor (EF), a key virulence factor in anthrax pat

60 Edema factor (EF), a potent adenylyl cyclase, is one of

61 Edema factor (EF), a toxin from Bacillus anthracis (anth

62 nd Bacillus pertussis produce the AC toxins, edema factor (EF), and adenylyl cyclase toxin (ACT), res

63 e proteins, namely, protective antigen (PA), edema factor (EF), and lethal factor (LF), encoded by th

64 nent toxin consisting of lethal factor (LF), edema factor (EF), and protective antigen (PA).

65 the pXO1-encoded toxins lethal factor (LF), edema factor (EF), and protective antigen (PA).

66 rotective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal fact

67 the proteins, called Lethal Factor (LF) and Edema Factor (EF), are enzymes that act on cytosolic sub

68 nts of anthrax toxin, lethal factor (LF) and edema factor (EF), are transported to the cytosol of mam

69 n, consisting of protective antigen (PA) and edema factor (EF), causes the edema associated with cuta

70 protective antigen and an adenylate cyclase edema factor (EF), elicits edema in host tissues, but th

71 er enzyme components, lethal factor (LF) and edema factor (EF), into the cytosol of the host cell und

72 hrax toxin is made up of three proteins: the edema factor (EF), lethal factor (LF) enzymes, and the m

73 three proteins that comprise anthrax toxin, edema factor (EF), lethal factor (LF), and protective an

74 Intact LF, edema factor (EF), or fusion proteins containing LFN fus

75 tigen (PA) plus either lethal factor (LF) or edema factor (EF), respectively, play an important yet i

76 ), necessary for host cell toxin uptake, and edema factor (EF), the toxic moiety which increases host

77 ponents of the toxin, lethal factor (LF) and edema factor (EF), to form toxic complexes.

78 ective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mamm

79 oieties of the toxin--lethal factor (LF) and edema factor (EF)--across the endosomal membrane of mamm

80 ective antigen (PA), lethal factor (LF), and edema factor (EF)-that come together in binary combinati

81 ective antigen (PA), lethal factor (LF), and edema factor (EF).

82 e enzymatic moieties, lethal factor (LF) and edema factor (EF).

83 er enzyme components, lethal factor (LF) and edema factor (EF).

84 nd of the adenylyl cyclase catalytic moiety, edema factor (EF).

85 (PA) and two enzymes, lethal factor (LF) and edema factor (EF).

86 ective antigen (PA), lethal factor (LF), and edema factor (EF).

87 of the anthrax toxin, lethal factor (LF) and edema factor (EF).

88 enzymatic components lethal factor (LF) and edema factor (EF).

89 ure and mechanism of activation with anthrax edema factor (EF).

90 enzymatic components: lethal factor (LF) and edema factor (EF).

91 PA, 83 kDa), lethal factor (LF, 90 kDa), and edema factor (EF, 89 kDa).

92 the effects of the anthrax edema toxin (ET; edema factor [EF] plus protective antigen [PA]) and leth

93 oieties of the toxin (lethal factor [LF] and edema factor [EF]).

94 ng monoclonal antibody (mAb) against anthrax edema factor, EF13D.

95 ent corresponding to the catalytic domain of edema factor (EF3) was cloned, overexpressed in Escheric

96 ino-terminal 32-kDa fragment of B. anthracis edema factor, EGFP-EF32, was used to confirm specificity

97 pose that the N terminus of PA63-bound LF or edema factor enters the PA63-channel under the influence

98 The edema factor exotoxin produced by Bacillus anthracis is

99 ected mutations based on the homology of the edema factor family revealed a conserved pair of asparta

100 Da domain (EF3-N) of EF3, the sole domain of edema factor homologous to adenylyl cyclases from Bordet

101 factor, and all were able to detect purified edema factor in Western blot analysis.

102 ax virulence factors, lethal factor (LF) and edema factor, in transgenic Drosophila.

103 Lethal factor and edema factor, individually or in combination, are incapa

104 ranes that allow for the transport of LF and edema factor into the cytosol.

105 entry of the toxin's lethal factor (LF) and edema factor into the cytosolic compartment of mammalian

106 orchestrates the delivery of the lethal and edema factors into the cytosol.

107 he delivery of the other two (the lethal and edema factors) into the cytosol.

108 its two enzyme components, lethal factor and edema factor, into the host cytosol under the proton mot

109 nts of anthrax toxin [lethal factor (LF) and edema factor] into the cytosol of mammalian cells depend

110 This suggests that edema factor may utilize a similar catalytic mechanism.

111 d to establish lethal infection, whereas its edema factor modulates progression and dissemination of

112 combination with either the lethal-factor or edema-factor moiety.

113 h the two catalytic parts (lethal factor and edema factor) or other proteins can be transported into

114 surface and docking of lethal factor and/or edema factor, PA is internalized and undergoes a conform

115 Hence, ExoY is a promiscuous cyclase and edema factor that uses cAMP and, to some extent, cGMP to

116 pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into t

117 Edema factor, the catalytic subunit of ET, is an adenyla

118 Edema factor, the enzymatic A subunit of EdTx, is an ade

119 Protective antigen (PA), lethal factor, and edema factor, the protein toxins of Bacillus anthracis ,

120 r their cellular uptake and either lethal or edema factors, the toxigenic moieties.

121 ential for the delivery of lethal factor and edema factor to the cell cytosol.

122 pore that facilitates delivery of lethal and edema factors to the cytosol of the infected host.

123 lethal factor, and/or the adenylate cyclase edema factor, to generate lethal toxin (LTx) and edema t

124 y the adenylyl cyclase domain of the anthrax edema factor toxin was simulated using the empirical val

125 ective antigen (PA), lethal factor (LF), and edema factor-translocates large proteins across membrane

126 roteolytically, attaches to lethal factor or edema factor, undergoes oligomerization and internalizat

127 Abs) produced against PA, lethal factor, and edema factor, were examined in animals infected with Bac

128 xins (lethal factor, protective antigen, and edema factor) where expressed 4-6-log10-fold less than i

129 ludes protective antigen, lethal factor, and edema factor, which are the components of anthrax toxin,

130 s from the interaction of N-CaM with anthrax edema factor, which binds N-CaM via its helical domain.

131 ve antigen (PA) and traces of the lethal and edema factors, which may contribute to adverse side effe