ライフサイエンスコーパス: editor

1 ocated within the editing window of the base editor.

2 ftware tools, including the Protege ontology editor.

3 University of Colorado, Denver, USA, and the Editor.

4 heir reverter, and come to defend a reverted editor.

5 URE", the first cytidine-specific C-to-U RNA Editor.

6 Public Health, who serves as our Statistical Editor.

7 rget editing efficiencies with Cas9 and base editor.

8 use embryos using either CRISPR-Cas9 or base editors.

9 ing the research applications of CRISPR base editors.

10 ientists based in 70 countries who served as editors.

11 nd authors, reviewers, funding agencies, and editors.

12 tive social dynamics within the community of editors.

13 ular mechanistic model of ERAP1/2 as peptide editors.

14 e interactions to the status of the involved editors.

15 ed and the commentaries written by the Blood Editors.

16 ists, health care professionals, and journal editors.

17 h to understanding the specificity of genome editors.

18 box by developing cytosine transversion base editors.

19 mRNA encoding five of these next-generation editors.

20 environment for all authors, reviewers, and editors.

21 utcomes and inform the future design of base editors.

22 which precludes the use of full-length base editors.

23 use embryos using either CRISPR-Cas9 or base editors.

24 sing CRISPR-based cytidine- and adenine-base editors.

25 erature, serving as editors (20%), associate editors (18%), or editorial board members (60%).

26 peer-reviewed journal literature, serving as editors (20%), associate editors (18%), or editorial boa

27 difications, including those induced by base-editors, (3) an output in an easily searchable file form

28 Twenty-four editors (68.6%) believed that RGs should be adopted by a

29 Finally, we show that an adenine base editor(7) can also induce transcriptome-wide RNA edits.

30 Twenty-six editors (74.3%) stated that they knew what RGs were befo

31 e developed a dual adenine and cytosine base editor (A&C-BEmax) by fusing both deaminases with a Cas9

32 Compared to single base editors, A&C-BEmax's activity on adenines is slightly re

33 ion of plasmid DNA encoding the adenine base editor (ABE) and a single-guide RNA (sgRNA) can correct

34 The adenine base editor (ABE), capable of catalyzing A*T to G*C conversio

35 rs, we engineered six optimized adenine base editors (ABEmax variants) that use SpCas9 variants compa

36 Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably a

37 Applications of adenine base editors (ABEs) have been constrained by the limited comp

38 Here we describe adenine base editors (ABEs) that mediate the conversion of A*T to G*C

39 or DNA adenosine deamination by adenine base editors (ABEs), we determined a 3.2-angstrom resolution

40 Together with previous base editors, ABEs enable the direct, programmable introducti

41 In an Editorial, Guest Editors Alexander Tsai, Margarita Alegria and Steffanie

42 These new programmable epigenetic editors allow unprecedented control of the DNA methylati

43 converting adenine to guanine, adenine base editors also convert cytosine to guanine or thymine in a

44 These epi-editors altered critical histone marks and subsequently

45 We provide a 3D editor and inspector for the manual curation of the segm

46 ew (conducted by Annual Review of Psychology Editor and long-time collaborator Susan Fiske) touches o

47 data representations derived from them, the editor and suite of advanced data presentation tools fac

48 re-conditional expression of a cytidine base editor and tested their utility for precise somatic engi

49 lic information about the identities of 9000 editors and 43000 reviewers from the Frontiers series of

50 Cytosine base editors and adenine base editors (ABEs) can correct poin

51 le to assess the relationship between D-loop editors and D-loop characteristics such as length and po

52 stinct advantages in the eyes of prospective editors and employers.

53 y interdisciplinary, and were reviewed by 24 editors and experts chosen from the wide range of commun

54 the goal of stimulating authors, reviewers, editors and funders to put experimental guidelines into

55 ific basis for calling on all investigators, editors and funding agencies to embrace changes that wil

56 tablish a system for rapid evolution of base editors and inform their use and improvement.

57 nly the track records of authors but also of editors and journals.

58 of virology and to assist and annoy journal editors and others in regard to viral taxonomy.

59 We encourage editors and peer reviewers to consider requiring these k

60 It will assist editors and peer reviewers, as well as the general reade

61 Its use will assist editors and peer reviewers, as well as the general reade

62 cles that received different appraisals from editors and peer reviewers.

63 llen formats easily, these data suggest that editors and publishing staff should encourage authors to

64 eLife editors and reviewers consult with one another before se

65 This helps journal editors and reviewers verify that the most important ite

66 ion is required to generate true single base editors and the eGFP reporters described here have the p

67 Through the co-injection of two base editors and two sgRNAs into mouse zygotes, we introduced

68 print, with research papers, letters to the editor, and all other exchanges just appearing in issues

69 ial Board beginning in 1961, as an Associate Editor, and as Editor-in-Chief for 40 years, from 1971 u

70 engine which we see as a formidable workflow editor, and the Grid and User Support Environment, a web

71 is provided using the WebApollo online gene editor, and we are working with interested communities t

72 led by a lack of accountability of journals, editors, and authors.

73 estigators, sponsors, regulators, societies, editors, and journals are needed to improve data dissemi

74 r involved in guideline development, journal editors, and manuscript reviewers.

75 for NPT trial abstracts should help authors, editors, and peer reviewers improve the transparency of

76 working closely with the editors, associate editors, and staff.

77 The editors apologize for this error.

78 Here we describe the engineering of two base editor architectures that can efficiently induce targete

79 ure that researchers, reviewers, and journal editors are better equipped to improve the rigour and tr

80 , precision and delivery of DNA and RNA base editors are revealing exciting therapeutic opportunities

81 Although base editors are useful tools for precise genome editing, cur

82 CRISPR-guided DNA cytosine and adenine base editors are widely used for many applications(1-4) but p

83 Although base editors are widely used to install targeted point mutati

84 editors, transposases/recombinases and prime editors-are currently available for modifying genomes in

85 Our findings highlight base editor as a powerful platform for genetic modification o

86 that have been selected by NAR reviewers and editors as 'breakthrough' contributions, denovo-db, the

87 end-of-the-year editorial, the PLOS Medicine editors asked 7 global health leaders to discuss develop

88 ively serving in one or more positions as an editor, associate editor, reviewer, and/or editorial boa

89 nd RadioGraphics by working closely with the editors, associate editors, and staff.

90 This document represents an effort from editors at 31 respiratory, sleep, and critical care medi

91 The editors at JEM share their views on gender bias in scien

92 Efforts by editors, authors, and reviewers should be made to increa

93 Nevertheless, editors based outside the "Global North" (the group of e

94 phage-assisted continuous evolution of base editors (BE-PACE) to improve their editing efficiency an

95 ing mutations into our third-generation base editor (BE3) to generate a high-fidelity base editor (HF

96 lants treated with the third-generation base editor (BE3), high-fidelity BE3 (HF1-BE3), or ABE reveal

97 Current base editors (BEs) catalyze only base transitions (C to T and

98 See also the response to this Letter to the Editor by Slette et al., 26, e1-e3.

99 statistical sophistication of the scientific editors by bringing in an expert in study design and sta

100 way for the first set of DNA precision base editors (C*G->T*A and A*T->G*C), with wide-ranging impli

101 ally, we demonstrate how the Galaxy workflow editor can be used to compose integrative models from co

102 eic CAR-T platform and demonstrate that base editor can mediate highly efficient multiplex gene disru

103 l for the first transversion (C*G->G*C) base editor can now be proposed.

104 ate that Cas9-ribonucleoprotein-based genome editors can correct two distinct mutant alleles within a

105 pe that researchers, regulators, funders and editors can embrace this paradigm shift.

106 ols for precise genome editing, current base editors can only convert either adenines or cytosines.

107 ever, the existing cytosine and adenine base editors can only install transition mutations.

108 ve bias analysis in the peer-review process, editors can potentially avoid unnecessary rejections, id

109 In this month's Editorial, Guest Editors Carol Brayne and Bruce Miller discuss research a

110 Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achi

111 elationships of 11 cytosine and adenine base editors (CBEs and ABEs) on 38,538 genomically integrated

112 Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T

113 Cytosine base editors (CBEs) enable efficient, programmable reversion

114 Cytosine base editors (CBEs) enable targeted C*G-to-T*A conversions in

115 Cytosine base editors (CBEs) generate C-to-T nucleotide substitutions

116 The most widely used cytosine base editors (CBEs) induce deamination of DNA cytosines using

117 We used BE-PACE to evolve cytosine base editors (CBEs) that overcome target sequence context con

118 One of these C-to-G base editors (CGBE1), consists of an RNA-guided Cas9 nickase,

119 ISPR-associated protein 9-fused adenine base editor (CjABE).

120 This Letter to the Editor clarifies the landscape approach as an ethic for

121 In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Ha

122 ts, thereby leading to heterogeneity in base-editor coding sequences.

123 Adenine base editors comprise an adenosine deaminase, evolved in vitr

124 Additionally, we engineered base editors containing mutated cytidine deaminase domains th

125 different forms of cytosine or adenine base editors containing SpCas9-NG worked efficiently in rice

126 However, base editors containing xCas9 failed to edit most of the test

127 CRISPR-Cas-guided base editors convert A*T to G*C, or C*G to T*A, in cellular D

128 The resulting 'base editors' convert cytidines within a window of approximat

129 , targeting of multiple alleles using genome editors could lead to mixed genotypes and adverse events

130 The new editor created, dubbed REPAIRx, is precise yet highly ef

131 omes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thou

132 ulted in RNA-free DddA-derived cytosine base editors (DdCBEs) that catalyse C*G-to-T*A conversions in

133 he smallest Streptococcus pyogenes Cas9 base editors described to date.

134 Annals of Internal Medicine editors develop In the Clinic from these primary sources

135 Annals of Internal Medicine editors develop In the Clinic in collaboration with the

136 The PLOS Medicine Editors discuss issues of vaccination uptake in the cont

137 The PLOS Medicine Editors discuss migrant and refugee health, and announce

138 The resulting suite of plant prime editors enable point mutations, insertions and deletions

139 We request to retract our Letter to the Editor entitled "DNAJC6 variants in Parkinson's disease

140 sequencing after sustained or transient base editor expression.

141 article has been retracted at the request of Editor following concerns raised by a reader.

142 e-curated cancer pathways, or as a graphical editor for creating new pathways, with the ability to ov

143 this study, we purified A3A (N57Q)-BE3 base editor for ribonucleoprotein (RNP) electroporation of hu

144 serve as a basis for optimizing C-to-G base editors for research and therapeutic applications.

145 The Guest Editors for the PLOS Medicine Special Issue on Maternal

146 The success of base editors for the study and treatment of genetic diseases

147 We adapted prime editors for use in plants through codon, promoter, and e

148 The foundational adenine base editors (for example, ABE7.10) enable programmable A*T t

149 The pilot engaged over 25 biomedical journal editors from most major publishers, as well as scientist

150 These glycosylase base editors (GBEs) consist of a Cas9 nickase, a cytidine dea

151 analyses were used to assess differences in editors' H-indices, academic rank, and number of advance

152 e editing and in which modification via base editors has not been previously reported.

153 Association of Immunologists, a JEM Advisory Editor, has been awarded numerous prizes, and is a true

154 A variety of editors have been created, but a genetically encoded edi

155 Base editors have drawn considerable academic and industrial

156 DNA base editors have enabled genome editing without generating D

157 ditor (BE3) to generate a high-fidelity base editor (HF-BE3).

158 lls express decreased levels of the class II editor HLA-DM, lysosomal thiol-reductase GILT, and a 47-

159 observed in HLA-I genes, the HLA-II peptide editor HLA-DMB, or its antagonist HLA-DOB, showing high

160 e International Committee of Medical Journal Editors (ICMJE).

161 altering reports from reviewers, but 91% of editors identified at least one situation in which it wa

162 This set of base editors improves the targeting scope of cytosine and ade

163 Gordon Tomaselli as the next editor in chief, I pass on the editorial duties for the

164 lts implicate ADAR1 p150 as the major A-to-I editor in mouse embryo fibroblasts, acting as a feedback

165 esults have implications for the use of base editors in both research and clinical settings, illustra

166 opinions, and future plans of dental journal editors in chief (EICs) on RGs.

167 o reveals the potential of APOBEC-based base editors in inducing unintended point mutations outside o

168 the whole-genome sequencing (WGS) of 10 base editors in regenerated rice plants.

169 cle has been retracted at the request of the Editor-in-Chief and Deputy Editor-in-Chief following an

170 cle has been retracted at the request of the Editor-in-Chief and the Corresponding Author, Muhammad K

171 he request of the Editor-in-Chief and Deputy Editor-in-Chief following an investigation into the data

172 cle has been retracted at the request of the Editor-in-Chief following concerns raised by a reader.

173 ning in 1961, as an Associate Editor, and as Editor-in-Chief for 40 years, from 1971 until 2010.

174 Herbert Tabor, JBC's Editor-in-Chief for 40 years, I will review here JBC's e

175 During Herbert Tabor's tenure as Editor-in-Chief from 1971 to 2010, JBC has published man

176 As he prepares to step down as the Editor-in-Chief of eLife, Randy Schekman reflects on the

177 Herb Tabor was the Editor-in-Chief of the Journal of Biological Chemistry (

178 Herbert Tabor, Editor-in-Chief of the Journal of Biological Chemistry (

179 John was the Founder and first Editor-in-Chief of the Journal of Molecular Biology, Dep

180 n withdrawn by agreement between the journal Editor-in-Chief, Patrick R. Hof and Wiley Periodicals, I

181 ed by Uppsala University and reviewed by the Editor-in-Chief.

182 Chemistry under the tenure of Herb Tabor as Editor-in-Chief.

183 Herb Tabor served as the JBC's editor-in-chief.

184 elebrating Blood's birthday authored by past Editors-in-Chief.

185 Existing adenine and cytosine base editors induce only a single type of modification, limit

186 Adenine base editor-induced cytosine substitutions occur independentl

187 Here, we report that injecting base editors into human cleaving two-cell and four-cell embry

188 ico model for the in vivo delivery of genome editors into the developing human infant liver, we ident

189 Support from researchers, reviewers, and editors is key to success.

190 tion in B cells impairs selection of Igkappa editor L chains typically arising through secondary Igk

191 rearrangement, but not selection of Iglambda editor L chains.

192 his month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient

193 These results demonstrate that cytosine base editor-mediated editing may result in unintended genetic

194 tificial transcription factors or epigenetic editors (methylating H3K9).

195 DO is moving to a multi-editor model utilizing Protege to curate DO in web ontol

196 mized chemical modifications of adenine base editor mRNA and guide RNA expand the applicability of CR

197 ical industry statisticians (n = 3), journal editors (n = 9), and regulators (n = 2) (3 participants

198 Special Issue on Diabetes Prevention, Guest Editors Nicholas Wareham and William Herman discuss some

199 urther engineering of the CRISPR-Cas9 genome-editor nucleases.

200 the associated interview with Debbie Sweet, Editor of Cell Stem Cell, and Elena Porro, Editor of Cel

201 , Editor of Cell Stem Cell, and Elena Porro, Editor of Cell.

202 As Eve Marder stands down as a Deputy Editor of eLife, she reflects on the need for journals t

203 of repetitive sites and ADAR2 is the primary editor of non-repetitive coding sites, whereas the catal

204 itorial Fellowship, in honor of the founding editor of RadioGraphics, with the first Eyler fellow sel

205 Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary edit

206 Moreover, only much later as the editor of The American Journal of Clinical Nutrition did

207 At the behest of the editor of the American Journal of Ophthalmology, the IOL

208 the histone demethylase KDM5A as a critical editor of the cells' "histone code" that is required to

209 d submitted three papers to Dr Langley, then editor of The Journal of Physiology in England.

210 f Ophthalmology and Otolaryngology and first editor of the present (third) series American Journal of

211 Sharon Solomon, guest editor of this Retina Supplement, invited us to reminisc

212 represented in the peer-review process, that editors of both genders operate with substantial same-ge

213 In this narrative review, invited by the Editors of Gastroenterology, we summarize recent advance

214 The editors of JCI and JCI Insight are revisiting our editor

215 tudy presents the results of a survey of 322 editors of journals in ecology, economics, medicine, phy

216 an be traced to authors, peer reviewers, and editors of journals.

217 ll and Bertram as well as to the readers and editors of the Annals of Neurology for this action.

218 Karim Brohi and Martin Schreiber, Guest Editors of the Special Issue on Trauma, describe a new e

219 We measure editors' online ideological preferences by how much they

220 it and illustrates a novel strategy for base editor optimization.

221 Continuous analysis allows reviewers, editors or readers to verify reproducibility without man

222 In an Editorial, Guest Editors Paul Spiegel, Terry McGovern and Kol Wickramage

223 To the Editor: Petersen et al. (April 21 issue)(1) provide a de

224 The Editors' Pick by Echelman et al. applied single-molecule

225 the edited strains after curing of the base editor plasmid.

226 -target effects of deaminase enzymes in base editor platforms.

227 nced COS developers, methodologists, journal editors, potential users of COS (clinical trialists, sys

228 nced COS developers, methodologists, journal editors, potential users of COS (clinical trialists, sys

229 g of a balanced set of ideologically diverse editors produce articles of a higher quality than homoge

230 Transient expression of the editor proteins (e.g. Cas9 protein) is desirable to redu

231 iewers recommending citations to their work, editors publishing in their own journals, and replicatio

232 ly editorial conferences where the Associate Editors, Rebecca, and I consider which of the papers tha

233 cripts, deemed as unworthy of peer review by editors, received fewer citations than those sent for pe

234 we report a cytidine-to-uridine (C-to-U) RNA editor, referred to as RNA Editing for Specific C-to-U E

235 ticians, previous guideline authors, journal editors, regulators, and funders.

236 e International Committee of Medical Journal Editors released guidance on sharing clinical trial data

237 iency is exemplified in the state of the art editor REPAIR, which comprises the ADAR2 deaminase domai

238 recently been achieved using a bifunctional editor (RESCUE-S) capable of deaminating both adenine an

239 d data, experimental studies, letters to the editor, review articles, case reports, commentaries, and

240 ne or more positions as an editor, associate editor, reviewer, and/or editorial board member of vario

241 e simultaneously eliminating outcome bias by editors, reviewers, and authors.

242 sured and reinforced by funders, publishers, editors, reviewers, and, ultimately, the authors.

243 The Reviewing Editor's assessment is that all the issues have been add

244 The Reviewing Editor's assessment is that major issues remain unresolv

245 The Reviewing Editor's assessment is that minor issues remain unresolv

246 ion of this article initially published, the Editor's Note indicating that the article has been peer-

247 s the relevance of patient care to a journal editor's work.

248 community increased over time-the number of editors serving in 2014 was 4-fold greater than in 1985-

249 course, and why professional journalists and editors should adjust the disproportionate attention giv

250 ve methods, as well as journal reviewers and editors, should understand this framework well.

251 ynchronous programmable adenine and cytosine editor (SPACE) that can concurrently introduce A-to-G an

252 ntion, Treatment and Cure of HIV/AIDS, Guest Editors Steven Deeks, Sharon Lewin, and Linda-Gail Bekke

253 Editor surveys suggest that online contributions associa

254 Our results suggest that Wikipedia editors systematically revert the same person, revert ba

255 hin the peptide-loading complex, the peptide editor tapasin is key to the selection of MHC-I-bound pe

256 r there are two MHC class I specific peptide editors, tapasin and TAPBPR, intimately involved in cont

257 ructure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin h

258 suggest that in addition to being a peptide editor, TAPBPR improves peptide optimisation by promotin

259 CRISPR-Cas base-editor technology enables targeted nucleotide alteration

260 Here, we apply base editor technology for multiplex gene modification in pri

261 The authors and editors thank T.

262 sgRNA and an mRNA of a codon-optimized base editor that displayed higher base-editing efficiency tha

263 have been created, but a genetically encoded editor that is both precise and efficient has not been d

264 hemically modified mRNA-encoded adenine base editor that mediates robust editing at various cellular

265 delivery of split cytosine and adenine base editors that are then reconstituted by trans-splicing in

266 requires cellular exposure to levels of base editors that can be difficult to attain in hard-to-trans

267 ell lines, second- and third-generation base editors that fuse uracil glycosylase inhibitor, and that

268 2020) engineered new variants of CRISPR base editors that make precise genomic edits in rice protopla

269 development of five C to T (or G to A) base editors that use natural and engineered Cas9 variants wi

270 situation in which it was appropriate for an editor to alter a report.

271 into the middle of CasRx, and redirected the editor to the nucleus.

272 Here, we use CRISPR base editors to knock out genes by changing single nucleotide

273 ough user interactions that employ different editors to modify the original nanorod.

274 to a tree is crucial for openness, allowing editors to receive credit for their work and making erro

275 achinery, translational activators, and base editors to target transcripts.

276 community, as well as journal reviewers and editors, to utilize and further develop this framework t

277 erived genome editing agents-nucleases, base editors, transposases/recombinases and prime editors-are

278 ials; and conducted a consensus meeting with editors, trialists, and methodologists.

279 Differences in editor turnover and multiple board positions were evalua

280 Base editors use DNA-modifying enzymes targeted with a cataly

281 SpRY nuclease and base-editor variants can target almost all PAMs, exhibiting r

282 Moreover, these 2 base editor variants were more precise at their target sites

283 BFP-to-GFP conversion assay to optimize base editor vector design in human pluripotent stem cells (hP

284 nd Apollo, a collaborative genome annotation editor, visualizes the results of these analyses.

285 To increase the targeting scope of base editors, we engineered six optimized adenine base editor

286 Editors were also asked for their views on five issues r

287 Furthermore, 67.18% of all editors were based in either the United States or the Un

288 1985-as did the number of countries in which editors were based.

289 Because the editors were no longer confident in the conclusions of t

290 ally been done manually using a DNA sequence editor which becomes error-prone as scale and complexity

291 Prime editors, which are CRISPR-Cas9 nickase (H840A)-reverse t

292 ut meta-analyses and for readers and journal editors, who must interpret the findings and gauge metho

293 The editors wish to note that concerns were raised regarding

294 produce four cytosine and four adenine base editors with an editing window expanded from ~4-5 nucleo

295 ly intractable targets, and provide new base editors with improved editing capabilities.

296 Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided c

297 mbryos edited by CRISPR-Cas9 or adenine base editor, with a frequency close to the spontaneous mutati

298 ober 15, 2020, at the request of the journal editors, with agreement from the authors, owing to a sub

299 d), conference abstracts, and Letters to the Editor without clear peer review.

300 ingle-base mutations produced by CRISPR base editors without requiring barcode expression in live cel

301 is month's Editorial, PLOS Medicine Academic Editor Zirui Song and his colleague Adrianna McIntyre di