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1 ) for eflornithine-sulindac as compared with eflornithine.
2 signed in a 1:1:1 ratio to receive 750 mg of eflornithine, 150 mg of sulindac, or both once daily for
6 significantly lower with the combination of eflornithine and sulindac than with either drug alone.
7 he efficacy and safety of the combination of eflornithine and sulindac, as compared with either drug
8 icacy and safety of combination therapy with eflornithine and sulindac, as compared with either drug
10 t the BBB, but also the impact of nifurtimox-eflornithine combination therapy (NECT) and other anti-H
12 Health Organization approved the nifurtimox-eflornithine combination therapy for the treatment of hu
14 reatment options, pentamidine and nifurtimox-eflornithine combination therapy, have been expanded to
16 ornithine decarboxylase (ODC) using low-dose eflornithine (DFMO, CPP-1X), combined with maximal PA ex
19 he sulindac group, and 23 of 57 (40%) in the eflornithine group, with a hazard ratio of 0.71 (95% con
20 e biosynthesis by the anti-trypanosomal drug Eflornithine impairs the ability of the cytosol and mito
22 Food and Drug Administration (FDA) approved eflornithine (IWILFIN, US WorldMeds) to reduce the risk
23 were related to reversible myelosuppression (eflornithine + lomustine 42% v lomustine monotherapy 29%
24 there was no difference in survival between eflornithine + lomustine and lomustine monotherapy (medi
25 cally meaningful improvements were observed; eflornithine + lomustine doubled PFS and improved OS in
26 ly meaningful improvements in median OS with eflornithine + lomustine versus lomustine monotherapy (3
30 confidence interval [CI], 0.39 to 1.32) for eflornithine-sulindac as compared with sulindac (P = 0.2
31 n occurred in 18 of 56 patients (32%) in the eflornithine-sulindac group, 22 of 58 (38%) in the sulin
32 rom previous studies and metabolic profiles, eflornithine was identified as potentially beneficial wi
33 : difluoromethylornithine (DFMO; also called eflornithine), which is a suicide inhibitor of ornithine
34 s the target of the WHO "essential medicine" eflornithine, which is antagonistic to another anti-HAT