ライフサイエンスコーパス: electronegative

1 brane, while the opposite surface is largely electronegative.

2 letes its electron density as X becomes more electronegative.

3 However, small electronegative 2'-O-substituents, while enhancing the R

4 ing and in vitro activity, (2) small, highly electronegative 4'-substituents such as hydroxy, fluoro,

5 bserved in a protein, despite the ability of electronegative 4S substituents to enforce the more comm

6 actions between electropositive hydrogen and electronegative acceptors, fail to quantitatively captur

7 site entrance provides a landing pad for the electronegative acyl-ACP surface.

8 For electronegative adsorbates, such as O and Cl, both mu(S)

9 f galactose behaves as an H-bond donor to an electronegative amino acid side chain in the SH1 binding

10 r to identify whether specific cluster(s) of electronegative amino acids in pro-Crp4-(20-43) are resp

11 To test whether specific cluster(s) of electronegative amino acids in pro-Crp4-(20-43) have spe

12 However, growth is dependent only on electronegative and electropositive properties near the

13 -defined electronegative cavity and confined electronegative and hydrophobic patches.

14 sitively charged molecules in which the most electronegative and least polarizable element fluorine e

15 More electronegative and less bulky oxygen of OTIs compared t

16 odels, it can be stated that the presence of electronegative and lipophilic features greatly enhance

17 protein-protein complex in which Ugi mimics electronegative and structural features of duplex DNA.

18 Oxygen, for example, is highly electronegative, and for energies of approximately 10-30

19 structure-activity relationships showed that electronegative aromatic substituents in the para-positi

20 nformer of the cation to be stabilized by an electronegative atom at C-3.

21 Other analogs in which the electronegative atom was moved to different positions su

22 arbon atom acts as the hydrogen donor and an electronegative atom Y (Y=N, O or S) acts as the accepto

23 with 3-HPC to the alpha-effect, where tandem electronegative atoms exhibit exceptionally high nucleop

24 ty, number of rotatable bonds, and number of electronegative atoms of a compound were negatively corr

25 s consistent with coordination of lithium to electronegative atoms on adjacent molecules in the solid

26 stabilizing electrostatic interactions with electronegative atoms on the 3'-side, are responsible fo

27 he coumarin lactone of 2, we identified that electronegative atoms placed at the meta-position of the

28 l that outer-sphere Mg(2+) are positioned by electronegative atoms, hydration layers, and a preferenc

29 y fluorinated compounds with a set number of electronegative atoms, the overall absorption in the IR

30 a deep peptide-binding groove comprising two electronegative B- and E-pockets that coincide with the

31 This suggests that the electronegative benzylic oxygen of veratryl alcohol incr

32 results from preferential association of the electronegative beta-globin chains with the alpha(M)-glo

33 The highly electronegative [BF(4) ](-) enriched at the SnO(2) inter

34 nding that agrees well with PelA(h)'s highly electronegative binding cleft versus the neutral surface

35 ucture of riboflavin-bound TmRibU reveals an electronegative binding pocket at the extracellular surf

36 hifting mutations in RS1 consistently caused electronegative bright-flash ERG, delayed flicker respon

37 Electronegative but lone pair-donating groups NR2, OR, a

38 s are oxygen and fluorine, now somewhat less electronegative, but in better agreement with their chem

39 DL was fractionated into L1-L5, increasingly electronegative, by ion-exchange chromatography.

40 ctrophilic groups form close contact with an electronegative C=O oxygen.

41 the electronegative CO4' oxygen for the less electronegative carbon in 4-6 presumably reduces the cap

42 bon-nitrogen bond is formed between the more electronegative carbon of the alkyne and the terminal, e

43 e encapsulated protonated azobenzene and the electronegative carbonyl oxygens on CB7, (ii) inclusion

44 switching barriers are dominated by the more-electronegative cations.

45 Large electronegative cavities on either side of the membrane

46 lpha-helical segments forming a well-defined electronegative cavity and confined electronegative and

47 acophore maps (one cationic nitrogen and two electronegative centers) for the two dopamine receptors,

48 macophore map (one cationic nitrogen and two electronegative centers) of the D1A DA receptor.

49 ning the magnitude of beta: smaller and more electronegative central atoms better accommodate a pair

50 n microscopy, shows mutations surrounding an electronegative central drug-binding cavity where they p

51 metal-ligand covalency by introducing a less electronegative chalcogen ligand (sulfur) in the cathode

52 dent protein kinase (PKG) caused (i) a large electronegative charge shift of each enzyme on ion excha

53 rylation or cGMP-binding alone causes (i) an electronegative charge shift on ion exchange chromatogra

54 sn) mutant proteins have incorporated a more electronegative Cl- in place of the Asp carboxylate.

55 The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in th

56 a modified (beta/alpha)(8)-fold with a deep electronegative cleft, which upon ligand binding is capp

57 This intramolecular interaction restrains an electronegative cluster of amino acid residues near the

58 cted repetitive sequence family we define as electronegative clusters (ENCs) that contain acidic resi

59 trongest known Hg-Hg single bonds as the two electronegative CN ligands withdraw antibonding electron

60 e stable than zebularine, replacement of the electronegative CO4' oxygen for the less electronegative

61 geometry is impetus enough to make even the electronegative cobalt weaken the N-N bond of N(2).

62 by Isenman and coworkers have implicated an electronegative "concave" surface on C3d in the binding

63 Dark-adapted ERG responses showed an electronegative configuration, with b-wave reduction in

64 ectropositive platform in the ATPase and the electronegative Cu(+) chaperone.

65 hain (H95) stabilized the orientation of the electronegative cyano group of the hapten.

66 H2 helix and L1 loop of p53 interact with an electronegative domain on the N-terminal alpha-helix of

67 There were no other causes of an electronegative electroretinogram identified in any of t

68 other murine night-blindness models with an electronegative electroretinogram response, which is als

69 he preference in FCCX systems, where X is an electronegative element from Period 2, is widely exploit

70 configuration when the anomeric group is an electronegative element such as oxygen or a halogen.

71 The electronegative elements in such compounds form a polyat

72 ease in the range between the most and least electronegative elements with compression; a rearrangeme

73 Halogens are among the most electronegative elements, and the variations in size and

74 acceptor in Photosystem I (PS I) is a highly electronegative (Em = -705 mV) interpolypeptide [4Fe-4S]

75 As the electronegative entrance is widely conserved in the TolC

76 The electronegative entrance is widely conserved throughout

77 lasmic domain (CD) that provides a favorable electronegative environment for cations.

78 halogen's electron-deficient sigma-hole and electronegative equatorial band.

79 ribution of Kir2.1 channel activity in these electronegative ERG potentials.

80 An electronegative ERG was present in 4 patients (50%), but

81 oreceptor-degenerated mice (hrhoG/hrhoG), an electronegative ERG wave recorded with K+X+A, was conver

82 The Rs1h-KO functional deficit results in an electronegative ERG waveform that is characteristic of h

83 old had substantial b-wave loss and strongly electronegative ERGs; three had overt macular atrophy.

84 of benzyl azide trapping increased with more electronegative esters and/or increasingly polar solvent

85 o through a corresponding interaction of the electronegative exocyclic substituent with O5 (exo-anome

86 Direct repulsion between the electronegative exon 7-encoded residues of the heparin b

87 near the TF binding site, and (iii) a large electronegative exosite which is in a position analogous

88 In addition, electronegative features located around the A-, B-, or C

89 onferred on the acceptor centre by the small electronegative fluoride ligands compared to the heavier

90 The addition of an electronegative fluorine atom at the 2-position of dI lo

91 aligned triaxially, clustering three highly electronegative fluorine atoms in close proximity.

92 lective than F, despite the lack of strongly electronegative fluorine atoms.

93 ve Columbic interaction to exist between the electronegative fluorines of the CF(3) group and the rin

94 shape, branching, symmetry, and presence of electronegative fragments, can modulate the hepatoprotec

95 erately polarized bonding between Ba and the electronegative framework.

96 an be replaced by heteroatoms with different electronegative from that of the carbon atom (i.e., hete

97 A conserved electronegative funnel connects this region to the intra

98 brane, and propose that PelC functions as an electronegative funnel to guide the positively charged P

99 to lipoprotein interaction with these highly electronegative glycoconjugates.

100 from the N-terminal domain active site to an electronegative groove on the C-terminal domain that wou

101 placement of the H-atom in CH(4) with a less electronegative group makes the H(b)-abstraction transit

102 fect of substituting the 24 hydrogen with an electronegative group such as hydroxyl or fluorine was i

103 f a H-atom in a methane molecule with a more electronegative group tends to make the H(b)-abstraction

104 the presence of the alkyne with an attached electronegative group.

105 converted to their borohydrides by replacing electronegative groups (e.g., OR, halogen) with hydrogen

106 e substrates with electropositive groups and electronegative groups have different conformational pre

107 The overlap of this ketone with electronegative groups of other 2C9 substrates suggests

108 ing at site 1 requires substrates with three electronegative groups.

109 and (3) subsite S2 prefers nonbulky modestly electronegative groups.

110 ng of compound 3 (B/P = 1/33) with different electronegative groups.

111 ity functional theory calculations show that electronegative H(-) occupies the apical oxygen sites an

112 Less electronegative halogens such as bromine increase the ac

113 ct, which is attributed to the preference of electronegative halogens to be attached to a more highly

114 he privileged reactivity of alcohols bearing electronegative hetero- atoms (O, F, N, Cl) in the beta-

115 m polyhedron, 12 atoms of which are the more electronegative Hg.

116 data confirm a role for the highly conserved electronegative/hydrophobic residues along ACP helix alp

117 obic surface feature that interacts with the electronegative/hydrophobic residues along helix alpha2

118 A) ERG (11.0 candela.sec.m(-2)) waveform was electronegative in 62% of group A eyes and 100% of group

119 ATPase underneath the basal region also have electronegative interiors.

120 sidues of the heparin binding domain and the electronegative L1 loop found only in Nrp2 is found to s

121 Electronegative L5 LDL exhibits atherogenic properties i

122 opositive alkali elements for the former and electronegative later 2p elements for the latter, respec

123 One circulating subfraction, electronegative LDL (LDL(-)), which is increased in fami

124 ined whether it mediates EC uptake of L5, an electronegative LDL abundant in dyslipidemic but not nor

125 Electronegative LDL has been shown to be highly enriched

126 L5, a circulating electronegative LDL identified in patients with hypercho

127 Electronegative LDL may underlie downregulation of KChIP

128 ly abolishes the proapoptotic effects of the electronegative LDL on vascular endothelial cells.

129 ent binding of Hb fragments and formation of electronegative LDL particles (LDL-).

130 atic attraction between the cationic dye and electronegative LDL rather than from dye binding to amyl

131 erformance liquid chromatography analyses of electronegative LDL species, described as LDL- and LDL2-

132 E-deficient mice, and (4) pretreatment of an electronegative LDL subfraction isolated from hyperchole

133 and examined the distribution of L5-the most electronegative LDL subfraction-in total LDL (i.e. L5%).

134 Results showed that the serine of apoB100 in electronegative LDL was highly O-glycosylated, including

135 dothelial uptake of oxidized LDL (oxLDL) and electronegative LDL, contributes to the initiation, prog

136 confirm the activation of SMase activity by electronegative LDL.

137 strongly attracted to specifically arranged electronegative ligands that desolvate the ion and the R

138 cent of XeO4 : an octet of electrons to bind electronegative ligands, and no low-lying acceptor orbit

139 illary ligands and becomes stronger for more electronegative ligands.

140 Incubation of plasma electronegative low-density lipoprotein (LDL) from UNx r

141 Electronegative low-density lipoprotein (LDL) has been s

142 Our data indicate that electronegative low-density lipoprotein (LDL) shows SMas

143 L5-highly electronegative low-density lipoprotein (LDL)-is signifi

144 much larger energy difference was found for electronegative meta substituents (up to 0.66 kcal/mol f

145 Lithium, the lightest and most electronegative metallic element, has long been consider

146 Our findings indicate that a highly electronegative, mildly oxidized LDL subfraction present

147 the low-polarity pore surfaces with abundant electronegative N/O sites provide stronger multiple supr

148 Removal of CBPs conferred a greater electronegative net surface charge than that which cells

149 valence electron charge density moves toward electronegative O atoms in the intuitive charge-transfer

150 e described mechanisms by which L5, the most electronegative of 5 recognized fractions of low density

151 lements, while Ne, He, and F remain the most electronegative ones.

152 level that outward rotation is preferred for electronegative or anionic substituents while electropos

153 scribe a strategy for synthesizing a surface electronegative organic-inorganic hybrid mesoporous mate

154 Although the electronegative oxygen at the C8 position of 8-oxodG may

155 arge that increases upon coordination to the electronegative oxygen in ethanol and decreases upon des

156 sitively charged sulfonium sulfur is near an electronegative oxygen in the ribose ring is common.

157 rizontal lineO](2+) intermediate unless more electronegative (oxygen containing) ligands are introduc

158 P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*0

159 e highest potency was achieved with polar or electronegative para-substituents, whereas neutral para-

160 mensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two

161 Furthermore, mutation of a specific electronegative patch on the CopZ surface abolishes the

162 he B2-B3 segment of RRS1(WRKY) that binds an electronegative patch on the surface of AvrRps4(C) Struc

163 Insect-selective neonicotinoids have an electronegative pharmacophore (tip) in place of the ammo

164 The neonicotinoid electronegative pharmacophore is nestled in an inverted

165 d selective interaction of the neonicotinoid electronegative pharmacophore with a unique subsite of t

166 Imidacloprid and imidacloprid urea (electronegative pharmacophores) sorbed most extensively

167 2)P catalysts; however, the addition of more electronegative phosphorus atoms that withdraw a small c

168 ctropositive CcmM(S) may bind to an extended electronegative pocket between RbcL dimers.

169 t negative missense variants localized to an electronegative pocket considered critical for back-to-b

170 plexation of otherwise mobile counterions in electronegative pockets in the grooves of DNA helices in

171 tially desolvated ions that are attracted to electronegative pockets on the RNA surface.

172 ional presence of chelation sites, which are electronegative pockets that selectively bind ions of an

173 By contrast, five electronegative pockets were identified in the moderate

174 ditional basic residues binding to the other electronegative pockets.

175 ENT3 and that the size, ionization state, or electronegative polarity at these positions is crucial f

176 Conversely, enhancing the electronegative potential (B-NRP2 R287E,N290D and R287E,

177 stingly, the channel interior with excessive electronegative potential creates an energy barrier for

178 Reduction of the electronegative potential of B-NRP2 by exchanging acidic

179 Effector proteins also have considerable electronegative potential patches on their surfaces.

180 The dramatic reduction in electronegative potential resulting from this mutation d

181 sites are dictated by coordination geometry, electronegative potential, avoidance of electropositive

182 Both vestibules of the channel are strongly electronegative, providing a cation-stabilising environm

183 that helices 5, 7, 8, 10, and 11 surround an electronegative putative active site ( approximately 830

184 esults suggest that the HHR folds to form an electronegative recruiting pocket that attracts high loc

185 anes, which makes the surface of these cells electronegative relative to the surface of noncancerous

186 Each mutation replaced an electroneutral or electronegative residue with one that was positively cha

187 rophobic pattern, preference for intervening electronegative residues and inhibition by leptomycin B.

188 Removal of these electronegative residues located less than 8 A from the

189 Exon 7-encoded electronegative residues make additional interactions wi

190 firmed by site-directed mutagenesis of these electronegative residues, resulting in loss of binding o

191 ixed cone and rod dysfunction and a scotopic electronegative response to bright flashes.

192 electroretinography testing that revealed an electronegative response.

193 alue for patients and families with scotopic electronegative responses to bright flashes.

194 Full-field electroretinography revealed an electronegative Schubert-Bornschein appearance, combinin

195 n of the C-terminal domain to neutralize the electronegative site.

196 zes the C3'-endo conformation while the less electronegative SMe group stabilizes the C2'-endo confor

197 We aimed to examine whether the most electronegative subfraction of low-density lipoprotein (

198 r model, the initiating component is L5, the electronegative subfraction of low-density lipoproteins

199 ered carbohydrate rings when they contain an electronegative substituent at the C1 position of the ri

200 5, revealed an important additional internal electronegative substituent effect on 3JCC in saccharide

201 heterocyclic and imine planes, including the electronegative substituent in the trans configuration.

202 e or S,C-sulfonium ylide is stabilized by an electronegative substituent on N or C, respectively.

203 re of the alpha-heteroatom substituent, with electronegative substituents (F, OMe, Cl) favoring Cornf

204 l) favoring Cornforth structures, while less electronegative substituents (PMe(2), SMe, NMe(2)) favor

205 gioisomeric ratio = 87/13 to >95/5), whereas electronegative substituents (X = OH, OAc, F) showed a c

206 roline-pi interaction also demonstrated that electronegative substituents and the number of CH donors

207 Electronegative substituents arrayed in 1,3-relationship

208 Electronegative substituents on C-4 (that is, C(gamma))

209 relationship studies have demonstrated that electronegative substituents on the 2-phenyl portion of

210 pend not only on the relative orientation of electronegative substituents on the C1-C2 fragment but a

211 electron-poor hydrogens on one ring with the electronegative substituents on the other ring.

212 theory (DFT) calculations show that internal electronegative substituents perturb 3JCOCC Karplus curv

213 Substitution of the hydroxyl group with electronegative substituents such as fluoro, chloro, all

214 tracenes and pentacenes allow for additional electronegative substituents to induce unexpected redshi

215 Electronegative substituents with lone pairs, such as ha

216 It was found that introducing electronegative substituents, either as protecting group

217 including terminal alkynes, strained rings, electronegative substituents, or lone-pair-bearing heter

218 compound is especially important for geminal electronegative substitutents.

219 Electronegative substitution impacts the electronic prop

220 and Val-9) on the surface of prothrombin was electronegative, suggesting a role in the electrostatic

221 at the beta-sheet concavity is predominately electronegative, suggesting that the protein-protein int

222 uce C-C coupling, while isolated Cu atoms on electronegative supports cause over-polarization and com

223 CD3-delta has a more electronegative surface and a more compact Ig fold than

224 The highly electronegative surface atoms of MXene and sufficient ac

225 aled that PilA(AB5075) exhibits a distinctly electronegative surface chemistry.

226 N-terminal positive clusters and the alpha3 electronegative surface dictate the secondary structure,

227 ues in the 30-loop and 70-loop of APC and an electronegative surface of FVa.

228 to its lipidation site positions the highly electronegative surface of PelC toward the periplasm.

229 A homology model of SmgGDS highlights an electronegative surface patch and a highly conserved bin

230 Structure-informed mutagenesis reveals an electronegative surface patch in AvrRps4(C) required for

231 ove flanked on one side by an area of strong electronegative surface potential.

232 mutagenesis to investigate the roles of six electronegative surface residues of the FMN module in el

233 t of mutating nine conserved hydrophobic and electronegative surface-exposed amino acids of SigE on S

234 2(Nme) mediates its activity through a large electronegative surface.

235 en the polybasic 23-30 region and the alpha3 electronegative surface.

236 results highlight that both hydrophobic and electronegative surfaces are required for the function o

237 Structure-directed neutralization of electronegative surfaces on PsiB abrogates RecA inhibiti

238 ional (2D) electride, even though Sc is more electronegative than any metal previously found adjacent

239 14 and -584 mV, respectively, which are more electronegative than any previously studied Fds in which

240 eneration of a new C-X bond, where X is more electronegative than carbon requires an oxidation event.

241 for the hydrolytic step, despite being less electronegative than Co2+, the function of the metal ion

242 oxidized LDL and acetyl-LDL, which are more electronegative than native LDL, did not bind to either

243 2, S1, S1', S2', and S3' pockets and is more electronegative than rhizopuspepsin or endothiapepsin.

244 As X is made more electronegative, the magnitude of the apparent imbalance

245 The coplanar system between the electronegative tip and guanidine-amidine moiety extends

246 e usual neonicotinoid N-nitroimine (=NNO(2)) electronegative tip is replaced with N-nitrosoimine (=NN

247 d coplanarity and projection of the strongly electronegative tip.

248 Although carbon is too electronegative to affect the reduction of elements with

249 xygen ligands) increases electron density on electronegative transition metal ions, preventing them f

250 s determined to be -87 mV, which is the most electronegative value reported for Rd from any source.

251 S) had significantly higher plasma levels of electronegative very-low-density lipoprotein (VLDL) than

252 Our findings suggest that electronegative-VLDL levels may represent a new therapeu

253 However, the effects of electronegative-VLDL on the brain and cognitive function

254 e, and ERG recordings showed reversal of the electronegative waveform and restoration of the normal p

255 e PA103 pilin disulfide loop environment was electronegative, whereas that of strain 1244 pilin had a

256 re shows that this face of the FMN module is electronegative, whereas the complementary interacting s

257 Using a highly electronegative X is recognized as unwise, but it is not

258 ies observed for (BDI)AlX2 systems with more electronegative X(1-) ligands could be ascribed to a dec

259 epulsion between the plasma membrane and the electronegative X/Y linker.